Dr. Nora Schmidt
| My Research Interest in RESIST |
My research within RESIST focuses on deciphering the role of RNA-protein interactions in viral disease mechanisms and antiviral defense processes in RSV and HSV-1 infections. We will identify candidate RNA-binding proteins and illuminate their mechanistic function in modulating viral or host RNAs during the viral life cycle and the IFN response. Our methodology includes advanced sequencing techniques, as well as cell-based virological and biochemical assays. By integrating information of genetic variants from the RESIST cohorts, we will contribute to a better understanding of disease processes and susceptibility in patients at risk for severe viral disease.
Dr. Nora Schmidt in the MHH virology laboratory
Dr. Nora Schmidt – Curriculum Vitae
Current Position
Undergraduate and Postgraduate Training
Academic and Research Posts
Awards and Prizes
10 Selected Publications
Aydin, J., A. Gabel, S. Zielinski, S. Ganskih, N. Schmidt, C. R. Hartigan, M. Schenone, S. A. Carr, and M. Munschauer. 2024. SHIFTR enables the unbiased identification of proteins bound to specific RNA regions in live cells. Nucleic Acids Res 52: e26. PMID: 38281241.
Schmidt, N., S. Ganskih, Y. Wei, A. Gabel, S. Zielinski, H. Keshishian, C. A. Lareau, L. Zimmermann, J. Makroczyova, C. Pearce, K. Krey, T. Hennig, S. Stegmaier, L. Moyon, M. Horlacher, S. Werner, J. Aydin, M. Olguin-Nava, R. Potabattula, A. Kibe, L. Dolken, R. P. Smyth, N. Caliskan, A. Marsico, C. Krempl, J. Bodem, A. Pichlmair, S. A. Carr, P. Chlanda, F. Erhard, and M. Munschauer. 2023. SND1 binds SARS-CoV-2 negative-sense RNA and promotes viral RNA synthesis through NSP9. Cell 186: 4834-4850 e4823. PMID: 37794589.
Pekayvaz, K., A. Leunig, R. Kaiser, M. Joppich, S. Brambs, A. Janjic, O. Popp, D. Nixdorf, V. Fumagalli, N. Schmidt, V. Polewka, A. Anjum, V. Knottenberg, L. Eivers, L. E. Wange, C. Gold, M. Kirchner, M. Muenchhoff, J. C. Hellmuth, C. Scherer, R. Rubio-Acero, T. Eser, F. Deak, K. Puchinger, N. Kuhl, A. Linder, K. Saar, L. Tomas, C. Schulz, A. Wieser, W. Enard, I. Kroidl, C. Geldmacher, M. von Bergwelt-Baildon, O. T. Keppler, M. Munschauer, M. Iannacone, R. Zimmer, P. Mertins, N. Hubner, M. Hoelscher, S. Massberg, K. Stark, and L. Nicolai. 2022. Protective immune trajectories in early viral containment of non-pneumonic SARS-CoV-2 infection. Nat Commun 13: 1018. PMID: 35197461.
Borold, J., D. Eletto, I. Busnadiego, N. K. Mair, E. Moritz, S. Schiefer, N. Schmidt, P. P. Petric, W. W. Wong, M. Schwemmle, and B. G. Hale. 2021. BRD9 is a druggable component of interferon-stimulated gene expression and antiviral activity. EMBO Rep 22: e52823. PMID: 34397140.
Schmidt, N., C. A. Lareau, H. Keshishian, S. Ganskih, C. Schneider, T. Hennig, R. Melanson, S. Werner, Y. Wei, M. Zimmer, J. Ade, L. Kirschner, S. Zielinski, L. Dolken, E. S. Lander, N. Caliskan, U. Fischer, J. Vogel, S. A. Carr, J. Bodem, and M. Munschauer. 2021. The SARS-CoV-2 RNA-protein interactome in infected human cells. Nat Microbiol 6: 339-353. PMID: 33349665.
Schmidt, N., P. Domingues, F. Golebiowski, C. Patzina, M. H. Tatham, R. T. Hay, and B. G. Hale. 2019. An influenza virus-triggered SUMO switch orchestrates co-opted endogenous retroviruses to stimulate host antiviral immunity. Proc Natl Acad Sci U S A 116: 17399-17408. PMID: 31391303.
Sekine, E., N. Schmidt, D. Gaboriau, and P. O’Hare. 2017. Spatiotemporal dynamics of HSV genome nuclear entry and compaction state transitions using bioorthogonal chemistry and super-resolution microscopy. PLoS Pathog 13: e1006721. PMID: 29121649.
Schmidt, N., T. Hennig, R. A. Serwa, M. Marchetti, and P. O’Hare. 2015. Remote Activation of Host Cell DNA Synthesis in Uninfected Cells Signaled by Infected Cells in Advance of Virus Transmission. J Virol 89: 11107-11115. PMID: 26311877.
Shukla, S., F. J. Eber, A. S. Nagarajan, N. A. DiFranco, N. Schmidt, A. M. Wen, S. Eiben, R. M. Twyman, C. Wege, and N. F. Steinmetz. 2015. The Impact of Aspect Ratio on the Biodistribution and Tumor Homing of Rigid Soft-Matter Nanorods. Adv Healthc Mater 4: 874-882. PMID: 25641794.
