Prof. Dr. Françoise Routier
| My Research Interest in RESIST |
Biofilms are a matrix consisting of proteins, extracellular DNA, and polysaccharides embedding microbial communities. They not only shield the microorganism from the host immune system but also limit the efficacy of antimicrobials. Our aim is RESIST is to develop molecules preventing biofilm formation to ease clearance of the microbes by the host immune system and potentiate the efficacy of existing drugs. We characterise bacterial and fungal enzymes involved in the biosynthesis of the polysaccharide component of biofilm, define the structure of these enzymes and search for inhibitors.
Prof. Routier about her scientific work
Prof. Dr. Françoise Routier – Curriculum Vitae
Current Position
Undergraduate and Postgraduate Training
Academic and Research Posts
Other Scientific Roles
Awards and Prizes
10 Selected Publications
Albuquerque-Wendt A, Jacot D, Dos Santos Pacheco N, Seegers C, Zarnovican P, Buettner FFR, Bakker H, Soldati-Favre D, Routier FH. C-Mannosylation of Toxoplasma gondii proteins promotes attachment to host cells and parasite virulence. J. Biol. Chem. 2020; 295:1066-1076.
Lee DJ, O’Donnell H, Routier FH, Tiralongo J, Haselhorst T. Glycobiology of Human Fungal Pathogens: New Avenues for Drug Development. Cells 2019; 8: E1348.
Albuquerque-Wendt A, Hütte HJ, Buettner FFR, Routier FH, Bakker H. Membrane Topological Model of Glycosyltransferases of the GT-C Superfamily. Int. J. Mol. Sci. 2019; 29: E4842.
Prakash O, Fuhring J, Post J, Shepherd SM, Eadsforth TC, Gray D, Fedorov R, Routier FH. Identification of Leishmania major UDP-Sugar Pyrophosphorylase Inhibitors Using Biosensor-Based Small Molecule Fragment Library Screening. Molecules 2019; 24: E996
Kruger AT, Engel J, Buettner FF, Routier FH. Aspergillus fumigatus Cap59-like protein A is involved in alpha1,3-mannosylation of GPI-anchors. Glycobiology 2016; 26:30-38.
Engel J, Schmalhorst PS, Kruger AT, Muller CT, Buettner FF, Routier FH. Characterization of an N-acetylglucosaminyltransferase involved in Aspergillus fumigatus zwitterionic glycoinositolphosphoceramide biosynthesis. Glycobiology 2015; 25:1423-1430.
Führing J, Cramer JT, Routier FH, Lamerz AC, Baruch P, Gerardy-Schahn R and Fedorov R. Catalytic Mechanism and Allosteric Regulation of UDP-Glucose Pyrophosphorylase from Leishmania major. ACS Catal. 2013; 3: 2976−2985.
Engel J, Schmalhorst PS and Routier FH. Biosynthesis of the fungal cell wall polysaccharide galactomannan requires intraluminal GDP-mannose. J. Biol. Chem. 2012; 287(53): 44418-44424.
Engel J, Schmalhorst PS, Dork-Bousset T, Ferrieres V and Routier FH. A single UDP-galactofuranose transporter is required for galactofuranosylation in Aspergillus fumigatus. J Biol Chem 2009; 284: 33859-33868.
Schmalhorst PS, Krappmann S, Vervecken W, Rohde M, Muller M, Braus GH, Contreras R, Braun A, Bakker H and Routier FH. Contribution of galactofuranose to the virulence of the opportunistic pathogen Aspergillus fumigatus. Eukaryot Cell 2008; 7: 1268-1277.
