Prof. Dr. Susanne Häußler participates in RESIST research projects C1 and C2.
| My Research Interest in RESIST |
Our research focus in RESIST is the study of molecular mechanisms that determine Pseudomonas aeruginosa adaptation to chronic states of infections, and of antibiotic tolerance under biofilm growth conditions. Our work is committed to develop innovative diagnostics and to strive for therapeutic solutions in patients suffering from infections due to multi-drug resistant pathogens as well as therapy refractory biofilm-associated infections.
The core of our approach are genome-wide association studies on large sequence variation (DNA-sequencing) and gene expression (RNA-sequencing) datasets that are associated with phenotypic data such as resistance profiles, information on biofilm structures, pathogenicity and motility traits of the individual isolates. The combination of basic research, technology-driven approaches and data-driven science holds promise to become the basis for the development of a molecular antimicrobial resistance/biofilm tolerance test system.
In the laboratory of Prof. Häußler
Prof. Dr. Susanne Häußler – Curriculum Vitae
Current Position
Undergraduate and Postgraduate Training
Academic and Research Posts
Other Scientific Roles
Awards and Prizes
10 Selected Publications
Arce-Rodríguez A, Pankratz D, Preusse M, Nikel PI, Häussler S. (2022) Dual Effect: High NADH Levels Contribute to Efflux-Mediated Antibiotic Resistance but Drive Lethality Mediated by Reactive Oxygen Species. mBio. 2022 Jan 18;13(1):e0243421. doi: 10.1128/mbio.02434-21.
Jeske A, Arce-Rodriguez A, Thöming JG, Tomasch J, Häussler S. (2022) Evolution of biofilm-adapted gene expression profiles in lasR-deficient clinical Pseudomonas aeruginosa isolates. NPJ Biofilms Microbiomes. 14;8(1):6. doi: 10.1038/s41522-022-00268-1.
Grekov I, Thöming GJ, Kordes A, Häussler S (2021) Evolution of Pseudomonas aeruginosa towards higher fitness under standard laboratory conditions. ISME J.;15(4):1165-1177. doi: 10.1038/s41396-020-00841-6.
Donnert M, Elsheikh S, Arce Rodriguez A, Pawar V, Braubach P, Jonigk D, Haverich A, Weiss S, Müsken M, Häussler S. (2020) Targeting bioenergetics is key to counteracting the drug-tolerant state of biofilm-grown bacteria. PLoS Pathogens, 22; 16(12):e1009126. doi: 10.1371
Felgner S, Preusse M, Beutling U, Stahnke S, Pawar V, Rohde M, Brönstrup M, Stradal T, Häussler S. (2020) Host-induced spermidine production in motile Pseudomonas aeruginosa triggers phagocytic uptake. Elife. doi: 10.7554/eLife.55744.
Thöming JG, Tomasch J, Preusse M, Koska M, Grahl N, Pohl S, Willger SD, Kaever V, Müsken M, Häussler S (2020) Parallel evolutionary paths to produce more than one Pseudomonas aeruginosa biofilm phenotype. NPJ Biofilms Microbiomes. doi: 10.1038/s41522-019-0113-6. eCollection 2020.
Khaledi A, Weimann A, Schniederjans M, Asgari E, Kuo TH, Oliver A, Cabot G, Kola A, Gastmeier P, Hogardt M, Jonas D, Mofrad MR, Bremges A, McHardy AC, Häussler S. Predicting antimicrobial resistance in Pseudomonas aeruginosa with machine learning-enabled molecular diagnostics. EMBO Mol Med. 2020 Mar 6;12(3):e10264. doi: 10.15252/emmm.201910264.
Kordes A, Preusse M, Willger SD, Braubach P, Jonigk D, Haverich A, Warnecke G, Häussler S. Genetically diverse Pseudomonas aeruginosa populations display similar transcriptomic profiles in a cystic fibrosis explanted lung. Nat Commun. 2019 Jul 30;10(1):3397. doi: 10.1038/s41467-019-11414-3.
Hornischer K, Khaledi A, Pohl S, Schniederjans M, Pezoldt L, Casilag F, Muthukumarasamy U, Bruchmann S, Thöming J, Kordes A, Häussler S. (2018) BACTOME-a reference database to explore the sequence- and gene expression-variation landscape of Pseudomonas aeruginosa clinical isolates. Nucleic Acids Res. doi: 10.1093/nar/gky895.
