Prof. Dr. Dorothee Viemann participates in RESIST research project B1.
| My Research Interest in RESIST |
Our group is interested in the maturation processes of systemic as well as mucosal immunity in preterm infants. Within RESIST we focus on the reciprocal host-microbiota interactions and how human microbiota shapes the immune system during the phase of environmental adaptation in this patient group. Our work program aims at providing detailed insights about what host factors and what microbiota members promote increased resistance against bacterial and viral infections and the development life-long immune homeostasis and overall health. The long-term aim is to characterize based on the immune profile at birth what babies would profit from iatrogenic immunomodulation and second to identify host- and microbiota-related mechanisms that could be exploited to induce and accelerate immune maturation and colonization in preterm infants.
Candidate host factors in this context are S100-alarmins. We previously revealed that healthy term neonates massively release S100-alarmins in the blood and receive a huge supply of S100-alarmins via breast milk. The S100-priming of immunity at birth induces a tolerant state and prevents hyperinflammatory responses against the new extra-uterine world without impairing pathogen defense. In RESIST we keep track of whether S100-alarmins essentially prepare the host in a superior manner for the colonization of a favourable microbiota thereby ensuring long-term health.
Prof. Viemann about her scientific work
Prof. Dr. Dorothee Viemann – Curriculum Vitae
Current Position
Undergraduate and Postgraduate Training
Academic and Research Posts
Other Scientific Roles
Awards and Prizes
10 Selected Publications
León-Lara X, Fichtner AS, Willers M, Yang T, Schaper K, Riemann L, Schöning J, Harms A, Almeida V, Schimrock A, Janssen A, Ospina L, von Kaisenberg C, Förster R, Eberl M, Richter MF, Pirr S, Viemann D*, Ravens S*. γδ T cell profiling in a cohort of preterm infants reveals elevated frequencies of CD83+ γδ T cells in sepsis. JEM. 2024. *shared senior authorship (accepted for publication)
Heinemann AS, Stalp JL, Pereira Bonifacio JP, Silva F, Willers M, Heckmann J, Fehlhaber B, Völlger L, Raafat D, Normann N, Klos A, Hansen G, Schmolke M, Viemann D. Silent neonatal influenza A virus infection primes systemic antimicrobial immunity. Front Immunol. 2023;14:1072142. doi: 10.3389/fimmu.2023.1072142
Pirr S, Dauter L, Vogl T, Ulas T, Bohnhorst B, Roth J, Viemann D. S100A8/A9 is the first predictive marker for neonatal sepsis. Clin Transl Med. 2021;11(4):e338. doi: 10.1002/ctm2.338
Willers M, Ulas T, Völlger L, Vogl T, Heinemann AS, Pirr S, Pagel J, Fehlhaber B, Halle O, Schöning J, Schreek S, Löber U, Essex M, Hombach P, Graspeuntner S, Basic M, Bleich A, Cloppenborg-Schmidt K, Künzel S, Jonigk D, Rupp J, Hansen G, Förster R, Baines JF, Härtel C, Schultze JL, Forslund SK, Roth J, Viemann D. S100A8 and S100A9 Are Important for Postnatal Development of Gut Microbiota and Immune System in Mice and Infants. Gastroenterology. 2020;159(6):2130-2145.e5. doi: 10.1053/j.gastro.2020.08.019
Ravens S, Fichtner AS, Willers M, Torkornoo D, Pirr S, Schöning J, Deseke M, Sandrock I, Bubke A, Wilharm A, Dodoo D, Egyir B, Flanagan KL, Steinbrück L, Dickinson P, Ghazal P, Adu B, Viemann D*, Prinz I*. Microbial exposure drives polyclonal expansion of innate γδ T cells immediately after birth. Proc Natl Acad Sci U S A. 2020;117(31):18649-18660. doi: 10.1073/pnas.1922588117. *shared senior authorship
Bickes MS, Pirr S, Heinemann AS, Fehlhaber B, Halle S, Völlger L, Willers M, Richter M, Böhne C, Albrecht M, Langer M, Pfeifer S, Jonigk D, Vieten G, Ure B, von Kaisenberg C, Förster R, von Köckritz-Blickwede M, Hansen G, Viemann D. Constitutive TNF-α signaling in neonates is essential for the development of tissue-resident leukocyte profiles at barrier sites. FASEB J. 2019;33(10):10633-10647. doi: 10.1096/fj.201900796R
Ulas T*, Pirr S*, Fehlhaber B, Bickes MS, Loof TG, Vogl T, Mellinger L, Heinemann AS, Burgmann J, Schoning J, Schreek S, Pfeifer S, Reuner F, Vollger L, Stanulla M, von Kockritz-Blickwede M, Glander S, Barczyk-Kahlert K, von Kaisenberg CS, Friesenhagen J, Fischer-Riepe L, Zenker S, Schultze JL, Roth J, Viemann D. S100-alarmin-induced innate immune programming protects newborn infants from sepsis. Nat Immunol. 2017;18(6):622–632. doi: 10.1038/ni.3745. *contributed equally
Austermann J*, Friesenhagen J*, Fassl SK, Petersen B, Ortkras T, Burgmann J, Barczyk-Kahlert K, Faist E, Zedler S, Pirr S, Rohde C, Muller-Tidow C, von Kockritz-Blickwede M, von Kaisenberg CS, Flohe SB, Ulas T, Schultze JL, Roth J, Vogl T, Viemann D. Alarmins MRP8 and MRP14 induce stress tolerance in phagocytes under sterile inflammatory conditions. Cell Rep. 2014;9(6):2112–23. doi: 10.1016/j.celrep.2014.11.020. *contributed equally
Viemann D, Barczyk K, Vogl T, Fischer U, Sunderkötter C, Schulze-Osthoff K, Roth J. MRP8/MRP14 impairs endothelial integrity and induces a caspase-dependent and -independent cell death program. Blood. 2007;109(6):2453-60. doi: 10.1182/blood-2006-08-040444
Viemann D, Strey A, Janning A, Jurk K, Klimmek K, Vogl T, Hirono K, Ichida F, Foell D, Kehrel B, Gerke V, Sorg C, Roth J. Myeloid-related proteins 8 and 14 induce a specific inflammatory response in human microvascular endothelial cells. Blood. 2005;105(7):2955-62. doi: 10.1182/blood-2004-07-2520
