Prof. Dr. Abel Viejo-Borbolla participates in RESIST research projects A3 and A4.

My Research Interest in RESIST

Varicella zoster virus (VZV) is a highly prevalent human pathogen that infects most human beings. During primary infection VZV causes chickenpox and establishes latency in neurons. Reactivation from neurons normally results in shingles. Most people control the infection but some individuals suffer from extreme chronic pain or life-threatening diseases.

Within RESIST we are interested in the identification and characterization of host and viral genetic determinants that are responsible for exacerbated VZV disease. A second focus of our research is the study of epigenetic modifications on the viral and human genomes during establishment of VZV latency. To do so we have established relevant viral and cellular models, including those to study VZV latency in human neurons derived from induced pluripotent stem cells. The patient cohorts and collaborations established within RESIST will ensure the achievement of the proposed aims. 

Contact

Prof. Viejo-Borbolla about his scientific work

Prof. Dr. Abel Viejo-Borbolla – Curriculum Vitae

Current Position

  • Since 2018 APL Professor in Experimental Virology, Institute of Virology, MHH 

Undergraduate and Postgraduate Training

  • 1992 – 1997 BSc (Hons) in Biological Sciences, specialized in Molecular Biology and Biochemistry, Universidad Autónoma de Madrid, Madrid, Spain; University of Leeds U.K. T

  • 1997 Diploma in Biological Sciences, specialized in Molecular Biology and Biochemistry, Universidad Autónoma de Madrid, Madrid, Spain 

  • 1997 – 2001 Undergraduate training, University of Liverpool, GlaxoSmithKline U.K., Institute of Virology, Hannover Medical School

  • 2002 PhD Title. The University of Liverpool, UK (Supervisors Prof. Dr. med. Thomas F. Schulz and Dr. Edward D. Blair) 

Academic and Research Posts

  • 2002 – 2004 Postdoctoral fellow, Institute of Virology, Hannover Medical School, Hannover 

  • 2004 – 2007 Postdoctoral fellow, Centro Nacional de Biotecnología, CSIC, Madrid, Spain 

  • 2008 – 2009 Visiting postdoctoral fellow, Mount Sinai School of Medicine, New York, U.S.A.

  • 2011 – 2012 Lecturer in Human Anatomy & Physiology, European University of Madrid, Spain 

  • 2012 – 2013 Lecturer in Virology, European University of Madrid, Spain 

  • 2009 – 2013 Postdoctoral fellow, Centro de Biología Molecular Severo Ochoa, CSIC, Madrid, Spain 

  • 2013 – 2018 W1 Professor in Experimental Virology, Institute of Virology, MHH

  • Since 2018 APL Professor in Experimental Virology, Institute of Virology, MHH 

Other Scientific Roles

  • 2006 – 2007 Managing Editor, Frontiers in Biosciences

  • Since 2007 Member of the Spanish Society for Virology

  • Since 2010 Organizer of the “II Intergroup Meeting: Herpesviruses and Gene Therapy”

  • Since 2013 Member of the Collaborative Research Centre “Chronic infections: microbial persistence and its control”

  • 2013 – 2018 Member of the Niedersachsen-Research Network on Neuroinfectiology

  • Since 2014 Member of the European Society for Virology

  • Since 2014 Member of the German Society for Virology

  • 2016 – 2017 Lead Guest Editor in the Journal of Immunology Research

Awards and Prizes

  • 1996 – 1997 Erasmus Fellow, University of Leeds, U.K.

  • 1998 Safety award at GlaxoSmithKline, UK

  • 1999 First prize in the ‘Business game’ (organized by MRC and BBSRC)

  • 2006 – 2010 “Sara Borrel” Fellow, Centro de Biología Molecular Severo Ochoa, CSIC, Madrid, Spain and Mount Sinai School of Medicine, New York, U.S.A.

  • 2010 – 2013 “JAE” Fellow, Centro de Biología Molecular Severo Ochoa, CSIC, Madrid, Spain

  • 2014 – 2018 Marie Curie Career Integration Grant

  • 2017 Marie Skłodowska-Curie “Fellow of the month” 

Recommended Links

For further information about Prof. Viejo-Borbolla’s scientific work please check the following links:

10 Selected Publications (of > 31 original publications)

Baird NL, Zhu S, Pearce CM, Viejo-Borbolla A. Current in vitro models to study varicella zoster virus latency and reactivation. Viruses. 2019; 26: 11. 

Khera T, Behrendt P, Bankwitz D, Brown RJP, Todt D, Doepke M, Khan AG, Schulze K, Law J, Logan M, Hockman D, Wong JAJ, Dold L, Gonzalez-Motos V, Spengler U, Viejo-Borbolla A, Ströh LJ, Krey T, Tarr AW, Steinmann E, Manns MP, Klein F, Guzman CA, Marcotrigiano J, Houghton M, Pietschmann T. Functional and immunogenic characterization of diverse HCV glycoprotein E2 variants. J Hepatol. 2019; 70(4): 593-602. 

González-Motos V, Jürgens C, Ritter B, Kropp KA, Durán V, Larsen O, Binz A, Ouwendijk WJD, Rovis TL, Jonjic S, Verjans GMGM, Sodeik B, Krey T, Bauerfeind R, Schulz TF, Kaufer BB, Kalinke U, Proudfoot AEI, Rosenkilde MM, Viejo-Borbolla A. Varicella zoster virus glycoprotein C increases chemokine-mediated leukocyte migration. PLoS Pathog. 2017; 13(5): e1006346. 

Martinez-Martin N, Viejo-Borbolla A, Martín R, Blanco S, Benovic JL, Thelen M, Alcamí A. Herpes simplex virus enhances chemokine function through modulation of receptor trafficking and oligomerization. Nat Commun. 2015; 6: 6163. 

Cabrera JR*, Viejo-Borbolla A*, Martinez-Martin N, Blanco S, Wandosell F, Alcami A. Secreted herpes simplex virus-2 glycoprotein G modifies NGF-TrkA signaling to attract free nerve endings to the site of infection. PLoS Pathog. 2015; 11(1): e1004571. *Both authors contributed equally. 

Viejo-Borbolla A, Martinez-Martín N, Nel HJ, Rueda P, Martín R, Blanco S, Arenzana-Seisdedos F, Thelen M, Fallon PG, Alcamí A. Enhancement of chemokine function as an immunomodulatory strategy employed by human herpesviruses. PLoS Pathog. 2012; 8(2): e1002497. 

Viejo-Borbolla A, Martin AP, Muniz LR, Shang L, Marchesi F, Thirunarayanan N, Harpaz N, Garcia RA, Apostolaki M, Furtado GC, Mayer L, Kollias G, Alcami A, Lira SA. Attenuation of TNF-driven murine ileitis by intestinal expression of the viral immunomodulator CrmD. Mucosal Immunol. 2010; 3(6): 633-644. 

Viejo-Borbolla A, Munoz A, Tabares E, Alcami A. Glycoprotein G from pseudorabies virus binds to chemokines with high affinity and inhibits their function. J Gen Virol. 2010; 91(Pt 1): 23-31. 

Shang L, Thirunarayanan N, Viejo-Borbolla A, Martin AP, Bogunovic M, Marchesi F, Unkeless JC, Ho Y, Furtado GC, Alcami A, Merad M, Mayer L, Lira SA. Expression of the chemokine binding protein M3 promotes marked changes in the accumulation of specific leukocytes subsets within the intestine. Gastroenterology. 2009; 137(3): 1006-1018. 

Viejo-Borbolla A, Ottinger M, Brüning E, Bürger A, König R, Kati E, Sheldon JA, Schulz TF. Brd2/RING3 interacts with a chromatin-binding domain in the Kaposi’s Sarcoma-associated herpesvirus latency-associated nuclear antigen 1 (LANA-1) that is required for multiple functions of LANA-1. J Virol. 2005; 79(21): 13618-29. 

Contact

  Prof. Dr. Abel Viejo-Borbolla
  Research group Viejo-Borbolla, Institute of Virology, Hannover Medical School
  Carl-Neuberg-Str. 1
30625 Hannover
  +49 511 532 – 4382
  Viejo-Borbolla.Abel
@mh-hannover.de