Prof. Dr. Ulrich Kalinke participates in RESIST research projects A4 and B9.
| My Research Interest in RESIST |
Our research focus in RESIST is to identify factors for Hepatitis B Virus (HBV) vaccination non- responsiveness in single individuals. Additionally, we strive towards a better understanding of how protective immunity against HBV is induced. In this regard, we intensively collaborate with clinical institutes and occupational health physicians of the MHH to ultimately generate a comprehensive model of HBV vaccination non-responsiveness to improve vaccination schemes for HBV vaccination non-responders and to develop innovative vaccination strategies.
Prof. Kalinke about his scientific work
Prof. Dr. Ulrich Kalinke – Curriculum Vitae
Current Position
Undergraduate and Postgraduate Training
Academic and Research Posts
Other Scientific Roles
Awards and Prizes
10 Selected Publications
Tegtmeyer, PK, Spanier J, Borst K, Becker J, Riedl A, Hirche C, Ghita L, Skerra J, Baumann K, Lienenklaus S, Döring M, Ruzsics Z, Kalinke U. STING induces early IFN-β in the liver and constrains myeloid cell-mediated dissemination of murine cytomegalovirus. Nat Commun. 2019; 10(1): 2830.
Chhatbar C, Detje CN, Grabski E, Borst K, Spanier J, Ghita L, Elliott DA, Costa Jordão MJ, Mueller N, Sutton J, Prajeeth CK, Gudi V, Klein MA, Prinz M, Bradke F, Stangel M, Kalinke U. Type I interferon receptor signaling of neurons and astrocytes regulates microglia activation during viral encephalitis. Cell Rep. 2018; 25: 118-129.e4.
Borst K, Frenz T, Spanier J, Tegtmeyer PK, Chhatbar C, Skerra J, Ghita L, Namineni S, Lienenklaus S, Köster M, Heikenwaelder M, Sutter G, Kalinke U. Type I interferon receptor signaling delays Kupffer cell replenishment during acute fulminant viral hepatitis. J Hepatol. 2018; 68(4): 682-690.
Hirche C, Frenz T, Haas SF, Döring M, Borst K, Tegtmeyer PK, Brizic I, Jordan S, Keyser K, Chhatbar C, Pronk E, Lin S, Messerle M, Jonjic S, Falk CS, Trumpp A, Essers MAG, Kalinke U. Systemic virus infections differentially modulate cell cycle state and functionality of long-term hematopoietic stem cells in vivo. Cell Rep. 2017; 19(11): 2345-56.
Ziegler A, Soldner C, Lienenklaus S, Spanier J, Trittel S, Riese P, Kramps T, Weiss S, Heidenreich R, Jasny E, Guzmán CA, Kallen KJ, Fotin-Mleczek M, Kalinke U. A new RNA-based adjuvant enhances virus-specific vaccine responses by locally triggering TLR- and RLH-dependent effects. J Immunol. 2017; 198(4): 1595-605.
Frenz T, Grabski E, Buschjager D, Vaas LA, Burgdorf N, Schmidt RE, Witte T, Kalinke U. CD4(+) T cells in patients with chronic inflammatory rheumatic disorders show distinct levels of exhaustion. J Allergy Clin Immunol. 2016; 138(2): 586-589 e10.
Paijo J, Döring M, Spanier J, Grabski E, Nooruzzaman M, Schmidt T, Witte G, Messerle M, Hornung V, Kaever V, Kalinke U. cGAS senses human cytomegalovirus and induces Type I interferon responses in human monocyte- derived cells. PLoS Pathog. 2016; 12(4): e1005546.
Fischbach H, Döring M, Nikles D, Lehnert E, Baldauf C, Kalinke U*, Tampé R*. Ultrasensitive quantification of TAP- dependent antigen compartmentalization in scarce primary immune cell subsets. Nat Commun. 2015; 6: 6199. *joint senior authors
Prinz M, Schmidt H, Mildner A, Knobeloch KP, Hanisch UK, Raasch J, Merkler D, Detje C, Gutcher I, Mages J, Lang R, Martin R, Gold R, Becher B, Bruck W, Kalinke U. Distinct and nonredundant in vivo functions of IFNAR on myeloid cells limit autoimmunity in the central nervous system. Immunity 2008; 28(5): 675-86.
Kamphuis E, Junt T, Waibler Z, Forster R, Kalinke U. Type I interferons directly regulate lymphocyte recirculation and cause transient blood lymphopenia. Blood. 2006; 108(10): 3253-61.
