Prof. Dr. Luka Čičin-Šain participates in RESIST research projects B6 and B9.
| My Research Interest in RESIST |
Our research focus in RESIST is the identification of HCMV-related immune pathology in aging populations. Our lab will assay the functional capacity of HCMV specific T cells to respond to stimulation by viral antigens and to control HCMV replication in aging populations and will analyse the effect of any immunological dysfunctions on latent viral burden and on clinical disease with inflammatory basis of unknown ethiology.
Prof. Čičin-Šain about his scientific work
Prof. Dr. Luka Čičin-Šain – Curriculum Vitae
Current Position
Undergraduate and Postgraduate Training
Academic and Research Posts
Other Scientific Roles
Awards and Prizes
10 Selected Publications (of > 35 original publications)
Contreras, NA; Sitnik, KM; Jeftic, I; Coplen, C; Čičin-Šain, L; Nikolich-Zugich, J. Lifelong control of cytomegalovirus (CMV) by T resident memory cells in the adipose tissue results in inflammation and hyperglycemia. PLOS Pathogens 15(6):e1007890. doi: 10.1371/journal.ppat.1007890
Kasmapour B, Kubsch T, Rand U, Eiz-Vesper B, Messerle M, Vondran FWR, Wiegmann B, Haverich A, Čičin- Šain L. Myeloid dendritic cells repress human cytomegalovirus gene expression and spread by releasing interferon-unrelated soluble antiviral factors 2018 J Virol. 92(1). pii: e01138-17. doi: 10.1128/JVI.01138-17.
Borkner L, Sitnik KM, Dekhtiarenko I, Tao R, Pulm AK, Drexler I, Čičin-Šain L. Immune Protection by a Cytomegalovirus Vaccine Vector Expressing a Single Low-avidity Epitope. J. Immunol. 2017 199(5):1737-1747
Dekhtiarenko I, Ratts RB, Blatnik R, Lee LN, Fischer S, Borkner L, Oduro JD, Marandu TF, Hoppe S, Ruzsics Z, Sonnemann JK, Mansouri M, Meyer C, Lemmermann NAW, Holtappels R, Arens R, Klenerman P, Früh K, Reddehase MJ, Riemer AB, Čičin-Šain L. Peptide processing is critical for T-cell memory inflation and may be optimized to improve immune protection by CMV-based vaccine vectors PLOS Pathog. 2016; 12(12):e1006072
Dağ F, Dölken L, Holzki J, Drabig A, Weingärtner A, Conte I, Geffers R, Davenport C, Rand U, Adler A, Wirth D, Messerle M, Hauser H, Čičin-Šain L. Reversible Silencing of Cytomegalovirus Genomes by Type I Interferon Governs Virus Latency PLoS Pathogens. 2014; 10(2): e1003962.
Dekhtiarenko I., Jarvis M.A., Ruzcics Z., Čičin-Šain L. The Context of Gene Expression Defines the Immunodominance Hierarchy of CMV Antigens. Journal of Immunology. 2013; 190(7):3399-409
Čičin-Šain L., Brien J.D., Uhrlaub J., Drabig, A., Marandu T.F., Nikolich-Zugich, J*. Cytomegalovirus Infection Impairs Immune Responses and Accentuates T-cell pool Changes Observed in Aging Mice. PLoS Pathogens. 2012; 8(8): e1002849.
Čičin-Šain L., Hagen S., Sylwester, A., Siess, D., Currier, N. Legasse, A., Fischer, M.B., Koudelka, C., Mori, T., Axthelm, M.J., Nikolich-Zugich J. Picker L.J. Cytomegalovirus-Specific T-cell Immunity Is not Compromised in Old Rhesus Monkeys. Journal of Immunology. 2011; 187(4):1722-32.
Čičin-Šain L., Smyk-Pearson S., Fisher M.B., Currier N., Koudelka C., Nikolich-Zugich D., Legasse, A., Tackit S., Axthelm, M.J., Mori, M. Lewinsohn D., Nikolich-Zugich J. Loss of naïve T-cells and repertoire constriction predict poor response to vaccination in old primates. Journal of Immunology; 2010; 184(12):6739-45.
Čičin-Šain L., Messaoudi I., Park B., Currier N., Planer S., Fischer M, Tackitt S., Nikolich-Zugich D., Legasse A., Axthelm M.K., Picker L.J., Mori M. and Nikolich-Zugich J. Dramatic Increase in Naïve T-Cell Turnover is Linked to Loss of Naïve T-cells from Old Primates. Proc Natl Acad Sci U S A. 2007; 104(50):19960-5.
