Prof. Dr. Jochen Hühn participates in RESIST research projects A3 and B1.
| My Research Interest in RESIST |
Within RESIST we study the impact of microbiota during the neonatal period on the development, maturation and functional specialization of the gastrointestinal and systemic immune system, which is determining the individual’s immune status and susceptibility towards infectious diseases long- lastingly. Although it is widely accepted that microbiota are critically involved in this process, a detailed understanding of the involved microbial communities and microbiota-derived metabolites is still lacking.
Our research programme is based on our recent finding that early-life colonization by microbiota results in an epigenetic imprinting of unique functional properties within the gastrointestinal immune system and that neonatal infections can interfere with this process. Our long-term goal is to contribute to the development of therapeutic strategies based on early-life microbiome editing leading to a better development, maturation and functional specialization of the gastrointestinal and systemic immune system, thereby improving the health status of individuals long-lastingly.
Prof. Hühn about his scientific work
Prof. Dr. Jochen Hühn – Curriculum Vitae
Current Position
Undergraduate and Postgraduate Training
Academic and Research Posts
Other Scientific Roles
Awards and Prizes
10 Selected Publications
Zou M, Pezoldt J, Mohr J, Philipsen L, Leufgen A, Cerovic V, Wiechers C, Pils M, Ortiz D, Hao L, Yang J, Beckstette M, Dupont A, Hornef M, Dersch P, Strowig T, Müller AJ, Raila J, Huehn J. Early-life vitamin A treatment rescues neonatal infection-induced durably impaired tolerogenic properties of celiac lymph nodes. Cell Rep. 2024 May 28;43(5):114153. Epub 2024 Apr 29.
Pezoldt, J.*, Wiechers, C.*, Zou, M., Litovchenko, M., Biocanin, M., Beckstette, M., Sitnik, K., Palatella, M., van Mierlo, G., Chen, W., Gardeux, V., Floess, S., Ebel, M., Russeil, J., Arampatzi, P., Vafardanejad, E., Saliba, A.E., Deplancke, B., and Huehn, J. (2022). Postnatal expansion of mesenteric lymph node stromal cells towards reticular and CD34+ stromal cell subsets. Nat Commun 13, 7227. PMID: 36433946 Open Access
Nikolouli, E., Elfaki, Y., Herppich, S., Schelmbauer, C., Delacher, M., Falk, C., Mufazalov, I.A., Waisman, A., Feuerer, M., and Huehn, J. (2021). Recirculating IL 1R2+ Tregs fine-tune intrathymic Treg development under inflammatory conditions. Cell Mol Immunol 18, 182-193. PMID: 31988493
Wiechers, C., Zou, M., Galvez, E., Beckstette, M., Ebel, M., Strowig, T., Huehn, J., and Pezoldt, J. (2021). The microbiota is dispensable for the early stages of peripheral regulatory T cell induction within mesenteric lymph nodes. Cell Mol Immunol 18, 1211-1221. PMID: 33762684 Open Access
Pezoldt, J., Pasztoi, M., Zou, M., Wiechers, C., Beckstette, M., Thierry, G.R., Vafadarnejad, E., Floess, S., Arampatzi, P., Buettner, M., Schweer, J., Fleissner, D., Vital, M., Pieper, D.H., Basic, M., Dersch, P., Strowig, T., Hornef, M., Bleich, A., Bode, U., Pabst, O., Bajenoff, M., Saliba, A.E., and Huehn, J. (2018). Neonatally imprinted stromal cell subsets induce tolerogenic dendritic cells in mesenteric lymph nodes. Nat Commun 9, 3903. PMID: 30254319 Open Access
Pasztoi, M., Bonifacius, A., Pezoldt, J., Kulkarni, D., Niemz, J., Yang, J., Teich, R., Hajek, J., Pisano, F., Rohde, M., Dersch, P., and Huehn, J. (2017). Yersinia pseudotuberculosis supports Th17 differentiation and limits de novo regulatory T cell induction by directly interfering with T cell receptor signaling. Cell Mol Life Sci 74, 2839-2850. PMID: 28378044 Open Access
Yang, B.H., Floess, S., Hagemann, S., Deyneko, I.V., Groebe, L., Pezoldt, J., Sparwasser, T., Lochner, M., and Huehn, J. (2015). Development of a unique epigenetic signature during in vivo Th17 differentiation. Nucleic Acids Res 43, 1537-1548. PMID: 25593324 Open Access
Cording, S.*, Wahl, B.*, Kulkarni, D., Chopra, H., Pezoldt, J., Buettner, M., Dummer, A., Hadis, U., Heimesaat, M., Bereswill, S., Falk, C., Bode, U., Hamann, A., Fleissner, D., Huehn, J.*, and Pabst, O*. (2014). The intestinal micro-environment imprints stromal cells to promote efficient Treg induction in gut-draining lymph nodes. Mucosal Immunol 7, 359-368. PMID: 23945546 Open Access
Floess, S., Freyer, J., Siewert, C., Baron, U., Olek, S., Polansky, J., Schlawe, K., Chang, H.D., Bopp, T., Schmitt, E., Klein-Hessling, S., Serfling, E., Hamann, A., and Huehn, J. (2007). Epigenetic control of the foxp3 locus in regulatory T cells. PLoS Biol 5, e38. PMID: 17298177 Open Access
Huehn, J., Siegmund, K., Lehmann, J.C., Siewert, C., Haubold, U., Feuerer, M., Debes, G.F., Lauber, J., Frey, O., Przybylski, G.K., Niesner, U., de la Rosa, M., Schmidt, C.A., Brauer, R., Buer, J., Scheffold, A., and Hamann, A. (2004). Developmental stage, phenotype, and migration distinguish naive- and effector/memory-like CD4+ regulatory T cells. J Exp Med 199, 303-313. PMID: 14757740
