This can be crucial for furvival of some individuals infected by the cold virus RSV. For example, RSV can cause severe to life-threatening respiratory infections in young children.
Varicella zoster and herpes simplex viruses may also cause serious diseases, such as shingles or encephalitis.
RESIST will also explore the genetic causes of severe congenital immune deficiencies. In many cases, it remains unclear which genetic defects cause these deficiencies and why the immune system does not respond effectively. Bacteria and fungi are for example able to cause severe infection in people with a genetically determined susceptibility to infection.