Prof. Dr. Hortense Slevogt participates in RESIST research project C3.

My Research Interest in RESIST

As part of RESIST, together with my team, I explore the interactions between commensals and microbial pathogens and the influence of this interaction on the shaping of the immunological milieu in the airways and lungs. Among other things, we analyse the effects of the direct interaction of bacterial commensals of the lung microbiome of healthy individuals on the epithelium of the airways and we characterise these effects on infections of the airway epithelium with bacterial lung pathogens.

Contact

Prof. Slevogt

Prof. Dr. Hortense Slevogt – Curriculum Vitae

Current Position

  • Since 07/2022
    Professorship for Infections of the Respiratory Tract (W3)
    Senior Physician for Clinical Infectiology, Department of Pneumology,
    Hannover Medical School (MHH)

  • Head of the Research Unit „Respiratory Infection Dynamics“
    Helmholtz Centre for Infection Research (HZI), Braunschweig

Undergraduate and Postgraduate Training

  • 1986-1993 Studies in Medicine, Freie Universität Berlin, Study stays: Hadassah University Hospital, Jerusalem, Israel, Mount Sinai School of Medicine, New York, USA, Stanford University Hospital, Palo Alto, USA

  • 1993-1998 Resident (physician in internship) and assistant physician, Med. Clinic / Focus on Infectiology, Charité Berlin

  • 1996 PhD: „Reflex timing measurements of muscle intrinsic reflexes inhealthy children and children suffering from diabetes mellitus“. Department of Neurology, Charité, Berlin

  • 1998-2005 Research associate and since 2003 Specialist for Internal Medicine, Med. clinic with focus on infectiology and pneumology, Charité Berlin

Academic and Research Posts

  • 2005-2011 Head of the working group “Host-Pathogen Interactions and innate immunity in the lung”, Laboratory of Prof. N. Suttorp, Med. Clinic with focus on Infectiology and Pneumology, Charité Universitätsmedizin Berlin

  • 2017-2021 Clinical work as internist and infectiologist at the Clinic for Internal Medicine I, Clinic for Pneumology & Allergology / Immunology, University Hospital Jena.

  • 2011-2022 W2-Professorship for Immunology of Serious Infections, Head of Research Group for Infection and Microbiom Research „Host Septomics“, Centre for Innovation Competence (ZIK) Septomics and Clinic for Internal Medicine I, Department of Pneumology & Allergology / Immunology, University Hospital Jena

Other Scientific Roles

  • Since 2019 Member of the Commission Antiinfectives, Resistance and Therapy (ART) of the Robert Koch Institute

  • Since 2020 Co-Editor of the „Journal of Pneumology and Respiratory Medicine” (Georg Thieme Verlag)

  • 2021 Certification as specialist for internal medicine and pneumology (Landesärztekammer Thüringen) State Medical Association of Thuringia

  • Since 2021 Chairwoman of the Animal Commission at the University Hospital Jena

  • Since 2021 Appointment as Treasurer of the German Society for Pneumology and Respiratory Medicine e.V. (DGP)

Awards and Prizes

  • 2007 Curt-Dehner-Prize of the Society for Lung and Respiratory Research

  • 2010 Rudolf-Ackermann-Prize of the German Society for Infectiology

  • 2014 Best abstract award of the 18. Symposium of the International Immunocompromised Society (ICHS) in Berlin

Recommended Links

For further information about Prof. Slevogts’s scientific work please check the following links:

10 Selected Publications

Klassert TE, Leistner R, Zubiria-Barrera C, Stock M, López M, Neubert R, Driesch D, Gastmeier P, Slevogt H (2021) Bacterial colonization dynamics and antibiotic resistance gene dissemination in the hospital environment after first patient occupancy: a longitudinal metagenetic study. Microbiome 9 (1):169

Klassert TE, Goyal S, Stock M, Driesch M, Hussain A, Berrocal-Almanza L, Myakala R, Sumanlatha G, Valluri V, Ahmed N, Schumann RR, Flores C, Slevogt H. (2018) AmpliSeq screening of genes encoding the C-type lectin receptors and their signaling components reveals a common variant in MASP1 associated with pulmonary tuberculosis in an Indian population. Frontiers in Immunology; 9:242.

Lehmann R, Müller MM, Klassert TE, Driesch D, Stock M, Heinrich A., Conrad T, Moore C, Schier UK, Guthke R, Slevogt H, (2018) Differential regulation of the transcriptomic and secretomic landscape of sensor and effector functions of human airway epithelial cells, Mucosal Immunology

Klaile E, Müller MM, Schäfer MR, Clauder AK, Feer S, Heyl KA, Stock M, Klassert TE, Zipfel PF, Singer BB, Slevogt H. (2017) Binding of Candida albicans to Human CEACAM1 and CEACAM6 Modulates the Inflammatory Response of Intestinal Epithelial Cells. MBio.

Slevogt H, Zabel S, Opitz B, Hocke A, Eitel J, N´Guessan P, Lucka L, Riesbeck K, Zimmermann W, Zweigner J, Temmesfeld-Wollbrueck B, Suttorp N, Singer B. (2008) CEACAM1 inhibits Tolllike receptor 2-triggered anti-bacterial responses of human pulmonary epithelial cells. Nat Immunol.

Mario M Müller, Christian Baldauf, Stella Hornischer, Tilman E Klassert, Antony Schneegans, Andrea Behnert, Mathias W Pletz, Stefan Hagel, Hortense Slevogt (2023) Staphylococcus aureus induces tolerance in human monocytes accompanied with expression changes of cell surface markers. Front Immunol.

Kerstin A Heyl, Tilman E Klassert, Annina Heinrich, Mario M Müller, Esther Klaile, Hendrik Dienemann, Christiane Grünewald, Robert Bals, Bernhard B Singer, Hortense Slevogt (2014) Dectin-1 is expressed in human lung and mediates the proinflammatory immune response to nontypeable Haemophilus influenzae. mBio

Anahita Javaheri, Tobias Kruse, Kristof Moonens, Raquel Mejías-Luque, Ayla Debraekeleer, Carmen I. Asche, Nicole Tegtmeyer, Behnam Kalali, Nina C. Bach, Stephan A. Sieber, Darryl J. Hill, Verena Königer, Christof R. Hauck, Roman Moskalenko, Rainer Haas, Dirk H. Busch, Esther Klaile, Hortense Slevogt, Alexej Schmidt, Steffen Backert, Han Remaut, Bernhard B. Singer & Markus Gerhard. (2017) Helicobacter pylori adhesin HopQ engages in a virulence-enhancing interaction with human CEACAMs, Nature Microbiology

Kristina Dietert, Birgitt Gutbier, Sandra M Wienhold, Katrin Reppe, Xiaohui Jiang, Ling Yao, Catherine Chaput, Jan Naujoks, Markus Brack, Alexandra Kupke, Christin Peteranderl, Stephan Becker, Carolin von Lachner, Nelli Baal, Hortense Slevogt, Andreas C Hocke, Martin Witzenrath, Bastian Opitz, Susanne Herold, Holger Hackstein, Leif E Sander, Norbert Suttorp, Achim D Gruber (2017) Spectrum of pathogen- and model-specific histopathologies in mouse models of acute pneumonia, PLoS One

Mohammad H Mirhakkak, Sascha Schäuble, Tilman E Klassert, Sascha Brunke, Philipp Brandt, Daniel Loos, Ruben V Uribe, Felipe Senne de Oliveira Lino, Yueqiong Ni, Slavena Vylkova, Hortense Slevogt, Bernhard Hube, Glen J Weiss, Morten O A Sommer, Gianni Panagiotou (2021) Metabolic modeling predicts specific gut bacteria as key determinants for Candida albicans colonization levels. ISME J.

Tilman E Klassert, Cristina Zubiria-Barrera, Stefanie Kankel, Magdalena Stock, Robert Neubert, Fabian Lorenzo-Diaz, Norman Doehring, Dominik Driesch, Doris Fischer, Hortense Slevogt (2020) Early Bacterial Colonization and Antibiotic Resistance Gene Acquisition in Newborns. Front Cell Infect Microbiol.

Contact

  Clinic for Pneumology and Infectiology
Hannover Medical School
  Carl-Neuberg-Str. 1
30625 Hannover
Germany
  +49 511 532-84061
  Slevogt.Hortense@mh-hannover.de