Prof. Dr. Meike Stiesch participates in RESIST research projects C1 and C2.
|My Research Interest in RESIST|
Our major scientific interest in RESIST is the investigation of mechanisms of biofilm formation and resistance in patients with biofilm-associated periimplant infections. The long-term goal is the identification of biomarkers for periimplant infections and the development of new diagnostic systems and effective intervention strategies for the control of these chronic infections.
In pursuing this research programme, we build on our longterm experience with biofilm-associated periimplant infections and our Europe wide collection of biofilms, implants and implant-associated human tissues (Biobank). We have established innovative biofilm model systems that allow for the investigation of new anti-biofilm strategies in vitro, in vivo and in silico. Over the course of the next 6 years we want to gain new insights into biofilm resistance mechanisms that have the potential to discover new and promising targets for diagnostics and effective anti-biofilm therapies.
Prof. Stiesch about her scientific work
Prof. Dr. Meike Stiesch – Curriculum Vitae
Since 2005 Full (W3) Professor and Director, Department of Prosthetic Dentistry and Biomedical Materials Science, MHH
Undergraduate and Postgraduate Training
1988 – 1994 Dental Medicine, University of Hamburg, Germany
1994 Doctorate in Dentistry (Dr. med. dent.)
2001 Diplomate of the German Society of Prosthodontics and Dental Materials
2002 Habilitation and Venia legendi in Dental and Oro- Maxillofacial Sciences, MHH
Academic and Research Posts
1994 – 1998 Research fellow, Department of Operative Dentistry and Periodontology, Christian- Albrechts-University of Kiel, Germany
1998 – 2000 Postgraduate programme in Implantology, Dental School, New York University, NY, USA
1998 – 2005 Senior lecturer at Dental School, MHH
Since 2005 Appointment as Full Professor (W3), Head of the Department of Prosthetic Dentistry and Biomedical Materials Science, MHH
Other Scientific Roles
Since 2011 Coordinator, research consortium BIOFABRICATION for NIFE (Volkswagen Foundation/State of Lower Saxony)
Since 2011 Board of Guideline Committee VDI 5701 – Biomaterials in Medical Technology
Since 2011 Management Board of NIFE (Lower Saxony Centre for Biomedical Engineering, Implant Research and Development)
Since 2013 Member, Cluster of Excellence “REBIRTH”
Since 2016 Member of the DFG review board (Fachkollegium) medicine
Since 2016 President of German Society of Prosthodontics and Dental Materials
Since 2018 Member, Cluster of Excellence 2155 “RESIST” – Resolving Infection Susceptibility
Since 2019 Member of the DFG Senate Committee for Guidelines in Clinical Science
Awards and Prizes
2005 Mieg Forschungspreis
2007 Dentaprime Forschungspreis
2009 Peers Forschungspreis
10 Selected Publications (of > 250 original publications)
Ingendoh-Tsakmakidis A, Mikolai C, Winkel A, Szafrański SP, Falk CS, Rossi A, Walles H, Stiesch M. Commensal and pathogenic biofilms differently modulate peri-implant oral mucosa in an organotypic model. Cell Microbiol. 2019 Jul 3:e13078. doi: 10.1111/cmi.13078.
Szafrański SP, Kilian M, Yang I, Bei der Wieden G, Winkel A, Hegermann J, Stiesch M. Diversity patterns of bacteriophages infecting Aggregatibacter and Haemophilus species across clades and niches. ISME J. 2019 Jun 14. doi: 10.1038/s41396-019-0450-8.
Doll K, Yang I, Fadeeva E, Kommerein N, Szafrański SP, Bei der Wieden G, Greuling A, Winkel A, Chichkov BN, Stumpp NS, Stiesch M. Liquid-Infused Structured Titanium Surfaces: Antiadhesive Mechanism to Repel Streptococcus oralis Biofilms. ACS Appl Mater Interfaces. 2019 Jul 3;11(26):23026-23038. doi: 10.1021/acsami.9b06817.
Ingendoh-Tsakmakidis A, Nolte L, Winkel A, Meyer H, Koroleva A, Shpichka A, Ripken T, Heisterkamp A, Stiesch M. Time resolved 3D live-cell imaging on implants. PLoS One. 2018; doi: 10.1371.
Dreyer H, Grischke J, Tiede C, Eberhard J, Schweitzer A, Toikkanen SE, Glöckner S, Krause G, Stiesch M. Epidemiology and risk factors of peri- implantitis: A systematic review. J Periodontal Res. 2018; doi: 10.1111/jre.12562. (Epub ahead of print)
Kommerein N, Doll K, Stumpp NS, Stiesch M. Development and characterization of an oral multispecies biofilm implant flow chamber model. PLoS One. 2018; 5: doi: 10.1371
Doll K, Fadeeva E, Schaeske J, Ehmke T, Winkel A, Heisterkamp A, Chichkov BN, Stiesch M, Stumpp NS. Development of laser-structured liquid-infused titanium with strong biofilm-repellent properties. ACS Appl Mater Interfaces. 2017; 11: 9359-9368.
Kommerein N, Stumpp SN, Müsken M, Ehlert N, Winkel A, Häussler S, Behrens P, Buettner FF, Stiesch M. An oral multispecies biofilm model for high content screening applications. PLoS One 2017;12: e0173973.
Rath H, Feng D, Neuweiler I, Stumpp NS, Nackenhorst U, Stiesch M. Biofilm formation by the oral pioneer colonizer Streptococcus gordonii: an experimental and numerical study. FEMS Microbiol Ecol 2017; 93.
Szafrański SP, Winkel A, Stiesch M. The use of bacteriophages to biocontrol oral biofilms. J Biotechnol. 2017; 250:29-44.