Prof. Dr. Albert Osterhaus participates in RESIST research project B7.
| My Research Interest in RESIST |
During aging, the performance of the immune system decreases, due to so-called immuno-senescence. This is an important reason why older adults are more susceptible to cancer and infections, like influenza. Therefore, vaccinations against some infections are specifically recommended for them. However, due to immuno-senescence also vaccination does not work as well as in younger people. Our research interest in RESIST is to better understand the mechanisms of the reduced immune response to infections and vaccinations, as well as immune control in persistent infections such as those caused by the varicella zoster virus. This will allow the development of more effective vaccines and therapies.
Prof. Osterhaus about his scientific work
Prof. Dr. Albert Osterhaus – Curriculum Vitae
Current Position
Undergraduate and Postgraduate Training
Academic and Research Posts
Other Scientific Roles
Awards and Prizes
Patents
10 Selected Publications (of > 1250 original publications)
Haagmans BL, van den Brand JM, Raj VS, Volz A, Wohlsein P, Smits SL, Schipper D, Bestebroer TM, Okba N, Fux R, Bensaid A, Solanes Foz D, Kuiken T, Baumgärtner W, Segalés J, Sutter G, Osterhaus AD. An orthopoxvirus-based vaccine reduces virus excretion after MERS-CoV infection in dromedary camels. Science. 2016; 351: 77-81.
Mina MJ, Metcalf CJ, de Swart RL, Osterhaus AD, Grenfell BT. Long-term measles-induced immunomodulation increases overall childhood infectious disease mortality. Science. 2015; 348: 694-9.
Zaki AM, van Boheemen S, Bestebroer TM, Osterhaus AD, Fouchier RA: Isolation of a novel coronavirus from a man with pneumonia in Saudi Arabia. N Engl J Med. 2012; 19: 1814-20.
Herfst S, Schrauwen EJ, Linster M, Chutinimitkul S, de Wit E, Munster VJ, Sorrell EM, Bestebroer TM, Burke DF, Smith DJ, Rimmelzwaan GF, Osterhaus AD, Fouchier RA. Airborne transmission of influenza A/ H5N1 virus between ferrets. Science. 2012; 336: 1534-41.
Stittelaar KJ, Neyts J, Naesens L, van Amerongen G, van Lavieren RF, Holý A, De Clercq E, Niesters HG, Fries E, Maas C, Mulder PG, van der Zeijst BA, Osterhaus AD. Antiviral treatment is more effective than smallpox vaccination upon lethal monkeypox virus infection. Nature. 2006; 439: 745-8.
Haagmans BL, Kuiken T, Martina BE, Fouchier RA, Rimmelzwaan GF, van Amerongen G, van Riel D, de Jong T, Itamura S, Chan KH, Tashiro M, Osterhaus AD. Pegylated interferon-alpha protects type 1 pneumocytes against SARS coronavirus infection in macaques. Nat Med. 2004; 10(3): 290-3.
Kuiken T, Rimmelzwaan G, van Riel D, van Amerongen G, Baars M, Fouchier R, Osterhaus AD. Avian H5N1 influenza in cats. Science. 2004; 306: 241.
Fouchier RA, Kuiken T, Schutten M, van Amerongen G, van Doornum GJ, van den Hoogen BG, Peiris M, Lim W, Stöhr K, Osterhaus AD. Aetiology: Koch’s postulates fulfilled for SARS virus. Nature. 2003; 423: 240.
Martina BE, Haagmans BL, Kuiken T, Fouchier RA, Rimmelzwaan GF, Van Amerongen G, Peiris JS, Lim W, Osterhaus AD: SARS virus infection of cats and ferrets. Nature. 2003; 425: 915.
van den Hoogen BG, de Jong JC, Groen J, Kuiken T, de Groot R, Fouchier RA, Osterhaus AD. A newly discovered human pneumovirus isolated from young children with respiratory tract disease. Nat Med. 2001; 7(6): 719-24.
