Dr. Berislav Bošnjak

My Research Interest in RESIST

The initiation of T cell immune responses by dendritic cells lies in the center of protection from pathogens but also for the induction of allergic diseases. My research focus is the differences between antiviral and allergic T-cell response initiation. Moreover, I am interested in studying the interaction of those responses in vulnerable population groups, such as people with chronic infections or asthmaics. I have joined the RESIST as an associated investigator to contribute to the research on the T cell responses in human cytomegalovirus infections.

Dr. Berislav Bošnjak in the lab

Dr. Berislav Bošnjak – Curriculum Vitae

Current Position

  • Since 2016 Postdoctoral research fellow and Senior scientist at Institute of Immunology,
    MHH

Undergraduate and Postgraduate Training

  • 1996 – 2001 Molecular Biology study, graduated Engineer in Molecular Biology, Faculty of Science, University of Zagreb, Zagreb, Croatia;

  • 2004 – 2006 Master of Science degree in Biology: Physiology and Immunobiology, Faculty of Science, University of Zagreb, Zagreb, Croatia

  • 2015 Dr.rer.nat. in Biology: Molecular Biology at University of Vienna, Vienna, Austria

Academic and Research Posts

  • Since 02/2016: Postdoctoral research fellow and Senior scientist at Institute of Immunology, Hanover Medical School, Hanover, Germany

  • 02/2002 – 03/2006 Researcher Immunologist/pharmacologist, PLIVA Inc. and PLIVA Research Institute Ltd., Zagreb, Croatia

  • 04/2006 – 12/2008: Senior researcher Immunopharmacologist, GlaxoSmithKline Research Centre Zagreb Ltd., Zagreb, Croatia

  • 01/2009 – 11/2015: PhD student, Experimental Allergy Lab, Medical University of Vienna, Vienna, Austria

  • 12/2015-01/2016: Postdoctoral research fellow, Experimental Allergy Lab, Medical University of Vienna, Vienna, Austria

Other Scientific Roles

  • Since 2019 Successfully supervised two MSc students

  • Since 2020 Supervising three PhD students and one medical doctorate student

Awards and Prizes

  • 2008 Exceptional Science Award given by the Research and Development department, GlaxoSmithKline Inc.

  • 2005 Annual award by PLIVA Inc. for excellent team work

Recommended Links

For further information about Dr. Bošnjak’s scientific work please check the following links:

10 Selected Publications

Bošnjak B**, Henze E**, Lueder Y, Do KTH, Rezalotfi A, Čuvalo B, Ritter C, Schimrock A, Willenzon S, Georgiev H, Fritz L, Galla M, Wagner K, Messerle M, Förster R. MCK2-mediated MCMV infection of macrophages and virus dissemination to the salivary gland depends on MHC class I molecules. Cell Rep. 2023 Jun 7;42(6):112597. doi: 10.1016/j.celrep.2023.112597. Epub ahead of print. PMID: 37289588.

Barros-Martins J**, Hammerschmidt SI**, Cossmann A**, Odak I, Stankov MV, Morillas Ramos G, Dopfer-Jablonka A, Heidemann A, Ritter C, Friedrichsen M, Schultze-Florey C, Ravens I, Willenzon S, Bubke A, Ristenpart J, Janssen A, Ssebyatika G, Bernhardt G, Münch J, Hoffmann M, Pöhlmann S, Krey T, Bošnjak B*, Förster R*, Behrens GMN*. Immune responses against SARS-CoV-2 variants after heterologous and homologous ChAdOx1 nCoV-19/BNT162b2 vaccination. Nat Med. 2021 Sep;27(9):1525-1529. doi: 10.1038/s41591-021-01449-9.

Bošnjak B, Stein SC, Willenzon S, Cordes AK, Puppe W, Bernhardt G, Ravens I, Ritter C, Schultze-Florey CR, Gödecke N, Martens J, Kleine-Weber H, Hoffmann M, Cossmann A, Yilmaz M, Pink I, Hoeper MM, Behrens GMN, Pöhlmann S, Blasczyk R, Schulz TF, Förster R. Low serum neutralizing anti-SARS-CoV-2 S antibody levels in mildly affected COVID-19 convalescent patients revealed by two different detection methods. Cell Mol Immunol. 2021 Apr;18(4):936-944. doi: 10.1038/s41423-020-00573-9.

Bošnjak B**, Odak I**, Barros-Martins J**, Sandrock I**, Hammerschmidt SI, Permanyer M, Patzer GE, Greorgiev H, Gutierrez Jauregui R, Tscherne A, Schwarz JH, Kalodimou G, Ssebyatika G, Ciurkiewicz M, Willenzon S, Bubke A, Ristenpart J, Ritter C, Tuchel T, Meyer Zu Natrup C, Shin DL, Clever S, Limpinsel L, Baumgärtner W, Krey T, Volz A, Sutter G, Förster R. Intranasal Delivery of MVA Vector Vaccine Induces Effective Pulmonary Immunity Against SARS-CoV-2 in Rodents. Front Immunol. 2021 Nov 11;12:772240. doi: 10.3389/fimmu.2021.772240.

Durán V**, Grabski E**, Hozsa C, Becker J, Yasar H, Monteiro JT, Costa B, Koller N, Lueder Y, Wiegmann B, Brandes G, Kaever V, Lehr CM, Lepenies B, Tampé R, Förster R, Bošnjak B*, Furch M*, Graalmann T*, Kalinke U*. Fucosylated lipid nanocarriers loaded with antibiotics efficiently inhibit mycobacterial propagation in human myeloid cells. J Control Release. 2021 Jun 10;334:201-212. doi: 10.1016/j.jconrel.2021.04.012.

Bošnjak B**, Kazemi S**, Altenburger LM, Mokrović G, Epstein MM. Th2-TRMs Maintain Life-Long Allergic Memory in Experimental Asthma in Mice. Front Immunol. 2019 Apr 24;10:840. doi: 10.3389/fimmu.2019.00840.

Hammerschmidt SI**, Werth K**, Rothe M, Galla M, Permanyer M, Patzer GE, Bubke A, Frenk DN, Selich A, Lange L, Schambach A, Bošnjak B*, Förster R*. CRISPR/Cas9 Immunoengineering of Hoxb8-Immortalized Progenitor Cells for Revealing CCR7-Mediated Dendritic Cell Signaling and Migration Mechanisms in vivo. Front Immunol. 2018 Aug 28;9:1949. doi: 10.3389/fimmu.2018.01949.

Riba M**, Garcia Manteiga JM**, Bošnjak B**, Cittaro D, Mikolka P, Le C, Epstein MM*, Stupka E*. Revealing the acute asthma ignorome: characterization and validation of uninvestigated gene networks. Sci Rep. 2016 Apr 21;6:24647. doi: 10.1038/srep24647.

Bosnjak B, Tilp C, Tomsic C, Dekan G, Pieper MP, Erb KJ, Epstein MM. Tiotropium bromide inhibits relapsing allergic asthma in BALB/c mice. Pulm Pharmacol Ther. 2014 Feb;27(1):44-51. doi: 10.1016/j.pupt.2013.09.004.

Bosnar M**, Bosnjak B**, Cuzic S, Hrvacic B, Marjanovic N, Glojnaric I, Culic O, Parnham MJ, Erakovic Haber V. Azithromycin and clarithromycin inhibit lipopolysaccharide-induced murine pulmonary neutrophilia mainly through effects on macrophage-derived granulocyte-macrophage colony-stimulating factor and interleukin-1beta. J Pharmacol Exp Ther. 2009 Oct;331(1):104-13. doi: 10.1124/jpet.109.155838.

Contact

Dr. Berislav Bošnjak
   Institut für Immunologie
Medizinische Hochschule Hannover
  Carl-Neuberg-Str. 1
30625 Hannover
  +49 511 532 – 9729
  bosnjak.berislav@
mh-hannover.de