Herpes viruses can cause a number of diseases such as chickenpox, shingles, herpes encephalitis, neonatal infections and Pfeiffer’s glandular fever. They pose a serious threat to susceptible and immunocompromised individuals such as newborns, the elderly, transplant recipients and people with other immunodeficiencies or concurrent infections. For example, cytomegalovirus (HCMV) can cause severe disease in transplant recipients, and Kaposi’s Sarcoma Herpesvirus (KSHV) and Epstein-Barr virus (EBV) can cause cancer.
We aim to expand the portfolio of currently available antiviral agents. Additional inhibitors could enable new therapeutic options, thereby suppressing viral replication in persistent infections or even eliminating the infection.