Prof. Dr. Nico Lachmann participates in RESIST research project B13.

My Research Interest in RESIST

Our research focus in RESIST is the development of alternative therapies targeting infections of the lower respiratory tract. In our research, we aim to combine stem cell research and blood cell farming with infection research to open new avenues towards anti-bacterial therapies. The laboratory has unique expertise in the generation of hematopoietic cells from different sources of stem cells, which will be provided to all members of RESIST to study e.g host-pathogen interaction or the development of novel drugs/small molecules by screening libraries. 

Drugs, such as antibiotics, are the backbone in antibacterial therapies. However, the increasing numbers of antibiotic-resistant bacteria and therapy failures highlight the need for alternative approaches. Our team builds on long-standing expertise in regenerative medicine and research on macrophages to provide new insights into the protective role of macrophages against various pathogens in the airways. Together with other RESIST scientists, we are going to explore the impact of macrophages on the onset and progression of infections of the lower respiratory tract with direct implications for the development of novel therapies for various groups of patients. 

Contact

Prof. Lachmann about his scientific work

Prof. Dr. Nico Lachmann – Curriculum Vitae

Current Position

  • Since 2020 Associate (W2) Professor, Department of Pediatric Pneumology, Allergology and Neonatology, Hannover Medical School (MHH)

Undergraduate and Postgraduate Training

  • 2003 – 2006 Bachelor of Science “Life Science”, Leibniz University Hannover (LUH)

  • 2006 – 2008 Master of Science “Biomedicine”, Hannover Medical School and Yale University School of Medicine, USA

  • 2008 – 2012 PhD Thesis (Dr. rer. nat.; Supervisor Prof. Dr. med. Thomas Moritz)

  • 2016 Habilitation (Supervisor Prof. Dr. med. Axel Schambach) 

Academic and Research Posts

  • 2012 – 2013 Postdoctoral Fellow at the Max-Planck-Institute for Molecular Biomedicine, Germany

  • 2012 – 2015 Postdoctoral Fellow at the Institute of Experimental Hematology, Hannover Medical School, Germany

  • 2013 – 2019 Adjunct Instructor, Division of Pulmonary Biology, Cincinnati Childrens Hospital Medical Center, USA

  • 2015 – 2020 Group-Leader, Institute of Experimental Hematology, Hannover Medical School, Germany

Other Scientific Roles

  • Since 2009 Initiator and founder of “Stem Cells – Goes Back to School”, High-School Lectures in Lower Saxony

  • Since 2018 Member of section II (Department of Internal Medicine, Pediatrics and Surgery), Hannover Medical School

  • Since 2018 Member, steering committee REBIRTH Center for Translational and Regenerative Medicine, Hannover Medical School

  • Since 2018 Ad-Hoc Reviewer European Research Council (ERC)

Awards and Prizes

  • 2013 Eva-Luise Köhler Research Award for Rare Diseases, Berlin, Germany

  • 2014 Top Abstract and Best Translational Research Award, German Society of Hematology and Oncology (DGHO), Hamburg, Germany

  • 2015 Klaus Betke Fellowship, Munich

  • 2015 Best Clinical Research Award, German Society for Pulmonology (DGP), Berlin

  • 2015 Fellowship for Interdisciplinary Sciences, Joachim Herz Stiftung

  • 2019 Young Investigator Award, German Stem Cell Network (GSCN), Berlin

  • 2019 ERC Starting Grant

Recommended Links

For further information about Prof. Lachmann’s scientific work please check the following links:

10 Selected Publications

Ackermann M, Haake K, Kempf H, Kaschutnig P, Weiss AC, Nguyen AHH, Abeln M, Merkert S, KĂŒhnel MP, Hartmann D, Jonigk D, Thum T, Kispert A, Milsom MD, Lachmann N. “A 3D iPSC-differentiation Model Identifies interleukin-3 as a Regulator of Early Human Hematopoietic Specification” Haematologica. 2020 Apr 23:haematol.2019.228064. doi: 10.3324/haematol.2019.228064

Hahn K, Pollmann L, Nowak J, Nguyeh AHH, Haake K, Neehus AL, Waqas SF, Pessler F, Baumann U, Hetzel M, Casanova JL, Schulz A, Bustamante J, Ackermann M, Lachmann N, “Human Lentiviral Gene Therapy Restores the Cellular Phenotype of Autosomal Recessive Complete IFN-γR1 Deficiency” Molecular Therapy Methods and Clinical Development 2020 [accepted]

Haake K, Neehus AL, Buchegger T, KĂŒhnel MP, Blank P, Philipp F, Olega-Quintas C, Schulz A, Grimley M, Goethe R, Jonigk D, Kalinke U, Boisson-Dupuis S, Casanova JL, Bustamante J, Lachmann N “Patient iPSC-Derived Macrophages to Study Inborn Errors of the IFN-Îł Responsive Pathway” Cells, 9 (2) 2020 Feb 19 DOI: 10.3390/cells9020483

Haake K, Lachmann N, “New Drugs for an Old Foe: Mycobacterium Tuberculosis Meets PSC-Derived Macrophages” Stem Cell Reports 13 (6), 957-959  2019 Dec 10 DOI: 10.1016/j.stemcr.2019.11.006

Ackermann M*, Kempf H*, Hetzel M, Hesse C, Hashtchin AR, Brinkert K, Schott JW, Haake K, KĂŒhnel MP, Glage S, Figueiredo C, Jonigk D, Sewald K, Schambach A, Wronski S, Moritz T, Martin U, Zweigerdt R, Munder A, Lachmann N „Bioreactor-based mass production of human iPSC-derived macrophages enables immunotherapies against bacterial airway infections.“, Nature Communications. 2018 Nov 30;9(1):5088. doi: 10.1038/s41467-018-07570-7.

Happle C*, Lachmann N*, Ackermann M, Wetzke M, Mirenska A, Göhring G, Thomay K, Mucci A, Glomb T, Suzuki T, Glage S, Dittrich-Breiholz O, Trapnell B, Moritz T, Hansen G “Pulmonary transplantation of human iPSC-derived macrophages ameliorates hereditary lung disease” Am J Respir Crit Care Med. 2018 Apr 13. doi: 10.1164/rccm.201708-1562OC

Hetzel M, Mucci A, Blank P, Nguyen AHH, Schiller J, Halle O, KĂŒhnel MP, Billig S, Meineke R, Brand D, Herder V, BaumgĂ€rtner W, Bange FC, Goethe R, Jonigk D, Förster R, Gentner B, Casanova JL, Bustamante J, Schambach A, Kalinke U, Lachmann N. „Hematopoietic stem cell gene therapy for IFNÎłR1 deficiency protects mice from mycobacterial infections.“ Blood. 2018 Feb 1;131(5):533-545. doi: 10.1182/blood-2017-10-812859.

Neehus AL, Lam J, Haake K, Merkert S, Schmidt N, Mucci A, Ackermann M, Schubert M, Happle C, KĂŒhnel MP, Blank P, Philipp F, Goethe R, Jonigk D, Martin U, Kalinke U, Baumann U, Schambach A, Roesler J, Lachmann N “Impaired IFNg-Signaling and Mycobacterial Clearance in IFNgR1 Deficient Human iPSC-Derived Macrophages” Stem Cell Reports. 2018 Jan 9;10(1):7-16

Happle C*, Lachmann N*, Skuljec J, Wetzke M, Ackermann M, Brennig S, Mucci A, Jirmo AC, Groos S, Mirenska A, Hennig C, Rodt T, Bankstahl JP, Schwerk N, Moritz T, Hansen G. „Pulmonary transplantation of macrophage progenitors as effective and long-lasting therapy for hereditary pulmonary alveolar proteinosis„ Science Transl Med. 2014 Aug 20;6(250):250ra113. *contributed equally

Lachmann N*, Happle C*, LĂŒttge D, Wetzke M, Merkert S, Ackermann M, Kensah J, Jara-Avaca M, Mucci A, Skuljec J, Dittrich AM, Pfaff N, Brennig S, Schambach A, Steinemann D, Göhring G, Cantz T, Martin U, Schwerk N, Hansen G, Moritz T “Gene correction of human induced Pluripotent Stem Cells repairs the cellular phenotype in Pulmonary Alveolar Proteinosis” Am J Respir Crit Care Med. 2014 Jan 15;189(2):167-82 *contributed equally

Contact

  Prof. Dr. Nico Lachmann
  Translational Hematology, Hannover Medical School (MHH)
  Hannover Medical School (MHH)
Carl-Neuberg-Straße 1
30625 Hannover
  +49 511 532 5266
  Lachmann.Nico
@mh-hannover.de