Prof. Dr. Jochen Hühn participates in RESIST research projects A3 and B1.

My Research Interest in RESIST

Within RESIST we study the impact of microbiota during the neonatal period on the development, maturation and functional specialization of the gastrointestinal and systemic immune system, which is determining the individual’s immune status and susceptibility towards infectious diseases long- lastingly. Although it is widely accepted that microbiota are critically involved in this process, a detailed understanding of the involved microbial communities and microbiota-derived metabolites is still lacking.

Our research programme is based on our recent finding that early-life colonization by microbiota results in an epigenetic imprinting of unique functional properties within the gastrointestinal immune system and that neonatal infections can interfere with this process. Our long-term goal is to contribute to the development of therapeutic strategies based on early-life microbiome editing leading to a better development, maturation and functional specialization of the gastrointestinal and systemic immune system, thereby improving the health status of individuals long-lastingly.

Contact

Prof. Hühn about his scientific work

Prof. Dr. Jochen Hühn – Curriculum Vitae

Current Position

  • Since 2008 Full (W3) Professor of Experimental Immunology, MHH and Head of Department Experimental Immunology, HZI

Undergraduate and Postgraduate Training

  • 1991 – 1996 Study of Biochemistry/Molecular Biology, University of Hamburg

  • 1996 Diploma, Bernhard Nocht Institute for Tropical Medicine (BNI), Hamburg

  • 1996 – 1999 Dissertation at BNI, Hamburg

  • 1999 Dr. rer. nat. (PhD)

  • 2000 Postdoctoral fellow at BNI, Hamburg

  • 2000 – 2006 Postdoctoral fellow “Experimental Rheumatology”, Charité University Medicine, Berlin

Academic and Research Posts

  • 2006 – 2008 Junior Professor for Immune Regulation, Charité University Medicine, Berlin

  • Since 2008 Full (W3) Professor of Experimental Immunology, MHH and Head of Department Experimental Immunology, HZI

Other Scientific Roles

  • Since 2007 Organizer of annual German Meeting on Immune Regulation

  • Since 2010 Board member, DFG Collaborative Research Centre 854

  • 2011 – 2019 Board member, DFG Collaborative Research Centre 738

  • Since 2012 Organizer of annual European Midwinter Workshop on Immunology

  • Since 2013 Member of Editorial Board of “Immunity, Inflammation and Disease”

  • Since 2014 Advisory Board Member of the German Society of Immunology (DGfI)

  • 2015 – 2019 Coordinator of EU-funded Innovative Training Network “ENLIGHT-TEN”

  • 2017 Co-initiator of EFIS Study Group “T cell connect Europe”

  • 2020 Coordinator of EU-funded Innovative Training Network „ENLIGHT-TEN+“

Awards and Prizes

  • 2002 Avrion Mitchison Award for Rheumatism Research

  • 2007 Wolfgang Schulze Award for Rheumatism Research

  • 2007 Langener Science Award

Recommended Links

For further information about Prof. Hühn’s scientific work please check the following links:

10 Selected Publications

Pezoldt J, Pasztoi M, Zou M, Wiechers C, Beckstette M, Thierry GH, Vafadarnejad E, Floess S, Arampatzi P, Buettner M, Schweer J, Fleissner D, Vital M, Pieper DH, Basic M, Dersch P, Strowig T, Hornef M, Bleich A, Bode U, Pabst O, Bajenoff M, Saliba AE, Huehn J. Neonatally imprinted stromal cell subsets induce tolerogenic dendritic cells in mesenteric lymph nodes. Nat Commun. 2018; 9:3903

Pezoldt J*, Pisano F*, Heine W, Pasztoi M, Rosenheinrich M, Nuss AM, Pils MC, Prinz I, Förster R, Huehn J*, Dersch P*. CCR7 deficiency modulates T cell response and increases susceptibility to Yersinia pseudotuberculosis infection. J Infec Dis. 2017; 216:752-760. *equal contribution

Yang BH*, Hagemann S*, Mamareli P, Lauer U, Hoffmann U, Beckstette M, Föhse L, Prinz I, Pezoldt J, Suerbaum S, Sparwasser T, Hamann A, Floess S, Huehn J*, Lochner M*. Foxp3+ T cells expressing RORt represent a stable regulatory T cell effector lineage with enhanced suppressive capacity during intestinal inflammation. Mucosal Immunol. 2016; 9:444-457. *equal contribution

Yang BH, Floess S, Hagemann S, Deyneko IV, Groebe L, Pezoldt J, Sparwasser T, Lochner M, Huehn J. Imprinting of a unique epigenetic signature during in vivo Th17 differentiation. Nucleic Acids Res. 2015; 43:1537-1548.

Cording S*, Wahl B*, Kulkarni D, Chopra H, Pezoldt J, Buettner M, Dummer A, Hadis U, Heimesaat M, Bereswill S, Falk C, Bode U, Hamann A, Fleissner D, Huehn J*, and Pabst O*. The intestinal micro-environment imprints stromal cells to promote efficient Treg induction in gut-draining lymph nodes. Mucosal Immunol. 2014; 7:359-368. *equal contribution

Toker A, Engelbert D, Garg G, Polansky JK, Floess S, Miyao T, Baron U, Düber S, Geffers G, Giehr P, Schallenberg S, Kretschmer K, Olek S, Walter J, Weiss S, Hori S, Hamann A, Huehn J. Active demethylation of the Foxp3 locus leads to the generation of stable regulatory T cells within the thymus. J Immunol. 2013; 190:3180-3188.

Miyao T, Floess S, Setoguchi R, Luche H, Fehling HJ, Waldmann H, Huehn J, and Hori S. Plasticity of Foxp3+ T cells reflects promiscuous Foxp3 expression in conventional T cells but not reprogramming of regulatory T cells. Immunity 2012; 36:262-275.

Lahl K, Loddenkemper C, Drouin C, Freyer J, Arnason J, Eberl G, Hamann A, Wagner H, Huehn J*, Sparwasser T*. Selective depletion of Foxp3+ regulatory T cells induces a scurfy-like disease. J Exp Med. 2007; 204:57-63. *equal contribution

Floess S, Freyer J, Siewert C, Baron U, Olek S, Polansky J, Schlawe K, Chang HD, Bopp T, Schmitt E, Klein- Hessling S, Serfling E, Hamann A, Huehn J. Epigenetic control of the foxp3 locus in regulatory T cells. PLoS Biol. 2007; 5:e38.

Huehn J*, Siegmund K*, Lehmann JC, Siewert C, Haubold U, Feuerer M, Debes GF, Lauber J, Frey O, Przybylski GK, Niesner U, de la Rosa M, Schmidt CA, Brauer R, Buer J, Scheffold A, Hamann A. Developmental stage, phenotype, and migration distinguish naive- and effector/memory-like CD4+ regulatory T cells. J Exp Med. 2004; 199:303-313. *equal contribution

Contact

  Prof. Dr. Jochen Hühn
  „Experimental Immunology“,
Helmholtz Centre for Infection Research (HZI)
  Inhoffenstraße 7
38124 Braunschweig
  +49 531 6181-3310
  Jochen.Huehn
@helmholtz-hzi.de