Prof. Dr. Jens Bosse participates in RESIST research projects D1, D2 and D3.

My Research Interest in RESIST

Our research focus in RESIST is illuminating the rules that govern the dynamic assembly of herpesviruses in infected cells. Right now, we know little about the virus particle intermediates in their native cellular environment. Using live-cell microscopy and three-dimensional electron microscopy, we can define how and where viruses assemble at single-particle precision. Using this knowledge will enable our colleagues and us in RESIST to identify potential bottlenecks in viral productivity as specific pharmacological target structures. 

Contact

Prof. Bosse about his scientific work

Prof. Dr. Jens Bosse – Curriculum Vitae

Current Position

  • Since 2020 Junior Professor, RESIST at CSSB Hamburg

Undergraduate and Postgraduate Training

  • 2002 – 2008 Studies in Molecular Biotechnology, RWTH Aachen

  • 2005 B.Sc. in Molecular Biotechnology, RWTH Aachen

  • 2008 M.Sc. in Molecular Biotechnology, RWTH Aachen

  • 2011 PhD (Dr. rer. nat.; Supervisor Prof. Dr. med. U. Koszinowski)

Academic and Research Posts

  • 2011 – 2015 Post-doctoral research fellow at Princeton University, USA  (with Lynn Enquist)

  • 2015 – 2016 DFG Return Fellow at Heinrich Pette Institute (HPI), Hamburg

  • 2016 – 2020 Head of subgroup “Quantitative Virology” in the Dept. Of Structural Cell Biology of Viruses

  • 2018 – 2020 Head of Light microscopy core and Nikon Center of Excellence, Heinrich Pette Institute (HPI), Hamburg

Other Scientific Roles

  • Since 2018 Member of the advisory board of the UKE Microscopy Imaging Facility, University Medical Center Hamburg-Eppendorf, Hamburg 

Awards and Prizes

  • 2006 Heinrich-Hertz Foundation visiting fellowship, University of Cambridge, UK

  • 2006 – 2008 German National Academic Foundation (Studienstiftung) Student Fellowship

  • 2009 – 2011 German National Academic Foundation (Studienstiftung) Graduate Student Fellowship

  • 2013 – 2015 DFG Postdoctoral Fellowship

  • 2015 DFG Return Fellowship

  • 2016 Robert-Koch Postdoctoral Award

  • 2018 – 2025 Wellcome Trust Collaborative Award

Recommended Links

For further information about Prof. Bosse’s scientific work please check the following links:

10 Selected Publications

Maninger S*, Bosse JB*, Lemnitzer F, Pogoda M, Mohr CA, von Einem J, Walther P, Koszinowski UH, Ruzsics Z. 2011. M94 Is Essential for the Secondary Envelopment of Murine Cytomegalovirus. Journal of Virology 85:9254-9267.

Bosse JB, Bauerfeind R, Popilka L, Marcinowski L, Taeglich M, Jung C, Striebinger H, von Einem J, Gaul U, Walther P, Koszinowski UH, Ruzsics Z. 2012. A beta-herpesvirus with fluorescent capsids to study transport in living cells. PLoS One 7:e40585.

Granstedt AE, Bosse JB, Thiberge SY, Enquist LW. 2013. In vivo imaging of alphaherpesvirus infection reveals synchronized activity dependent on axonal sorting of viral proteins. Proc Natl Acad Sci U S A 110:E3516-3525.

Bosse JB, Virding S, Thiberge SY, Scherer J, Wodrich H, Ruzsics Z, Koszinowski UH, Enquist LW. 2014. Nuclear herpesvirus capsid motility is not dependent on F-actin. MBio 5:e01909-01914.

Hogue IB, Bosse JB, Hu JR, Thiberge SY, Enquist LW. 2014. Cellular mechanisms of alpha herpesvirus egress: live cell fluorescence microscopy of pseudorabies virus exocytosis. PLoS Pathog 10:e1004535.

Bosse JB, Hogue IB, Feric M, Thiberge SY, Sodeik B, Brangwynne CP, Enquist LW. 2015. Remodeling nuclear architecture allows efficient transport of herpesvirus capsids by diffusion. Proc Natl Acad Sci U S A 112:E5725-5733.

Hagen C*, Dent KC*, Zeev-Ben-Mordehai T*, Grange M*, Bosse JB*, Whittle C, Klupp BG, Siebert CA, Vasishtan D, Bauerlein FJ, Cheleski J, Werner S, Guttmann P, Rehbein S, Henzler K, Demmerle J, Adler B, Koszinowski U, Schermelleh L, Schneider G, Enquist LW, Plitzko JM, Mettenleiter TC, Grunewald K. 2015. Structural Basis of Vesicle Formation at the Inner Nuclear Membrane. Cell 163:1692-1701.

Hogue IB, Bosse JB, Engel EA, Scherer J, Hu JR, Del Rio T, Enquist LW. 2015. Fluorescent Protein Approaches in Alpha Herpesvirus Research. Viruses 7:5933-5961.

Bosse JB, Enquist LW. 2016. The diffusive way out: Herpesviruses remodel the host nucleus, enabling capsids to access the inner nuclear membrane. Nucleus 7:13-19.

Flomm F, Bosse JB. 2017. Potential mechanisms facilitating herpesvirus-induced nuclear remodeling: how are herpesvirus capsids able to leave the nucleus? Future Virology 12:583-592.

Contact

  Prof. Dr. Jens Bosse
  Centre for Structural Systems Biology (CSSB)
Quantitative Virology, HPI Hamburg
  Notkestraße 85
22607 Hamburg
  +49 40 899887645 (CSSB) – ab 1.8.2020
+49 40 48051-273 (HPI)
  bosse.jens
@mh-hannover.de