Prof. Dr. Gisa Gerold

My Research Interest in RESIST

Within RESIST we focus on elucidating inter-individual differences in the susceptibility to chronic arthritis causing viruses. Particularly, we focus on the mosquito-transmitted Chikungunya virus, which is emerging in Europe. To date, we lack knowledge on whether certain individuals are at higher risk of contracting the disease and progressing to chronic arthritis. Recently, we identified a novel human factor, which is critical for Chikungunya infection. Using experimental models of virus infection in conjunction with ectopic expression of genetic variants of the human factor, we aim to understand how our genetic make up shapes the interaction with the virus. The knowledge gained will enable our colleagues and us in RESIST to define potential risk groups in the human population.

Prof. Dr. Gerold about her scientific work

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Prof. Dr. Gisa Gerold – Curriculum Vitae

Current Position

  • Since 2020 Professor, Institute of Biochemistry, University of Veterinary Medicine Hannover

Undergraduate and Postgraduate Training

  • 1998 – 2003 Studies in Biochemistry, Eberhard Karls University Tübingen

  • 2000 Student exchange at Montana State University, Bozeman, MT, USA

  • 2003 Diploma in Biochemistry, Eberhard Karls University Tübingen

  • 2008 PhD. (Dr. rer. nat.; Supervisor Prof. Dr. Arturo Zychlinsky), Max Planck Institute for Infection Biology & Humboldt University Berlin

Academic and Research Posts

  • 2009 – 2012 Post-doctoral research fellow at The Rockefeller University, NYC, NY, USA  (with Prof. Dr. Charles M. Rice)

  • 2012 – 2013 HFSP Return Fellow at Twincore, Hannover

  • 2013 – 2018 Postdoctoral Fellow at Twincore, Hannover

  • Since 2018 Guest Associate Professor, Umea University, Sweden

  • 2018 – 2020 Group leader at Twincore, Hannover

  • Since 2020 Professor for Biochemistry, University of Veterinary Medicine Hannover

Other Scientific Roles

  • Since 2018 Member of the Robert Koch Society

  • Since 2020 Member of the advisory board of the German Society of Virology

Awards and Prizes

  • 2009 Otto Hahn Medal for Outstanding Scientific Achievements awarded by the Max Planck Society

  • 2009 – 2010 German National Academy of Sciences Leopoldina Fellowship

  • 2010 – 2013 Human Frontier Science Foundation Program Fellowship

  • 2011 German Liver Foundation Stipend

  • 2017 German Liver Foundation Stipend

  • 2017 Robert Koch Postdoctoral Award

Recommended Links

For further information about Prof. Dr. Gisa Gerold’s scientific work please check the following links:

  • Research Group Prof. Gerold

10 Selected Publications

Alberione MP, Moeller R, Kirui J, Ginkel C, Doepke M, Ströh LJ, Machtens JP, Pietschmann T, Gerold G. Single-nucleotide variants in human CD81 influence hepatitis C virus infection of hepatoma cells. Med Microbiol Immunol. 2020 Aug;209(4):499-514. doi: 10.1007/s00430-020-00675-1.

Uckeley ZM, Moeller R, Kühn LI, Nilsson E, Robens C, Lasswitz L, Lindqvist R, Lenman A, Passos V, Voss Y, Sommerauer C, Kampmann M, Goffinet C, Meissner F, Överby AK, Lozach PY, Gerold G. Quantitative Proteomics of Uukuniemi Virus-host Cell Interactions Reveals GBF1 as Proviral Host Factor for Phleboviruses. Mol Cell Proteomics. 2019 Dec;18(12):2401-2417. doi: 10.1074/mcp.RA119.001631.

Moreno H, Möller R, Fedeli C, Gerold G, Kunz S. Comparison of the Innate Immune Responses to Pathogenic and Nonpathogenic Clade B New World Arenaviruses. J Virol. 2019 Sep 12;93(19):e00148-19. doi: 10.1128/JVI.00148-19. Print 2019 Oct 1.

Herrador A, Fedeli C, Radulovic E, Campbell KP, Moreno H, Gerold G, Kunz S. Dynamic Dystroglycan Complexes Mediate Cell Entry of Lassa Virus. mBio. 2019 Mar 26;10(2):e02869-18. doi: 10.1128/mBio.02869-18.

Bruening J, Lasswitz L, Banse P, Kahl S, Marinach C, Vondran FW, Kaderali L, Silvie O, Pietschmann T, Meissner F, Gerold G. Hepatitis C virus enters liver cells using the CD81 receptor complex proteins calpain-5 and CBLB. PLoS Pathog. 2018 Jul 19;14(7):e1007111. doi: 10.1371/journal.ppat.1007111.

Banse P, Moeller R, Bruening J, Lasswitz L, Kahl S, Khan AG, Marcotrigiano J, Pietschmann T, Gerold G. CD81 Receptor Regions outside the Large Extracellular Loop Determine Hepatitis C Virus Entry into Hepatoma Cells. Viruses. 2018 Apr 20;10(4):207. doi: 10.3390/v10040207.

Fedeli C, Torriani G, Galan-Navarro C, Moraz ML, Moreno H, Gerold G, Kunz S. Axl Can Serve as Entry Factor for Lassa Virus Depending on the Functional Glycosylation of Dystroglycan. J Virol. 2018 Feb 12;92(5):e01613-17. doi: 10.1128/JVI.01613-17.

Gerold G, Meissner F, Bruening J, Welsch K, Perin PM, Baumert TF, Vondran FW, Kaderali L, Marcotrigiano J, Khan AG, Mann M, Rice CM, Pietschmann T. Quantitative Proteomics Identifies Serum Response Factor Binding Protein 1 as a Host Factor for Hepatitis C Virus Entry. Cell Rep. 2015 Aug 4;12(5):864-78. doi: 10.1016/j.celrep.2015.06.063.

Kapoor A, Simmonds P, Gerold G, Qaisar N, Jain K, Henriquez JA, Firth C, Hirschberg DL, Rice CM, Shields S, Lipkin WI. Characterization of a canine homolog of hepatitis C virus. Proc Natl Acad Sci U S A. 2011 Jul 12;108(28):11608-13. doi: 10.1073/pnas.1101794108.

Gerold G, Abu Ajaj K, Bienert M, Laws HJ, Zychlinsky A, de Diego JL. A Toll-like receptor 2-integrin beta3 complex senses bacterial lipopeptides via vitronectin. Nat Immunol. 2008 Jul;9(7):761-8. doi: 10.1038/ni.1618. Epub 2008 May 30. PMID: 18516040 

Contact

  Prof. Dr. Gisa Gerold
   University of Veterinary Medicine Hannover
Department of Biochemistry
& Research Center for Emerging Infections and Zoonosis (RIZ)
  Bünteweg 17
30559 Hannover
  +49 (0)511 – 953 6146
  Gisa.Gerold@tiho-hannover.de