Prof. Dr. Nico Lachmann participates in RESIST research project B13.
| My Research Interest in RESIST |
Our research focus in RESIST is the development of alternative therapies targeting infections of the lower respiratory tract. In our research, we aim to combine stem cell research and blood cell farming with infection research to open new avenues towards anti-bacterial therapies. The laboratory has unique expertise in the generation of hematopoietic cells from different sources of stem cells, which will be provided to all members of RESIST to study e.g host-pathogen interaction or the development of novel drugs/small molecules by screening libraries.
Drugs, such as antibiotics, are the backbone in antibacterial therapies. However, the increasing numbers of antibiotic-resistant bacteria and therapy failures highlight the need for alternative approaches. Our team builds on long-standing expertise in regenerative medicine and research on macrophages to provide new insights into the protective role of macrophages against various pathogens in the airways. Together with other RESIST scientists, we are going to explore the impact of macrophages on the onset and progression of infections of the lower respiratory tract with direct implications for the development of novel therapies for various groups of patients.
Prof. Lachmann about his scientific work
Prof. Dr. Nico Lachmann – Curriculum Vitae
Current Position
Undergraduate and Postgraduate Training
Academic and Research Posts
Other Scientific Roles
Awards and Prizes
10 Selected Publications
Ackermann M, Haake K, Kempf H, Kaschutnig P, Weiss AC, Nguyen AHH, Abeln M, Merkert S, Kühnel MP, Hartmann D, Jonigk D, Thum T, Kispert A, Milsom MD, Lachmann N. “A 3D iPSC-differentiation Model Identifies interleukin-3 as a Regulator of Early Human Hematopoietic Specification” Haematologica. 2020 Apr 23:haematol.2019.228064. doi: 10.3324/haematol.2019.228064
Hahn K, Pollmann L, Nowak J, Nguyeh AHH, Haake K, Neehus AL, Waqas SF, Pessler F, Baumann U, Hetzel M, Casanova JL, Schulz A, Bustamante J, Ackermann M, Lachmann N, “Human Lentiviral Gene Therapy Restores the Cellular Phenotype of Autosomal Recessive Complete IFN-γR1 Deficiency” Molecular Therapy Methods and Clinical Development 2020 [accepted]
Haake K, Neehus AL, Buchegger T, Kühnel MP, Blank P, Philipp F, Olega-Quintas C, Schulz A, Grimley M, Goethe R, Jonigk D, Kalinke U, Boisson-Dupuis S, Casanova JL, Bustamante J, Lachmann N “Patient iPSC-Derived Macrophages to Study Inborn Errors of the IFN-γ Responsive Pathway” Cells, 9 (2) 2020 Feb 19 DOI: 10.3390/cells9020483
Haake K, Lachmann N, “New Drugs for an Old Foe: Mycobacterium Tuberculosis Meets PSC-Derived Macrophages” Stem Cell Reports 13 (6), 957-959 2019 Dec 10 DOI: 10.1016/j.stemcr.2019.11.006
Ackermann M*, Kempf H*, Hetzel M, Hesse C, Hashtchin AR, Brinkert K, Schott JW, Haake K, Kühnel MP, Glage S, Figueiredo C, Jonigk D, Sewald K, Schambach A, Wronski S, Moritz T, Martin U, Zweigerdt R, Munder A, Lachmann N „Bioreactor-based mass production of human iPSC-derived macrophages enables immunotherapies against bacterial airway infections.“, Nature Communications. 2018 Nov 30;9(1):5088. doi: 10.1038/s41467-018-07570-7.
Happle C*, Lachmann N*, Ackermann M, Wetzke M, Mirenska A, Göhring G, Thomay K, Mucci A, Glomb T, Suzuki T, Glage S, Dittrich-Breiholz O, Trapnell B, Moritz T, Hansen G “Pulmonary transplantation of human iPSC-derived macrophages ameliorates hereditary lung disease” Am J Respir Crit Care Med. 2018 Apr 13. doi: 10.1164/rccm.201708-1562OC
Hetzel M, Mucci A, Blank P, Nguyen AHH, Schiller J, Halle O, Kühnel MP, Billig S, Meineke R, Brand D, Herder V, Baumgärtner W, Bange FC, Goethe R, Jonigk D, Förster R, Gentner B, Casanova JL, Bustamante J, Schambach A, Kalinke U, Lachmann N. „Hematopoietic stem cell gene therapy for IFNγR1 deficiency protects mice from mycobacterial infections.“ Blood. 2018 Feb 1;131(5):533-545. doi: 10.1182/blood-2017-10-812859.
Neehus AL, Lam J, Haake K, Merkert S, Schmidt N, Mucci A, Ackermann M, Schubert M, Happle C, Kühnel MP, Blank P, Philipp F, Goethe R, Jonigk D, Martin U, Kalinke U, Baumann U, Schambach A, Roesler J, Lachmann N “Impaired IFNg-Signaling and Mycobacterial Clearance in IFNgR1 Deficient Human iPSC-Derived Macrophages” Stem Cell Reports. 2018 Jan 9;10(1):7-16
Happle C*, Lachmann N*, Skuljec J, Wetzke M, Ackermann M, Brennig S, Mucci A, Jirmo AC, Groos S, Mirenska A, Hennig C, Rodt T, Bankstahl JP, Schwerk N, Moritz T, Hansen G. „Pulmonary transplantation of macrophage progenitors as effective and long-lasting therapy for hereditary pulmonary alveolar proteinosis„ Science Transl Med. 2014 Aug 20;6(250):250ra113. *contributed equally
Lachmann N*, Happle C*, Lüttge D, Wetzke M, Merkert S, Ackermann M, Kensah J, Jara-Avaca M, Mucci A, Skuljec J, Dittrich AM, Pfaff N, Brennig S, Schambach A, Steinemann D, Göhring G, Cantz T, Martin U, Schwerk N, Hansen G, Moritz T “Gene correction of human induced Pluripotent Stem Cells repairs the cellular phenotype in Pulmonary Alveolar Proteinosis” Am J Respir Crit Care Med. 2014 Jan 15;189(2):167-82 *contributed equally
