Prof. Dr. Ulrich Kalinke participates in RESIST research projects A4 and B9.

My Research Interest in RESIST

Our research focus in RESIST is to identify factors for Hepatitis B Virus (HBV) vaccination non- responsiveness in single individuals. Additionally, we strive towards a better understanding of how protective immunity against HBV is induced. In this regard, we intensively collaborate with clinical institutes and occupational health physicians of the MHH to ultimately generate a comprehensive model of HBV vaccination non-responsiveness to improve vaccination schemes for HBV vaccination non-responders and to develop innovative vaccination strategies.

Contact

Prof. Kalinke about his scientific work

Prof. Dr. Ulrich Kalinke – Curriculum Vitae

Current Position

  • Since 2008 Full (W3) Professor for Translational Infection Research at the Hannover Medical School; Director of the Institute for Experimental Infection Research, Twincore, Centre for Experimental and Clinical Infection Research; Executive Director of Twincore

Undergraduate and Postgraduate Training

  • 1980 – 1985 Technical University Hannover

  • 1986 Diploma thesis, Technical University Hannover (Supervisor Prof. Dr. rer. nat. Hans Diekmann)

  • 1986 – 1990 PhD thesis at the German Cancer Research Centre (DKFZ), Heidelberg, Germany

  • 1990 Doctorate (Dr. rer. nat.; Supervisor Prof. Dr. Günther Hämmerling and Prof. Dr. Bernd Arnold) 

Academic and Research Posts

  • 1990 – 1992 Postdoctoral Research Fellow at the Institute for Experimental Immunology, University of Zurich, Switzerland (Prof. Dr. med. Rolf Zinkernagel and Prof. Dr. rer. nat. Hans Hengartner)

  • 1992 – 1994 DFG Fellow at the Institute for Experimental Immunology, University of Zurich, Switzerland 

  • 1994 – 1998 Research Assistant and Senior Assistant at the Institute for Experimental Immunology, University of Zurich, Switzerland

  • 1998 – 2001 Staff Scientist and Leader of the “Anti-Viral Defense Group” at the Mouse Biology Programme, European Molecular Biology Laboratory (EMBL)-Monterotondo, Monterotondo (Rome), Italy (Programme Coordinator Prof. Dr. Klaus Rajewsky) 

  • 2002 – 2008 Professor and Director, Division of Immunology, Paul-Ehrlich-Institut, Langen, Germany 

  • Since 2008 Full (W3) Professor for Translational Infection Research at the Hannover Medical School; Director of the Institute for Experimental Infection Research, Twincore, Centre for Experimental and Clinical Infection Research; Executive Director of Twincore 

Other Scientific Roles

  • 2008 – 2016 Member of the Board of Directors of the Cancer Immunotherapy (CIMT)-Consortium 

  • Since 2008 Head of the Regulatory Research Group of the CIMT

  • 2009 – 2010 Speaker of the HZI Topic “Translational Infection Research”

  • 2011 Speaker of the HZI Cross-Topic “Translational Infection Research” 

  • 2011 – 2013 Speaker of the HZI Programme “Infection Research”

  • Since 2010 Member of the Scientific Advisory Board of the Vakzine Projekt Management GmbH (VPM)

  • Since 2013 Head of the Translational Alliance in Lower Saxony (TRAIN)

  • Since 2015 Board Member of the Foundation for the Combat of Neuroviral Diseases

  • Since 2015 Chair of the Steering Group of the TRAIN-Academy

  • Since 2018 Director of the Lower Saxony International Summer Academy (LISA)

  • Since 2018 Board Member of the Fraunhofer Institute for Cell Therapy and Immunology 

Awards and Prizes

  • 1998 Pfizer Award for Medicine (Immunology and Rheumatology)

  • 2005 Ferid Murad Award (by ISICR for “Outstanding contributions to interferon and cytokine research”) 

Recommended Links

For further information about Prof. Kalinke’s scientific work please check the following links:

10 Selected Publications (of > 196 original publications)

Tegtmeyer, PK, Spanier J, Borst K, Becker J, Riedl A, Hirche C, Ghita L, Skerra J, Baumann K, Lienenklaus S, Döring M, Ruzsics Z, Kalinke U. STING induces early IFN-β in the liver and constrains myeloid cell-mediated dissemination of murine cytomegalovirus. Nat Commun. 2019; 10(1): 2830.

Chhatbar C, Detje CN, Grabski E, Borst K, Spanier J, Ghita L, Elliott DA, Costa Jordão MJ, Mueller N, Sutton J, Prajeeth CK, Gudi V, Klein MA, Prinz M, Bradke F, Stangel M, Kalinke U. Type I interferon receptor signaling of neurons and astrocytes regulates microglia activation during viral encephalitis. Cell Rep. 2018; 25: 118-129.e4.

Borst K, Frenz T, Spanier J, Tegtmeyer PK, Chhatbar C, Skerra J, Ghita L, Namineni S, Lienenklaus S, Köster M, Heikenwaelder M, Sutter G, Kalinke U. Type I interferon receptor signaling delays Kupffer cell replenishment during acute fulminant viral hepatitis. J Hepatol. 2018; 68(4): 682-690.

Hirche C, Frenz T, Haas SF, Döring M, Borst K, Tegtmeyer PK, Brizic I, Jordan S, Keyser K, Chhatbar C, Pronk E, Lin S, Messerle M, Jonjic S, Falk CS, Trumpp A, Essers MAG, Kalinke U. Systemic virus infections differentially modulate cell cycle state and functionality of long-term hematopoietic stem cells in vivo. Cell Rep. 2017; 19(11): 2345-56.

Ziegler A, Soldner C, Lienenklaus S, Spanier J, Trittel S, Riese P, Kramps T, Weiss S, Heidenreich R, Jasny E, Guzmán CA, Kallen KJ, Fotin-Mleczek M, Kalinke U. A new RNA-based adjuvant enhances virus-specific vaccine responses by locally triggering TLR- and RLH-dependent effects. J Immunol. 2017; 198(4): 1595-605.

Frenz T, Grabski E, Buschjager D, Vaas LA, Burgdorf N, Schmidt RE, Witte T, Kalinke U. CD4(+) T cells in patients with chronic inflammatory rheumatic disorders show distinct levels of exhaustion. J Allergy Clin Immunol. 2016; 138(2): 586-589 e10.

Paijo J, Döring M, Spanier J, Grabski E, Nooruzzaman M, Schmidt T, Witte G, Messerle M, Hornung V, Kaever V, Kalinke U. cGAS senses human cytomegalovirus and induces Type I interferon responses in human monocyte- derived cells. PLoS Pathog. 2016; 12(4): e1005546.

Fischbach H, Döring M, Nikles D, Lehnert E, Baldauf C, Kalinke U*, Tampé R*. Ultrasensitive quantification of TAP- dependent antigen compartmentalization in scarce primary immune cell subsets. Nat Commun. 2015; 6: 6199. *joint senior authors

Prinz M, Schmidt H, Mildner A, Knobeloch KP, Hanisch UK, Raasch J, Merkler D, Detje C, Gutcher I, Mages J, Lang R, Martin R, Gold R, Becher B, Bruck W, Kalinke U. Distinct and nonredundant in vivo functions of IFNAR on myeloid cells limit autoimmunity in the central nervous system. Immunity 2008; 28(5): 675-86.

Kamphuis E, Junt T, Waibler Z, Forster R, Kalinke U. Type I interferons directly regulate lymphocyte recirculation and cause transient blood lymphopenia. Blood. 2006; 108(10): 3253-61.

Contact

  Prof. Dr. Ulrich Kalinke
  Institute of Experimental Infection Research, Helmholtz Centre for Infection Research (HZI)
  TWINCORE, Centre for Experimental and Clinical Infection Research GmbH
Feodor-Lynen-Str. 7
30625 Hannover
  +49 511 220027-112
  Ulrich.Kalinke
@twincore.de