Prof. Dr. Thomas Skripuletz participates in RESIST research project B2.

My Research Interest in RESIST

My research in RESIST focuses on severe virus associated diseases of the central nervous system in immunocompromised patients, particularly Progressive Multifocal Leukoencephalopathy caused by JC Polyomavirus reactivation. We investigate why some patients benefit from adoptive transfer of virus specific T cells while others do not. By combining clinical data with immunological and biomarker analyses from blood and cerebrospinal fluid, our goal is to identify host and virus specific factors that determine treatment response and viral control. Ultimately, this work aims to support the development of improved and personalized immunotherapies for severe viral infections of the nervous system.

Contact

Prof. Dr. Thomas Skripuletz – Curriculum Vitae

Current Position

  • Since 2021 Head of the Laboratory for Cerebrospinal Fluid Diagnostics and Neurochemistry, Department of Neurology, Hannover Medical School, Hannover, Germany

Undergraduate and Postgraduate Training

  • 1999 to 2006 Medical School, Hannover Medical School, Hannover, Germany

  • 2006 Doctor of Medicine, summa cum laude. Dissertation: Influence of postnatal experiences on asthma symptoms in adult rats, Department of Functional and Applied Anatomy, Hannover Medical School

  • 2013 Qualification in Cerebrospinal Fluid Diagnostics and Clinical Neurochemistry

  • 2014 Habilitation and venia legendi in Neurology, Hannover Medical School, Hannover, Germany

  • 2018 Appointed adjunct professor

  • 2018 Authorized trainer in Cerebrospinal Fluid Diagnostics and Clinical Neurochemistry

    Since 2021 Deputy Head of the Amyloidosis Center of Lower Saxony, Hannover Medical School, Hannover, Germany

Academic and Research Posts

  • 2006 Research Associate, Institute of Functional and Applied Anatomy, Hannover Medical School, Hannover, Germany

  • 2006 to 2013 Resident and Speaker of the Residents, Department of Neurology, Hannover Medical School, Hannover, Germany

  • 2013 Board certification in Neurology

  • 2013 to 2021 Deputy Head of the Laboratory for Cerebrospinal Fluid Diagnostics and Neurochemistry, Hannover Medical School, Hannover, Germany

  • Since 2018 Founding Member and Speaker, Immune Cooperative Oncology Group

  • Since 2019 Founding Member and Speaker of the Neurology Section, Cerebrospinal Fluid Analysis in Psychiatry Consortium

Other Scientific Roles

  • Since 2025 First Chairman of the Board, German Society for Cerebrospinal Fluid Diagnostics and Clinical Neurochemistry

  • Since 2024 Second Chairman of the Board, Neuritis Network

  • Since 2023 Member of the Education Committee, German Society for Cerebrospinal Fluid Diagnostics and Clinical Neurochemistry

  • 2023 Member of the Medical Advisory Board, German Multiple Sclerosis Society

  • 2023 to 2025 Member of the Extended Board, German Society for Cerebrospinal Fluid Diagnostics and Clinical Neurochemistry

  • Since 2019 Member of the Neuroimmunology Commission, German Society of Neurology

Awards and Prizes

  • 2007 Dissertation Award, German Lung Foundation

  • 2012 Poster Award, German Society of Neurology

  • 2013 Award for the Best Presentation, European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS)

  • 2013 Genzyme Neuroimmunology Fellowship

  • 2015 Recognition of the publication Pivotal role of choline metabolites in remyelination as the best basic science paper in multiple sclerosis in 2014, Multiple Sclerosis Journal

Recommended Links

For further information about Prof. Skripuletz’s scientific work please check the following links:

10 Selected Publications

Möhn N, Grote-Levi L, Bonifacius A, Tischer-Zimmermann S, Nay S, Jendretzky KF, Sassmann ML, Karacondi K, Zent M, Konen FF, Sühs KW, Meuth SG, Pawlitzki M, Warnke C, Ayzenberg I, Schneider R, Helmchen C, Brüggemann N, Klebe S, Hildner M, Grefkes C, Nitsch L, Hühnchen P, Böltz S, Alt L, Tumani H, Kleinschnitz C, Pul R, Grauer O, Clifford D, Gnanapavan S, Wicklein R, Perpoint T, Beudel M, Del Bello A, Rauer S, Wiendl H, Jelcic I, Gasnault J, Cimini E, Antinori A, Pinnetti C, Pourcher V, Weiss N, Lambert N, Maecker-Kolhoff B, Höglinger GU, Zahraeifard S, Cortese I, Eiz-Vesper B, Martin-Blondel G, Skripuletz T; Immunotherapy for PML Study Group. JAMA Neurol 2026 Jan 20:e255318. Online ahead of print.

Konen FF, Axhausen F, Wolff S, Mühlenbrock P, Gingele S, Jendretzky KF, Nay S, Grote-Levi LM, Schwenkenbecher P, Meuth SG, Skripuletz T*, Pfeuffer S*. Discontinuation of ocrelizumab in multiple sclerosis: reoccurrence of disease activity. J Neurol Neurosurg Psychiatry 2026 Jan 20:jnnp-2025-337944. Online ahead of print.

Schröder LJ, Konen FF, Thiesler H, Gudi V, Hildebrandt H, Schwenkenbecher P, Skripuletz T. Altered microglial polarization reduces demyelination in cerebellar slices treated with serum from CD20-depleted multiple sclerosis patients. Neurobiol Dis 2025;215:107096.

Möhn N, Grote-Levi L, Wattjes MP, Bonifacius A, Holzwart D, Hopfner F, Nay S, Tischer-Zimmermann S, Saßmann ML, Schwenkenbecher P, Sühs KW, Mahmoudi N, Warnke C, Zimmermann J, Hagin D, Goudeva L, Blasczyk R, Koch A, Maecker-Kolhoff B, Eiz-Vesper B, Höglinger G, Skripuletz T. Directly Isolated Allogeneic Virus-Specific T Cells in Progressive Multifocal Leukoencephalopathy. JAMA Neurol 2024;81:1187-98.

Maier HB, Stadler J, Deest-Gaubatz S, Borlak F, Türker SN, Konen FF, Seifert J, Kesen C, Frieling H, Bleich S, Lüdecke D, Gallinat J, Hansen N, Wiltfang J, Skripuletz T*, Neyazi A*; CAP (Cerebrospinal Fluid Analysis in Psychiatry) Consortium. The significance of cerebrospinal fluid analysis in the differential diagnosis of 564 psychiatric patients: Multiple sclerosis is more common than autoimmune-encephalitis. Psychiatry Res 2024;333:115725.

Möhn N, Hounchonou HF, Nay S, Schwenkenbecher P, Grote-Levi L, Al-Tarawni F, Esmailezadeh M, Schuchardt S, Schwabe K, Hildebrandt H, Thiesler H, Feuerhake F, Hartmann C, Skripuletz T*, Krauss JK*. Metabolomic profile of cerebrospinal fluid from patients with diffuse gliomas. J Neurol 2024;271:6970-6982.

Konen FF, Möhn N, Witte T, Schefzyk M, Wiestler M, Lovric S, Hufendiek K, Schwenkenbecher P, Sühs KW, Friese MA, Klotz L, Pul R, Pawlitzki M, Hagin D, Kleinschnitz C, Meuth SG, Skripuletz T. Treatment of autoimmunity: the impact of disease modifying therapies in multiple sclerosis and comorbid autoimmune disorders. Autoimmun Rev 2023;22:103312.

Gingele S, Jendretzky KF, Bajor A, Meuth SG, Skripuletz T. Application of diagnostic criteria for optic neuritis. Lancet Neurol. 2023;22:375-6.

Molina-Gonzalez I, Holloway RK, Jiwaji Z, Dando O, Kent SA, Emelianova K, Lloyd AF, Forbes LH, Mahmood A, Skripuletz T, Gudi V, Febery JA, Johnson JA, Fowler JH, Kuhlmann T, Williams A, Chandran S, Stangel M, Howden AJM, Hardingham GE, Miron VE. Astrocyte-oligodendrocyte interaction regulates central nervous system regeneration. Nat Commun 2023;14:3372.

Hopfner F, Möhn N, Eiz-Vesper B, Maecker-Kolhoff B, Gottlieb J, Blasczyk R, Mahmoudi N, Pars K, Adams O, Stangel M, Wattjes MP, Höglinger G, Skripuletz T. Allogeneic BK virus-specific T-cell treatment in 2 patients with progressive multifocal leukoencephalopathy. Neurol Neuroimmunol Neuroinflamm 2021;8:e1020.

Contact

  Prof. Dr. Thomas Skripuletz
  Klinik für Neurologie mit Klinischer Neurophysiologie
  Carl-Neuberg-Str. 1
D-30625 Hannover
  +49 511 532-3120
  Skripuletz.Thomas@mh-hannover.de