Prof. Dr. Kay Grünewald participates in RESIST research projects D1 and D2.
| My Research Interest in RESIST |
Our research focus in RESIST is the structural characterisation of stages in the herpesvirus assembly pathway. For this, we use cellular electron cryo microscopy and tomography guided by advanced light microscopy techniques. Studying processes directly inside the infected cell will significantly advance the field as the current understanding of early steps was mainly derived from in vitro studies of isolated particles or bulk assays. Capturing metastable assembly intermediates will allow for novel mechanistic insights. Together with other researchers in RESIST the long-term aim is to contribute to new interventions for herpesviral diseases and improving the options for combination therapies that utilize drugs acting at different stages of the viral life cycle.
Prof. Grünewald about his scientific work
Prof. Dr. Kay Grünewald – Curriculum Vitae
Current Position
Undergraduate and Postgraduate Training
Academic and Research Posts
Other Scientific Roles
Awards and Prizes
10 Selected Publications (of > 74 original publications)
Hernández-Durán A, Greco TM, Vollmer B, Cristea IM, Grünewald K, Topf M. (2019) Protein interactions and consensus clustering analysis uncover insights into herpesvirus virion structure and function relationships, PLoS Biology 17(6): e3000316.
Moser F, Pražák V, Mordhorst V, Andrade DM, Baker LA, Hagen C, Grünewald K, Kaufmann R. (2019) Cryo-SOFI enabling low-dose super-resolution correlative light and electron cryo-microscopy. Proc Natl Acad Sci U S A. 116(11): 4804-4809.
Chorev, DS, Baker LA, Wu D, Beilsten-Edmands V, Rouse SL, Zeev-Ben-Mordehai T, Jiko C, Samsudin F, Gerle C, Khalid S, Stewart AG, Matthews SJ, Grünewald K, Robinson CV. (2018) Protein assemblies ejected directly from native membranes yield complexes for mass spectrometry. Science 362: 829–834.
Zeev-Ben-Mordehai T, Vasishtan D, Hernández Durán A, Vollmer B, White P, Prasad Pandurangan A, Siebert CA Topf M, Grünewald K. (2016) Two distinct trimeric conformations of natively membrane-anchored full-length Herpes simplex virus 1 glycoprotein B. Proc Natl Acad Sci U S A. 113, 4176-81.
Hagen C, Dent KC, Zeev-Ben-Mordehai T, Grange M, Bosse JB, Whittle C, Klupp BG, Siebert CA, Vasishtan D, Bäuerlein FJB, Cheleski J, Werner S, Guttmann P, Rehbein S, Henzler K, Demmerle J, Adler B, Koszinowski U, Schermelleh L, Schneider G, Enquist LW, Plitzko JM, Mettenleiter TC, Grünewald K. (2015) Structural Basis of Vesicle Formation at the Inner Nuclear Membrane. Cell 163, 1692–1701.
Kaufmann R, Schellenberger P, Seiradake E, Dobbie IM, Jones EY, Davis I, Hagen C, Grünewald K. (2014) Super-Resolution Microscopy Using Standard Fluorescent Proteins in Intact Cells under Cryo-Conditions. Nano Letters 4, 4171-4175.
Ibiricu I, Huiskonen JT, Döhner K, Bradke F, Sodeik B, Grünewald K. (2011) Cryo Electron Tomography of Herpes Simplex Virus during Axonal Transport and Secondary Envelopment in Primary Neurons. PLoS Pathog. 7: e1002406.
Maurer, UE, Sodeik B, Grünewald K. (2008) Intermediates of membrane fusion in herpesvirus entry captured by cryo electron tomography. Proc Natl Acad Sci U S A. 105(30): 10559-10564.
Schelhaas M, Pelkmans L, Malmström J, Aebersold R, Haugstetter J, Ellgaard L, Grünewald K, Helenius A. (2007) Simian Virus 40 depends on ER protein folding and quality control factors for entry into host cells. Cell 131: 516-529.
Grünewald K, Desai P, Winkler DC, Heymann JB, Belnap DM, Baumeister W, Steven AC. (2003) Three-dimensional structure of Herpes simplex virus from cryo-electron tomography, Science 302: 1396-1398.
