Prof. Dr. Chris Lauber participates in RESIST research project A6.
| My Research Interest in RESIST |
Each person carries millions of small changes in his or her genome that define who we are but which also can make us more susceptible to diseases. We are interested in computationally dissecting the complex interplay of this genetic variation in order to identify those changes that are associated with course or severity of disease. Within RESIST we closely collaborate with Gesine Hansen and Thomas Pietschmann with the aim to uncover such genetic determinants for severe infection with the human respiratory syncytial virus (RSV) among young children.
In addition, we want to understand whether the human virome constitutes another factor that influences infection susceptibility. We have recently developed a high-performance computing workflow for the identification of viral genomes in sequencing data that we will use to characterize the virome composition of a large collection of samples from diseased and healthy individuals. Ultimately, we aim at associating known or newly discovered viruses to diseases with unexplained cause.
Prof. Lauber about his scientific work
Prof. Dr. Chris Lauber – Curriculum Vitae
Current Position
Undergraduate and Postgraduate Training
Academic and Research Posts
Other Scientific Roles
Awards and Prizes
10 Selected Publications (of > 30 original publications)
Gorbalenya, Baker, Baric, de Groot, Drosten, Gulyaeva, Haagmans, Lauber, Leontovich, Neuman, Penzar, Perlman, Poon, Samborskiy, Sidorov, Sola, Ziebuhr â The species Severe acute respiratory syndrome-related coronavirus: classifying 2019-nCoV and naming it SARS-CoV-2. â Nature Microbiology 2020; 5:536
Lauber, Seifert, Bartenschlager, Seitz. â Discovery of highly divergent lineages of plant-associated astro-like viruses sheds light on the emergence of potyviruses â Virus Research 2019; 260:38-48 â special issue Virus Bioinformatics
Lauber*, Seitz*, Mattei, Suh, Beck, Herstein, Börold, Salzburger, Kaderali, Briggs, Bartenschlager â Deciphering the origin and evolution of hepatitis B viruses by means of a family of non-enveloped fish viruses â Cell Host & Microbe 2017; 22:387-399 ; * equal contribution
Moens, Krumbholz, Ehlers, Zell, Johne, Calvignac-Spencer, Lauber â Biology, evolution, and medical importance of polyomaviruses: An update â Infection, Genetics and Evolution 2017; 54:18-38
Lauber*, Kazem*, Kravchenko, Feltkamp, Gorbalenya â Interspecific adaptation by binary choice at de novo polyomavirus T antigen site through accelerated codon-constrained Val-Ala toggling within an intrinsically disordered region â Nucleic Acids Research 2015; 43:4800 ;* equal contribution
Lauber*, Vieyres*, Terczynska-Dyla, Anggakusuma, Dijkman, Gad, Akhtar, Geffers, Vondran, Thiel, Kaderali, Pietschmann, Hartman â Transcriptome analysis reveals a classical interferon signature induced by IFNL4 in primary cells â Genes and Immunity 2015; 16:414 ;* equal contribution
Lauber, Goeman, Parquet, Nga, Snijder, Morita, Gorbalenya â The Footprint of Genome Architecture in the Largest Genome Expansion in RNA Viruses â PLoS Pathogens 2013; 9:e003500
Lauber, Gorbalenya â Toward genetics-based virus taxonomy: comparative analysis of a genetics-based classification and the taxonomy of picornaviruses â Journal of Virology 2012; 86:3905 â J.Virol. spotlight feature
Lauber, Gorbalenya â Partitioning the genetic diversity of a virus family: approach and evaluation through a case study of picornaviruses â Journal of Virology 2012; 86:3890 â J.Virol. spotlight feature â recommended by the Faculty of 1000
Nga*, Parquet*, Lauber*, Parida, Nabeshima, Yu, Thuy, Inoue, Ito, Okamoto, Ichinose, Snijder, Morita, Gorbalenyaâ Discovery of the first insect nidovirus, a missing evolutionary link in the emergence of the largest RNA virus genomes â PLoS Pathogens 2011; 7:e1002215; * equal contribution
