Prof. Dr. Jens Bosse participates in RESIST research project D3.

My Research Interest in RESIST

Our research focus in RESIST is illuminating the rules that govern the dynamic assembly of herpesviruses in infected cells. Right now, we know little about the virus particle intermediates in their native cellular environment. Using live-cell microscopy and three-dimensional electron microscopy, we can define how and where viruses assemble at single-particle precision. Using this knowledge will enable our colleagues and us in RESIST to identify potential bottlenecks in viral productivity as specific pharmacological target structures.

Contact

Prof. Bosse about his scientific work

This Video was recorded in 2021.

Prof. Dr. Jens Bosse – Curriculum Vitae

Current Position

  • Since 2020 Junior Professor, RESIST at CSSB Hamburg

Undergraduate and Postgraduate Training

  • 2002 – 2008 Studies in Molecular Biotechnology, RWTH Aachen

  • 2005 B.Sc. in Molecular Biotechnology, RWTH Aachen

  • 2008 M.Sc. in Molecular Biotechnology, RWTH Aachen

  • 2011 PhD (Dr. rer. nat.; Supervisor Prof. Dr. med. U. Koszinowski)

Academic and Research Posts

  • 2011 – 2015 Post-doctoral research fellow at Princeton University, USA  (with Lynn Enquist)

  • 2015 – 2016 DFG Return Fellow at Heinrich Pette Institute (HPI), Hamburg

  • 2016 – 2020 Head of subgroup “Quantitative Virology” in the Dept. Of Structural Cell Biology of Viruses

  • 2018 – 2020 Head of Light microscopy core and Nikon Center of Excellence, Heinrich Pette Institute (HPI), Hamburg

Other Scientific Roles

  • Since 2022 Ad hoc Reviewer for DFG, Institute Pasteur, ANR and SNF

  • Since 2018 Member of the advisory board of the UKE Microscopy Imaging Facility, University Medical Center Hamburg-Eppendorf, Hamburg 

  • Since 2015 Peer reviewer for Nature Microbiology, Journal of Virology, PLoS Pathogens, Scientific Reports, FEBS letters, mSphere, Viruses etc.

Awards and Prizes

  • 2006 Heinrich-Hertz Foundation visiting fellowship, University of Cambridge, UK

  • 2006 – 2008 German National Academic Foundation (Studienstiftung) Student Fellowship

  • 2009 – 2011 German National Academic Foundation (Studienstiftung) Graduate Student Fellowship

  • 2013 – 2015 DFG Postdoctoral Fellowship

  • 2015 DFG Return Fellowship

  • 2016 Robert-Koch Postdoctoral Award

  • 2018 – 2025 Wellcome Trust Collaborative Award

Recommended Links

For further information about Prof. Bosse’s scientific work please check the following links:

10 Selected Publications

A proteome-wide structural systems approach reveals insights into protein families of all human herpesviruses. Soh, T.K., Ognibene, S., Sanders, S. et al.  Nat Commun 15, 10230 (2024)

Molecular plasticity of herpesvirus nuclear egress analysed in situ. Pražák V, Mironova Y, Vasishtan D, Hagen C, Laugks U, Jensen Y, Sanders S, Heumann JM, Bosse JB, Klupp BG, Mettenleiter TC, Grange M, Grünewald K. Nat Microbiol. 2024 Jul;9(7):1842-1855.

A TriPPPro-Nucleotide Reporter with Optimized Cell-Permeable Dyes for Metabolic Labeling of Cellular and Viral DNA in Living Cells. Sterrenberg VT, Stalling D , Knaack JIH, Soh TK., Bosse JB*, Meier C*. Angew Chem Int Ed Engl 18; 62(38): e202308271 (2023). Open access.

HSV-1 exploits host heterochromatin for nuclear egress. Lewis HC, Kelnhofer-Millevolte LE, Brinkley MR, Arbach HE, Arnold EA, Sanders S, Bosse JB, Ramachandran S, Avgousti DC. J Cell Biol. 2023 Sep 4;222(9):e202304106.

Spatially resolved protein map of intact human cytomegalovirus virions. Bogdanow B, Gruska I, Mühlberg L, Protze J, Hohensee S, Vetter B, Bosse JB, Lehmann M, Sadeghi M, Wiebusch L, Liu F. Nat Microbiol. 2023 Aug 7.

A validated protocol to UV-inactivate SARS-CoV-2 and herpesvirus-infected cells. Soh TK, Pfefferle S, Wurr S, von Possel R, Oestereich L, Rieger T, Uetrecht C, Rosenthal M, Bosse JB. PLoS One. 2023 May 10;18(5):e0274065.

Viral dew: Phase separation and the formation of viral replication compartments.Bosse JB, Brune W. Viral dew. PLoS Pathog. 2023 Feb 16;19(2):e1011145.

From the beginnings to multidimensional light and electron microscopy of virus morphogenesis. Saskia Sanders, Yannick Jensen, Rudolph Reimer, Jens B. Bosse, Chapter Two – , Editor(s): Stefan Finke, Dmitry Ushakov, Advances in Virus Research, Academic Press, Volume 116, 2023, Pages 45-88

Intermittent bulk release of Human Cytomegalovirus. Flomm F, Soh TK, Britt H, Schneider C, Wedemann L, Britt HM, Thalassinos K, Pfitzner S, Reimer R, Grünewald K, Bosse JB (2022) PLoS Pathogens. 2022 Aug 4

The unconventional way out – Egress of HCMV through multiviral bodies. Wedemann L, Flomm FJ, Bosse JB.  Mol Microbiol. 2022 Jun;117(6):1317-1323.

Contact

  Prof. Dr. Jens Bosse
  Centre for Structural Systems Biology (CSSB)
Quantitative Virology, HPI Hamburg
  Notkestraße 85
22607 Hamburg
  +49 40 899887645
  bosse.jens
@mh-hannover.de