Prof. Dr. Till Strowig participates in RESIST research projects B1 and B2.

My Research Interest in RESIST

Our research focus in RESIST is the identification and validation of the role of the gastrointestinal microbiome in infections and inflammatory conditions affecting susceptible and immunocompromised individuals. Therefore, we are employing sequencing-based, microbiological and immunological approaches applying them to gnotobiotic animal models and patient cohorts in collaboration with other RESIST scientists. The long-term aim is to identify pathophysiological conditions, which could be improved by targeting the microbiome therapeutically. 

Contact

Prof. Strowig about his scientific work

Prof. Dr. Till Strowig – Curriculum Vitae

Current Position

  • Since 2019 W3 Professor, Head of Department, Dept. of Microbial Immune Regulation, Helmholtz Centre for Infection Research 

Undergraduate and Postgraduate Training

  • 1999 – 2004 Studies in Medical Biotechnology, Dipl.Ing., Technische Universität Berlin, Berlin, Germany, Supervisor of Master thesis: Prof. Dr. Christian Münz (The Rockefller University)

  • 2009 PhD in Viral Immunobiology, The Rockefeller University, Supervisor: Prof. Dr. Christian Münz. Scientific Degree XY 

  • 2009 – 2013 Postdoc in the group of Prof. Dr. Richard Flavell in the department of Immunobiology at Yale University, New Haven, USA 

Academic and Research Posts

  • 2013 – 2019 Head of Young Invesitagor Research group at the Helmholtz Centre for Infection Research 

  • Since 2019 W3-Professorship at MHH

  • Since 2019 Head of Department “Microbial Immune Regulation” at the Helmholtz Centre for Infection Research.

Other Scientific Roles

  • Since 2019 Member of executive board, FG Microbiota of the DGHM

  • Since 2019 Member of the steering committee, DZIF Academy

  • Since 2019 Member of the steering committee, Excellence Cluster RESIST

  • Since 2022 Spokesperson of the DZIF Working Group “Microbiome”

Recommended Links

For further information about Prof. Strowig’s scientific work please check the following links:

10 Selected Publications

Osbelt L, Almási E, Wende M, Kienesberger S, Voltz A, Lesker TR, Muthukumarasamy U, Knischewski N, Nordmann E, Bielecka AA, Giralt-Zúñiga M, Kaganovitch E, Kühne C, Baier C, Pietsch M, Müsken M, Greweling-Pils MC, Breinbauer R, Flieger A, Schlüter D, Müller R, Erhardt M, Zechner EL, Strowig T. Klebsiella oxytoca inhibits Salmonella infection through multiple microbiota-context-dependent mechanisms. Nat Microbiol. in press.

Huang KD, Amend L, Gálvez EJC, Lesker TR, de Oliveira R, Bielecka AA,  Blanco-Míguez A, Valles-Colomer M, Ruf I, Pasolli E, Buer J, Segata N, Esser S, Strowig T*, Kehrmann J*. Establishment of a non-Westernized gut microbiota in men who have sex with men is associated with sexual practices. Cell Rep Med. 2024 Mar 19;5(3):101426. DOI: 10.1016/j.xcrm.2024.101426. Open Access

Blanco-Míguez A, Gálvez EJC, Pasolli E, De Filippis F, Amend L, Huang KD, Manghi P, Lesker TR, Riedel T, Cova L, Punčochář M, Thomas AM, Valles-Colomer M, Schober I, Hitch TCA, Clavel T, Berry SE, Davies R, Wolf J, Spector TD, Overmann J, Tett A, Ercolini D, Segata N*, Strowig T*. Extension of the Segatella copri complex to 13 species with distinct large extrachromosomal elements and associations with host conditions. Cell Host Microbe. 2023; Nov 8;31(11):1804-1819e9. DOI: 10.1016/j.chom.2023.09.013. Open Access

Bublitz A, Brauer M, Wagner S, Hofer W, Müsken M, Deschner F, Lesker TR, Neumann-Schaal M, Paul LS, Nübel U, Bartel J, Kany AM, Zühlke D, Bernecker S, Jansen R, Sievers S, Riedel K, Herrmann J, Müller R, Fuchs TM*, Strowig T*. The natural product chlorotonil A preserves colonization resistance and prevents relapsing Clostridioides difficile infection. Cell Host Microbe. 2023; May 10;31(5):734-750. DOI: 10.1016/j.chom.2023.04.003. Open Access

Li J, Galvez EJC, Amend L, Almási E, Iljazovic A, Lesker TR, Bielecka AA, Schorr EM, Strowig, T. A versatile genetic toolbox for Prevotella copri enables studying polysaccharide utilization systems. EMBO J. 2021; 40(23). DOI: 10.15252/embj.2021108287. Open Access

Osbelt L, Wende M, Almási E, Derksen E, Muthukumarasamy U, Lesker TR, Galvez EJC, Pils MC, Schalk E, Chhatwal P, Färber J, Neumann-Schaal M, Fischer T, Schlüter D, Strowig T. Klebsiella oxytoca causes colonization resistance against multidrug-resistant Klebsiella pneumoniae in the gut via cooperative carbohydrate competition. Cell Host & Microbe. 2021; 29(11), 1663-1679. DOI: 10.1016/j.chom.2021.09.003. Open Access

Gálvez EJC, Iljazovic A, Amend L, Lesker TR, Renault T, Thiemann S, Hao L, Roy U, Gronow A, Charpentier E, Strowig T. Distinct polysaccharide utilization as determinants for interspecies competition between intestinal Prevotella spp. Cell Host & Microbe. 2020; 28(6), 838-852. DOI: 10.1016/j.chom.2020.09.012. Open Access

Iljazovic A, Roy U, Gálvez EJC, Lesker TR, Zhao B, Gronow A, Amend L, Will SE, Hofmann JD, Pils MC, Schmidt-Hohagen K, Neumann-Schaal M, Strowig T. Perturbation of the gut microbiome by Prevotella spp. enhances host susceptibility to mucosal inflammation. Mucosal Immunol. 2020; 14(1), 113-124. DOI: 10.1038/s41385-020-0296-4. Open Access

Lesker TR, Durairaj AC, Gálvez EJC, Lagkouvardos I, Baines JF, Clavel T, Sczyrba A, McHardy AC, Strowig T. 2020. An Integrated Metagenome Catalog Reveals New Insights into the Murine Gut Microbiome. Cell Rep  DOI: 10.1016/j.celrep.2020.02.036. Open Access

Thiemann S, Smit N, Roy U, Lesker TR, Galvez EJC, Helmecke J, Basic M, Bleich A, Goodman AL, Kalinke U, Flavell RA, Erhardt M, Strowig T. Enhancement of IFNγ production by distinct commensals ameliorates Salmonella-induced disease. Cell Host & Microbe. 2017; 21(6), 682-694. DOI: 10.1016/j.chom.2017.05.005. Open Access

Contact

  Prof. Dr. Till Strowig
  Microbial Immune Regulation, Helmholtz Centre for Infection Research (HZI)
  Inhoffenstraße 7
38124 Braunschweig
  +49 531 6181 – 4612
  Till.Strowig@helmholtz-hzi.de