Prof. Dr. Luka Čičin-Šain participates in RESIST research projects B6 and B9.
| My Research Interest in RESIST |
Our research focus in RESIST is the identification of HCMV-related immune pathology in aging populations. Our lab will assay the functional capacity of HCMV specific T cells to respond to stimulation by viral antigens and to control HCMV replication in aging populations and will analyse the effect of any immunological dysfunctions on latent viral burden and on clinical disease with inflammatory basis of unknown ethiology.
Prof. Čičin-Šain about his scientific work
Prof. Dr. Luka Čičin-Šain – Curriculum Vitae
Current Position
Undergraduate and Postgraduate Training
Academic and Research Posts
Other Scientific Roles
Awards and Prizes
10 Selected Publications
Chaudhry MZ, Borkner L, Kulkarni U, Berberich-Siebelt F, Cicin-Sain L. NFAT signaling is indispensable for persistent memory responses of MCMV-specific CD8+ T cells. PLoS Pathog. 2024 Feb 12;20(2):e1012025.
Sitnik KM, Krstanović F, Gödecke N, Rand U, Kubsch T, Maaß H, Kim Y, Brizić I, Čičin-Šain L. Fibroblasts are a site of murine cytomegalovirus lytic replication and Stat1-dependent latent persistence in vivo. Nat Commun. 2023 May 29;14(1):3087.
Kim Y, Zheng X, Eschke K, Chaudhry MZ, Bertoglio F, Tomić A, Krmpotić A, Hoffmann M, Bar-On Y, Boehme J, Bruder D, Ebensen T, Brunotte L, Ludwig S, Messerle M, Guzman C, Mandelboim O, Hust M, Pöhlmann S, Jonjić S, Čičin-Šain L. MCMV-based vaccine vectors expressing full-length viral proteins provide long-term humoral immune protection upon a single-shot vaccination. Cell Mol Immunol. 2022 Feb;19(2):234-244. Epub 2022 Jan 7.
Chaudhry MZ, Casalegno-Garduno R, Sitnik KM, Kasmapour B, Pulm AK, Brizic I, Eiz-Vesper B, Moosmann A, Jonjic S, Mocarski ES, Cicin-Sain L. Cytomegalovirus inhibition of extrinsic apoptosis determines fitness and resistance to cytotoxic CD8 T cells. Proc Natl Acad Sci U S A. 2020 Jun 9;117(23):12961-12968. doi: 10.1073/pnas.1914667117. Epub 2020 May 22. Erratum in: Proc Natl Acad Sci U S A. 2020 Aug 11;117(32):19606.
Zheng X, Oduro JD, Boehme JD, Borkner L, Ebensen T, Heise U, Gereke M, Pils MC, Krmpotic A, Guzmán CA, Bruder D, Čičin-Šain L. Mucosal CD8+ T cell responses induced by an MCMV based vaccine vector confer protection against influenza challenge. PLoS Pathog. 2019 Sep 16;15(9):e1008036.
Dekhtiarenko I, Ratts RB, Blatnik R, Lee LN, Fischer S, Borkner L, Oduro JD, Marandu TF, Hoppe S, Ruzsics Z, Sonnemann JK, Mansouri M, Meyer C, Lemmermann NAW, Holtappels R, Arens R, Klenerman P, Früh K, Reddehase MJ, Riemer AB, Čičin-Šain L. Peptide processing is critical for T-cell memory inflation and may be optimized to improve immune protection by CMV-based vaccine vectors PLOS Pathog. 2016; 12(12):e1006072
Dağ F, Dölken L, Holzki J, Drabig A, Weingärtner A, Conte I, Geffers R, Davenport C, Rand U, Adler A, Wirth D, Messerle M, Hauser H, Čičin-Šain L. Reversible Silencing of Cytomegalovirus Genomes by Type I Interferon Governs Virus Latency PLoS Pathogens. 2014; 10(2): e1003962.
Čičin-Šain L., Brien J.D., Uhrlaub J., Drabig, A., Marandu T.F., Nikolich-Zugich, J*. Cytomegalovirus Infection Impairs Immune Responses and Accentuates T-cell pool Changes Observed in Aging Mice. PLoS Pathogens. 2012; 8(8): e1002849.
Čičin-Šain L., Hagen S., Sylwester, A., Siess, D., Currier, N. Legasse, A., Fischer, M.B., Koudelka, C., Mori, T., Axthelm, M.J., Nikolich-Zugich J. Picker L.J. Cytomegalovirus-Specific T-cell Immunity Is not Compromised in Old Rhesus Monkeys. Journal of Immunology. 2011; 187(4):1722-32.
Čičin-Šain L., Messaoudi I., Park B., Currier N., Planer S., Fischer M, Tackitt S., Nikolich-Zugich D., Legasse A., Axthelm M.K., Picker L.J., Mori M. and Nikolich-Zugich J. Dramatic Increase in Naïve T-Cell Turnover is Linked to Loss of Naïve T-cells from Old Primates. Proc Natl Acad Sci U S A. 2007; 104(50):19960-5.
