Prof. Dr. Marco Galardini participates in RESIST research project area C.
| My Research Interest in RESIST |
My research interest concern understanding how genetic variants that distinguish members of the same bacterial species („strains“) affect their phenotype, in the environment or in vivo. As bacterial strains can differ from each other by more than half their genetic content, these differences have the potential to influence important processes such as pathogenicity and antimicrobial resistance. Lastly, I am interested in how these differences across strains can affect the evolution of antimicrobial resistance, particularly its speed and predictability.
Prof. Galardini about his scientific work
Prof. Dr. Marco Galardini – Curriculum Vitae
Current Position
Undergraduate and Postgraduate Training
Academic and Research Posts
Awards and Prizes
10 Selected Publications
Burgaya, J., Marin, J., Royer, G., Condamine, B., Gachet, B., Clermont, O., Jaureguy, F., Burdet, C., Lefort, A., Lastours, V. de, Denamur, E., Galardini, M., Blanquart, F. (2023). The bacterial genetic determinants of Escherichia coli capacity to cause bloodstream infections in humans. PLOS Genetics, 19(8), e1010842.
Denamur, E., Condamine, B., Esposito-Farèse, M., Royer, G., Clermont, O., Laouenan, C., … & Galardini, M. (2022). Genome wide association study of human bacteremia Escherichia coli isolates identifies genetic determinants for the portal of entry but not fatal outcome. PLoS Genet. 2022;18(3):e1010112.
Innocenti, G., & Galardini, M. (2023). Real-time identification of epistatic interactions in SARS-CoV-2 from large genome collections (p. 2023.08.22.554253). bioRxiv. doi.org/10.1101/2023.08.22.554253
Galardini, M., Koumoutsi, A., Herrera, C. M., Cordero Varela, J. A., Telzerow, A., Wagih O., Wartel M., Clermont O., Denamur E., Typas, A., Beltrao, P. (2017). Phenotype inference in an Escherichia coli strain panel. eLife, 6.
Galardini, M., Busby, B. P., Vieitez, C., Dunham, A. S., Typas, A., & Beltrao, P. (2019). The impact of the genetic background on gene deletion phenotypes in Saccharomyces cerevisiae. Molecular Systems Biology, 15(12).
Galardini, M., Clermont, O., Baron, A., Busby, B., Dion, S., Schubert, S., … & Denamur, E. (2020). Major role of iron uptake systems in the intrinsic extra-intestinal virulence of the genus Escherichia revealed by a genome-wide association study. PLoS Genetics.
Wagih, O., Galardini, M., Busby, B. P., Memon, D., Typas, A., & Beltrao, P. (2018). A resource of variant effect predictions of single nucleotide variants in model organisms. Molecular systems biology, 14(12), e8430.
Neubauer, H., & Galardini, M. (2023). Improved interpretability of bacterial genome-wide associations using gene cluster centric k-mers. bioRxiv. 10.1101/2023.04.11.536385
Lees, J. A., Galardini, M., Bentley, S. D., Weiser, J. N., & Corander, J. (2018). pyseer: a comprehensive tool for microbial pangenome-wide association studies. Bioinformatics, 34(24), 4310-4312.
Royer, G., Clermont, O., Marin, J., Condamine, B., Dion, S., Blanquart, F., … Galardini, M. & Denamur, E. (2023). Epistatic interactions between the high pathogenicity island and other iron uptake systems shape Escherichia coli extra-intestinal virulence. Nature Communications, 14(1), 3667.
