My Research Interest in RESIST |
Antibodies are key components of the adaptive immune system and are critical for defense against infectious diseases. While antibodies can directly block and prevent pathogens from infecting the host through a process called neutralization, recruitment of additional innate effector mechanisms such as phagocytosis or cytotoxicity is often required for effective protection. Within RESIST, we aim to define antibody properties and effector functions that track with protection or susceptibility to infectious diseases. A better understanding of antibody-mediated immunity may lead to the development of better vaccines or antibody-based therapies.
Prof. Bartsch
Prof. Dr. Yannic Bartsch
Current Position
Undergraduate and Postgraduate Training
Academic and Research Posts

10 Selected Publications
Bartsch, Y. C., Cizmeci, D., Yuan, D., Mehta, N., Tolboom, J., De Paepe, E., . . . Bastian, A. R. (2023). Vaccine-induced antibody Fc-effector functions in humans immunized with a combination Ad26.RSV.preF/RSV preF protein vaccine. J Virol, 97(11), e0077123. doi:10.1128/jvi.00771-23
Bartsch, Y. C., Cizmeci, D., Kang, J., Gao, H., Shi, W., Chandrashekar, A., . . . Alter, G. (2023). Selective SARS-CoV2 BA.2 escape of antibody Fc/Fc-receptor interactions. iScience, 26(5), 106582. doi:10.1016/j.isci.2023.106582
Yonker, L. M., Swank, Z., Bartsch, Y. C.*, Burns, M. D., Kane, A., Boribong, B. P., . . . Walt, D. R. (2023). Circulating Spike Protein Detected in Post-COVID-19 mRNA Vaccine Myocarditis. Circulation, 147(11), 867-876. doi:10.1161/CIRCULATIONAHA.122.061025. *shared first author
Bartsch, Y. C., Cizmeci, D., Kang, J., Zohar, T., Periasamy, S., Mehta, N., . . . Alter, G. (2022). Antibody effector functions are associated with protection from respiratory syncytial virus. Cell, 185(26), 4873-4886 e4810. doi:10.1016/j.cell.2022.11.012
Bartsch, Y. C., St Denis, K. J., Kaplonek, P., Kang, J., Lam, E. C., Burns, M. D., . . . Alter, G. (2022). SARS-CoV-2 mRNA vaccination elicits robust antibody responses in children. Sci Transl Med, 14(672), eabn9237. doi:10.1126/scitranslmed.abn9237
Karsten, C. B., Bartsch, Y. C.*, Shin, S. A., Slein, M. D., Heller, H. M., Kolandaivelu, K., . . . Julg, B. (2022). Evolution of functional antibodies following acute Epstein-Barr virus infection. PLoS Pathog, 18(9), e1010738. doi:10.1371/journal.ppat.1010738. *shared first author
Bartsch, Y. C., Tong, X., Kang, J., Avendano, M. J., Serrano, E. F., Garcia-Salum, T., . . . Alter, G. (2022). Omicron variant Spike-specific antibody binding and Fc activity are preserved in recipients of mRNA or inactivated COVID-19 vaccines. Sci Transl Med, 14(642), eabn9243. doi:10.1126/scitranslmed.abn9243
Bartsch, Y. C., Loos, C., Rossignol, E., Fajnzylber, J. M., Yuan, D., Avihingsanon, A., . . . Julg, B. (2021). Viral Rebound Kinetics Correlate with Distinct HIV Antibody Features. mBio, 12(2). doi:10.1128/mBio.00170-21
Bartsch, Y. C., Wang, C., Zohar, T., Fischinger, S., Atyeo, C., Burke, J. S., . . . Alter, G. (2021). Humoral signatures of protective and pathological SARS-CoV-2 infection in children. Nat Med, 27(3), 454-462. doi:10.1038/s41591-021-01263-3
Bartsch, Y. C., Eschweiler, S., Leliavski, A., Lunding, H. B., Wagt, S., Petry, J., . . . Ehlers, M. (2020). IgG Fc sialylation is regulated during the germinal center reaction following immunization with different adjuvants. J Allergy Clin Immunol, 146(3), 652-666 e611. doi:10.1016/j.jaci.2020.04.059
