Prof. Dr. Martin Stangel participates in RESIST research projects A3 and A4.

My Research Interest in RESIST

We are generally interested in infections of the nervous system. Within RESIST our focus is on neurovirological infections and in particular with herpes viruses. The most common neuroinfectios condition is herpes zoster that is caused by varicella zoster virus (VZV). Since the clinical course of VZV infection varies tremendously between patients we want to identify determinants for a complicated clinical course with involvement of the central nervous system or with disabling post zoster neuralgia (PZN).

We want to achieve this on one hand be investigating genetic determinants these patients and on the other hand by searching for biomarker in the cerebrospinal fluid of patients suffering VZV infection. These informations will give clues for a better clinical management of patients with VZV infections and may also be the basis to identify new targets for the treatment of severe courses of VZV infections. 

Contact

Prof. Stangel about his scientific work

Prof. Dr. Martin Stangel – Curriculum Vitae

Current Position

  • Since 2011 Full Professor and head Clinical Neuroimmunology and Neurochemistry, Dept. of Neurology, Hannover Medical School (MHH) 

Undergraduate and Postgraduate Training

  • 1984 – 1992 Medical school, Georg August University, Göttingen, Germany 

  • 1989 Bachelor of Medical Sciences, University of Melbourne, Australia 

  • 1989 – 1990 MD studies, University of California San Diego and Salk Institute, U.S.A. 

  • 1992 Medical board exam

  • 1992 MD thesis (Dr. med.), Georg August University, Göttingen, Germany 

  • 2001 Board certification Neurology

  • 2002 Habilitation, Free University Berlin

Academic and Research Posts

  • 1992 – 1994 Internship in Neurology, University of Würzburg 

  • 1994 – 1997 Resident in Neurology, University Hospital Benjamin Franklin, Berlin 

  • 1997 – 1999 Research Fellow, MRC Center for Brain Repair, University of Cambridge, UK 

  • 1999 – 2002 Resident in Neurology and Psychiatry, University Hospital Benjamin Franklin 

  • 2002 – 2005 Attending (Oberarzt), Department of Neurology, Hannover Medical School 

  • 2005 – 2015 Vice chairman, Department of Neurology, Hannover Medical School (MHH) 

  • 2007 Associate Professor, Hannover Medical School

  • 2015 – 2019 Acting head of Department of Neurology, Hannover Medical School (MHH) 

  • Since 2011 Head Department of Clinical Neuroimmunology and Neurochemistry (MHH)

  • Since 2011 Full professor for Clinical Neuroimmunology and Neurochemistry, Hannover Medical School

Other Scientific Roles

  • Since 2001 Member, scientific advisory board, German MS Society (DMSG) 

  • Since 2004 Member, Center for Systems Neuroscience (ZSN), Hannover

  • Since 2010 Chair, Myelin Netzwerk e.V.

  • Since 2013 Member of the extended executive board of the German CSF society (DGLN) 

Awards and Prizes

  • 1998 Pfizer Award for Medicine (Immunology and Rheumatology)

  • 2005 Ferid Murad Award (by ISICR for “Outstanding contributions to interferon and cytokine research”) 

Recommended Links

For further information about Prof. Stangel’s scientific work please check the following links:

Selected Publications

Chhatbar C, Detje CN, Grabski E, Borst K, Spanier J, Ghita L,  Elliott DA, Costa Jordão MJ, Mueller N, Sutton J, Prajeeth CK, Gudi V, Klein MA, Prinz M, Bradke F, Stangel M*, Kalinke U*. Type I interferon receptor signaling of neurons and astrocytes regulates microglia activation during viral encephalitis. Cell Reports 2018;25:118-129. IF 8.032

Stangel M, Kuhlmann T, Matthews PM, Kilpatrick TJ. Achievements and obstacles for remyelinating therapies in multiple sclerosis. Nat Rev Neurol 2017;13:742-754. IF 19.819

Skripuletz T, Manzel A, Gropengießer K, Schäfer N, Gudi V, Singh V, Salinas Tejedor L,  Jörg S, Hammer A, Voss E, Vulinovic F, Degen D, Wolf R, Lee D-H, Pul R, Moharregh-Khiabani D, Baumgärtner W, Gold R, Linker RA, Stangel M. Pivotal role of choline metabolites in remyelination. Brain 2015;138:398-413. IF 9.196

Bénardais K, Gudi V, Gai L, Neβler J, Singh V, Prajeeth CK, Skripuletz T, Stangel M. Long-term impact of neonatal inflammation on de- and remyelination in the central nervous system. Glia 2014;62:1659-1670. IF 6.031

Skripuletz T, Hackstette D, Bauer K, Gudi V, Pul R, Voss E, Berger K, Kipp M,  Baumgärtner W, Stangel M. Astrocytes regulate myelin clearance through recruitment of microglia during cuprizone induced demyelination. Brain 2013;136:147-167. IF 9.196

Stangel M, Fredrikson S, Meinl E, Petzold A, Stüve O, Tumani H. The utility of CSF analysis in patients with multiple sclerosis. Nat Rev Neurol 2013;9:267-276. IF 15.358

Voß EV, Škuljec J, Gudi V, Skripuletz T, Pul R, Trebst C, Stangel M. Characterisation of microglia during de- and remyelination: can they create a repair promoting environment? Neurobiol Dis 2012;45:519-528. IF 4.856

Skripuletz T, Lindner M, Kotsiari A, Garde N, Fokuhl J, Linsmeier F, Trebst C, Stangel M. Cortical demyelination is prominent in mice using the cuprizone model and is strain dependent. Am J Pathol 2008;172:1053-1061. IF 4.206

Stangel M, Boegner F, Klatt CH, Hofmeister C, Seyfert S. A placebo-controlled pilot trial to study the remyelinating potential of intravenous immunoglobulins in multiple sclerosis. J Neurol Neurosurg Psychiatry 2000;68:89-92. IF 6,431

Collawn JF, Stangel M, Kuhn L, Esekogwu V, Jing S, Trowbridge IS, Tainer JA. Transferrin receptor internalization sequence YXRF implicates a tight turn as the structural recognition motif for endocytosis. Cell 1990;63:1061-1072. IF 28.710

Contact

  Prof. Dr. Martin Stangel
  Clinical Neuroimmunology and Neurochemistry, Dept. of Neurology, Hannover Medical School (MHH)
  Carl-Neuberg-Str. 1
30625 Hannover
  +49 511 532 – 6676
  Stangel.Martin
@mh-hannover.de