Prof. Dr. Jens Bosse participates in RESIST research project D3.
| My Research Interest in RESIST |
Our research focus in RESIST is illuminating the rules that govern the dynamic assembly of herpesviruses in infected cells. Right now, we know little about the virus particle intermediates in their native cellular environment. Using live-cell microscopy and three-dimensional electron microscopy, we can define how and where viruses assemble at single-particle precision. Using this knowledge will enable our colleagues and us in RESIST to identify potential bottlenecks in viral productivity as specific pharmacological target structures.
Prof. Bosse about his scientific work
Prof. Dr. Jens Bosse – Curriculum Vitae
Current Position
Since 2020 Junior Professor, RESIST at CSSB Hamburg
Undergraduate and Postgraduate Training
2002 – 2008 Studies in Molecular Biotechnology, RWTH Aachen
2005 B.Sc. in Molecular Biotechnology, RWTH Aachen
2008 M.Sc. in Molecular Biotechnology, RWTH Aachen
2011 PhD (Dr. rer. nat.; Supervisor Prof. Dr. med. U. Koszinowski)
Academic and Research Posts
2011 – 2015 Post-doctoral research fellow at Princeton University, USA (with Lynn Enquist)
2015 – 2016 DFG Return Fellow at Heinrich Pette Institute (HPI), Hamburg
2016 – 2020 Head of subgroup “Quantitative Virology” in the Dept. Of Structural Cell Biology of Viruses
2018 – 2020 Head of Light microscopy core and Nikon Center of Excellence, Heinrich Pette Institute (HPI), Hamburg
Other Scientific Roles
Since 2018 Member of the advisory board of the UKE Microscopy Imaging Facility, University Medical Center Hamburg-Eppendorf, Hamburg
Awards and Prizes
2006 Heinrich-Hertz Foundation visiting fellowship, University of Cambridge, UK
2006 – 2008 German National Academic Foundation (Studienstiftung) Student Fellowship
2009 – 2011 German National Academic Foundation (Studienstiftung) Graduate Student Fellowship
2013 – 2015 DFG Postdoctoral Fellowship
2015 DFG Return Fellowship
2016 Robert-Koch Postdoctoral Award
2018 – 2025 Wellcome Trust Collaborative Award
10 Selected Publications
Flomm F, Soh TK, Britt H, Schneider C, Wedemann L, Britt HM, Thalassinos K, Pfitzner S, Reimer R, Grünewald K, Bosse JB (2022) Intermittent bulk release of Human Cytomegalovirus. PLoS Pathogens, https://doi.org/10.1371/journal.ppat.1010575
Caragliano E, Bonazza S, Frascaroli G, Tang J, Soh TK, Grünewald K, Bosse JB*, Brune W* (2022) Human cytomegalovirus forms phase-separated compartments at viral genomes to facilitate viral replication. Cell Reports, https://doi.org/10.1016/j.celrep.2022.110469
Jung J, Ching W, Baumdick M, Hoffmann-Sieber H, Bosse JB, Koyro TF, Moeller K, Wegner L, Niehrs A, Russu K, Ohms M, Zhang W, Ehrhardt A, Duisters K, Spierings E, Hoelzemer A, Koerner C, Jansen S, Peine S, Koenigs I, Luetgehetmann M, Perez D, Reinshagen K, Lindemanns AA, Altfeld M, Berlderbos ME, Dobner T, Bunders M (2021), KIR3DS1 directs NK cell-mediated protection against human adenovirus infections. Science Immunology
Bosse JB, Hogue IB, Feric M, Thiberge SY, Sodeik B, Brangwynne CP, Enquist LW (2015) Remodeling nuclear architecture allows efficient transport of herpesvirus capsids by diffusion. Proc Natl Acad Sci U S A 112:E5725–E5733.
Hagen C*, Dent KC*, Zeev-Ben-Mordehai T*, Grange M*, Bosse JB*, Whittle C, Klupp BG, Siebert CA, Vasishtan D, Bäuerlein FJB, Cheleski J, Werner S, Guttmann P, Rehbein S, Henzler K, Demmerle J, Adler B, Koszinowski U, Schermelleh L, Schneider G, Enquist LW, Plitzko JP, Mettenleiter TC, Grünewald K (2015) Structural Basis of Vesicle Formation at the Inner Nuclear Membrane. Cell 163:1692-701.
Bosse JB, Virding S, Thiberge SY, Scherer J, Wodrich H, Ruzsics Z, Koszinowski UH, Enquist LW, Racaniello VR (2014) Nuclear Herpesvirus Capsid Motility Is Not Dependent on F-Actin. mBio 5:429-14.
Hogue IB, Bosse JB, Hu J-R, Thiberge SY, Enquist LW (2014) Cellular mechanisms of alphaherpesvirus egress: live-cell fluorescence microscopy of pseudorabies virus exocytosis. PLoS Pathog 10:e1004535.
Granstedt AE, Bosse JB, Thiberge SY, LW Enquist (2013) In vivo imaging of alphaherpesvirus infection reveals synchronized activity dependent on axonal sorting of viral proteins. Proc Natl Acad Sci U S A 110: E3516-25.
Bosse JB, Bauerfeind R, Popilka L, Marcinowski L, Taeglich M, Jung C, Striebinger H, von Einem J, Gaul U, Walther P, Koszinowski UH, Ruzsics Z (2012) A Beta-herpesvirus with fluorescent capsids to study transport in living cells. PLoS One 7:e40585.
Maninger, S*, Bosse JB*, Lemnitzer F, Pogoda M, Mohr CA, von Einem J, Walther P, Koszinowski UH, Ruzsics Z (2011) M94 Is Essential for the Secondary Envelopment of Murine Cytomegalovirus. J Virol 85:9254-67.
