My Research Interest in RESIST |
In our research on the cell biology of alphaherpesviruses, we analyse the interactions of viral proteins with host proteins and their relevance for pathogenesis in epithelial cells and fibroblasts of the skin, in immune cells and in neurons. For RESIST, we investigate capsid assembly and early tegumentation of alphaherpesviruses (area D2). In a phenotypic screen, we have identified several small chemical compounds that block assembly of herpes simplex virus (HSV) in the nucleus or the cytoplasm. We now characterize the viral targets of these compounds and evaluate their potential for the development of novel antiviral therapies. The most promising candidates will be validated in primary human keratinocytes and iPSC-derived neurons, and in our recently developed ex vivo and in vivo murine skin HSV-1 infections models. Furthermore, we support the characterization of the function of potential susceptibility host factors which might contribute to the development of severe HSV and VZV diseases (area A1), and which are identified by the RESIST AD cohort (Atopic dermatitis and disseminated HSV infections) and the Zoster cohort (Severe manifestations of Herpes Zoster).
Prof. Sodeik about her scientific work
Prof. Dr. Beate Sodeik – Curriculum Vitae
Current Position
Undergraduate and Postgraduate Training
Academic and Research Posts
Other Scientific Roles
Awards and Prizes

10 Selected Publications
Moschonas GD, Delhaye L, Cooreman R, Hüsers F, Bhat A, Stylianidou Z, De Bousser E, De Pryck L, Grzesik H, De Sutter D, Parthoens E, De Smet AS, Maciejczuk A, Lippens S, Callewaert N, Vandekerckhove L, Debyser Z, Sodeik B, Eyckerman S, Saelens X. MX2 forms nucleoporin-comprising cytoplasmic biomolecular condensates that lure viral capsids. Cell Host Microbe 2024; 32:1705-1724.e14.
Döhner K, Serrero MC, Viejo-Borbolla A, Sodeik B. A Hitchhiker’s Guide Through the Cell: The World According to the Capsids of Alphaherpesviruses. Annual Review Virology 2024; 11:215-238.
Zeitvogel J, Döhner K, Klug I, Richardo T, Sodeik B, Werfel T. Short-form thymic stromal lymphopoietin (sfTSLP) restricts herpes simplex virus infection of human primary keratinocytes. J Medical Virology 2024; 96(9):e29865.
Döhner K, Serrero MC, Sodeik B. The role of nuclear pores and importins for herpes simplex virus infection. Current Opinion Virology 2023; 62:101361.
Bodda C, Reinert LS, Fruhwürth S, Richardo T, Sun C, Zhang BC, Maria Kalamvoki, Anja Pohlmann P, Mogensen TH, Bergström P, Agholme L, O’Hare P, Sodeik B, Gyrd-Hansen M, Zetterberg H, & Paludan SR. HSV1 VP1-2 deubiquitinates STING to block type I interferon expression and promote brain infection. J Experimental Medicine 2020; 217: e20191422.
Döhner K*, Ramos-Nascimento A*, Bialy D*, Anderson F, Hickford-Martinez A, Rother F, Koithan T, Rudolph K, Buch A, Prank U, Binz A, Hügel S, Lebbink RJ, Hoeben RC, Hartmann E, Bader M, Bauerfeind R, Sodeik B. Importin α1 is required for nuclear import of Herpes Simplex Virus proteins and capsid assembly in fibroblasts and neurons. PLoS Pathogens 2018; 14(1):e1006823.
Buch A, Müller O, Ivanova L, Döhner K, Bialy D, Bosse JB, Pohlmann A, Binz A, Hegemann M, Nagel CH, Koltzenburg M, Viejo-Borbolla A, Rosenhahn B, Bauerfeind R, Sodeik B. Inner tegument proteins of Herpes Simplex Virus are sufficient for intracellular capsid motility but not for axonal targeting. PLoS Pathogens 2017; 13:e1006813.
Ivanova L, Buch A, Döhner K, Pohlmann A, Binz A, Prank U, Sandbaumhüter M, Bauerfeind R (corresponding), Sodeik B (corresponding). Conserved tryptophan motifs in the large tegument protein pUL36 are required for efficient secondary envelopment of herpes simplex virus capsids. J Virology 2016; 90: 5368-5383, Cover Image.
Radtke K, Kieneke D, Wolfstein A, Michael K, Steffen W, Scholz T, Karger A, Sodeik B. Plus- and minus-end directed microtubule motors bind simultaneously to herpes simplex virus capsids using different inner tegument structures. PLoS Pathogens 2010; 6: e1000991.
Roos WH (joint first), Radtke R (joint first), Kniesmeijer E, Geertsema H, Sodeik B (corresponding) & Wuite G (corresponding author). Scaffold expulsion and genome packaging trigger stabilization of Herpes Simplex Virus capsids. Proc Natl Acad Sci USA 2009; 106:9673-9678.
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