My Research Interest in RESIST |
Respiratory Syncytial Virus (RSV) is the most common cause of lower respiratory tract infections in young children and a major cause of hospital admissions and health-care expenditures globally. One of our major scientific interests in RESIST is to identify susceptibility factors for severe RSV infections in infants and to find biomarkers that predict the course of the disease. The long-term goal is to develop preventive and therapeutic strategies for protection of infants and elderly people from severe RSV infections. Another major research focus is the identification of environmental factors that favour the development of a protective immunity in premature and mature babies with long term effects on a healthy life.
Prof. Hansen about her scientific work
Prof. Dr. Gesine Hansen – Curriculum Vitae
Current Position
Undergraduate and Postgraduate Training
Academic and Research Posts
Other Scientific Roles
Awards and Prizes
10 Selected Publications
Happle C, Lachmann N, Ackermann M, Mirenska A, Göhring G, Thomay K, Mucci A, Glomb T, Suzuki T, Chalk C, Glage S, Dittrich-Breiholz O, Trapnell B, Moritz T, Hansen G. Pulmonary Transplantation of human iPSC-derived Macrophages ameliorates Pulmonary Alveolar Proteinosis, Am J Respir Crit Care Med 2018; 198:350-360
Happle C, Jirmo A, Meyer-Bahlburg A, Habener A, Hoymann H.G, Hennig C, Skuljec J, Hansen G, B cells control maternofetal priming of allergy and tolerance in a murine model of allergic airway inflammation. J Allergy Clin Immunol 2018. 141: 685-696 e686
Happle, C., Lachmann, N., Skuljec, J., Wetzke, M., Ackermann, M., Brennig, S., Mucci, A., Jirmo, A. C., Groos, S., Mirenska, A., Hennig, C., Rodt, T., Bankstahl, J. P., Schwerk, N., Moritz, T. and Hansen, G., Pulmonary transplantation of macrophage progenitors as effective and long-lasting therapy for hereditary pulmonary alveolar proteinosis. Science Transl Med 2014. 6: 250ra113.
Lachmann, N., Happle, C., Ackermann, M., Luttge, D., Wetzke, M., Merkert, S., Hetzel, M., Kensah, G., Jara- Avaca, M., Mucci, A., Skuljec, J., Dittrich, A. M., Pfaff, N., Brennig, S., Schambach, A., Steinemann, D., Gohring, G., Cantz, T., Martin, U., Schwerk, N., Hansen, G.* and Moritz, T*., Gene correction of human induced pluripotent stem cells repairs the cellular phenotype in pulmonary alveolar proteinosis. Am J Respir Crit Care Med 2014. 189: 167-182.* Equal contribution.
Hennig, C., Ilginus, C., Boztug, K., Skokowa, J., Marodi, L., Szaflarska, A., Sass, M., Pignata, C., Kilic, S. S., Caragol, I., Baumann, U., Klein, C., Welte, K. and Hansen, G., High-content cytometry and transcriptomic biomarker profiling of human B-cell activation. J Allergy Clin Immunol 2014. 133: 172-180 e171-110.
Dijkstra, D., Hennig, C., Witte, T. and Hansen, G., Basophils from humans with systemic lupus erythematosus do not express MHC-II. Nature Medicine 2012.18: 488-489;489-490.
Polte, T., Hennig, C. and Hansen, G., Allergy prevention starts before conception: maternofetal transfer of tolerance protects against the development of asthma. J Allergy Clin Immunol 2008. 122: 1022-1030 e1025.
Polte, T., Foell, J., Werner, C., Hoymann, H. G., Braun, A., Burdach, S., Mittler, R. S. and Hansen, G., CD137- mediated immunotherapy for allergic asthma. J Clin Invest 2006. 116: 1025-1036.
Polte, T., Behrendt, A. K. and Hansen, G., Direct evidence for a critical role of CD30 in the development of allergic asthma. J Allergy Clin Immunol 2006. 118: 942-948.
Hansen, G., Berry, G., DeKruyff, R. H. and Umetsu, D. T., Allergen-specific Th1 cells fail to counterbalance Th2 cell-induced airway hyperreactivity but cause severe airway inflammation. J Clin Invest 1999. 103: 175-183.