Prof. Dr. Michele Proietti participates in RESIST research project A5.

My Research Interest in RESIST

Within RESIST we work in close collaboration with Professor Dr. Torsten Witte (MHH) and with Prof. Bodo Grimbacher (Institute for Immunodeficiency IFI, Center of Chronic Immunodeficiency, CCI, Uniklinikum Freiburg Freiburg). We are interested in identifying the genetic changes in our genome that can cause increased susceptibility to infections and immune-mediated pathology. I’am in particular interested in ADA2 and genes involved in the regulation of the nucleic acid sensing and type-I interferon response. Nucleic acid sensing and type-I interferon response are extraordinary instruments to protect the host from invading pathogens; however if not properly regulated their activation is at risk of triggering potentially life-threatening inflammation, as seen in auto-inflammatory syndromes and more recently in the outbreak of covid 19. Moreover, together with my cooperation partners in Freiburg I am currently developing a bioinformatics immunogenetic platform that integrates bioinformatics pipeline with a dedicated database for the analysis of genetic data in subjects with immune mediated diseases.

Contact

Prof. Proietti

Prof. Dr. Michele Proietti – Curriculum Vitae

Current Position

Since 2020 Professor for Genetics of Immundysregulation, MHH
2018 – 2020 Junior group leader and Head of the Genetic Unit, CCI Uniklinik Freiburg

Undergraduate and Postgraduate Training

2001 Medical degree, University of Rome “La Sapienza”, Italy
2006 Doctor in Internal Medicine, University of Rome “La Sapienza”, Italy
2010 PhD in Clinical and Experimental Immunology, University of Genova, Italy

Academic and Research Posts

2001 – 2006 Residency in Internal Medicine, University of Rome “La Sapienza”
2006 Physician, Hospital Mama Ashu, Chacas Perú
2007 – 2010 PhD clinical and experimental Immunology University of Genova, Italy
2007 – 2010 Internist, University of Genova, Italy
2010 – 2015 Postdoc, Institute of Research in Biomedicine (IRB), Bellinzona, Switzerland
2015 – 2017 Scientist, CCI, Uniklinik Freiburg, Freiburg im Breisgau (Germany), AG Grimbacher
Since 2017 Head of the CCI-Genetic-Unit
Since 2018 Junior Group Leader, CCI Uniklinik Freiburg, Germany

Awards and Prizes

2016 Italian Scleroderma Society “GILS”, Award as young researcher in Systemic Sclerosis
2018 Foreign postdoctoral fellow Instute Curie Research Centre

10 Selected Publications

GenIA, the Genetic Immunology Advisor database for inborn errors of immunity. A Caballero-Oteyza, L Crisponi, XP Peng, K Yauy, S Volpi, S Giardino, … Journal of Allergy and Clinical Immunology 153 (3), 831-843

OTULIN-related conditions: Report of a new case and review of the literature using GenIA. A Caballero-Oteyza, L Crisponi, XP Peng, H Wang, P Mrovecova, S Olla, …Clinical Immunology, 110292

ARPC5 deficiency leads to severe early-onset systemic inflammation and mortality. E Sindram, A Caballero-Oteyza, N Kogata, S Chor Mei Huang, Z Alizadeh, … Disease models & mechanisms 16 (7)

Copy number analysis in a large cohort suggestive of inborn errors of immunity indicates a wide spectrum of relevant chromosomal losses and gains R Wan, M Schieck, A Caballero-Oteyza, W Hofmann, AV Cochino, …Journal of clinical immunology 42 (5), 1083-1092 *co-last author

Establishing the molecular diagnoses in a cohort of 291 patients with predominantly antibody deficiency by targeted next-generation sequencing: experience from a monocentric study. J Rojas-Restrepo, A Caballero-Oteyza, K Huebscher, H Haberstroh, … Frontiers in Immunology 12, 786516. *co-last author

Screening of 181 patients with antibody deficiency for deficiency of adenosine deaminase 2 sheds new light on the disease in adulthood
J Schepp, M Proietti, N Frede, M Buchta, K Hübscher, J Rojas Restrepo, … Arthritis & Rheumatology 69 (8), 1689-1700. *co-first author

ATP-gated ionotropic P2X7 receptor controls follicular T helper cell numbers in Peyer’s patches to promote host-microbiota mutualism
M Proietti, V Cornacchione, TR Jost, A Romagnani, CE Faliti, L Perruzza, … Immunity 41 (5), 789-801

ATP released by intestinal bacteria limits the generation of protective IgA against enteropathogens M Proietti, L Perruzza, D Scribano, G Pellegrini, R D’Antuono, F Strati, … Nature communications 10 (1), 250

Gain-of-function variants in SYK cause immune dysregulation and systemic inflammation in humans and mice. L Wang, D Aschenbrenner, Z Zeng, X Cao, D Mayr, M Mehta, M Capitani, … Nature genetics 53 (4), 500-510

Agammaglobulinemia with normal B-cell numbers in a patient lacking Bob1. P Kury, J Staniek, O Wegehaupt, I Janowska, M Eckenweiler, … Journal of Allergy and Clinical Immunology 147 (5), 1977-1980

Contact

	Prof. Dr. Michele Proietti
	Klinik für Rheumatologie und Immunologie, Hannover Medical School (MHH) Center for Chronic Immunodeficiency, Uniklinik Freiburg
	Klinik für Rheumatologie und Immunologie, Hannover Medical School (MHH) Carl-Neuberg-Str. 1 30625 Hannover
	+49 761 270-77729
	proietti.michele @mh-hannover.de