Dr. Benjamin Nilsson-Payant
| My Research Interest in RESIST |
RNA viruses carry highly conserved RNA-dependent RNA polymerases that they use to copy and transcribe their genomes. However, as RNA-dependent RNA polymerases are inherently error-prone, all RNA viruses produce aberrant replication products, so-called “defective viral genomes”. My research interests focus on understanding how influenza A virus and other respiratory and emerging negative-sense RNA viruses replicate their RNA genomes and how their (aberrant) replication products induce the innate immune response. We use a combination approach of molecular biology tools, state-of-the-art transcriptomics and viral engineering to understand the molecular mechanisms of viral replication and how virus-host interactions affect viral replication and the innate immune response.
Dr. Benjamin Nilsson-Payant
Dr. Benjamin Nilsson-Payant – Curriculum Vitae
Current Position
Undergraduate and Postgraduate Training
Academic and Research Posts
Other Scientific Roles
Awards and Prizes
10 Selected Publications (of > 16 original publications)
Han Y, Zhu J, Yang L, Nilsson-Payant BE*, Hurtado R, Lacko LA, Sun X, Gade AR, Higgins CA, Sisso WJ, Dong X, Wang M, Chen Z, Ho DD, Pitt GS, Schwartz RE, tenOever BR, Evans T, Chen S (2022) SARS-CoV-2 infection induces ferroptosis of sinoatrial node pacemaker cells. Circulation Research, 130(7):963-977.
Nilsson-Payant BE#, tenOever BR, te Velthuis AJ. (2022) The host factor ANP32A is required for influenza A virus vRNA and cRNA synthesis. Journal of Virology, 96: e02092-21.
Nilsson-Payant BE*, Uhl S, Grimont A, Doane AS, Cohen P, Patel RS, Higgins CA, Acklin JA, Bram Y, Chandar V, Blanco-Melo D, Panis M, Lim JK, Elemento O, Schwartz RE, Rosenberg BR, Chandwani R, tenOever BR (2021) The NF-κB transcriptional footprint is essential for SARS-CoV-2 replication. Journal of Virology, 95:e01257-21.
Yang L, Han Y, Jaffré F, Nilsson-Payant BE*, Bram Y, Wang P, Zhu J, Zhang T, Redmond D, Houghton S, Uhl S, Borczuk A, Huang Y, Richardson C, Chandar V, Acklin JA, Lim JK, Xiang J, Ho DD, tenOever BR, Schwartz RE, Evans T, Chen S. (2021) An hPSC-Derived Immuno-Cardiomyocyte Co-culture Platform to Screen for Drugs that Block Macrophage-Mediated Hyper-inflammation in COVID-19 Hearts. Circulation Research, 129(1):33-46.
Nilsson-Payant BE*, Blanco-Melo D, Uhl S, Escudero-Pérez B, Olschewski S, Thibault P, Panis M, Rosenthal M, Muñoz-Fontela C, Lee B, tenOever BR. (2021) Reduced Nucleoprotein availability impairs negative-sense RNA virus replication and promotes host recognition. Journal of Virology, 95:e02274-20.
Han Y, Duan X, Yang L, Nilsson-Payant BE*, Wang P, Duan F, Tang X, Yaron TM, Zhang T, Uhl S, Bram Y, Richardson C, Zhu J, Zhao Z, Redmond D, Houghton S, Nguyen DT, Xu D, Wang X, Jessurun J, Borczuk A, Huan Y, Johnson JL, Liu Y, Xiang J, Wang H, Cantley LC, tenOever BR, Ho DD, Pan FC, Evans T, Chen HJ, Schwartz RE, Chen S. (2021) Identification of SARS-CoV-2 Inhibitors using Lung and Colonic Organoids. Nature, 589(7841):270-275.
Yang L, Han Y, Nilsson-Payant BE*, Gupta V, Wang P, Duan X, Tang X, Zhu J, Zhao Z, Jaffré F, Zhang T, Kim TW, Harschnitz O, Redmond D, Houghton S, Liu C, Naji A, Ciceri G, Guttikonda S, Bram Y, Nguyen DT, Cioffi M, Chandar V, Hoagland DA, Huang Y, Xiang J, Wang H, Lyden D, Borczuk A, Chen HJ, Studer L, Pan FC, Ho DD, tenOever BR, Evans T, Schwartz RE, Chen S. (2020) A Human Pluripotent Stem Cell-based Platform to Study SARS-CoV-2 Tropism and Model Virus Infection in Human Cells and Organoids. Cell Stem Cell, 27(1):125-136.e7.
Blanco-Melo D, Nilsson-Payant BE*, Liu WC, Uhl S, Hoagland D, Møller R, Jordan TX, Oishi K, Panis M, Sachs D, Wang TT, Schwartz RE, Lim JK, Albrecht RA, tenOever BR. (2020) Imbalanced host response to SARS-CoV-2 drives development of COVID-19. Cell, 181(5):1036-1045.e9.
Nilsson-Payant BE, Sharps J, Hengrung N, Fodor E. (2018) The surface-exposed PA51-72- loop of the influenza A virus polymerase is required for viral genome replication. Journal of Virology, 92:e00687-18.
Nilsson BE, te Velthuis AJW, Fodor E. (2017) Role of the PB2 627-domain in influenza A virus polymerase function. Journal of Virology, 91:e02467- 16.
