Prof. Dr. Michele Proietti participates in RESIST research project A5.

My Research Interest in RESIST

Within RESIST we work in close collaboration with Professor Dr. Torsten Witte (MHH) and with Prof. Bodo Grimbacher (Institute for Immunodeficiency IFI, Center of Chronic Immunodeficiency, CCI, Uniklinikum Freiburg Freiburg). We are interested in identifying the genetic changes in our genome that can cause increased susceptibility to infections and immune-mediated pathology. I’am in particular interested in ADA2 and genes involved in the regulation of the nucleic acid sensing and type-I interferon response. Nucleic acid sensing and type-I interferon response are extraordinary instruments to protect the host from invading pathogens; however if not properly regulated their activation is at risk of triggering potentially life-threatening inflammation, as seen in auto-inflammatory syndromes and more recently in the outbreak of covid 19. Moreover, together with my cooperation partners in Freiburg I am currently developing a bioinformatics immunogenetic platform that integrates bioinformatics pipeline with a dedicated database for the analysis of genetic data in subjects with immune mediated diseases. 

Prof. Proietti about his scientific work

Prof. Dr. Michele Proietti – Curriculum Vitae

Current Position

  • Since 2020 Professor for Genetics of Immundysregulation, MHH

  • 2018 – 2020 Junior group leader and Head of the Genetic Unit, CCI Uniklinik Freiburg

Undergraduate and Postgraduate Training

  • 2001 Medical degree, University of Rome “La Sapienza”, Italy 

  • 2006 Doctor in Internal Medicine, University of Rome “La Sapienza”, Italy

  • 2010 PhD in Clinical and Experimental Immunology, University of Genova, Italy 

Academic and Research Posts

  • 2001 – 2006 Residency in Internal Medicine, University of Rome “La Sapienza” 

  • 2006 Physician, Hospital Mama Ashu, Chacas PerĂș 

  • 2007 – 2010 PhD clinical and experimental Immunology University of Genova, Italy 

  • 2007 – 2010 Internist, University of Genova, Italy

  • 2010 – 2015 Postdoc, Institute of Research in Biomedicine (IRB), Bellinzona, Switzerland 

  • 2015 – 2017 Scientist, CCI, Uniklinik Freiburg, Freiburg im Breisgau (Germany), AG Grimbacher 

  • Since 2017 Head of the CCI-Genetic-Unit 

  • Since 2018 Junior Group Leader, CCI Uniklinik Freiburg, Germany 

Awards and Prizes

  • 2016 Italian Scleroderma Society “GILS”, Award as young researcher in Systemic Sclerosis 

  • 2018 Foreign postdoctoral fellow Instute Curie Research Centre

Recommended Links

For further information about Prof. Proietti’s scientific work please check the following links:

10 Selected Publications

Schepp, Johanna; Proietti, Michele; Frede, Natalie; Buchta, Mary; HĂŒbscher, Katrin; Rojas Restrepo, Jessica; Goldacker, Sigune; Warnatz, Klaus; Pachlopnik Schmid, Jana; Duppenthaler, Andrea; Screening of 181 patients with antibody deficiency for deficiency of adenosine deaminase 2 sheds new light on the disease in adulthood, Arthritis & rheumatology, 2017, 69, (8):1689-1700

Schubert, DesirĂ©e; Klein, Marie-Christine; Hassdenteufel, Sarah; Caballero-Oteyza, AndrĂ©s; Yang, Linlin; Proietti, Michele; Bulashevska, Alla; Kemming, Janine; KĂŒhn, Johannes; Winzer, Sandra; Journal of Allergy and Clinical Immunology, 2018, 141, (4):1427-1438

Lorenzini, Tiziana; Fliegauf, Manfred; Klammer, Nils; Frede, Natalie; Proietti, Michele; Bulashevska, Alla; Camacho-Ordonez, Nadezhda; Varjosalo, Markku; Kinnunen, Matias; de Vries, Esther; Journal of Allergy and Clinical Immunology, 2020

Schenk, Ursula; Frascoli, Michela; Proietti, Michele; Geffers, Robert; Traggiai, Elisabetta; Buer, Jan; Ricordi, Camillo; Westendorf, Astrid M; Grassi, Fabio; Sci. Signal., 2011, 4, (162):ra12-ra12

Proietti, Michele; Cornacchione, Vanessa; Jost, Tanja Rezzonico; Romagnani, Andrea; Faliti, Caterina Elisa; Perruzza, Lisa; Rigoni, Rosita; Radaelli, Enrico; Caprioli, Flavio; Preziuso, Silvia; Immunity, 2014, 41, (5):789-801

Proietti, Michele; Perruzza, Lisa; Scribano, Daniela; Pellegrini, Giovanni; D’Antuono, Rocco; Strati, Francesco; Raffaelli, Marco; Gonzalez, Santiago F; Thelen, Marcus; Hardt, Wolf-Dietrich; Nature communications, 2019, 10 , (1):1-Nov.

Filipello, Fabia; Pozzi, Davide; Proietti, Michele; Romagnani, Andrea; Mazzitelli, Sonia; Matteoli, Michela; Verderio, Claudia; Grassi, Fabio; Oncotarget, 2016, 7, (5): 5143

Perruzza, Lisa; Gargari, Giorgio; Proietti, Michele; Fosso, Bruno; D’Erchia, Anna Maria; Faliti, Caterina Elisa; Rezzonico-Jost, Tanja; Scribano, Daniela; Mauri, Laura; Colombo, Diego; Cell reports, 2017, 18, (11):2566-2575

Troilo, Arianna; Wehr, Claudia; Janowska, Iga; Venhoff, Nils; Thiel, Jens; Rawluk, Justyna; Frede, Natalie; Staniek, Julian; Lorenzetti, Raquel; Schleyer, Marei-Theresa; Blood, 2020, 135, (17):1452-1457

Schena, Francesca; Volpi, Stefano; Faliti, Caterina Elisa; Penco, Federica; Santi, Spartaco; Proietti, Michele; Schenk, Ursula; Damonte, Gianluca; Salis, Annalisa; Bellotti, Marta; Cell reports, 2013, 3, (6):1824-1831 


  Prof. Dr. Michele Proietti
  Klinik fĂŒr Rheumatologie und Immunologie, Hannover Medical School (MHH)

Center for Chronic Immunodeficiency, Uniklinik Freiburg

  Klinik fĂŒr Rheumatologie und Immunologie, Hannover Medical School (MHH)
Carl-Neuberg-Str. 1
30625 Hannover
  +49 761 270-77729