Prof. Dr. Marco Galardini participates in RESIST research project area C.

My Research Interest in RESIST

My research interest concern understanding how genetic variants that distinguish members of the same bacterial species („strains“) affect their phenotype, in the environment or in vivo. As bacterial strains can differ from each other by more than half their genetic content, these differences have the potential to influence important processes such as pathogenicity and antimicrobial resistance. Lastly, I am interested in how these differences across strains can affect the evolution of antimicrobial resistance, particularly its speed and predictability.

Prof. Galardini about his scientific work

Prof. Dr. Marco Galardini – Curriculum Vitae

Current Position

  • Since 10/2020 Head of Research Group ‚ÄúSystems Biology of Microbial Communities“ at TWINCORE

Undergraduate and Postgraduate Training

  • 2003 – 2006 Bachelor in environmental and industrial biotechnology, University of Florence, Italy

  • 2006 – 2008 Master in Bioinformatics, University of Bologna, Italy

  • 2010 – 2013 Microbial Genetics Laboratory, University of Florence, Italy

Academic and Research Posts

  • 2019 – 2020 Postdoctoral fellow, Boston University, Boston, USA

  • 2014 – 2019 Postdoctoral fellow, EMBL-EBI, Cambridge, UK

  • 2010 – 2014 PhD student, Microbial Genetics Laboratory, Univesity of Florence, Italy

Awards and Prizes

  • 2006 Bachelor graduation: 110/110 cum laude and special mention from the thesis committee

  • 2010 FEMS meeting attendance grant for the European Nitrogen Fixation Conference

  • 2017 PLOS early career travel award for the FEMS Conference

  • 2018 eLife early career travel award for the ICSB conference

Recommended Links

For further information about Prof. Galardinis scientific work please check the following links:

10 Selected Publications

Burgaya, J., Marin, J., Royer, G., Condamine, B., Gachet, B., Clermont, O., Jaureguy, F., Burdet, C., Lefort, A., Lastours, V. de, Denamur, E., Galardini, M., Blanquart, F. (2023). The bacterial genetic determinants of Escherichia coli capacity to cause bloodstream infections in humans. PLOS Genetics, 19(8), e1010842.

Denamur, E., Condamine, B., Esposito-Farèse, M., Royer, G., Clermont, O., Laouenan, C., … & Galardini, M. (2022). Genome wide association study of human bacteremia Escherichia coli isolates identifies genetic determinants for the portal of entry but not fatal outcome. PLoS Genet. 2022;18(3):e1010112.

Innocenti, G., & Galardini, M. (2023). Real-time identification of epistatic interactions in SARS-CoV-2 from large genome collections (p. 2023.08.22.554253). bioRxiv. doi.org/10.1101/2023.08.22.554253

Galardini, M., Koumoutsi, A., Herrera, C. M., Cordero Varela, J. A., Telzerow, A., Wagih O., Wartel M., Clermont O., Denamur E., Typas, A., Beltrao, P. (2017). Phenotype inference in an Escherichia coli strain panel. eLife, 6.

Galardini, M., Busby, B. P., Vieitez, C., Dunham, A. S., Typas, A., & Beltrao, P. (2019). The impact of the genetic background on gene deletion phenotypes in Saccharomyces cerevisiae. Molecular Systems Biology, 15(12).

Galardini, M., Clermont, O., Baron, A., Busby, B., Dion, S., Schubert, S., … & Denamur, E. (2020). Major role of iron uptake systems in the intrinsic extra-intestinal virulence of the genus Escherichia revealed by a genome-wide association study. PLoS Genetics.

Wagih, O., Galardini, M., Busby, B. P., Memon, D., Typas, A., & Beltrao, P. (2018). A resource of variant effect predictions of single nucleotide variants in model organisms. Molecular systems biology, 14(12), e8430.

Neubauer, H., & Galardini, M. (2023). Improved interpretability of bacterial genome-wide associations using gene cluster centric k-mers. bioRxiv. 10.1101/2023.04.11.536385

Lees, J. A., Galardini, M., Bentley, S. D., Weiser, J. N., & Corander, J. (2018). pyseer: a comprehensive tool for microbial pangenome-wide association studies. Bioinformatics, 34(24), 4310-4312.

Royer, G., Clermont, O., Marin, J., Condamine, B., Dion, S., Blanquart, F., … Galardini, M. & Denamur, E. (2023). Epistatic interactions between the high pathogenicity island and other iron uptake systems shape Escherichia coli extra-intestinal virulence. Nature Communications, 14(1), 3667.

Contact

  Prof. Dr. Marco Galardini
¬† Research group „Systems Biology of Microbial Communities“
  TWINCORE, Centre for Experimental and Clinical Infection Research
Feodor-Lynen-Str. 7
30625 Hannover
  +49 511 220027 208
  marco.galardini@twincore.de