Prof. Dr. Michele Proietti participates in RESIST research project A5.

My Research Interest in RESIST

Within RESIST we work in close collaboration with Professor Dr. Torsten Witte (MHH) and with Prof. Bodo Grimbacher (Institute for Immunodeficiency IFI, Center of Chronic Immunodeficiency, CCI, Uniklinikum Freiburg Freiburg). We are interested in identifying the genetic changes in our genome that can cause increased susceptibility to infections and immune-mediated pathology. I’am in particular interested in ADA2 and genes involved in the regulation of the nucleic acid sensing and type-I interferon response. Nucleic acid sensing and type-I interferon response are extraordinary instruments to protect the host from invading pathogens; however if not properly regulated their activation is at risk of triggering potentially life-threatening inflammation, as seen in auto-inflammatory syndromes and more recently in the outbreak of covid 19. Moreover, together with my cooperation partners in Freiburg I am currently developing a bioinformatics immunogenetic platform that integrates bioinformatics pipeline with a dedicated database for the analysis of genetic data in subjects with immune mediated diseases.¬†

Prof. Proietti about his scientific work

Prof. Dr. Michele Proietti – Curriculum Vitae

Current Position

  • Since 2020 Professor for Genetics of Immundysregulation, MHH

  • 2018 – 2020 Junior group leader and Head of the Genetic Unit, CCI Uniklinik Freiburg

Undergraduate and Postgraduate Training

  • 2001 Medical degree, University of Rome ‚ÄúLa Sapienza‚ÄĚ, Italy¬†

  • 2006 Doctor in Internal Medicine, University of Rome ‚ÄúLa Sapienza‚ÄĚ, Italy

  • 2010¬†PhD in Clinical and Experimental Immunology, University of Genova, Italy¬†

Academic and Research Posts

  • 2001 – 2006 Residency in Internal Medicine, University of Rome ‚ÄúLa Sapienza‚Ä̬†

  • 2006 Physician, Hospital Mama Ashu, Chacas Per√ļ¬†

  • 2007 – 2010 PhD clinical and experimental Immunology University of Genova, Italy¬†

  • 2007 – 2010 Internist, University of Genova, Italy

  • 2010 – 2015 Postdoc, Institute of Research in Biomedicine (IRB), Bellinzona, Switzerland¬†

  • 2015 – 2017 Scientist, CCI, Uniklinik Freiburg, Freiburg im Breisgau (Germany), AG Grimbacher¬†

  • Since 2017 Head of the CCI-Genetic-Unit¬†

  • Since 2018 Junior Group Leader, CCI Uniklinik Freiburg, Germany¬†

Awards and Prizes

  • 2016¬†Italian Scleroderma Society ‚ÄúGILS‚ÄĚ, Award as young researcher in Systemic Sclerosis¬†

  • 2018 Foreign postdoctoral fellow Instute Curie Research Centre

Recommended Links

For further information about Prof. Proietti’s scientific work please check the following links:

10 Selected Publications

Czech M, Schneider S, Peltokangas N, El Khawanky N, Ghimire S, Andrieux G, H√ľlsd√ľnker J, Krausz M, Proietti M, Braun LM, R√ľckert T, Langenbach M, Schmidt D, Martin I, Wenger V, de Vega E, Haring E, Pourjam M, Pfeifer D, Schmitt-Graeff A, Grimbacher B, Aumann K, Kircher B, Tilg H, Raffatellu M, Thiele Orberg E, H√§cker G, Duyster J, K√∂hler N, Holler E, Nachbaur D, Boerries M, Gerner RR, Gr√ľn D, Zeiser R. Lipocalin-2 expression identifies an intestinal regulatory neutrophil population during acute graft-versus-host disease. Sci Transl Med. 2024 Feb 21;16(735):eadi1501. doi: 10.1126/scitranslmed.adi1501. Epub 2024 Feb 21. PMID: 38381845.

Haring E, Andrieux G, Uhl FM, Krausz M, Proietti M, Sauer B, Esser PR, Martin SF, Pfeifer D, Schmitt-Graeff A, Duyster J, Köhler N, Grimbacher B, Boerries M, Aumann K, Zeiser R, Apostolova P. Therapeutic targeting of endoplasmic reticulum stress in acute graft-versus-host disease. Haematologica. 2022 Jul 1;107(7):1538-1554. doi: 10.3324/haematol.2021.278387. PMID: 34407601; PMCID:
PMC9244832.

Zmajkovicova K, Pawar S, Sharapova SO, Geier CB, Wiest I, Nguyen C, Monticelli H, Maier-Munsa S, Chen K, Sleasman JW, Aleshkevich S, Polyakova E, Sakovich I, Warnatz K, Grimbacher B, Proietti M, Sondheimer N, Ujhazi B, Gordon S, Ellison M, Yilmaz M, Walter JE, Badarau A, Taveras AG, Neff JL, Bledsoe JR, Tarrant TK. A Novel Transmembrane CXCR4 Variant That Expands the WHIM Genotype-Phenotype Paradigm. Blood Adv. 2024 May 20:bloodadvances.2023011875. doi: 10.1182/bloodadvances.2023011875. Epub ahead of print. PMID: 38768429.

Rolles B, Caballero-Oteyza A, Proietti M, Goldacker S, Warnatz K, Camacho-Ordonez N, Prader S, Schmid JP, Vieri M, Isfort S, Meyer R, Kirschner M, Br√ľmmendorf TH, Beier F, Grimbacher B. Telomere biology disorders may manifest as common variable immunodeficiency (CVID). Clin Immunol. 2023 Dec;257:109837. doi: 10.1016/j.clim.2023.109837. Epub 2023 Nov 8. PMID: 37944684.

Zeisbrich M, Schindler V, Krausz M, Proietti M, Mrovecova P, Voll RE, Glaser C, Röther F, Warnatz K, Venhoff N. Makrozytäre Anämie und Polychondritis: VEXAS-Syndrom [Macrocytic anemia and polychondritis: VEXAS syndrome]. Z Rheumatol. 2024 Apr;83(3):229-233. German. doi: 10.1007/s00393-023-01318-5. Epub 2023 Feb 3. PMID: 36735069; PMCID: PMC10973061.

Block V, Sevdali E, Recher M, Abolhassani H, Hammarstrom L, Smulski CR, Baronio M, Plebani A, Proietti M, Speletas M, Warnatz K, Voll RE, Lougaris V, Schneider P, Eibel H. CVID-Associated B Cell Activating Factor Receptor Variants Change Receptor Oligomerization, Ligand Binding, and Signaling Responses. J Clin Immunol. 2023 Feb;43(2): 391-405. doi: 10.1007/s10875-022-01378-3. Epub 2022 Oct 29. PMID: 36308663; PMCID: PMC9616699.

Strohmeier V, Andrieux G, Unger S, Pascual-Reguant A, Klocperk A, Seidl M, Marques OC, Eckert M, Gräwe K, Shabani M, von Spee-Mayer C, Friedmann D, Harder I, Gutenberger S, Keller B, Proietti M, Bulashevska A, Grimbacher B, Provaznik J, Benes V, Goldacker S, Schell C, Hauser AE, Boerries M, Hasselblatt P, Warnatz K. Interferon-Driven Immune Dysregulation in Common Variable Immunodeficiency-Associated Villous Atrophy and Norovirus Infection. J Clin Immunol. 2023 Feb;43(2):371-390. doi: 10.1007/s10875-022-01379-2. Epub 2022 Oct 25. PMID: 36282455; PMCID: PMC9892141.

Ramirez N, Posadas-Cantera S, Langer N, de Oteyza ACG, Proietti M, Keller B, Zhao F, Gernedl V, Pecoraro M, Eibel H, Warnatz K, Ballestar E, Geiger R, Bossen C, Grimbacher B. Multi-omics analysis of na√Įve B cells of patients harboring the C104R mutation in TACI. Front Immunol. 2022 Aug 16;13:938240. doi: 10.3389/fimmu.2022.938240. PMID: 36072607; PMCID: PMC9443529.

Globig AM, Strohmeier V, Surabattula R, Leeming DJ, Karsdal MA, Heeg M, Kindle G, Goldacker S, von Spee-Mayer C, Proietti M, Bausch B, Bettinger D, Schultheiß M, Thimme R, Schuppan D, Warnatz K. Evaluation of Laboratory and Sonographic Parameters for Detection of Portal Hypertension in Patients with Common Variable Immunodeficiency. J Clin Immunol. 2022 Nov;42(8):1626-1637. doi: 10.1007/s10875-022-01319-0. Epub 2022 Jul 11. PMID: 35821451; PMCID: PMC9700587.

Wang L, Aschenbrenner D, Zeng Z, Cao X, Mayr D, Mehta M, Capitani M, Warner N, Pan J, Wang L, Li Q, Zuo T, Cohen-Kedar S, Lu J, Ardy RC, Mulder DJ, Dissanayake D, Peng K, Huang Z, Li X, Wang Y, Wang X, Li S, Bullers S, Gammage AN, Warnatz K, Schiefer AI, Krivan G, Goda V, Kahr WHA, Lemaire M; Genomics England Research Consortium; Lu CY, Siddiqui I, Surette MG, Kotlarz D, Engelhardt KR, Griffin HR, Rottapel R, Decaluwe H, Laxer RM, Proietti M, Hambleton S, Elcombe S, Guo CH, Grimbacher B, Dotan I, Ng SC, Freeman SA, Snapper SB, Klein C, Boztug K, Huang Y, Li D, Uhlig HH, Muise AM. Author Correction: Gain-of-function variants in SYK cause immune dysregulation and systemic inflammation in humans and mice. Nat Genet. 2022 Feb;54(2):213. doi:10.1038/s41588-021-00998-6. Erratum for: Nat Genet. 2021 Apr;53(4): 500-510. doi:10.1038/s41588-021-00803-4. PMID: 34987219.

Contact

  Prof. Dr. Michele Proietti
¬† Klinik f√ľr Rheumatologie und Immunologie, Hannover Medical School (MHH)

Center for Chronic Immunodeficiency, Uniklinik Freiburg

¬† Klinik f√ľr Rheumatologie und Immunologie, Hannover Medical School (MHH)
Carl-Neuberg-Str. 1
30625 Hannover
  +49 761 270-77729
  proietti.michele
@mh-hannover.de