Prof. Dr. Chris Lauber participates in RESIST research project A6.
| My Research Interest in RESIST |
Each person carries millions of small changes in his or her genome that define who we are but which also can make us more susceptible to diseases. We are interested in computationally dissecting the complex interplay of this genetic variation in order to identify those changes that are associated with course or severity of disease. Within RESIST we closely collaborate with Gesine Hansen and Thomas Pietschmann with the aim to uncover such genetic determinants for severe infection with the human respiratory syncytial virus (RSV) among young children.
In addition, we want to understand whether the human virome constitutes another factor that influences infection susceptibility. We have recently developed a high-performance computing workflow for the identification of viral genomes in sequencing data that we will use to characterize the virome composition of a large collection of samples from diseased and healthy individuals. Ultimately, we aim at associating known or newly discovered viruses to diseases with unexplained cause.
Prof. Lauber about his scientific work
Prof. Dr. Chris Lauber – Curriculum Vitae
Current Position
Undergraduate and Postgraduate Training
Academic and Research Posts
Other Scientific Roles
Awards and Prizes
10 Selected Publications
Pathogen dynamics and discovery of novel viruses and enzymes by deep nucleic acid sequencing of wastewater. Wyler E, Lauber C, Manukyan A, Deter A, Quedenau C, Teixeira Alves LG, Wylezich C, Borodina T, Seitz S, Altmüller J, Landthaler M. Environ Int. 2024 Aug;190:108875. Epub 2024 Jul 8.
Deep mining of the Sequence Read Archive reveals major genetic innovations in coronaviruses and other nidoviruses of aquatic vertebrates. Lauber C, Zhang X, Vaas J, Klingler F, Mutz P, Dubin A, Pietschmann T, Roth O, Neuman BW, Gorbalenya AE, Bartenschlager R, Seitz S. PLoS Pathog. 2024 Apr 22;20(4):e1012163.
Drug repurposing screen identifies lonafarnib as respiratory syncytial virus fusion protein inhibitor. Sake SM, Zhang X, Rajak MK, Urbanek-Quaing M, Carpentier A, Gunesch AP, Grethe C, Matthaei A, Rückert J, Galloux M, Larcher T, Le Goffic R, Hontonnou F, Chatterjee AK, Johnson K, Morwood K, Rox K, Elgaher WAM, Huang J, Wetzke M, Hansen G, Fischer N, Eléouët JF, Rameix-Welti MA, Hirsch AKH, Herold E, Empting M, Lauber C, Schulz TF, Krey T, Haid S, Pietschmann T. Nat Commun. 2024 Feb 8;15(1):1173.
Evolutionary Insight into the Association between New Jersey Polyomavirus and Humans. Aghebatrafat AA, Lauber C, Merkel K, Fruth B, Langergraber K, Robbins MM, Wittig RM, Leendertz FH, Calvignac-Spencer S. Viruses. 2023 Nov 13;15(11):2248.
Viroid-like RNA-dependent RNA polymerase-encoding ambiviruses are abundant in complex fungi. Chong LC, Lauber C. Front Microbiol. 2023 May 12;14:1144003.
Opportunities and Challenges of Data-Driven Virus Discovery. Lauber C, Seitz S. Biomolecules. 2022 Aug 4;12(8):1073.
Bioinformatics of virus taxonomy: foundations and tools for developing sequence-based hierarchical classification. Gorbalenya AE, Lauber C. Curr Opin Virol. 2022 Feb;52:48-56. Epub 2021 Dec 6.
Initial HCV infection of adult hepatocytes triggers a temporally structured transcriptional program containing diverse pro- and anti-viral elements. Tegtmeyer B, Vieyres G, Todt D, Lauber C, Ginkel C, Engelmann M, Herrmann M, Pfaller CK, Vondran FWR, Broering R, Vafadarnejad E, Saliba AE, Puff C, Baumgärtner W, Miskey C, Ivics Z, Steinmann E, Pietschmann T, Brown RJP. J Virol. 2021 Apr 26;95(10):e00245-21. Epub 2021 Mar 3.
Coronaviridae Study Group of the International Committee on Taxonomy of Viruses. The species Severe acute respiratory syndrome-related coronavirus: classifying 2019-nCoV and naming it SARS-CoV-2. Nat Microbiol. 2020 Apr;5(4):536-544. Epub 2020 Mar 2.
Deciphering the Origin and Evolution of Hepatitis B Viruses by Means of a Family of Non-enveloped Fish Viruses. Lauber C, Seitz S, Mattei S, Suh A, Beck J, Herstein J, Börold J, Salzburger W, Kaderali L, Briggs JAG, Bartenschlager R. Cell Host Microbe. 2017 Sep 13;22(3):387-399.e6. Epub 2017 Aug 31.
