Publication highlights

The publications mentioned here show particularly noteworthy current results of our excellent research.

Genomic epidemiology of Enterococcus faecium bloodstream infections during a VanB-type VRE peak reveals an oligoclonal scenario: an observational study at a German university hospital (2017-2022).

Knegendorf, L., A. Sommer, C. Baier, R. E. Weber, M. A. Fischer, G. Werner, S. Ziesing, and D. Schlüter.
J Clin Microbiol

144 Weeks of bulevirtide monotherapy for chronic hepatitis D: Final and posttreatment results from a Phase 3 randomized trial.

Wedemeyer, H., S. Aleman, A. Blank, P. Andreone, P. Bogomolov, V. Chulanov, N. Mamonova, N. Geyvandova, V. Morozov, O. Sagalova, T. Stepanova, A. Berger, S. Ciesek, A. Lichtman, D. Manuilov, R. C. Mercier, S. Arterburn, F. Christian-Cox, S. Tseng, A. Osinusi, J. Schulze Zur Wiesch, M. Cornberg, S. Zeuzem, M. R. Brunetto, and P. Lampertico.
J Hepatol

CD16(+) γδ T cells mediate antibody-dependent cellular cytotoxicity and associate with viral control in chronic hepatitis B virus infection.

Schröter, P. E., K. Steppich, L. Fernández Carrera, Z. Song, S. Klein, R. Souleiman, M. Urbanek-Quaing, A. D. Lietzau, A. Schnieders, E. Freyer, B. Bremer, X. León-Lara, V. Almeida, R. Gutierrez Jauregui, C. Von Kaisenberg, M. Bruhn, C. Meineke, U. Kalinke, H. Wedemeyer, I. Prinz, S. Ravens, A. Carpentier, Y. C. Bartsch, A. R. M. Kraft, and M. Cornberg.
Gut

The MHV-68 nuclear egress complex supports C-capsid selective capsid egress.

Sanders, S., C. Schneider, T. K. Soh, E. Kotova, D. Stalling, B. Steer, R. Reimer, Z. Ruzsics, H. Adler, and J. B. Bosse.
J Virol

Selected RESIST publications

Here you will find publications by RESIST researchers.
  1. PEG is back: revisiting the role of pegylated interferon alfa and benchmarking its place in HBV cure strategies M. Cornberg Gut 2026 Accession Number: 41494801 DOI: 10.1136/gutjnl-2025-337336
  2. Differentiation-induced reduction in functional diversity restricts the ability of cytomegalovirus-specific CD8 T cells to eliminate virus-infected cells L. Fritz, A. Hassan, L. Riemann, B. Čuvalo, B. Costa, B. Wieland, et al. EBioMedicine 2026 Vol. 123 Pages 106107 Accession Number: 41494240 DOI: 10.1016/j.ebiom.2025.106107
  3. Defining expansions and perturbations to the RNA polymerase III transcriptome and epitranscriptome by modified direct RNA nanopore sequencing R. Verstraten, P. Cetraro, A. H. Fitzpatrick, Y. Alwie, Y. N. Frommeyer, E. Loliashvili, et al. Nat Commun 2026 Vol. 17 Issue 1 Pages 143 Accession Number: 41490974 DOI: 10.1038/s41467-025-68230-1
  4. Live-Cell RNA Imaging via Clickable TriPPPro Nucleotide Reporters J. I. H. Knaack, E. List, D. Stalling, V. T. Sterrenberg, C. Meier, H. A. Wagenknecht, et al. Angew Chem Int Ed Engl 2026 Vol. 65 Issue 2 Pages e16613 Accession Number: 41310986 PMCID: PMC12790367 DOI: 10.1002/anie.202516613
  5. Commensal microflora coating endows implants with biofilm-repellent, immunomodulatory and osteogenic properties M. I. Rahim, S. Baseer, D. Paasch, M. Steglich, S. F. H. Waqas, N. Lachmann, et al. Acta Biomater 2026 Accession Number: 41519361 DOI: 10.1016/j.actbio.2026.01.017
  6. A distinct monocyte transcriptional state links systemic immune dysregulation to pulmonary impairment in long COVID S. Kumar, C. Li, L. Zhou, Q. Zhan, A. Alaswad, S. Volland, et al. Nat Immunol 2026 Accession Number: 41535626 DOI: 10.1038/s41590-025-02387-1
  7. Immune activation and response dynamics of human iPSC-derived macrophages in tuberculosis infection models D. Paasch, H. Schevel, A. Riehle, B. Costa, H. Toufaili, T. Gehnen, et al. Clin Transl Immunology 2026 Vol. 15 Issue 1 Pages e70071 Accession Number: 41541231 PMCID: PMC12800570 DOI: 10.1002/cti2.70071
  8. Toward Anti-Herpesviral PROTACs: Assessing the Challenges for Targeted Protein Degradation on the Example of Kaposi’s Sarcoma-Associated Herpesvirus Latency-Associated Nuclear Antigen A. Berwanger, S. C. Stein, S. Brandner, A. M. Kany, S. Heinz, B. Loretz, et al. ChemMedChem 2026 Vol. 21 Issue 1 Pages e202500758 Accession Number: 41252598 PMCID: PMC12811992 DOI: 10.1002/cmdc.202500758
  9. Ten-Year Follow-Up After 96 Weeks Treatment With Peginterferon Plus Tenofovir in Hepatitis D (HIDIT-II): Improved Clinical Outcome After Combination Therapy C. Yurdaydin, J. Kahlhöfer, F. A. Caruntu, K. Yalcin, S. Gürel, U. S. Akarca, et al. United European Gastroenterol J 2026 Vol. 14 Issue 1 Pages e70153 Accession Number: 41317314 PMCID: PMC12799903 DOI: 10.1002/ueg2.70153
  10. SARS-CoV-2-infected cardiomyocytes exhibit upregulated necroptosis, but no evidence of mitochondrial permeability transition C. Gross, S. Chatterjee, B. E. Nilsson-Payant, S. D. Stojanović, H. Kefalakes, C. Bär, et al. J Mol Cell Cardiol Plus 2026 Vol. 15 Pages 100833 Accession Number: 41550884 PMCID: PMC12810347 DOI: 10.1016/j.jmccpl.2025.100833
  11. S100-alarmins, antenatal corticosteroids and the risk of late-onset sepsis in preterm infants: A prospective cohort study G. Kessler, T. Ulas, T. Vogl, J. Roth, F. Albrecht, G. Hansen, et al. PLoS One 2026 Vol. 21 Issue 1 Pages e0341544 Accession Number: 41591973 DOI: 10.1371/journal.pone.0341544
  12. Functional antibody signatures following therapeutic immunization in Simian and Human immunodeficiency virus infection S. Ilan, Y. Bartsch, W. Jung, E. Kliuchnikov, V. Roy, R. Bonifer, et al. NPJ Vaccines 2026 Accession Number: 41620471 DOI: 10.1038/s41541-026-01390-3
  13. Humoral correlates of clinical response to thymectomy in myasthenia gravis C. D. F. Sousa, P. Terroba-Navajas, J. Tzartos, I. D. Orešković, M. Pučić-Baković, G. Lauc, et al. J Autoimmun 2025 Vol. 158 Pages 103517 Accession Number: 41411760 DOI: 10.1016/j.jaut.2025.103517
  14. A monocyte-derived blood transcriptomic signature reveals systemic immunosuppression in HCC and partial reversal following curative therapy L. Zhou, A. Alaswad, A. Kumthekar, D. Machtens, Y. Xi, B. Costa, et al. Front Immunol 2025 Vol. 16 Pages 1717978 Accession Number: 41646974 PMCID: PMC12867797 DOI: 10.3389/fimmu.2025.1717978
  15. Effect of gestational age on lymphocyte phenotypes in hospitalized preterm infants J. Dirks, I. Fortmann, J. Marißen, J. Pagel, L. Reichert, H. Kipke, et al. J Allergy Clin Immunol 2026 Vol. 157 Issue 2 Pages 506-516 Accession Number: 41138924 DOI: 10.1016/j.jaci.2025.09.030
  16. Letter on: ‘Impact of Frailty on the Prognosis of Patients With Liver Cirrhosis Undergoing Insertion of a TIPS’. Authors’ Reply C. Labenz, M. A. Kabelitz, S. J. Gairing, L. Sandmann and B. Maasoumy Aliment Pharmacol Ther 2026 Accession Number: 41623226 DOI: 10.1111/apt.70554
  17. Pseudopaline-mediated zinc uptake by Pseudomonas aeruginosa drives clinically relevant phenotypes and infection outcomes L. Bosc, T. Sécher, G. Ball, D. Le Pennec, M. Tribout, M. Ba, et al. Infect Immun 2026 Vol. 94 Issue 2 Pages e0045325 Accession Number: 41532760 PMCID: PMC12890022 DOI: 10.1128/iai.00453-25
  18. A comparative ex vivo evaluation of colonization resistance against multidrug-resistant Enterobacterales in fecal samples from various animal species and strategies to augment it L. Osbelt, E. Eger, T. Homeier-Bachmann, M. Schwabe, M. Wende, B. Hammerschmidt, et al. Front Microbiol 2025 Vol. 16 Pages 1695208 Accession Number: 41669693 PMCID: PMC12883652 DOI: 10.3389/fmicb.2025.1695208
  19. Autoantibodies against IFN-γ in a subgroup of patients with atopic dermatitis and a history of eczema herpeticum S. Traidl, P. Kienlin, G. Begemann, I. Klug, K. Döhner, E. Moennig, et al. J Allergy Clin Immunol 2026 Accession Number: 41677483 DOI: 10.1016/j.jaci.2026.01.010
  20. Interpreting Survival Models in Post-TIPS Hepatic Encephalopathy M. A. Kabelitz, L. Sandmann and B. Maasoumy Clin Gastroenterol Hepatol 2026 Accession Number: 41687905 DOI: 10.1016/j.cgh.2026.02.004
  21. Treatment response to bulevirtide is linked to amelioration of portal hypertension in patients with chronic hepatitis D L. Sandmann, M. Jachs, T. L. Tergast, L. Hartl, B. Bremer, M. A. Kabelitz, et al. JHEP Rep 2026 Vol. 8 Issue 1 Pages 101643 Accession Number: 41674894 PMCID: PMC12890450 DOI: 10.1016/j.jhepr.2025.101643
  22. Harnessing intermediate-scale bioreactors for next-generation macrophage production and application F. Saleh, E. E. Valdivia Malqui, I. Gensch, M. Schinke, M. Kappelhøj, E. Nikolouli, et al. Nat Protoc 2026 Accession Number: 41709011 DOI: 10.1038/s41596-025-01313-x
  23. The Submucosal Microbiome Correlates with Peri-implantitis Severity – PubMed A. A. Joshi, S. P. Szafrański, M. Steglich, I. Yang, W. Behrens, P. Schaefer-Dreyer, et al. J Dent Res 2025 Pages 220345251352809 Accession Number: 40719760 DOI: 10.1177/00220345251352809
  24. Association between specialized nutrition support and 90-day mortality relative to standard of care in malnourished adults with decompensated cirrhosis: A retrospective cohort study K. L. Hupa-Breier, L. Buttler, C. Seipt, A. Markowski, M. Griemsmann, T. L. Tergast, et al. JPEN J Parenter Enteral Nutr 2026 Accession Number: 41720466 DOI: 10.1002/jpen.70066
  25. Acsbg1 maintains intestinal immune homeostasis and controls inflammation by regulating ST2(+) Tregs M. Palatella, F. Kruse, H. Ji, A. K. Loriani Fard, M. Becker, C. Daniel, et al. Mucosal Immunol 2026 Vol. 19 Issue 1 Pages 1526-1537 Accession Number: 41151718 DOI: 10.1016/j.mucimm.2025.10.009
  26. Human cytomegalovirus strain-specific differences in protein expression of type I IFN pathway proteins do not impact virus replication K. A. Latham, T. K. Soh, R. J. Stanton, J. B. Bosse, S. Goodbourn and B. L. Strang Access Microbiol 2026 Vol. 8 Issue 2 Accession Number: 41728058 PMCID: PMC12917765 DOI: 10.1099/acmi.0.001104.v3
  27. Spatial Transcriptomics Uncovers Hybrid, Pro-Inflammatory and Pro-Fibrotic Cellular Niches in Pulmonary Granuloma of Patients with Chronic Sarcoidosis L. Christian, H. Yilmaz, J. Ruwisch, L. Giercke, B. Seeliger, J. C. Kamp, et al. Am J Respir Crit Care Med 2026 Accession Number: 41738160 DOI: 10.1093/ajrccm/aamaf089
  28. Hepatitis delta virus co-infection in patients with hepatocellular carcinoma and people living with HIV in Nigeria I. Ifeorah, B. Bremer, Y. Musa, J. Kahlhöfer, O. Oguntoye, C. Tishiya, et al. BMC Infect Dis 2026 Accession Number: 41749169 DOI: 10.1186/s12879-026-12913-7
  29. RNA Polymerase III suppresses varicella zoster virus in human neurons J. Wang, M. E. Carter-Timofte, B. Ritter, M. M. Thomsen, A. Viejo-Borbolla and T. H. Mogensen J Infect Dis 2026 Accession Number: 41739639 DOI: 10.1093/infdis/jiag117
  30. Thymic stromal lymphopoietin (TSLP) – pro-inflammatory cytokine and antimicrobial peptide K. Döhner, O. P. John and T. Werfel Biochim Biophys Acta Mol Cell Res 2026 Pages 120127 Accession Number: 41791676 DOI: 10.1016/j.bbamcr.2026.120127
  31. Phenotypic spectrum of RNU4ATAC-related spliceosomopathies: four novel cases and integrated reevaluation of previously reported patients S. Lovric, A. C. Berking, F. C. Ringshausen, J. Körholz, J. Porrmann, S. Hütter, et al. Orphanet J Rare Dis 2026 Accession Number: 41808109 DOI: 10.1186/s13023-026-04300-x
  32. Neutrophil and macrophage zonation in liver disease: from spatiotemporal dynamics to advanced computational analysis H. Kim and N. Lachmann Front Immunol 2026 Vol. 17 Pages 1767691 Accession Number: 41816345 PMCID: PMC12971471 DOI: 10.3389/fimmu.2026.1767691
  33. Human Systems Immunology in the Omics Era: Challenges, Methods, and Emerging Directions L. Riemann and R. Förster Eur J Immunol 2026 Vol. 56 Issue 3 Pages e70164 Accession Number: 41830074 PMCID: PMC12988318 DOI: 10.1002/eji.70164
  34. Quality of Life of Patients With Multi-Organ Autoimmune Disease and Its Relationship to Patient-Centered Care: Protocol for a Longitudinal Cohort Study M. Bayrhuber, C. Schlett, J. Slesaczeck, S. Herbst, G. Mueller, A. Nieters, et al. JMIR Res Protoc 2026 Vol. 15 Pages e77786 Accession Number: 41813446 PMCID: PMC12978972 DOI: 10.2196/77786
  35. Functional spectrum of γδ T cells in perinatal infectious diseases I. Lorga, X. Léon-Lara and S. Ravens Immunol Lett 2026 Vol. 280 Pages 107167 Accession Number: 41812905 DOI: 10.1016/j.imlet.2026.107167
  36. Genomic epidemiology of Enterococcus faecium bloodstream infections during a VanB-type VRE peak reveals an oligoclonal scenario: an observational study at a German university hospital (2017-2022) L. Knegendorf, A. Sommer, C. Baier, R. E. Weber, M. A. Fischer, G. Werner, et al. J Clin Microbiol 2026 Pages e0104425 Accession Number: 41848334 DOI: 10.1128/jcm.01044-25
  37. Crystal structure of the Legionella pneumophila effector SidL (Lpg0437) in complex with its metaeffector LegA11 (Lpg0436) D. A. Machtens, C. A. Hutchison, A. M. Stein, J. Eberhage, J. M. Willerding, S. Eschenburg, et al. Virulence 2026 Pages 2646775 Accession Number: 41843741 DOI: 10.1080/21505594.2026.2646775
  38. Clinical and immunological differentiation of isolated IgG and combined IgG & IgM deficiencies from common variable immunodeficiency Y. Dogru, F. Atschekzei, D. Dogru, T. Witte and G. Sogkas Front Immunol 2026 Vol. 17 Pages 1777332 Accession Number: 41869311 PMCID: PMC13002413 DOI: 10.3389/fimmu.2026.1777332
  39. A transcriptomic microglia taxonomy across mouse and human pathologies C. Chhatbar, R. Sankowski, M. Schulz, T. Shimizu, M. Schwabenland, O. Staszewski, et al. Nat Immunol 2026 Accession Number: 41882205 DOI: 10.1038/s41590-026-02472-z
  40. B cell activating factor (BAFF) levels are associated with failed remission after 12 months of treatment with benralizumab and mepolizumab in severe asthma B. C. Fischer, N. Drick, B. Liu, L. Riemann, A. Habener, D. DeLuca, et al. Respir Res 2026 Accession Number: 41928209 DOI: 10.1186/s12931-026-03500-0
  41. [Inflammatory rheumatic diseases in patients with post-COVID syndrome] N. Kippenbroek, A. Stölting, D. Schröder, M. Wetzke, C. Happle, C. Dopfer, et al. Z Rheumatol 2026 Vol. 85 Issue 3 Pages 188-199 Accession Number: 41085647 PMCID: PMC13021862 DOI: 10.1007/s00393-025-01735-8
  42. 144 Weeks of bulevirtide monotherapy for chronic hepatitis D: Final and posttreatment results from a Phase 3 randomized trial H. Wedemeyer, S. Aleman, A. Blank, P. Andreone, P. Bogomolov, V. Chulanov, et al. J Hepatol 2026 Accession Number: 41966308 DOI: 10.1016/j.jhep.2026.03.046
  43. CD16(+) γδ T cells mediate antibody-dependent cellular cytotoxicity and associate with viral control in chronic hepatitis B virus infection P. E. Schröter, K. Steppich, L. Fernández Carrera, Z. Song, S. Klein, R. Souleiman, et al. Gut 2026 Accession Number: 41986134 DOI: 10.1136/gutjnl-2025-337640
  44. The MHV-68 nuclear egress complex supports C-capsid selective capsid egress S. Sanders, C. Schneider, T. K. Soh, E. Kotova, D. Stalling, B. Steer, et al. J Virol 2026 Pages e0007226 Accession Number: 41995350 DOI: 10.1128/jvi.00072-26
  45. Interferon-related inflammaging links epigenetic age acceleration to multimorbidity Z. Liu, A. Ziogas, Y. Zhang, M. K. Gupta, K. Föhse, E. Taks, et al. Cell Genom 2026 Pages 101218 Accession Number: 41999740 DOI: 10.1016/j.xgen.2026.101218
  46. STAT3 isoform dynamics reveal robust splice ratio maintenance across cytokine-activated human immune cells N. Ott, B. Grimbacher and V. Andreani Front Immunol 2026 Vol. 17 Pages 1792173 Accession Number: 41993160 PMCID: PMC13079131 DOI: 10.3389/fimmu.2026.1792173
  47. Exploiting the immunopathogenesis of hepatitis D virus infection to develop superior immunotherapeutic treatment options R. Albarghash, C. Jacobsen and H. Kefalakes Antiviral Res 2026 Pages 106416 Accession Number: 42002101 DOI: 10.1016/j.antiviral.2026.106416
  48. Combining epigenetic therapy and immunotherapeutic avenues for chronic HBV infection Y. H. Chou and M. Cornberg Epigenomics 2026 Pages 1-3 Accession Number: 42029745 DOI: 10.1080/17501911.2026.2664392
  49. Prospective genomic and epidemiologic surveillance of Klebsiella pneumoniae in a tertiary NICU C. Böhne, C. Baier, J. Erdmann, E. Ebadi, C. Zirkler, M. Lindenberg, et al. Antimicrob Resist Infect Control 2026 Accession Number: 42046161 DOI: 10.1186/s13756-026-01753-4
  1. Repression of varicella zoster virus gene expression during quiescent infection in the absence of detectable histone deposition. Wang J, Brückner N, Weissmann S, Günther T, Zhu S, Vogt C, Sun G, Guo R, Bruno R, Ritter B, Steinbrück L, Kaufer BB, Depledge DP, Grundhoff A, Viejo-Borbolla A. PLoS Pathog. 2025 Feb 10;21(2):e1012367. doi: 10.1371/journal.ppat.1012367. Epub ahead of print. PMID: 39928684.
  2. The effect of HLA genotype on disease onset and severity in CTLA-4 insufficiency
    S. Posadas-Cantera, N. Mitsuiki, F. Emmerich, V. Patiño, H. M. Lorenz, O. Neth, et al. Front Immunol 2025 Vol. 15 Pages 1447995 Accession Number: 39835139 PMCID: PMC11744039 DOI: 10.3389/fimmu.2024.1447995
  3. Influenza Immunization in Very-Low-Birth-Weight Infants: Epidemiology and Long-Term Outcomes M. T. Dammann, H. Kraft, G. Stichtenoth, K. Hanke, M. Zemlin, J. Soler Wenglein, et al. Vaccines (Basel) 2025 Vol. 13 Issue 1 Accession Number: 39852821 PMCID: PMC11769184 DOI: 10.3390/vaccines13010042
  4. A corpus of GA4GH phenopackets: Case-level phenotyping for genomic diagnostics and discovery D. Danis, M. J. Bamshad, Y. Bridges, A. Caballero-Oteyza, P. Cacheiro, L. C. Carmody, et al. HGG Adv 2025 Vol. 6 Issue 1 Pages 100371 Accession Number: 39394689 PMCID: PMC11564936 DOI: 10.1016/j.xhgg.2024.100371
  5. Identification of optimal portal pressure decrease to control ascites while minimizing hepatic encephalopathy after TIPS: A multicenter study M. A. Kabelitz, L. Hartl, G. Schaub, A. Tiede, H. Rieland, A. Kornfehl, et al. Hepatology 2025 Accession Number: 39773850 DOI: 10.1097/hep.0000000000001219
  6. Integrative deep immune profiling of the elderly reveals systems-level signatures of aging, sex, smoking, and clinical traits L. Riemann, R. Gutierrez, I. Odak, J. Barros-Martins, L. M. Roesner, X. Leon Lara, et al. EBioMedicine 2025 Vol. 112 Pages 105558 Accession Number: 39862806 DOI: 10.1016/j.ebiom.2025.105558
  7. Comparison of clinical outcomes in patients with refractory ascites treated with either TIPS, tunneled peritoneal catheter, or ascites pump S. L. Schütte, A. Tiede, J. B. Mauz, H. Rieland, M. Kabelitz, R. Iker, et al. Hepatol Commun 2025 Vol. 9 Issue 2 Accession Number: 39813591 PMCID: PMC11737501 DOI: 10.1097/hc9.0000000000000620
  8. A clinical protocol for a German birth cohort study of the Maturation of Immunity Against respiratory viral Infections (MIAI) C. R. Hartmann, R. Khan, J. Schöning, M. Richter, M. Willers, S. Pirr, et al. Front Immunol 2024 Vol. 15 Pages 1443665 Accession Number: 39355253 PMCID: PMC11442434 DOI: 10.3389/fimmu.2024.1443665
  9. Editorial: Stopping NUCs-When to Restart NUCs for the Best Outcome? M. Urbanek-Quaing and M. Cornberg Aliment Pharmacol Ther 2025 Vol. 61 Issue 1 Pages 204-205 Accession Number: 39499186 DOI: 10.1111/apt.18370
  10. Ablation of the deubiquitinating enzyme cylindromatosis (CYLD) augments STAT1-mediated M1 macrophage polarization and fosters Staphylococcus aureus control C. Schmidt, K. Harit, S. Traidl, M. Naumann, T. Werfel, L. M. Roesner, et al. Front Immunol 2025 Vol. 16 Pages 1507989 Accession Number: 39958342 PMCID: PMC11827430 DOI: 10.3389/fimmu.2025.1507989
  11. TIGIT-expression on natural killer cell subsets is an early indicator of alleviating liver inflammation following bulevirtide treatment in chronic hepatitis D P. C. Chen, K. Deterding, S. A. Engelskircher, K. Port, L. Sandmann, A. Chakkadath, et al. Hepatology 2025 Accession Number: 39847437 DOI: 10.1097/hep.0000000000001238
  12. Phase 2 Randomised Study of Bulevirtide as Monotherapy or Combined With Peg-IFNα-2a as Treatment for Chronic Hepatitis Delta P. Lampertico, P. O. Bogomolov, V. Chulanov, T. Stepanova, V. Morozov, L. Allweiss, et al. Liver Int 2025 Vol. 45 Issue 2 Pages e70008 Accession Number: 39853842 PMCID: PMC11760647 DOI: 10.1111/liv.70008
  13. Value and Kinetics of Virological Markers in the Natural Course of Chronic Hepatitis D Virus Infection L. Sandmann, V. Ohlendorf, A. Ehrenbauer, B. Bremer, A. R. M. Kraft, M. Cornberg, et al. Liver Int 2025 Vol. 45 Issue 2 Pages e70003 Accession Number: 39846714 PMCID: PMC11756344 DOI: 10.1111/liv.70003
  14. microGWAS: a computational pipeline to perform large-scale bacterial genome-wide association studies J. Burgaya, B. F. Damaris, J. Fiebig and M. Galardini Microb Genom 2025 Vol. 11 Issue 2 Accession Number: 39932497 DOI: 10.1099/mgen.0.001349
  15. Identification and characterization of the functional tetrameric UDP-glucose pyrophosphorylase from Klebsiella pneumoniae I. Ramón Roth, P. Kats, T. Fiebig, F. Routier, R. Fedorov, L. Dirr, et al. mBio 2025 Vol. 16 Issue 2 Pages e0207124 Accession Number: 39704542 PMCID: PMC11796359 DOI: 10.1128/mbio.02071-24
  16. Highly potent quinoxalinediones inhibit α-hemolysin and ameliorate Staphylococcus aureus lung infections A. Shekhar, R. Di Lucrezia, K. Jerye, V. S. Korotkov, K. Harmrolfs, K. Rox, et al. Cell Host Microbe 2025 Accession Number: 40168998 DOI: 10.1016/j.chom.2025.03.006
  17. Combinatorial Fc modifications for complementary antibody functionality Y. C. Bartsch, N. E. Webb, E. Burgess, J. Kang, D. A. Lauffenburger and B. D. Julg MAbs 2025 Vol. 17 Issue 1 Pages 2465391 Accession Number: 39950649 PMCID: PMC11834420 DOI: 10.1080/19420862.2025.2465391
  18. Dysphoric Milk Ejection Reflex: Prevalence, persistence, and implications R. Cappenberg, J. G. Garcia, I. Liolios, C. Happle and A. Zychlinsky Scharff Eur J Obstet Gynecol Reprod Biol 2025 Vol. 308 Pages 127-131 Accession Number: 40043530 DOI: 10.1016/j.ejogrb.2025.02.051
  19. Molecular mechanisms of hotspot variants in cytoskeletal β-actin associated with Baraitser-Winter syndrome  J. N. Greve and D. J. Manstein Febs j 2025 Accession Number: 39930656 DOI: 10.1111/febs.70018
  20. Single-cell immune aging clocks reveal inter-individual heterogeneity during infection and vaccination W. Li, Z. Zhang, S. Kumar, J. Botey-Bataller, M. Zoodsma, A. Ehsani, et al. Nat Aging 2025 Accession Number: 40044970 DOI: 10.1038/s43587-025-00819-z
  21. Acsbg1 regulates differentiation and inflammatory properties of CD4+ T cells M. Palatella, F. Kruse, S. Glage, A. Bleich, M. Greweling-Pils and J. Huehn Eur J Microbiol Immunol (Bp) 2025 Accession Number: 39937199 DOI: 10.1556/1886.2025.00003
  22. Distinctive CD8(+) T cell activation by antigen-presenting plasmacytoid dendritic cells compared to conventional dendritic cells R. M. van der Sluis, J. L. García-Rodríguez, I. H. Nielsen, A. Gris-Oliver, J. Becker, B. Costa, et al. Cell Rep 2025 Vol. 44 Issue 3 Pages 115413 Accession Number: 40073016 DOI: 10.1016/j.celrep.2025.115413
  23. TIPS insertion and systemic inflammation: Is it ever too late to lower portal pressure? A. Tiede and B. Maasoumy Clin Mol Hepatol 2025 Accession Number: 39925001 DOI: 10.3350/cmh.2025.0135
  24. Broadly neutralizing antibodies isolated from HEV convalescents confer protective effects in human liver-chimeric mice G. Ssebyatika, K. Dinkelborg, L. J. Ströh, F. Hinte, L. Corneillie, L. Hueffner, et al. Nat Commun 2025 Vol. 16 Issue 1 Pages 1995 Accession Number: 40011441 DOI: 10.1038/s41467-025-57182-1
  25. Reappraisal of IgG subclass deficiencies: a retrospective comparative cohort study D. Dogru, Y. Dogru, F. Atschekzei, A. Elsayed, N. Dubrowinskaja, D. Ernst, et al. Front Immunol 2025 Vol. 16 Pages 1552513 Accession Number: 40313941 PMCID: PMC12043879 DOI: 10.3389/fimmu.2025.1552513
  26. A novel hemizygous nonsense variant in DOCK11 causes systemic inflammation and immunodeficiency A. Elsayed, S. von Hardenberg, F. Atschekzei, P. Siek, T. Witte, G. Sogkas, et al. Clin Immunol 2025 Vol. 276 Pages 110504 Accession Number: 40274249 DOI: 10.1016/j.clim.2025.110504
  27. A precision medicine approach to primary immunodeficiency disease: Ataluren strikes nonsense mutations once again L. Lentini, R. Perriera, F. Corrao, R. Melfi, M. Tutone, P. S. Carollo, et al. Mol Ther 2025 Accession Number: 40158206 DOI: 10.1016/j.ymthe.2025.03.045
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  96. A circular RNA derived from the insulin receptor locus protects against doxorubicin-induced cardiotoxicity. Lu D, Chatterjee S, Xiao K, Riedel I, Huang CK, Costa A, Cushman S, Neufeldt D, Rode L, Schmidt A, Juchem M, Leonardy J, Büchler G, Blume J, Gern OL, Kalinke U, Wen Tan WL, Foo R, Vink A, van Laake LW, van der Meer P, Bär C, Thum T.  Eur Heart J. 2022 Nov 7;43(42):4496-4511. doi: 10.1093/eurheartj/ehac337. PMID: 35758064; PMCID: PMC9637424.
  97. A CMV-induced adaptive human Vδ1+ γδ T cell clone recognizes HLA-DR. Deseke M, Rampoldi F, Sandrock I, Borst E, Böning H, Ssebyatika GL, Jürgens C, Plückebaum N, Beck M, Hassan A, Tan L, Demera A, Janssen A, Steinberger P, Koenecke C, Viejo-Borbolla A, Messerle M, Krey T, Prinz I. J Exp Med. 2022 Sep 5;219(9):e20212525. doi: 10.1084/jem.20212525. Epub 2022 Jul 19. PMID: 35852466; PMCID: PMC9301659.
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  99. Association of SARS-CoV-2 Seropositivity With Myalgic Encephalomyelitis and/or Chronic Fatigue Syndrome Among Children and Adolescents in Germany. Sorg AL, Becht S, Jank M, Armann J, von Both U, Hufnagel M, Lander F, Liese JG, Niehues T, Verjans E, Wetzke M, Stojanov S, Behrends U, Drosten C, Schroten H, von Kries R.  JAMA Netw Open. 2022 Sep 1;5(9):e2233454. doi: 10.1001/jamanetworkopen.2022.33454. PMID: 36166227; PMCID: PMC9516317.
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  102. Confirmation of Hyperimmunoglobulin E Syndrome in Two Patients with an Ocular Problem: Detection of Two New DOCK8 Mutations. Saghafi S, Zandieh F, Fazlollahi MR, Glocker C, Frede N, Buchta M, Yang L, Mahmoudi AH, Houshmand M, Pourpak Z, Grimbacher B, Moin M.  Iran J Allergy Asthma Immunol. 2022 Jun 18;21(3):355-363. doi: 10.18502/ijaai.v21i3.9809. PMID: 35822685.
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  104. Detrimental NFKB1 missense variants affecting the Rel-homology domain of p105/p50. Fliegauf M, Kinnunen M, Posadas-Cantera S, Camacho-Ordonez N, Abolhassani H, Alsina L, Atschekzei F, Bogaert DJ, Burns SO, Church JA, Dückers G, Freeman AF, Hammarström L, Hanitsch LG, Kerre T, Kobbe R, Sharapova SO, Siepermann K, Speckmann C, Steiner S, Verma N, Walter JE, Westermann-Clark E, Goldacker S, Warnatz K, Varjosalo M, Grimbacher B.  Front Immunol. 2022 Aug 29;13:965326. doi: 10.3389/fimmu.2022.965326. PMID: 36105815; PMCID: PMC9465457.
  105. Entwicklungsansätze für Impfstoffe gegen Hepatitis-C-Virus-Infektionen [Development approaches for vaccines against hepatitis C virus infections]. Bankwitz D, Krey T, Pietschmann T.  Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz. 2022 Feb;65(2):183-191. German. doi: 10.1007/s00103-021-03477-9. Epub 2022 Jan 11. PMID: 35015104; PMCID: PMC8749110.
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  107. Effects of Pre-Existing Mental Conditions on Fatigue and Psychological Symptoms Post-COVID-19. Homann S, Mikuteit M, Niewolik J, Behrens GMN, Stölting A, Müller F, Schröder D, Heinemann S, Müllenmeister C, El-Sayed I, Happle C, Steffens S, Dopfer-Jablonka A. Int J Environ Res Public Health. 2022 Aug 11;19(16):9924. doi: 10.3390/ijerph19169924. PMID: 36011559; PMCID: PMC9408008.
  108. Efficacy of dupilumab for the treatment of severe skin disease in cytotoxic T lymphocyte antigen-4 insufficiency: A role of type 2 inflammation? Arruda LK, Cordeiro DL, Langer SS, Koenigham-Santos M, Calado RT, Dias MM, Anhesini LR, Oliveira JB, Grimbacher B, Ferriani MPL.  J Allergy Clin Immunol Glob. 2022 Sep 22;2(1):114-117. doi: 10.1016/j.jacig.2022.08.004. PMID: 37780100; PMCID: PMC10509893.
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  111. HBcrAg Levels Are Associated With Virological Response to Treatment With Interferon in Patients With Hepatitis Delta. Sandmann L, Yurdaydin C, Deterding K, Heidrich B, Hardtke S, Lehmann P, Bremer B, Manns MP, Cornberg M, Wedemeyer H, Maasoumy B; HIDIT‐II Study Group.  Hepatol Commun. 2022 Mar;6(3):480-495. doi: 10.1002/hep4.1821. Epub 2021 Sep 24. PMID: 34561972; PMCID: PMC8870014.
  112. Human Cytomegalovirus pUL11, a CD45 Ligand, Disrupts CD4 T Cell Control of Viral Spread in Epithelial Cells. Osanyinlusi SA, Zischke J, Jacobs R, Weissinger EM, Schulz TF, Kay-Fedorov PC. HmBio. 2022 Dec 20;13(6):e0294622. doi: 10.1128/mbio.02946-22. Epub 2022 Nov 29. PMID: 36445084; PMCID: PMC9765415.
  113. It’s All in the Mix: A New Interprofessional, Blended-Learning Masters’ Program for Biomedical Data Science Addressing Physicians and Students from Life Sciences – Didactic Concept and First Experiences AuthorsMichael Marschollek, Melina Celik, Marianne Behrends, Thomas Friedrich SchulzPages56 – 60DOI10.3233/SHTI220907CategoryResearch Article Series Studies in Health Technology and Informatics Ebook Volume 298: Digital Professionalism in Health and Care: Developing the Workforce, Building the Future
  114. Low Serum Cholinesterase Identifies Patients With Worse Outcome and Increased Mortality After TIPS. Stockhoff L, Muellner-Bucsics T, Markova AA, Schultalbers M, Keimburg SA, Tergast TL, Hinrichs JB, Simon N, Gerbel S, Manns MP, Mandorfer M, Cornberg M, Meyer BC, Wedemeyer H, Reiberger T, Maasoumy B. Hepatol Commun. 2022 Mar;6(3):621-632. doi: 10.1002/hep4.1829. Epub 2021 Sep 28. PMID: 34585537; PMCID: PMC8870033.
  115. Lymph node stromal cells support the maturation of pre-DCs into cDC-like cells via colony-stimulating factor 1. Wiechers C, Pezoldt J, Beckstette M, Berner J, Schraml BU, Huehn J.  Immunology. 2022 Aug;166(4):475-491. doi: 10.1111/imm.13497. Epub 2022 Jun 2. PMID: 35569092.
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  117. Multi-omics analysis of naïve B cells of patients harboring the C104R mutation in TACI. Ramirez N, Posadas-Cantera S, Langer N, de Oteyza ACG, Proietti M, Keller B, Zhao F, Gernedl V, Pecoraro M, Eibel H, Warnatz K, Ballestar E, Geiger R, Bossen C, Grimbacher B. Front Immunol. 2022 Aug 16;13:938240. doi: 10.3389/fimmu.2022.938240. PMID: 36072607; PMCID: PMC9443529.
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  119. Phenotype, genotype, treatment, and survival outcomes in patients with X-linked inhibitor of apoptosis deficiency. Yang L, Booth C, Speckmann C, Seidel MG, Worth AJJ, Kindle G, Lankester AC, Grimbacher B; ESID Clinical and Registry Working Parties; Gennery AR, Seppanen MRJ, Morris EC, Burns SO.  J Allergy Clin Immunol. 2022 Aug;150(2):456-466. doi: 10.1016/j.jaci.2021.10.037. Epub 2021 Dec 15. PMID: 34920033.
  120. pUL36 Deubiquitinase Activity Augments Both the Initiation and the Progression of Lytic Herpes Simplex Virus Infection in IFN-Primed Cells. Mohnke J, Stark I, Fischer M, Fischer PM, Schlosser A, Grothey A, O’Hare P, Sodeik B, Erhard F, Dölken L, Hennig T.  J Virol. 2022 Nov 23;96(22):e0096322. doi: 10.1128/jvi.00963-22. Epub 2022 Oct 31. PMID: 36314822; PMCID: PMC9683058.
  121. Resolving the polygenic aetiology of a late onset combined immune deficiency caused by NFKB1 haploinsufficiency and modified by PIK3R1 and TNFRSF13B variants. Hargreaves CE, Dhalla F, Patel AM, de Oteyza ACG, Bateman E, Miller J, Anzilotti C, Ayers L, Grimbacher B, Patel SY.  Clin Immunol. 2022 Jan;234:108910. doi: 10.1016/j.clim.2021.108910. Epub 2021 Dec 15. PMID: 34922003.
  122. SARS-CoV-2 Viral Load in the Pulmonary Compartment of Critically Ill COVID-19 Patients Correlates with Viral Serum Load and Fatal Outcomes. Ynga-Durand M, Maaß H, Milošević M, Krstanović F, Pribanić Matešić M, Jonjić S, Protić A, Brizić I, Šustić A, Čičin-Šain L.  Viruses. 2022 Jun 14;14(6):1292. doi: 10.3390/v14061292. PMID: 35746764; PMCID: PMC9228931.
  123. The First 4 Years – Outcome of Children Identified by Newborn Screening for CF in Germany. Schütz K, Kontsendorn J, Janzen N, Fuge J, Grewendorf S, Klemann C, Happle C, Junge S, Rudolf I, Dopfer C, Sedlacek L, Renz D, Hansen G, Dittrich AM. Klin Padiatr. 2022 Sep;234(5):284-292. English. doi: 10.1055/a-1700-5105. Epub 2022 Jan 28. PMID: 35098497.
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  125. Baseline Cellular Antiviral State Is Maintained by cGAS and Its Most Frequent Naturally Occurring Variant rs610913. Kazmierski J, Elsner C, Döhner K, Xu S, Ducroux A, Pott F, Jansen J, Thorball CW, Zeymer O, Zhou X, Fedorov R, Fellay J, Löffler MW, Weber ANR, Sodeik B, Goffinet C. A  J Immunol. 2022 Aug 1;209(3):535-547. doi: 10.4049/jimmunol.2100685. PMID: 35851540.
  126. The membrane-active polyaminoisoprenyl compound NV716 re-sensitizes Pseudomonas aeruginosa to antibiotics and reduces bacterial virulence. Wang G, Brunel JM, Preusse M, Mozaheb N, Willger SD, Larrouy-Maumus G, Baatsen P, Häussler S, Bolla JM, Van Bambeke F. Commun Biol. 2022 Aug 25;5(1):871. doi: 10.1038/s42003-022-03836-5. PMID: 36008485; PMCID: PMC9411590.
  127. NK cell dysfunction in severe COVID-19: TGF-β-induced downregulation of integrin beta-2 restricts NK cell cytotoxicity. Barros-Martins J, Förster R, Bošnjak B.  Signal Transduct Target Ther. 2022 Jan 31;7(1):32. doi: 10.1038/s41392-022-00892-5. PMID: 35102142; PMCID: PMC8801552.
  128. Atopic Eczema: Pathophysiological Findings as the Beginning of a New Era of Therapeutic Options. Traidl S, Werfel T, Traidl-Hoffmann C. Handb Exp Pharmacol. 2022;268:101-115. doi: 10.1007/164_2021_492. PMID: 34236520.
  129. Differential interferon-α subtype induced immune signatures are associated with suppression of SARS-CoV-2 infection. Schuhenn J, Meister TL, Todt D, Bracht T, Schork K, Billaud JN, Elsner C, Heinen N, Karakoese Z, Haid S, Kumar S, Brunotte L, Eisenacher M, Di Y, Lew J, Falzarano D, Chen J, Yuan Z, Pietschmann T, Wiegmann B, Uebner H, Taube C, Le-Trilling VTK, Trilling M, Krawczyk A, Ludwig S, Sitek B, Steinmann E, Dittmer U, Lavender KJ, Sutter K, Pfaender S.  Proc Natl Acad Sci U S A. 2022 Feb 22;119(8):e2111600119. doi: 10.1073/pnas.2111600119. PMID: 35131898; PMCID: PMC8872780.
  130. Editorial: Neuronal and Glial Alterations Caused by Viral Infections. Hernáez B, Viejo-Borbolla A, Cabrera JR.  Front Cell Neurosci. 2022 Apr 5;16:883221. doi: 10.3389/fncel.2022.883221. PMID: 35450209; PMCID: PMC9016110.
  131. Interventional Bronchus Occlusion Using Amplatzer Devices – A Promising Treatment Option for Children with Persistent Air Leak. Schütz K, Happel CM, Keil O, Dingemann J, Carlens J, Wetzke M, Müller C, Köditz H, Griese M, Reiter K, Schweiger-Kabesch A, Backendorf A, Scharff A, Bertram H, Schwerk N.  Klin Padiatr. 2022 Sep;234(5):293-300. English. doi: 10.1055/a-1697-5624. Epub 2022 Jan 3. PMID: 34979579.
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  133. Therapeutic targeting of endoplasmic reticulum stress in acute graft-versus-host disease. Haring E, Andrieux G, Uhl FM, Krausz M, Proietti M, Sauer B, Esser PR, Martin SF, Pfeifer D, Schmitt-Graeff A, Duyster J, Köhler N, Grimbacher B, Boerries M, Aumann K, Zeiser R, Apostolova P.  Haematologica. 2022 Jul 1;107(7):1538-1554. PMID: 34407601; PMCID: PMC9244832.
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  8. Bile acids regulate intestinal antigen presentation and reduce graft-versus-host disease without impairing the graft-versus-leukemia effect. Haematologica. Haring E, Uhl FM, Andrieux G, Proietti M, Bulashevska A, Sauer B, Braun LM, de Vega Gomez E, Esser PR, Martin SF, Pfeifer D, Follo M, Schmitt-Graeff A, Buescher J, Duyster J, Grimbacher B, Boerries M, Pearce EL, Zeiser R, Apostolova P. 2021 Aug 1;106(8):2131-2146. doi: 10.3324/haematol.2019.242990. PMID: 32675222; PMCID: PMC8327708.
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  20. Tbx21 and Foxp3 Are Epigenetically Stabilized in T-Bet+ Tregs That Transiently Accumulate in Influenza A Virus-Infected Lungs. Elfaki Y, Yang J, Boehme J, Schultz K, Bruder D, Falk CS, Huehn J, Floess S. Int J Mol Sci. 2021 Jul 14;22(14):7522. doi: 10.3390/ijms22147522. PMID: 34299148 Free PMC article.
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  27. A rare case of neuro- and otosyphilis in secondary syphilis. Traidl S, Angela Y, Stender A, Kulberg A, Tronnier M, Prenzler NK, Wattjes MP, Kapp A, Stangel M, Schacht V, Werfel T. J Eur Acad Dermatol Venereol. 2021 Jul 9. doi: 10.1111/jdv.17512. Online ahead of print. PMID: 34242450 No abstract available.
  28. Atopic Eczema: Pathophysiological Findings as the Beginning of a New Era of Therapeutic Options. Traidl S, Werfel T, Traidl-Hoffmann C. Handb Exp Pharmacol. 2021 Jul 9. doi: 10.1007/164_2021_492. Online ahead of print. PMID: 34236520
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  33. Free human DNA attenuates the activity of antimicrobial peptides in atopic dermatitis. Kopfnagel V, Dreyer S, Zeitvogel J, Pieper DH, Buch A, Sodeik B, Rademacher F, Harder J, Werfel T. Allergy. 2021 Jun 27. doi: 10.1111/all.14992. Online ahead of print. PMID: 34176149
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  62. A Novel Triple-Fluorescent HCMV Strain Reveals Gene Expression Dynamics and Anti-Herpesviral Drug Mechanisms. Rand U, Kubsch T, Kasmapour B, Cicin-Sain L. Front Cell Infect Microbiol. 2021 Jan 8;10:536150. doi: 10.3389/fcimb.2020.536150. eCollection 2020. PMID: 33489928 Free PMC article.
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