Publikations-Highlights
Die hier genannten Veröffentlichungen zeigen besonders hervorzuhebende Ergebnisse unserer exzellenten Forschung.
Ausgewählte RESIST-Publikationen
Hier finden Sie Publikationen von RESIST-Forscherinnen und Forschern.
- Abnormal biomarkers predict complex FAS or FADD defects missed by exome sequencing. Rensing-Ehl A, Lorenz MR, Führer M, Willenbacher W, Willenbacher E, Sopper S, Abinun M, Maccari ME, König C, Haegele P, Fuchs S, Castro C, Kury P, Pelle O, Klemann C, Heeg M, Thalhammer J, Wegehaupt O, Fischer M, Goldacker S, Schulte B, Biskup S, Chatelain P, Schuster V, Warnatz K, Grimbacher B, Meinhardt A, Holzinger D, Oommen PT, Hinze T, Hebart H, Seeger K, Lehmberg K, Leahy TR, Claviez A, Vieth S, Schilling FH, Fuchs I, Groß M, Rieux-Laucat F, Magerus A, Speckmann C, Schwarz K, Ehl S; ALPS Study Group. J Allergy Clin Immunol. 2024 Jan;153(1):297-308.e12. doi: 10.1016/j.jaci.2023.11.006. Epub 2023 Nov 17. PMID: 37979702.
- CAR macrophages on a fast track to solid tumor therapy. Abdin SM, Paasch D, Lachmann N. Nat Immunol. 2024 Jan;25(1):11-12. doi: 10.1038/s41590-023-01696-7. PMID: 38168956.
- Epigenetic immune cell quantification for diagnostic evaluation and monitoring of patients with inborn errors of immunity and secondary immune deficiencies. Ramirez NJ, Schulze JJ, Walter S, Werner J, Mrovecova P, Olek S, Sachsenmaier C, Grimbacher B, Salzer U. Clin Immunol. 2024 Mar;260:109920. doi: 10.1016/j.clim.2024.109920. Epub 2024 Feb 1. PMID: 38307474.
- Humoral and cellular immune responses following BNT162b2 XBB.1.5 vaccination. Stankov MV, Hoffmann M, Gutierrez Jauregui R, Cossmann A, Morillas Ramos G, Graalmann T, Winter EJ, Friedrichsen M, Ravens I, Ilievska T, Ristenpart J, Schimrock A, Willenzon S, Ahrenstorf G, Witte T, Förster R, Kempf A, Pöhlmann S, Hammerschmidt SI, Dopfer-Jablonka A, Behrens GMN. Lancet Infect Dis. 2024 Jan;24(1):e1-e3. doi: 10.1016/S1473-3099(23)00690-4. Epub 2023 Nov 20. PMID: 37995739.
- Innate immune response to SARS-CoV-2 infection contributes to neuronal damage in human iPSC-derived peripheral neurons. Passos V, Henkel LM, Wang J, Zapatero-Belinchón FJ, Möller R, Sun G, Waltl I, Schneider T, Wachs A, Ritter B, Kropp KA, Zhu S, Deleidi M, Kalinke U, Schulz TF, Höglinger G, Gerold G, Wegner F, Viejo-Borbolla A. J Med Virol. 2024 Feb;96(2):e29455. doi: 10.1002/jmv.29455. PMID: 38323709.
- Ten-year experience of whole lung lavage in pediatric Pulmonary Alveolar Proteinosis. Nickel K, Schütz K, Carlens J, Grewendorf S, Wetzke M, Keil O, Dennhardt N, Rigterink V, Köditz H, Sasse M, Happle C, Beck CE, Schwerk N. Klin Padiatr. 2024 Feb;236(2):64-72. doi: 10.1055/a-2194-3467. Epub 2024 Jan 23. PMID: 38262422; PMCID: PMC10883753.
- The Challenge of Anticoagulation in Liver Cirrhosis. Eichholz JC, Wedemeyer H, Maasoumy B. Visc Med. 2024 Jan;39(6):169-176. doi: 10.1159/000535438. Epub 2023 Dec 21. PMID: 38205270; PMCID: PMC10775854.
- The effector program of human CD8 T cells supports tissue remodeling. Delacher M, Schmidleithner L, Simon M, Stüve P, Sanderink L, Hotz-Wagenblatt A, Wuttke M, Schambeck K, Ruhland B, Hofmann V, Bittner S, Ritter U, Pant A, Helbich SS, Voss M, Lemmermann NA, Bessiri-Schake L, Bohn T, Eigenberger A, Menevse AN, Gebhard C, Strieder N, Abken H, Rehli M, Huehn J, Beckhove P, Hehlgans T, Junger H, Geissler EK, Prantl L, Werner JM, Schmidl C, Brors B, Imbusch CD, Feuerer M. J Exp Med. 2024 Feb 5;221(2):e20230488. doi: 10.1084/jem.20230488. Epub 2024 Jan 16. PMID: 38226976; PMCID: PMC10791561.
- E4orf1: The triple agent of adenovirus – Unraveling its roles in oncogenesis, infectious obesity and immune responses in virus replication and vector therapy. Göttig L, Schreiner S. Tumour Virus Res. 2024 Feb 28:200277. doi: 10.1016/j.tvr.2024.200277. Online ahead of print. PMID: 38428735 Review.
- Human cytomegalovirus exploits STING signaling and counteracts IFN/ISG induction to facilitate infection of dendritic cells. Costa B, Becker J, Krammer T, Mulenge F, Durán V, Pavlou A, Gern OL, Chu X, Li Y, Čičin-Šain L, Eiz-Vesper B, Messerle M, Dölken L, Saliba AE, Erhard F, Kalinke U. Nat Commun. 2024 Feb 26;15(1):1745. doi: 10.1038/s41467-024-45614-3. PMID: 38409141 Free PMC article.
- Pulmonary Alveolar Proteinosis and new therapeutic concepts. Rodriguez Gonzalez C, Schevel H, Hansen G, Schwerk N, Lachmann N.
Klin Padiatr. 2024 Feb;236(2):73-79. doi: 10.1055/a-2233-1243. Epub 2024 Jan 29. PMID: 38286410 Free PMC article. - Crystal structure of the tegument protein UL82 (pp71) from human cytomegalovirus. Eberhage J, Bresch IP, Ramani R, Viohl N, Buchta T, Rehfeld CL, Hinse P, Reubold TF, Brinkmann MM, Eschenburg S. Protein Sci. 2024 Mar;33(3):e4915. doi: 10.1002/pro.4915. PMID: 38358250
- Drug repurposing screen identifies lonafarnib as respiratory syncytial virus fusion protein inhibitor. Sake SM, Zhang X, Rajak MK, Urbanek-Quaing M, Carpentier A, Gunesch AP, Grethe C, Matthaei A, Rückert J, Galloux M, Larcher T, Le Goffic R, Hontonnou F, Chatterjee AK, Johnson K, Morwood K, Rox K, Elgaher WAM, Huang J, Wetzke M, Hansen G, Fischer N, Eléouët JF, Rameix-Welti MA, Hirsch AKH, Herold E, Empting M, Lauber C, Schulz TF, Krey T, Haid S, Pietschmann T. Nat Commun. 2024 Feb 8;15(1):1173. doi: 10.1038/s41467-024-45241-y. PMID: 38332002 Free PMC article.
- Unraveling the dynamics of hepatitis C virus adaptive mutations and their impact on antiviral responses in primary human hepatocytes. Frericks N, Brown RJP, Reinecke BM, Herrmann M, Brüggemann Y, Todt D, Miskey C, Vondran FWR, Steinmann E, Pietschmann T, Sheldon J. J Virol. 2024 Feb 6:e0192123. doi: 10.1128/jvi.01921-23. Online ahead of print. PMID: 38319104
- Repurposing screen identifies novel candidates for broad-spectrum coronavirus antivirals and druggable host targets. Haid S, Matthaei A, Winkler M, Sake SM, Gunesch AP, Milke V, Köhler NM, Rückert J, Vieyres G, Kühl D, Nguyen T-T, Göhl M, Lasswitz L, Zapatero-Belinchón FJ, Brogden G, Gerold G, Wiegmann B, Bilitewski U, Brown RJP, Brönstrup M, Schulz TF, Pietschmann T. Antimicrob Agents Chemother. 2024 Feb 6:e0121023. doi: 10.1128/aac.01210-23. Online ahead of print. PMID: 38319076
- Anti-CRISPR Anopheles mosquitoes inhibit gene drive spread under challenging behavioural conditions in large cages. D’Amato R, Taxiarchi C, Galardini M, Trusso A, Minuz RL, Grilli S, Somerville AGT, Shittu D, Khalil AS, Galizi R, Crisanti A, Simoni A, Müller R. Nat Commun. 2024 Feb 1;15(1):952. doi: 10.1038/s41467-024-44907-x. PMID: 38296981
- Herpes simplex virus type 1 modifies the protein composition of extracellular vesicles to promote neurite outgrowth and neuroinfection. Sun G, Kropp KA, Kirchner M, Plückebaum N, Selich A, Serrero M, Dhingra A, Cabrera JR, Ritter B, Bauerfeind R, Wyler E, Landthaler M, Schambach A, Sodeik B, Mertins P, Viejo-Borbolla A. mBio. 2024 Jan 26:e0330823. doi: 10.1128/mbio.03308-23. Online ahead of print. PMID: 38275838
- CRISPR-Cas12a for Highly Efficient and Marker-Free Targeted Integration in Human Pluripotent Stem Cells. Hammad R, Alzubi J, Rhiel M, Chmielewski KO, Mosti L, Rositzka J, Heugel M, Lawrenz J, Pennucci V, Gläser B, Fischer J, Schambach A, Moritz T, Lachmann N, Cornu TI, Mussolino C, Schäfer R, Cathomen T. Int J Mol Sci. 2024 Jan 12;25(2):985. doi: 10.3390/ijms25020985. PMID: 38256061
- Human inherited CCR2 deficiency underlies progressive polycystic lung disease. Neehus AL, Carey B, Landekic M, Panikulam P, Deutsch G, Ogishi M, Arango-Franco CA, Philippot Q, Modaresi M, Mohammadzadeh I, Corcini Berndt M, Rinchai D, Le Voyer T, Rosain J, Momenilandi M, Martin-Fernandez M, Khan T, Bohlen J, Han JE, Deslys A, Bernard M, Gajardo-Carrasco T, Soudée C, Le Floc’h C, Migaud M, Seeleuthner Y, Jang MS, Nikolouli E, Seyedpour S, Begueret H, Emile JF, Le Guen P, Tavazzi G, Colombo CNJ, Marzani FC, Angelini M, Trespidi F, Ghirardello S, Alipour N, Molitor A, Carapito R, Mazloomrezaei M, Rokni-Zadeh H, Changi-Ashtiani M, Brouzes C, Vargas P, Borghesi A, Lachmann N, Bahram S, Crestani B, Pahari S, Schlesinger LS, Marr N, Bugonovic D, Boisson-Dupuis S, Béziat V, Abel L, Borie R, Young LR, Deterding R, Shahrooei M, Rezaei N, Parvaneh N, Craven D, Gros P, Malo D, Sepulveda FE, Nogee LM, Aladjidi N, Trapnell BC, Casanova JL, Bustamante J. Cell. 2024 Jan 18;187(2):390-408.e23. doi: 10.1016/j.cell.2023.11.036. Epub 2023 Dec 28. PMID: 38157855
- Clean Synthetic Strategies to Biologically Active Molecules from Lignin: A Green Path to Drug Discovery. Afanasenko AM, Wu X, De Santi A, Elgaher WAM, Kany AM, Shafiei R, Schulze MS, Schulz TF, Haupenthal J, Hirsch AKH, Barta K. Angew Chem Int Ed Engl. 2024 Jan 22;63(4):e202308131. doi: 10.1002/anie.202308131. Epub 2023 Nov 14. PMID: 37840425
- A tetravalent bispecific antibody outperforms the combination of its parental antibodies and neutralizes diverse SARS-CoV-2 variants. Chiyyeadu A, Asgedom G, Bruhn M, Rocha C, Schlegel TU, Neumann T, Galla M, Barbosa PV, Hoffmann M, Ehrhardt K, Ha TC, Morgan M, Schoeder CT, Pöhlmann S, Kalinke U, Schambach A. Clin Immunol. 2024 Jan 11:109902. doi: 10.1016/j.clim.2024.109902. Online ahead of print. PMID: 38218210
- Memory B cells anticipate SARS-CoV-2 variants through somatic hypermutation. Bruhn M, Obara M, Chiyyeadu A, Costa B, Salam A, Ziegler A, Waltl I, Pavlou A, Bonifacius A, Hoffmann M, Graalmann T, Pöhlmann S, Eiz-Vesper B, Schambach A, Kalinke U. J Infect. 2024 Jan;88(1):57-60. doi: 10.1016/j.jinf.2023.10.020. Epub 2023 Oct 31. PMID: 37913848 No abstract available.
- PLCG2-associated immune dysregulation (PLAID) comprises broad and distinct clinical presentations related to functional classes of genetic variants. Baysac K, Sun G, Nakano H, Schmitz EG, Cruz AC, Fisher C, Bailey AC; PLCG2-Immune Dysregulation Working Group; Mace E, Milner JD, Ombrello MJ. J Allergy Clin Immunol. 2024 Jan;153(1):230-242. doi: 10.1016/j.jaci.2023.08.036. Epub 2023 Sep 26. PMID: 37769878
- Systems biology analysis reveals distinct molecular signatures associated with immune responsiveness to the BNT162b COVID-19 vaccine. Odak I, Riemann L, Sandrock I, Cossmann A, Ramos GM, Hammerschmidt SI, Ritter C, Friedrichsen M, Hassan A, Dopfer-Jablonka A, Stankov MV, Weskamm LM, Addo MM, Ravens I, Willenzon S, Schimrock A, Ristenpart J, Janssen A, Barros-Martins J, Hansen G, Falk C, Behrens GMN, Förster R. EBioMedicine. 2023 Dec 30;99:104947. doi: 10.1016/j.ebiom.2023.104947. Online ahead of print. PMID: 38160529
- Early-life vitamin A treatment rescues neonatal infection-induced durably impaired tolerogenic properties of celiac lymph nodes. Mangge Zou, Joern Pezoldt, Juliane Mohr, Lars Philipsen, Andrea Leufgen, Vuk Cerovic, Carolin Wiechers, Marina Pils, Diego Ortiz, Lianxu Hao, Juhao Yang, Michael Beckstette, Aline Dupont, Mathias Hornef, Petra Dersch, Till Strowig, Andreas J. Müller, Jens Raila, Jochen Huehn, Cell Reports, Volume 43, Issue 5, 2024, 114153, ISSN 2211-1247.
- Identification of Compounds Preventing A. fumigatus Biofilm Formation by Inhibition of the Galactosaminogalactan Deacetylase Agd3 Seegers CII, Lee DJ, Zarnovican P, Kirsch SH, Müller R, Haselhorst T, Routier FH. Int J Mol Sci. 2023 Jan 17;24(3):1851. doi: 10.3390/ijms24031851. PMID: 36768176; PMCID: PMC9915216.
- Persicamidines-Unprecedented Sesquarterpenoids with Potent Antiviral Bioactivity against Coronaviruses Keller L, Oueis E, Kaur A, Safaei N, Kirsch SH, Gunesch AP, Haid S, Rand U, Čičin-Šain L, Fu C, Wink J, Pietschmann T, Müller R. Angew Chem Int Ed Engl. 2023 Feb 1;62(6):e202214595. doi: 10.1002/anie.202214595. Epub 2023 Jan 4. PMID: 36422061; PMCID: PMC10107436.
- Human IRF1 governs macrophagic IFN-γ immunity to mycobacteria. Rosain J, Neehus AL, Manry J, Yang R, Le Pen J, Daher W, Liu Z, Chan YH, Tahuil N, Türel Ö, Bourgey M, Ogishi M, Doisne JM, Izquierdo HM, Shirasaki T, Le Voyer T, Guérin A, Bastard P, Moncada-Vélez M, Han JE, Khan T, Rapaport F, Hong SH, Cheung A, Haake K, Mindt BC, Pérez L, Philippot Q, Lee D, Zhang P, Rinchai D, Al Ali F, Ahmad Ata MM, Rahman M, Peel JN, Heissel S, Molina H, Kendir-Demirkol Y, Bailey R, Zhao S, Bohlen J, Mancini M, Seeleuthner Y, Roelens M, Lorenzo L, Soudée C, Paz MEJ, González ML, Jeljeli M, Soulier J, Romana S, L’Honneur AS, Materna M, Martínez-Barricarte R, Pochon M, Oleaga-Quintas C, Michev A, Migaud M, Lévy R, Alyanakian MA, Rozenberg F, Croft CA, Vogt G, Emile JF, Kremer L, Ma CS, Fritz JH, Lemon SM, Spaan AN, Manel N, Abel L, MacDonald MR, Boisson-Dupuis S, Marr N, Tangye SG, Di Santo JP, Zhang Q, Zhang SY, Rice CM, Béziat V, Lachmann N, Langlais D, Casanova JL, Gros P, Bustamante J. Cell. 2023 Feb 2;186(3):621-645.e33. doi: 10.1016/j.cell.2022.12.038. PMID: 36736301; PMCID: PMC9907019.
- Silent neonatal influenza A virus infection primes systemic antimicrobial immunity. Heinemann AS, Stalp JL, Bonifacio JPP, Silva F, Willers M, Heckmann J, Fehlhaber B, Völlger L, Raafat D, Normann N, Klos A, Hansen G, Schmolke M, Viemann D. Front Immunol. 2023 Jan 24;14:1072142. doi: 10.3389/fimmu.2023.1072142. PMID: 36761727; PMCID: PMC9902881.
- Transcriptome Dynamics of Pseudomonas aeruginosa during Transition from Overlapping To Non-Overlapping Cell Cycles. Alpers K, Vatareck E, Gröbe L, Müsken M, Scharfe M, Häussler S, Tomasch J. mSystems. 2023 Apr 27;8(2):e0113022. doi: 10.1128/msystems.01130-22. Epub 2023 Feb 14. PMID: 36786632; PMCID: PMC10134858.
- Viral dew: Phase separation and the formation of viral replication compartments. Bosse JB, Brune W. PLoS Pathog. 2023 Feb 16;19(2):e1011145. doi: 10.1371/journal.ppat.1011145. PMID: 36795674; PMCID: PMC9934448.
- Sequencing the B Cell Receptor Repertoires of Antibody-Deficient Individuals With and Without Infection Susceptibility. Lim YW, Ramirez NJ, Asensio MA, Chiang Y, Müller G, Mrovecova P, Mitsuiki N, Krausz M, Camacho-Ordonez N, Warnatz K, Adler AS, Grimbacher B. J Clin Immunol. 2023 Jul;43(5):940-950. doi: 10.1007/s10875-023-01448-0. Epub 2023 Feb 24. PMID: 36826743; PMCID: PMC10276080.
- Brief report: Assessment of mucosal barrier integrity using serological biomarkers in preclinical stages of rheumatoid arthritis. Gilbert BTP, Lamacchia C, Amend L, Strowig T, Rodriguez E, Palmer G, Finckh A. Front Immunol. 2023 Feb 16;14:1117742. doi: 10.3389/fimmu.2023.1117742. PMID: 36875067; PMCID: PMC9977794.
- Insights into B cell ontogeny inferred from human immunology. Dirks J, Viemann D, Beyersdorf N, Härtel C, Morbach H. 2023 Jun;53(6):e2250116. doi: 10.1002/eji.202250116. Epub 2023 Apr 5. PMID: 36905220.
- Pathogen spectra in hospitalised and nonhospitalised children with community-acquired pneumonia. Wetzke M, Schütz K, Kopp MV, Seidenberg J, Vogelberg C, Ankermann T, Happle C, Voigt G, Köster H, Illig T, Lex C, Schuster A, Maier R, Panning M, Barten G, Rohde G, Welte T, Hansen G. ERJ Open Res. 2023 Mar 13;9(2):00286-2022. doi: 10.1183/23120541.00286-2022. PMID: 36923566; PMCID: PMC10009707.
- Imaging cytomegalovirus infection and ensuing immune responses. Bošnjak B, Lueder Y, Messerle M, Förster R. Curr Opin Immunol. 2023 Jun;82:102307. doi: 10.1016/j.coi.2023.102307. Epub 2023 Mar 28. PMID: 36996701.
- Structural insights into hepatitis C virus neutralization. Ströh LJ, Krey T. Curr Opin Virol. 2023 Jun;60:101316. doi: 10.1016/j.coviro.2023.101316. Epub 2023 Mar 29. PMID: 37001334.
- ChemGAPP: a tool for chemical genomics analysis and phenotypic profiling. Doherty HM, Kritikos G, Galardini M, Banzhaf M, Moradigaravand D. Bioinformatics. 2023 Apr 3;39(4):btad171. doi: 10.1093/bioinformatics/btad171. PMID: 37014365; PMCID: PMC10085634.oherty HM, Kritikos G, Galardini M, Banzhaf M, Moradigaravand D. Bioinformatics. 2023 Apr 3;39(4):btad171.
- Immunological scars after cure of hepatitis C virus infection: Long-HepC? Cornberg M, Mischke J, Kraft AR, Wedemeyer H. Curr Opin Immunol. 2023 Jun;82:102324. doi: 10.1016/j.coi.2023.102324. Epub 2023 Apr 10. PMID: 37043890.
- The link between rheumatic disorders and inborn errors of immunity. Sogkas G, Witte T. EBioMedicine. 2023 Apr;90:104501. doi: 10.1016/j.ebiom.2023.104501. Epub 2023 Mar 2. PMID: 36870198; PMCID: PMC9996386.
- The GAIN Registry – a New Prospective Study for Patients with Multi-organ Autoimmunity and Autoinflammation. Staus P, Rusch S, El-Helou S, Müller G, Krausz M, Geisen U, Caballero-Oteyza A, Krüger R, Bakhtiar S, Lee-Kirsch MA, Fasshauer M, Baumann U, Hoyer BF, Farela Neves J, Borte M, Carrabba M, Hauck F, Ehl S, Bader P, von Bernuth H, Atschekzei F, Seppänen MRJ, Warnatz K, Nieters A, Kindle G, Grimbacher B. J Clin Immunol. 2023 Aug;43(6):1289-1301. doi: 10.1007/s10875-023-01472-0. Epub 2023 Apr 21. PMID: 37084016; PMCID: PMC10119522.
- Crystal structure of the N-terminal domain of the effector protein SidI of Legionella pneumophila reveals a glucosyl transferase domain. Machtens DA, Willerding JM, Eschenburg S, Reubold TF. Biochem Biophys Res Commun. 2023 Jun 18;661:50-55. doi: 10.1016/j.bbrc.2023.04.029. Epub 2023 Apr 14. PMID: 37087798.
- The natural product chlorotonil A preserves colonization resistance and prevents relapsing Clostridioides difficile infection. Bublitz A, Brauer M, Wagner S, Hofer W, Müsken M, Deschner F, Lesker TR, Neumann-Schaal M, Paul LS, Nübel U, Bartel J, Kany AM, Zühlke D, Bernecker S, Jansen R, Sievers S, Riedel K, Herrmann J, Müller R, Fuchs TM, Strowig T.
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A validated protocol to UV-inactivate SARS-CoV-2 and herpesvirus-infected cells. PLoS One. 2023 May 10;18(5):e0274065. Soh TK, Pfefferle S, Wurr S, von Possel R, Oestereich L, Rieger T, Uetrecht C, Rosenthal M, Bosse JB. PLoS One. 2023 May 10;18(5):e0274065. doi: 10.1371/journal.pone.0274065. PMID: 37163509; PMCID: PMC10171616.
- Apobec3A Deamination Functions Are Involved in Antagonizing Efficient Human Adenovirus Replication and Gene Expression. Göttig L, Weiß C, Stubbe M, Hanrieder L, Hofmann S, Grodziecki A, Stadler D, Carpentier A, Protzer U, Schreiner S. mBio. 2023 Jun 27;14(3):e0347822. doi: 10.1128/mbio.03478-22. Epub 2023 May 8. PMID: 37154747; PMCID: PMC10294656.
- SUMO Modification of Hepatitis B Virus Core Mediates Nuclear Entry, Promyelocytic Leukemia Nuclear Body Association, and Efficient Formation of Covalently Closed Circular DNA. Hofmann S, Plank V, Groitl P, Skvorc N, Hofmann K, Luther J, Ko C, Zimmerman P, Bruss V, Stadler D, Carpentier A, Rezk S, Nassal M, Protzer U, Schreiner S. Microbiol Spectr. 2023 Jun 15;11(3):e0044623. doi: 10.1128/spectrum.00446-23. Epub 2023 May 18. PMID: 37199632; PMCID: PMC10269885.
- Hand eczema leaves systemic traces. Roesner LM, Wittmann M. Br J Dermatol. 2023 Aug 24;189(3):e56-e59. doi: 10.1093/bjd/ljad178. PMID: 37226228.
- Helicobacter spp. are prevalent in wild mice and protect from lethal Citrobacter rodentium infection in the absence of adaptive immunity. Zhao B, Osbelt L, Lesker TR, Wende M, Galvez EJC, Hönicke L, Bublitz A, Greweling-Pils MC, Grassl GA, Neumann-Schaal M, Strowig T. Cell Rep. 2023 Jun 27;42(6):112549. doi: 10.1016/j.celrep.2023.112549. Epub 2023 May 26. PMID: 37245209.
- Single cell RNA sequencing reveals distinct clusters of Irf8-expressing pulmonary conventional dendritic cells. Jirmo AC, Grychtol R, Gaedcke S, Liu B, DeStefano S, Happle C, Halle O, Monteiro JT, Habener A, Breiholz OD, DeLuca D, Hansen G. Front Immunol. 2023 May 12;14:1127485. doi: 10.3389/fimmu.2023.1127485. PMID: 37251386; PMCID: PMC10213693.
- Colonization of peripheral ganglia by herpes simplex virus type 1 and 2; Kai A Kropp, Guorong Sun, Abel Viejo-Borbolla, Current Opinion in Virology, Volume 60, June 2023, 101333, ISSN 1879-6257, https://doi.org/10.1016/j.coviro.2023.101333.
- Pulsed antibiotic treatments of gnotobiotic mice manifest in complex bacterial community dynamics and resistance effects. Münch PC, Eberl C, Woelfel S, Ring D, Fritz A, Herp S, Lade I, Geffers R, Franzosa EA, Huttenhower C, McHardy AC, Stecher B. Cell Host Microbe. 2023 Jun 14;31(6):1007-1020.e4. doi: 10.1016/j.chom.2023.05.013. Epub 2023 Jun 5. PMID: 37279755.
- MCK2-mediated MCMV infection of macrophages and virus dissemination to the salivary gland depends on MHC class I molecules. Bošnjak B, Henze E, Lueder Y, Do KTH, Rezalotfi A, Čuvalo B, Ritter C, Schimrock A, Willenzon S, Georgiev H, Fritz L, Galla M, Wagner K, Messerle M, Förster R. Cell Rep. 2023 Jun 27;42(6):112597. doi: 10.1016/j.celrep.2023.112597. Epub 2023 Jun 7. PMID: 37289588.
- C4b-binding protein inhibits particulate- and crystalline-induced NLRP3 inflammasome activation. Bierschenk D, Papac-Milicevic N, Bresch IP, Kovacic V, Bettoni S, Dziedzic M, Wetsel RA, Eschenburg S, Binder CJ, Blom AM, King BC.
- Validation of the Asthma Severity Scoring System (ASSESS) in the ALLIANCE Cohort. Grychtol R, Riemann L, Gaedcke S, Liu B, DeLuca D, Förster R, Maison N, Thiele D, Jakobs N, Bahmer T, Meyer M, Foth S, Weber S, Rietschel E, Rabe KF, Kopp MV, von Mutius E, Dittrich AM, Hansen G; ALLIANCE Study Group as part of the German Center for Lung Research (DZL). J Allergy Clin Immunol. 2023 Jun;151(6):1525-1535.e4. doi: 10.1016/j.jaci.2023.01.027. Epub 2023 Feb 15. PMID: 36804993.
- SPI-1 virulence gene expression modulates motility of Salmonella Typhimurium in a proton motive force- and adhesins-dependent manner. Saleh DO, Horstmann JA, Giralt-Zúñiga M, Weber W, Kaganovitch E, Durairaj AC, Klotzsch E, Strowig T, Erhardt M. PLoS Pathog. 2023 Jun 14;19(6):e1011451. doi: 10.1371/journal.ppat.1011451. PMID: 37315106; PMCID: PMC10298799.
- Epistatic interactions between the high pathogenicity island and other iron uptake systems shape Escherichia coli extra-intestinal virulence. Royer G, Clermont O, Marin J, Condamine B, Dion S, Blanquart F, Galardini M, Denamur E. Nat Commun. 2023 Jun 20;14(1):3667. doi: 10.1038/s41467-023-39428-y. PMID: 37339949; PMCID: PMC10282060.
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- Hepatitis D virus infection, innate immune response and antiviral treatments in stem cell-derived hepatocytes. Lange F, Garn J, Anagho HA, Vondran FWR, von Hahn T, Pietschmann T, Carpentier A. Liver Int. 2023 Oct;43(10):2116-2129. doi: 10.1111/liv.15655. Epub 2023 Jun 27. PMID: 37366005.
- Differentiation of IL-26+ TH17 intermediates into IL-17A producers via epithelial crosstalk in psoriasis. Fries A, Saidoune F, Kuonen F, Dupanloup I, Fournier N, Guerra de Souza AC, Haniffa M, Ma F, Gudjonsson JE, Roesner L, Li Y, Werfel T, Conrad C, Gottardo R, Modlin RL, Di Domizio J, Gilliet M. Nat Commun. 2023 Jun 30;14(1):3878. doi: 10.1038/s41467-023-39484-4. PMID: 37391412; PMCID: PMC10313793.
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- Dynamics of reactive astrocytes fosters tissue regeneration after cuprizone-induced demyelination. Schröder LJ, Mulenge F, Pavlou A, Skripuletz T, Stangel M, Gudi V, Kalinke U. Glia. 2023 Nov;71(11):2573-2590. doi: 10.1002/glia.24440. Epub 2023 Jul 17. PMID: 37455566.
- S100A9 is indispensable for survival of pneumococcal pneumonia in mice. Ostermann L, Seeliger B, David S, Flasche C, Maus R, Reinboth MS, Christmann M, Neumann K, Brand K, Seltmann S, Bühling F, Paton JC, Roth J, Vogl T, Viemann D, Welte T, Maus UA. PLoS Pathog. 2023 Jul 19;19(7):e1011493. doi: 10.1371/journal.ppat.1011493. PMID: 37467233; PMCID: PMC10355425.
- Longitudinal development of the airway metagenome of preterm very low birth weight infants during the first two years of life. Rosenboom I, Pust MM, Pirr S, Bakker A, Willers M, Davenport CF, Wiehlmann L, Viemann D, Tümmler B. ISME Commun. 2023 Jul 20;3(1):75. doi: 10.1038/s43705-023-00285-x. PMID: 37474785; PMCID: PMC10359316.
- Fecal Immunoglobulin Levels as a Modifier of the Gut Microbiome in Patients with Common Variable Immunodeficiency. NNöltner C, Bulashevska A, Hübscher K, Haberstroh H, Grimbacher B, Proietti M. J Clin Immunol. 2023 Aug;43(6):1208-1220. doi: 10.1007/s10875-023-01469-9. Epub 2023 Mar 24. PMID: 36961604; PMCID: PMC10354144.
- HSV-1 exploits host heterochromatin for nuclear egress. Lewis HC, Kelnhofer-Millevolte LE, Brinkley MR, Arbach HE, Arnold EA, Sanders S, Bosse JB, Ramachandran S, Avgousti DC. J Cell Biol. 2023 Sep 4;222(9):e202304106. doi: 10.1083/jcb.202304106. Epub 2023 Jul 26. PMID: 37516914; PMCID: PMC10373338.
- Proteomics reveals a global phenotypic shift of NK cells in HCV patients treated with direct-acting antivirals. Bi W, Kraft A, Engelskircher S, Mischke J, Witte M, Klawonn F, van Ham M, Cornberg M, Wedemeyer H, Hengst J, Jänsch L. Eur J Immunol. 2023 Nov;53(11):e2250291. doi: 10.1002/eji.202250291. Epub 2023 Aug 6. PMID: 37515498.
- Spatially resolved protein map of intact human cytomegalovirus virions. Bogdanow B, Gruska I, Mühlberg L, Protze J, Hohensee S, Vetter B, Bosse JB, Lehmann M, Sadeghi M, Wiebusch L, Liu F. Nat Microbiol. 2023 Sep;8(9):1732-1747. doi: 10.1038/s41564-023-01433-8. Epub 2023 Aug 7. PMID: 37550507; PMCID: PMC10465357.
- Metabolic rewiring tunes dermal macrophages in staphylococcal skin infection. Sci Immunol. Forde AJ, Kolter J, Zwicky P, Baasch S, Lohrmann F, Eckert M, Gres V, Lagies S, Gorka O, Rambold AS, Buescher JM, Kammerer B, Lachmann N, Prinz M, Groß O, Pearce EJ, Becher B, Henneke P. Sci Immunol. 2023 Aug 18;8(86):eadg3517. doi: 10.1126/sciimmunol.adg3517. Epub 2023 Aug 11. PMID: 37566679.orde AJ, Kolter J, Zwicky P, Baasch S, Lohrmann F, Eckert M, Gres V, Lagies S, Gorka O, Rambold AS, Buescher JM, Kammerer B, Lachmann N, Prinz M, Groß O, Pearce EJ, Becher B, Henneke P. 2023 Aug 18;8(86):eadg3517.
- Cultivation-based characterization of biliary microbiota in bile samples collected during routine endoscopic retrograde cholangiography: 10 years of experience at a tertiary center. Forster K, Klein F, Simon N, Chhatwal P, Ziesing S, Heidrich B, Solbach P. Eur J Gastroenterol Hepatol. 2023 Oct 1;35(10):1159-1167. doi: 10.1097/MEG.0000000000002633. Epub 2023 Aug 11. PMID: 37577778.
- Establishment of an In Bacterio Assay for the Assessment of Carbon Storage Regulator A (CsrA) Inhibitors. Wu Y, Zoller BGE, Kamal MAM, Hotop SK, Lehr CM, Brönstrup M, Dersch P, Empting M. Chembiochem. 2023 Aug 15;24(16):e202300369. doi: 10.1002/cbic.202300369. Epub 2023 Jul 25. PMID: 37435861.
- OTUB1 inhibits breast cancer by non-canonically stabilizing CCN6. Zhao Y, Ruan J, Li Z, Su X, Chen K, Lin Y, Cai Y, Wang P, Liu B, Schlüter D, Liang G, Wang X. Clin Transl Med. 2023 Aug;13(8):e1385. doi: 10.1002/ctm2.1385. PMID: 37608493; PMCID: PMC10444971.
- Virucidal activity of oral, hand, and surface disinfectants against respiratory syncytial virus. Meister TL, Friesland M, Frericks N, Wetzke M, Haid S, Steinmann J, Todt D, Pietschmann T, Steinmann E. J Hosp Infect. 2023 Nov;141:25-32. doi: 10.1016/j.jhin.2023.08.009. Epub 2023 Aug 23. PMID: 37625461.
- Adaptation of Human iPSC-Derived Macrophages Toward an Alveolar Macrophage-Like Phenotype Post-Intra-Pulmonary Transfer into Murine Models. Hetzel M, Gensch I, Ackermann M, Lachmann N. Methods Mol Biol. 2024;2713:463-479. doi: 10.1007/978-1-0716-3437-0_31. PMID: 37639142.
- A TriPPPro-Nucleotide Reporter with Optimized Cell-Permeable Dyes for Metabolic Labeling of Cellular and Viral DNA in Living Cells. Sterrenberg VT, Stalling D, Knaack JIH, Soh TK, Bosse JB, Meier C. Angew Chem Int Ed Engl. 2023 Sep 18;62(38):e202308271. doi: 10.1002/anie.202308271. Epub 2023 Aug 9. PMID: 37435767.
- Dupilumab strengthens herpes simplex virus type 1-specific immune responses in atopic dermatitis. Traidl S, Harries L, Kienlin P, Begemann G, Roesner LM, Werfel T. J Allergy Clin Immunol. 2023 Dec;152(6):1460-1469.e5. doi: 10.1016/j.jaci.2023.08.024. Epub 2023 Sep 1. PMID: 37660986.
- Secreted NS1 proteins of tick-borne encephalitis virus and West Nile virus block dendritic cell activation and effector functions. Camarão AAR, Gern OL, Stegmann F, Mulenge F, Costa B, Saremi B, Jung K, Lepenies B, Kalinke U, Steffen I. Microbiol Spectr. 2023 Sep 14;11(5):e0219223. doi: 10.1128/spectrum.02192-23. Epub ahead of print. PMID: 37707204; PMCID: PMC10581055.
- Non-Appearance of the RSV Season 2020/21 During the COVID-19 Pandemic–Prospective, Multicenter Data on the Incidence of Respiratory Syncytial Virus (RSV) Infection. Lange M, Happle C, Hamel J, Dördelmann M, Bangert M, Kramer R, Eberhardt F, Panning M, Heep A, Hansen G, Wetzke M. Dtsch Arztebl Int. 2021 Aug 23;118(33-34):561-562. doi: 10.3238/arztebl.m2021.0300. PMID: 34725031; PMCID: PMC8579425.
- Reverse inflammaging: Long-term effects of HCV cure on biological age. Oltmanns C, Liu Z, Mischke J, Tauwaldt J, Mekonnen YA, Urbanek-Quaing M, Debarry J, Maasoumy B, Wedemeyer H, Kraft ARM, Xu CJ, Cornberg M. J Hepatol. 2023 Jan;78(1):90-98. Pages 90-98, ISSN 0168-8278. https://doi.org/10.1016/j.jhep.2022.08.042.
- JAKs and STATs from a Clinical Perspective: Loss-of-Function Mutations, Gain-of-Function Mutations, and Their Multidimensional Consequences Ott N, Faletti L, Heeg M, Andreani V, Grimbacher B. J Clin Immunol. 2023 Aug;43(6):1326-1359. doi: 10.1007/s10875-023-01483-x. Epub 2023 May 4. PMID: 37140667; PMCID: PMC10354173.
- A Toolkit for Monitoring Immunoglobulin G Levels from Dried Blood Spots of Patients with Primary Immunodeficiencies. Haberstroh H, Hirsch A, Goldacker S, Zessack N, Warnatz K, Grimbacher B, Salzer U. J Clin Immunol. 2023 Aug;43(6):1185-1192. doi: 10.1007/s10875-023-01464-0. Epub 2023 Mar 21. PMID: 36941491; PMCID: PMC10027597.
- Inhibition of IL-17 ameliorates keratinocyte-borne cytokine responses in an in vitro model for house-dust-mite triggered atopic dermatitis. Haertlé J, Kienlin P, Begemann G, Werfel T, Roesner LM. Sci Rep. 2023 Oct 3;13(1):16628. doi: 10.1038/s41598-023-42595-z. PMID: 37789035; PMCID: PMC10547677.
- An expanded CRISPR-Cas9-assisted recombineering toolkit for engineering genetically intractable Pseudomonas aeruginosa isolates. Pankratz D, Gomez NO, Nielsen A, Mustafayeva A, Gür M, Arce-Rodriguez F, Nikel PI, Häussler S, Arce-Rodriguez A. Nat Protoc. 2023 Nov;18(11):3253-3288. doi: 10.1038/s41596-023-00882-z. Epub 2023 Oct 5. PMID: 37798358.
- High recurrence rate of eczema herpeticum in moderate/severe atopic dermatitis -TREATgermany registry analysis. Traidl S, Heinrich L, Siegels D, Rösner L, Haufe E, Harder I, Abraham S, Ertner K, Kleinheinz A, Schäkel K, Wollenberg A, Effendy I, Quist S, Asmussen A, Wildberger J, Weisshaar E, Wiemers F, Brücher JJ, Weidinger S, Schmitt J, Werfel T; TREATgermany Study Group. J Dtsch Dermatol Ges. 2023 Dec;21(12):1490-1498. doi: 10.1111/ddg.15205. Epub 2023 Oct 9. PMID: 37814394.
- RORγt+ c-Maf+ Vγ4+ γδ T cells are generated in the adult thymus but do not reach the periphery. Yang T, Barros-Martins J, Wang Z, Wencker M, Zhang J, Smout J, Gambhir P, Janssen A, Schimrock A, Georgiev H, León-Lara X, Weiss S, Huehn J, Prinz I, Krueger A, Foerster R, Walzer T, Ravens S. Cell Rep. 2023 Oct 31;42(10):113230. doi: 10.1016/j.celrep.2023.113230. Epub 2023 Oct 9. PMID: 37815917.
- The effect of Toll-like receptor agonists on the immunogenicity of MVA-SARS-2-S vaccine after intranasal administration in mice. Do KTH, Willenzon S, Ristenpart J, Janssen A, Volz A, Sutter G, Förster R, Bošnjak B. Front Cell Infect Microbiol. 2023 Oct 3;13:1259822. doi: 10.3389/fcimb.2023.1259822. PMID: 37854858; PMCID: PMC10580083.
- Future Directions in the Diagnosis and Treatment of APDS and IEI: a Survey of German IEI Centers. Vanselow S, Hanitsch L, Hauck F, Körholz J, Maccari ME, Meinhardt A, Sogkas G, Schuetz C, Grimbacher B. Front Immunol. 2023 Oct 5;14:1279652. doi: 10.3389/fimmu.2023.1279652. PMID: 37868971; PMCID: PMC10588788.
- Memory B cells anticipate SARS-CoV-2 variants through somatic hypermutation. Bruhn M, Obara M, Chiyyeadu A, Costa B, Salam A, Ziegler A, Waltl I, Pavlou A, Bonifacius A, Hoffmann M, Graalmann T, Pöhlmann S, Eiz-Vesper B, Schambach A, Kalinke U. J Infect. 2024 Jan;88(1):57-60. doi: 10.1016/j.jinf.2023.10.020. Epub 2023 Oct 31. PMID: 37913848.
- 3P and 5P models of limited value for the detection of clinically significant portal hypertension in patients with hepatitis delta. Sandmann L, Tergast TL, Wedemeyer H, Deterding K, Maasoumy B. J Hepatol. 2023 Jul;79(1):e47-e49. doi: 10.1016/j.jhep.2023.01.004. Epub 2023 Jan 18. PMID: 36669702.
- A Phase 3, Randomized Trial of Bulevirtide in Chronic Hepatitis D. Wedemeyer H, Aleman S, Brunetto MR, Blank A, Andreone P, Bogomolov P, Chulanov V, Mamonova N, Geyvandova N, Morozov V, Sagalova O, Stepanova T, Berger A, Manuilov D, Suri V, An Q, Da B, Flaherty J, Osinusi A, Liu Y, Merle U, Schulze Zur Wiesch J, Zeuzem S, Ciesek S, Cornberg M, Lampertico P; MYR 301 Study Group. N Engl J Med. 2023 Jul 6;389(1):22-32. doi: 10.1056/NEJMoa2213429. Epub 2023 Jun 22. PMID: 37345876.
- Alveolar macrophages in tissue homeostasis, inflammation, and infection: evolving concepts of therapeutic targeting. Malainou C, Abdin SM, Lachmann N, Matt U, Herold S. J Clin Invest. 2023 Oct 2;133(19):e170501. doi: 10.1172/JCI170501. PMID: 37781922; PMCID: PMC10541196.
- ARPC5 deficiency leads to severe early-onset systemic inflammation and mortality. Sindram E, Caballero-Oteyza A, Kogata N, Chor Mei Huang S, Alizadeh Z, Gámez-Díaz L, Fazlollhi MR, Peng X, Grimbacher B, Way M, Proietti M. Dis Model Mech. 2023 Jul 1;16(7):dmm050145. doi: 10.1242/dmm.050145. Epub 2023 Jul 20. PMID: 37382373; PMCID: PMC10387347.
- Bile acid increase during bulevirtide treatment of hepatitis D is not associated with a decline in HDV RNA. Deterding K, Xu C, Port K, Dietz-Fricke C, Xun J, Maasoumy B, Cornberg M, Wedemeyer H. J Viral Hepat. 2023 Jul;30(7):597-606. doi: 10.1111/jvh.13831. Epub 2023 Mar 28. PMID: 36924318.
- Clinical long-term outcome of hepatitis D compared to hepatitis B monoinfection. Wranke A, Heidrich B, Deterding K, Hupa-Breier KL, Kirschner J, Bremer B, Cornberg M, Wedemeyer H. Hepatol Int. 2023 Dec;17(6):1359-1367. doi: 10.1007/s12072-023-10575-0. Epub 2023 Oct 3. PMID: 37789170; PMCID: PMC10661878.
- Clinical, immunological and molecular findings of 8 patients with typical and atypical severe combined immunodeficiency: identification of 7 novel mutations by whole exome sequencing. Alizadeh Z, Fazlollahi MR, Mazinani M, Badalzadeh M, Heydarlou H, Carapito R, Molitor A, de Oteyza ACG, Proietti M, Bavani MS, Shariat M, Fallahpour M, Movahedi M, Moradi L, Grimbacher B, Bahram S, Pourpak Z. Genes Immun. 2023 Aug;24(4):207-214. doi: 10.1038/s41435-023-00215-w. Epub 2023 Jul 29. PMID: 37516813.
- Common Variable Immunodeficiency: More Pathways than Roads to Rome. Peng XP, Caballero-Oteyza A, Grimbacher B. Annu Rev Pathol. 2023 Jan 24;18:283-310. doi: 10.1146/annurev-pathmechdis-031521-024229. Epub 2022 Oct 20. PMID: 36266261.
- Comparing SARS-CoV-2 variants among children and adolescents in Germany: relative risk of COVID-19-related hospitalization, ICU admission and mortality. Jank M, Oechsle AL, Armann J, Behrends U, Berner R, Chao CM, Diffloth N, Doenhardt M, Hansen G, Hufnagel M, Lander F, Liese JG, Muntau AC, Niehues T, von Both U, Verjans E, Weil K, von Kries R, Schroten H. Infection. 2023 Oct;51(5):1357-1367. doi: 10.1007/s15010-023-01996-y. Epub 2023 Feb 14. PMID: 36787015; PMCID: PMC9925936.
- Comparison of Three Eradication Treatment Protocols for Pseudomonas Aeruginosa in Children and Adolescents with Cystic Fibrosis. Schütz K, Grewendorf S, Kontsendorn J, Fuge J, Happle C, Rudolf I, Dopfer C, Sedlacek L, Hansen G, Junge S, Dittrich AM. Klin Padiatr. 2023 Mar;235(2):75-83. English. doi: 10.1055/a-1996-0074. Epub 2023 Feb 9. PMID: 36758577.
- Controlled Attenuation Parameter Is Associated with a Distinct Systemic Inflammatory Milieu after Clearance of HCV Infection. Du Y, Khera T, Liu Z, Tudrujek-Zdunek M, Dworzanska A, Cornberg M, Xu CJ, Tomasiewicz K, Wedemeyer H. Biomedicines. 2023 May 25;11(6):1529. doi: 10.3390/biomedicines11061529. PMID: 37371624; PMCID: PMC10295384.
- CYP19A1 mediates severe SARS-CoV-2 disease outcome in males. Stanelle-Bertram S, Beck S, Mounogou NK, Schaumburg B, Stoll F, Al Jawazneh A, Schmal Z, Bai T, Zickler M, Beythien G, Becker K, de la Roi M, Heinrich F, Schulz C, Sauter M, Krasemann S, Lange P, Heinemann A, van Riel D, Leijten L, Bauer L, van den Bosch TPP, Lopuhaä B, Busche T, Wibberg D, Schaudien D, Goldmann T, Lüttjohann A, Ruschinski J, Jania H, Müller Z, Pinho Dos Reis V, Krupp-Buzimkic V, Wolff M, Fallerini C, Baldassarri M, Furini S, Norwood K, Käufer C, Schützenmeister N, von Köckritz-Blickwede M, Schroeder M, Jarczak D, Nierhaus A, Welte T, Kluge S, McHardy AC, Sommer F, Kalinowski J, Krauss-Etschmann S, Richter F, von der Thüsen J, Baumgärtner W, Klingel K, Ondruschka B; GEN-COVID Multicenter Study Group; Renieri A, Gabriel G. Cell Rep Med. 2023 Sep 19;4(9):101152. doi: 10.1016/j.xcrm.2023.101152. Epub 2023 Aug 12. PMID: 37572667; PMCID: PMC10518605.
- Deciphering the molecular complexity of the IKZF1plus genomic profile using Optical Genome Mapping. Lühmann JL, Zimmermann M, Hofmann W, Bergmann AK, Möricke A, Cario G, Schrappe M, Schlegelberger B, Stanulla M, Steinemann D. Haematologica. 2023 Nov 30. doi: 10.3324/haematol.2023.284115. Epub ahead of print. PMID: 38031808.
- Enhanced monitoring and detection of recent genotype 3 hepatitis E virus infection through urine antigen testing. Stahl Y, Kabar I, Heinzow H, Maasoumy B, Bremer B, Wedemeyer H, Schmidt HH, Pietschmann T, Schlevogt B, Behrendt P. Emerg Microbes Infect. 2023 Dec;12(2):2251598. doi: 10.1080/22221751.2023.2251598. Epub 2023 Aug 31. PMID: 37649441; PMCID: PMC10512750.
- Evolutionary Insight into the Association between New Jersey Polyomavirus and Humans. Aghebatrafat AA, Lauber C, Merkel K, Fruth B, Langergraber K, Robbins MM, Wittig RM, Leendertz FH, Calvignac-Spencer S. Viruses. 2023 Nov 13;15(11):2248. doi: 10.3390/v15112248. PMID: 38005925; PMCID: PMC10675294.
- Functional Relevance of CTLA4 Variants: an Upgraded Approach to Assess CTLA4-Dependent Transendocytosis by Flow Cytometry. Rojas-Restrepo J, Sindram E, Zenke S, Haberstroh H, Mitsuiki N, Gabrysch A, Huebscher K, Posadas-Cantera S, Krausz M, Kobbe R, Rohr JC, Grimbacher B, Gámez-Díaz L. J Clin Immunol. 2023 Nov;43(8):2076-2089. doi: 10.1007/s10875-023-01582-9. Epub 2023 Sep 23. Erratum in: J Clin Immunol. 2023 Oct 9;: PMID: 37740092; PMCID: PMC10661720.
- Genetic Predisposition to Neurological Complications in Patients with COVID-19. Biomolecules. Sahajpal NS, Hastie AR, Schieck M, Mondal AK, Felde M, van der Made CI, Chou JS, Randolph AG, Illig T, Zody MC, Brownstein CA, Beggs AH, Hoischen A, Chaubey A, Kolhe R; COVID19hostgenomesv Consortium. 2023 Jan 9;13(1):133. doi: 10.3390/biom13010133. PMID: 36671517; PMCID: PMC9855758.
- GenIA, the Genetic Immunology Advisor database for inborn errors of immunity. Caballero-Oteyza A, Crisponi L, Peng XP, Yauy K, Volpi S, Giardino S, Freeman AF, Grimbacher B, Proietti M. J Allergy Clin Immunol. 2023 Nov 30:S0091-6749(23)01513-0. doi: 10.1016/j.jaci.2023.11.022. Epub ahead of print. PMID: 38040041.
- HDV RNA assays: Performance characteristics, clinical utility, and challenges. Wedemeyer H, Leus M, Battersby TR, Glenn J, Gordien E, Kamili S, Kapoor H, Kessler HH, Lenz O, Lütgehetmann M, Mixson-Hayden T, Simon CO, Thomson M, Westman G, Miller V, Terrault N, Lampertico P; HDV RNA Assays Writing Group at the HBV Forum. Hepatology. 2023 Aug 28. doi: 10.1097/HEP.0000000000000584. Epub ahead of print. PMID: 37640384.
- Hohe Rezidivrate des Eczema herpeticatum bei mittelschwerer bis schwerer atopischer Dermatitis – eine TREATgermany Registeranalyse Stephan Traidl, Luise Heinrich, Doreen Siegels, Lennart Rösner, Eva Haufe, Inken Harder, Susanne Abraham, Konstantin Ertner, Andreas Kleinheinz, Knut Schäkel, Andreas Wollenberg, Isaak Effendy, Sven Quist, Andrea Asmussen, Julia Wildberger, Elke Weisshaar, Franka Wiemers, Jens-Joachim Brücher, Stephan Weidinger, Jochen Schmitt, Thomas Werfel, die TREATgermany Study Group. Journal der Deutschen Dermatologischen Gesellschaft. First published: 11 December 2023 https://doi.org/10.1111/ddg.15205_g
- Interferon-based treatment of chronic hepatitis D. Sandmann L, Wedemeyer H. Liver Int. 2023 Aug;43 Suppl 1:69-79. doi: 10.1111/liv.15410. Epub 2022 Sep 2. PMID: 36002390.
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- Association of SARS-CoV-2 Seropositivity With Myalgic Encephalomyelitis and/or Chronic Fatigue Syndrome Among Children and Adolescents in Germany. Sorg AL, Becht S, Jank M, Armann J, von Both U, Hufnagel M, Lander F, Liese JG, Niehues T, Verjans E, Wetzke M, Stojanov S, Behrends U, Drosten C, Schroten H, von Kries R. JAMA Netw Open. 2022 Sep 1;5(9):e2233454. doi: 10.1001/jamanetworkopen.2022.33454. PMID: 36166227; PMCID: PMC9516317.
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- Confirmation of Hyperimmunoglobulin E Syndrome in Two Patients with an Ocular Problem: Detection of Two New DOCK8 Mutations. Saghafi S, Zandieh F, Fazlollahi MR, Glocker C, Frede N, Buchta M, Yang L, Mahmoudi AH, Houshmand M, Pourpak Z, Grimbacher B, Moin M. Iran J Allergy Asthma Immunol. 2022 Jun 18;21(3):355-363. doi: 10.18502/ijaai.v21i3.9809. PMID: 35822685.
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- Distinct actin-tropomyosin cofilament populations drive the functional diversification of cytoskeletal myosin motor complexes. Reindl T, Giese S, Greve JN, Reinke PY, Chizhov I, Latham SL, Mulvihill DP, Taft MH, Manstein DJ. iScience. 2022 May 30;25(7):104484. doi: 10.1016/j.isci.2022.104484. PMID: 35720262; PMCID: PMC9204724.
- Effects of Pre-Existing Mental Conditions on Fatigue and Psychological Symptoms Post-COVID-19. Homann S, Mikuteit M, Niewolik J, Behrens GMN, Stölting A, Müller F, Schröder D, Heinemann S, Müllenmeister C, El-Sayed I, Happle C, Steffens S, Dopfer-Jablonka A. Int J Environ Res Public Health. 2022 Aug 11;19(16):9924. doi: 10.3390/ijerph19169924. PMID: 36011559; PMCID: PMC9408008.
- Efficacy of dupilumab for the treatment of severe skin disease in cytotoxic T lymphocyte antigen-4 insufficiency: A role of type 2 inflammation? Arruda LK, Cordeiro DL, Langer SS, Koenigham-Santos M, Calado RT, Dias MM, Anhesini LR, Oliveira JB, Grimbacher B, Ferriani MPL. J Allergy Clin Immunol Glob. 2022 Sep 22;2(1):114-117. doi: 10.1016/j.jacig.2022.08.004. PMID: 37780100; PMCID: PMC10509893.
- Frameshift mutation S368fs in the gene encoding cytoskeletal β-actin leads to ACTB-associated syndromic thrombocytopenia by impairing actin dynamics. Greve JN, Schwäbe FV, Pokrant T, Faix J, Di Donato N, Taft MH, Manstein DJ. Eur J Cell Biol. 2022 Apr;101(2):151216. doi: 10.1016/j.ejcb.2022.151216. Epub 2022 Mar 15. PMID: 35313204.
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- HBcrAg Levels Are Associated With Virological Response to Treatment With Interferon in Patients With Hepatitis Delta. Sandmann L, Yurdaydin C, Deterding K, Heidrich B, Hardtke S, Lehmann P, Bremer B, Manns MP, Cornberg M, Wedemeyer H, Maasoumy B; HIDIT‐II Study Group. Hepatol Commun. 2022 Mar;6(3):480-495. doi: 10.1002/hep4.1821. Epub 2021 Sep 24. PMID: 34561972; PMCID: PMC8870014.
- Human Cytomegalovirus pUL11, a CD45 Ligand, Disrupts CD4 T Cell Control of Viral Spread in Epithelial Cells. Osanyinlusi SA, Zischke J, Jacobs R, Weissinger EM, Schulz TF, Kay-Fedorov PC. HmBio. 2022 Dec 20;13(6):e0294622. doi: 10.1128/mbio.02946-22. Epub 2022 Nov 29. PMID: 36445084; PMCID: PMC9765415.
- It’s All in the Mix: A New Interprofessional, Blended-Learning Masters’ Program for Biomedical Data Science Addressing Physicians and Students from Life Sciences – Didactic Concept and First Experiences AuthorsMichael Marschollek, Melina Celik, Marianne Behrends, Thomas Friedrich SchulzPages56 – 60DOI10.3233/SHTI220907CategoryResearch Article Series Studies in Health Technology and Informatics Ebook Volume 298: Digital Professionalism in Health and Care: Developing the Workforce, Building the Future
- Low Serum Cholinesterase Identifies Patients With Worse Outcome and Increased Mortality After TIPS. Stockhoff L, Muellner-Bucsics T, Markova AA, Schultalbers M, Keimburg SA, Tergast TL, Hinrichs JB, Simon N, Gerbel S, Manns MP, Mandorfer M, Cornberg M, Meyer BC, Wedemeyer H, Reiberger T, Maasoumy B. Hepatol Commun. 2022 Mar;6(3):621-632. doi: 10.1002/hep4.1829. Epub 2021 Sep 28. PMID: 34585537; PMCID: PMC8870033.
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- Mepolizumab Treatment in Severe Pediatric Asthma: First Multicentric Real-World Data. Wetzke M, Funken D, Ahrens FO, Gappa M, Hansen G, Koerner-Rettberg C, Koester H, Schulze J, Schwerk N, Zielen S, Happle C. Klin Padiatr. 2022 Sep;234(5):305-308. English. doi: 10.1055/a-1717-2234. Epub 2022 Mar 22. PMID: 35319087.
- Metadata harmonization-Standards are the key for a better usage of omics data for integrative microbiome analysis. Cernava T, Rybakova D, Buscot F, Clavel T, McHardy AC, Meyer F, Meyer F, Overmann J, Stecher B, Sessitsch A, Schloter M, Berg G; MicrobiomeSupport Team. Environ Microbiome. 2022 Jun 24;17(1):33. doi: 10.1186/s40793-022-00425-1. PMID: 35751093; PMCID: PMC9233336.
- Multi-omics analysis of naïve B cells of patients harboring the C104R mutation in TACI. Ramirez N, Posadas-Cantera S, Langer N, de Oteyza ACG, Proietti M, Keller B, Zhao F, Gernedl V, Pecoraro M, Eibel H, Warnatz K, Ballestar E, Geiger R, Bossen C, Grimbacher B. Front Immunol. 2022 Aug 16;13:938240. doi: 10.3389/fimmu.2022.938240. PMID: 36072607; PMCID: PMC9443529.
- Nanoscale organization of the MHC I peptide-loading complex in human dendritic cells. Koller N, Höllthaler P, Barends M, Döring M, Spahn C, Durán V, Costa B, Becker J, Heilemann M, Kalinke U, Tampé R. Cell Mol Life Sci. 2022 Aug 10;79(9):477. doi: 10.1007/s00018-022-04472-2. PMID: 35947215; PMCID: PMC9365725.
- Phenotype, genotype, treatment, and survival outcomes in patients with X-linked inhibitor of apoptosis deficiency. Yang L, Booth C, Speckmann C, Seidel MG, Worth AJJ, Kindle G, Lankester AC, Grimbacher B; ESID Clinical and Registry Working Parties; Gennery AR, Seppanen MRJ, Morris EC, Burns SO. J Allergy Clin Immunol. 2022 Aug;150(2):456-466. doi: 10.1016/j.jaci.2021.10.037. Epub 2021 Dec 15. PMID: 34920033.
- pUL36 Deubiquitinase Activity Augments Both the Initiation and the Progression of Lytic Herpes Simplex Virus Infection in IFN-Primed Cells. Mohnke J, Stark I, Fischer M, Fischer PM, Schlosser A, Grothey A, O’Hare P, Sodeik B, Erhard F, Dölken L, Hennig T. J Virol. 2022 Nov 23;96(22):e0096322. doi: 10.1128/jvi.00963-22. Epub 2022 Oct 31. PMID: 36314822; PMCID: PMC9683058.
- Resolving the polygenic aetiology of a late onset combined immune deficiency caused by NFKB1 haploinsufficiency and modified by PIK3R1 and TNFRSF13B variants. Hargreaves CE, Dhalla F, Patel AM, de Oteyza ACG, Bateman E, Miller J, Anzilotti C, Ayers L, Grimbacher B, Patel SY. Clin Immunol. 2022 Jan;234:108910. doi: 10.1016/j.clim.2021.108910. Epub 2021 Dec 15. PMID: 34922003.
- SARS-CoV-2 Viral Load in the Pulmonary Compartment of Critically Ill COVID-19 Patients Correlates with Viral Serum Load and Fatal Outcomes. Ynga-Durand M, Maaß H, Milošević M, Krstanović F, Pribanić Matešić M, Jonjić S, Protić A, Brizić I, Šustić A, Čičin-Šain L. Viruses. 2022 Jun 14;14(6):1292. doi: 10.3390/v14061292. PMID: 35746764; PMCID: PMC9228931.
- The First 4 Years – Outcome of Children Identified by Newborn Screening for CF in Germany. Schütz K, Kontsendorn J, Janzen N, Fuge J, Grewendorf S, Klemann C, Happle C, Junge S, Rudolf I, Dopfer C, Sedlacek L, Renz D, Hansen G, Dittrich AM. Klin Padiatr. 2022 Sep;234(5):284-292. English. doi: 10.1055/a-1700-5105. Epub 2022 Jan 28. PMID: 35098497.
- The Impact of Evolving SARS-CoV-2 Mutations and Variants on COVID-19 Vaccines. McLean G, Kamil J, Lee B, Moore P, Schulz TF, Muik A, Sahin U, Türeci Ö, Pather S. mBio. 2022 Apr 26;13(2):e0297921. doi: 10.1128/mbio.02979-21. Epub 2022 Mar 30. PMID: 35352979; PMCID: PMC9040821.
- Baseline Cellular Antiviral State Is Maintained by cGAS and Its Most Frequent Naturally Occurring Variant rs610913. Kazmierski J, Elsner C, Döhner K, Xu S, Ducroux A, Pott F, Jansen J, Thorball CW, Zeymer O, Zhou X, Fedorov R, Fellay J, Löffler MW, Weber ANR, Sodeik B, Goffinet C. A J Immunol. 2022 Aug 1;209(3):535-547. doi: 10.4049/jimmunol.2100685. PMID: 35851540.
- The membrane-active polyaminoisoprenyl compound NV716 re-sensitizes Pseudomonas aeruginosa to antibiotics and reduces bacterial virulence. Wang G, Brunel JM, Preusse M, Mozaheb N, Willger SD, Larrouy-Maumus G, Baatsen P, Häussler S, Bolla JM, Van Bambeke F. Commun Biol. 2022 Aug 25;5(1):871. doi: 10.1038/s42003-022-03836-5. PMID: 36008485; PMCID: PMC9411590.
- NK cell dysfunction in severe COVID-19: TGF-β-induced downregulation of integrin beta-2 restricts NK cell cytotoxicity. Barros-Martins J, Förster R, Bošnjak B. Signal Transduct Target Ther. 2022 Jan 31;7(1):32. doi: 10.1038/s41392-022-00892-5. PMID: 35102142; PMCID: PMC8801552.
- Atopic Eczema: Pathophysiological Findings as the Beginning of a New Era of Therapeutic Options. Traidl S, Werfel T, Traidl-Hoffmann C. Handb Exp Pharmacol. 2022;268:101-115. doi: 10.1007/164_2021_492. PMID: 34236520.
- Differential interferon-α subtype induced immune signatures are associated with suppression of SARS-CoV-2 infection. Schuhenn J, Meister TL, Todt D, Bracht T, Schork K, Billaud JN, Elsner C, Heinen N, Karakoese Z, Haid S, Kumar S, Brunotte L, Eisenacher M, Di Y, Lew J, Falzarano D, Chen J, Yuan Z, Pietschmann T, Wiegmann B, Uebner H, Taube C, Le-Trilling VTK, Trilling M, Krawczyk A, Ludwig S, Sitek B, Steinmann E, Dittmer U, Lavender KJ, Sutter K, Pfaender S. Proc Natl Acad Sci U S A. 2022 Feb 22;119(8):e2111600119. doi: 10.1073/pnas.2111600119. PMID: 35131898; PMCID: PMC8872780.
- Editorial: Neuronal and Glial Alterations Caused by Viral Infections. Hernáez B, Viejo-Borbolla A, Cabrera JR. Front Cell Neurosci. 2022 Apr 5;16:883221. doi: 10.3389/fncel.2022.883221. PMID: 35450209; PMCID: PMC9016110.
- Interventional Bronchus Occlusion Using Amplatzer Devices – A Promising Treatment Option for Children with Persistent Air Leak. Schütz K, Happel CM, Keil O, Dingemann J, Carlens J, Wetzke M, Müller C, Köditz H, Griese M, Reiter K, Schweiger-Kabesch A, Backendorf A, Scharff A, Bertram H, Schwerk N. Klin Padiatr. 2022 Sep;234(5):293-300. English. doi: 10.1055/a-1697-5624. Epub 2022 Jan 3. PMID: 34979579.
- The Inflammasome Activity of NLRP3 Is Independent of NEK7 in HEK293 Cells Co-Expressing ASC. Machtens DA, Bresch IP, Eberhage J, Reubold TF, Eschenburg S. Int J Mol Sci. 2022 Sep 7;23(18):10269. doi: 10.3390/ijms231810269. PMID: 36142182; PMCID: PMC9499477.
- KIR3DS1 directs NK cell-mediated protection against human adenovirus infections. Jung JM, Ching W, Baumdick ME, Hofmann-Sieber H, Bosse JB, Koyro T, Möller KJ, Wegner L, Niehrs A, Russu K, Ohms M, Zhang W, Ehrhardt A, Duisters K, Spierings E, Hölzemer A, Körner C, Jansen SA, Peine S, Königs I, Lütgehetmann M, Perez D, Reinshagen K, Lindemans CA, Altfeld M, Belderbos M, Dobner T, Bunders MJ. Sci Immunol. 2021 Sep 17;6(63):eabe2942. doi: 10.1126/sciimmunol.abe2942. Epub 2021 Sep 17. PMID: 34533978.
- Role of the gut microbiota in airway immunity and host defense against respiratory infections. Willers M, Viemann D. Biol Chem. 2021 Oct 4. doi: 10.1515/hsz-2021-0281. Epub ahead of print. PMID: 34599869.
- Bowel Histology of CVID Patients Reveals Distinct Patterns of Mucosal Inflammation. van Schewick CM, Lowe DM, Burns SO, Workman S, Symes A, Guzman D, Moreira F, Watkins J, Clark I, Grimbacher B. J Clin Immunol. 2021 Oct 1. doi: 10.1007/s10875-021-01104-5. Epub ahead of print. PMID: 34599484.
- Specific T cells targeting Staphylococcus aureus fibronectin-binding protein 1 induce a type 2/type 1 inflammatory response in sensitized atopic dermatitis patients. Farag AK, Roesner LM, Wieschowski S, Heratizadeh A, Eiz-Vesper B, Kwok WW, Valenta R, Werfel T. Allergy. 2021 Oct 3. doi: 10.1111/all.15120. Epub ahead of print. PMID: 34601735.
- Regulatory B cells control airway hyperreactivity and lung remodeling in a murine asthma model. Habener A, Happle C, Grychtol R, Skuljec J, Busse M, Dalüge K, Obernolte H, Sewald K, Braun A, Meyer-Bahlburg A, Hansen G. J Allergy Clin Immunol. 2021 Jun;147(6):2281-2294.e7. doi: 10.1016/j.jaci.2020.09.041. Epub 2020 Nov 27. PMID: 33249168.
- The journey of herpesvirus capsids and genomes to the host cell nucleus. Döhner K, Cornelius A, Serrero MC, Sodeik B. Curr Opin Virol. 2021 Oct;50:147-158. doi: 10.1016/j.coviro.2021.08.005. Epub 2021 Aug 28. PMID: 34464845.
- Klebsiella oxytoca causes colonization resistance against multidrug-resistant K. pneumoniae in the gut via cooperative carbohydrate competition. Osbelt L, Wende M, Almási É, Derksen E, Muthukumarasamy U, Lesker TR, Galvez EJC, Pils MC, Schalk E, Chhatwal P, Färber J, Neumann-Schaal M, Fischer T, Schlüter D, Strowig T. Cell Host Microbe. 2021 Sep 29:S1931-3128(21)00419-4. doi: 10.1016/j.chom.2021.09.003. Epub ahead of print. PMID: 34610293.
- Bile acids regulate intestinal antigen presentation and reduce graft-versus-host disease without impairing the graft-versus-leukemia effect. Haematologica. Haring E, Uhl FM, Andrieux G, Proietti M, Bulashevska A, Sauer B, Braun LM, de Vega Gomez E, Esser PR, Martin SF, Pfeifer D, Follo M, Schmitt-Graeff A, Buescher J, Duyster J, Grimbacher B, Boerries M, Pearce EL, Zeiser R, Apostolova P. 2021 Aug 1;106(8):2131-2146. doi: 10.3324/haematol.2019.242990. PMID: 32675222; PMCID: PMC8327708.
- Diagnostic Yield and Therapeutic Consequences of Targeted Next-Generation Sequencing in Sporadic Primary Immunodeficiency. Sogkas G, Dubrowinskaja N, Schütz K, Steinbrück L, Götting J, Schwerk N, Baumann U, Grimbacher B, Witte T, Schmidt RE, Atschekzei F. Int Arch Allergy Immunol. 2021 Oct 7:1-13. doi: 10.1159/000519199. Epub ahead of print. PMID: 34619682.
- Neutralization of the SARS-CoV-2 Delta variant after heterologous and homologous BNT162b2 or ChAdOx1 nCoV-19 vaccination. Hammerschmidt SI, Bosnjak B, Bernhardt G, Friedrichsen M, Ravens I, Dopfer-Jablonka A, Hoffmann M, Pöhlmann S, Behrens GMN, Förster R. Cell Mol Immunol. 2021 Oct;18(10):2455-2456. doi: 10.1038/s41423-021-00755-z. Epub 2021 Aug 23. PMID: 34426672; PMCID: PMC8381713.
- Recent Advances in Developing Treatments of Kaposi’s Sarcoma Herpesvirus-Related Diseases. Naimo E, Zischke J, Schulz TF. Viruses. 2021 Sep 9;13(9):1797. doi: 10.3390/v13091797. PMID: 34578378; PMCID: PMC8473310.
- Generation of hiPSC-derived low threshold mechanoreceptors containing axonal termini resembling bulbous sensory nerve endings and expressing Piezo1 and Piezo2. Zhu S, Stanslowsky N, Fernández-Trillo J, Mamo TM, Yu P, Kalmbach N, Ritter B, Eggenschwiler R, Ouwendijk WJD, Mzinza D, Tan L, Leffler A, Spohn M, Brown RJP, Kropp KA, Kaever V, Ha TC, Narayanan P, Grundhoff A, Förster R, Schambach A, Verjans GMGM, Schmidt M, Kispert A, Cantz T, Gomis A, Wegner F, Viejo-Borbolla A. Stem Cell Res. 2021 Sep 11;56:102535. doi: 10.1016/j.scr.2021.102535. Epub ahead of print. PMID: 34607262.
- Pathogenesis and virulence of herpes simplex virus. Zhu S, Viejo-Borbolla A. Virulence. 2021 Dec;12(1):2670-2702. doi: 10.1080/21505594.2021.1982373. PMID: 34676800.
- Nitric oxide controls proliferation of Leishmania major by inhibiting the recruitment of permissive host cells. Formaglio P, Alabdullah M, Siokis A, Handschuh J, Sauerland I, Fu Y, Krone A, Gintschel P, Stettin J, Heyde S, Mohr J, Philipsen L, Schröder A, Robert PA, Zhao G, Khailaie S, Dudeck A, Bertrand J, Späth GF, Kahlfuß S, Bousso P, Schraven B, Huehn J, Binder S, Meyer-Hermann M, Müller AJ. Immunity. 2021 Oct 15:S1074-7613(21)00406-4. doi: 10.1016/j.immuni.2021.09.021. Epub ahead of print. PMID: 34687607.
- Toll-like Receptors in Viral Encephalitis. Gern OL, Mulenge F, Pavlou A, Ghita L, Steffen I, Stangel M, Kalinke U. Viruses. 2021 Oct 14;13(10):2065. doi: 10.3390/v13102065. PMID: 34696494.
- Impact of HBsAg and HBcrAg levels on phenotype and function of HBV-specific T cells in patients with chronic hepatitis B virus infection. Aliabadi E, Urbanek-Quaing M, Maasoumy B, Bremer B, Grasshoff M, Li Y, Niehaus CE, Wedemeyer H, Kraft ARM, Cornberg M. Gut. 2021 Oct 26:gutjnl-2021-324646. doi: 10.1136/gutjnl-2021-324646. Epub ahead of print. PMID: 34702717.
- Mesenteric Lymph Node Transplantation in Mice to Study Immune Responses of the Gastrointestinal Tract. Haroon Shaikh, Juan Gamboa Vargas, Zeinab Mokhtari, Katja J. Jarick, Maria Ulbrich, Josefina Peña Mosca, Estibaliz Arellano Viera, Caroline Graf, Duc-Dung Le, Katrin G. Heinze, Maike Büttner-Herold, Andreas Rosenwald, Joern Pezoldt, Jochen Huehn, Andreas Beilhack. Front Immunol. 2021; 12: 689896. Published online 2021 Jul 26.
- Concatemeric Broccoli reduces mRNA stability and induces aggregates. Rink MR, Baptista MAP, Flomm FJ, Hennig T, Whisnant AW, Wolf N, Seibel J, Dölken L, Bosse JB. PLoS One. 2021 Aug 4;16(8):e0244166. doi: 10.1371/journal.pone.0244166. eCollection 2021. PMID: 34347781 Free PMC article.
- Quo vadis clinical diagnostic microbiology? Haag S, Häussler S. Clin Microbiol Infect. 2021 Jul 26:S1198-743X(21)00404-3. doi: 10.1016/j.cmi.2021.07.013. Online ahead of print. PMID: 34325069 No abstract available.
- Tbx21 and Foxp3 Are Epigenetically Stabilized in T-Bet+ Tregs That Transiently Accumulate in Influenza A Virus-Infected Lungs. Elfaki Y, Yang J, Boehme J, Schultz K, Bruder D, Falk CS, Huehn J, Floess S. Int J Mol Sci. 2021 Jul 14;22(14):7522. doi: 10.3390/ijms22147522. PMID: 34299148 Free PMC article.
- Sequential MAVS and MyD88/TRIF signaling triggers anti-viral responses of tick-borne encephalitis virus-infected murine astrocytes. Ghita L, Breitkopf V, Mulenge F, Pavlou A, Gern OL, Durán V, Prajeeth CK, Kohls M, Jung K, Stangel M, Steffen I, Kalinke U. J Neurosci Res. 2021 Jul 23. doi: 10.1002/jnr.24923. Online ahead of print. PMID: 34296786
- Distribution of major lymphocyte subsets and memory T-cell subpopulations in healthy adults employing GLP-conforming multicolor flow cytometry. Schultze-Florey CR, Chukhno E, Goudeva L, Blasczyk R, Ganser A, Prinz I, Förster R, Koenecke C, Odak I. Leukemia. 2021 Jul 21. doi: 10.1038/s41375-021-01348-5. Online ahead of print. PMID: 34290358 No abstract available.
- Deubiquitinating enzymes (DUBs): decipher underlying basis of neurodegenerative diseases. Liu B, Ruan J, Chen M, Li Z, Manjengwa G, Schlüter D, Song W, Wang X. Mol Psychiatry. 2021 Jul 20. doi: 10.1038/s41380-021-01233-8. Online ahead of print. PMID: 34285347 Review.
- Immune responses against SARS-CoV-2 variants after heterologous and homologous ChAdOx1 nCoV-19/BNT162b2 vaccination. Barros-Martins J, Hammerschmidt SI, Cossmann A, Odak I, Stankov MV, Morillas Ramos G, Dopfer-Jablonka A, Heidemann A, Ritter C, Friedrichsen M, Schultze-Florey C, Ravens I, Willenzon S, Bubke A, Ristenpart J, Janssen A, Ssebyatika G, Bernhardt G, Münch J, Hoffmann M, Pöhlmann S, Krey T, Bošnjak B, Förster R, Behrens GMN. Nat Med. 2021 Jul 14. doi: 10.1038/s41591-021-01449-9. Online ahead of print. PMID: 34262158
- Expression of ACKR4 demarcates the „peri-marginal sinus,“ a specialized vascular compartment of the splenic red pulp. Werth K, Hub E, Gutjahr JC, Bosjnak B, Zheng X, Bubke A, Russo S, Rot A, Förster R. Cell Rep. 2021 Jul 13;36(2):109346. doi: 10.1016/j.celrep.2021.109346. PMID: 34260918
- TACI deficiency – a complex system out of balance. Salzer U, Grimbacher B. Curr Opin Immunol. 2021 Jul 8;71:81-88. doi: 10.1016/j.coi.2021.06.004. Online ahead of print. PMID: 34247095 Review.
- A rare case of neuro- and otosyphilis in secondary syphilis. Traidl S, Angela Y, Stender A, Kulberg A, Tronnier M, Prenzler NK, Wattjes MP, Kapp A, Stangel M, Schacht V, Werfel T. J Eur Acad Dermatol Venereol. 2021 Jul 9. doi: 10.1111/jdv.17512. Online ahead of print. PMID: 34242450 No abstract available.
- Atopic Eczema: Pathophysiological Findings as the Beginning of a New Era of Therapeutic Options. Traidl S, Werfel T, Traidl-Hoffmann C. Handb Exp Pharmacol. 2021 Jul 9. doi: 10.1007/164_2021_492. Online ahead of print. PMID: 34236520
- Transcriptome analysis following neurotropic virus infection reveals faulty innate immunity and delayed antigen presentation in mice susceptible to virus-induced demyelination. Ciurkiewicz M, Floess S, Beckstette M, Kummerfeld M, Baumgärtner W, Huehn J, Beineke A. Brain Pathol. 2021 Jul 6:e13000. doi: 10.1111/bpa.13000. Online ahead of print. PMID: 34231271
- Improvement of image resolution by combining enhanced confocal microscopy and quantum dot triexciton imaging. Hennig S, Manstein DJ.
FEBS Open Bio. 2021 Jul 6. doi: 10.1002/2211-5463.13246. Online ahead of print. PMID: 34228908 - Lymph-Derived Neutrophils Primarily Locate to the Subcapsular and Medullary Sinuses in Resting and Inflamed Lymph Nodes. de Castro Pinho J, Förster R. Cells. 2021 Jun 12;10(6):1486. doi: 10.3390/cells10061486. PMID: 34204825 Free PMC article.
- Structural and Biochemical Characterization of a Dye-Decolorizing Peroxidase from Dictyostelium discoideum. Rai A, Klare JP, Reinke PYA, Englmaier F, Fohrer J, Fedorov R, Taft MH, Chizhov I, Curth U, Plettenburg O, Manstein DJ. Int J Mol Sci. 2021 Jun 10;22(12):6265. doi: 10.3390/ijms22126265. PMID: 34200865 Free PMC article.
- Free human DNA attenuates the activity of antimicrobial peptides in atopic dermatitis. Kopfnagel V, Dreyer S, Zeitvogel J, Pieper DH, Buch A, Sodeik B, Rademacher F, Harder J, Werfel T. Allergy. 2021 Jun 27. doi: 10.1111/all.14992. Online ahead of print. PMID: 34176149
- Targeted delivery of regulatory macrophages to lymph nodes interferes with T cell priming by preventing the formation of stable immune synapses. Yu K, Hammerschmidt SI, Permanyer M, Galla M, Rothe M, Zheng X, Werth K, Martens R, Lueder Y, Janssen A, Friedrichsen M, Bernhardt G, Förster R. Cell Rep. 2021 Jun 22;35(12):109273. doi: 10.1016/j.celrep.2021.109273. PMID: 34161766
- There is no gene for CVID – novel monogenetic causes for primary antibody deficiency. Ramirez NJ, Posadas-Cantera S, Caballero-Oteyza A, Camacho-Ordonez N, Grimbacher B. Curr Opin Immunol. 2021 Jun 18;72:176-185. doi: 10.1016/j.coi.2021.05.010. Online ahead of print. PMID: 34153571 Review.
- Recruitment of phospholipase Cγ1 to the non-structural membrane protein pK15 of Kaposi Sarcoma-associated herpesvirus promotes its Src-dependent phosphorylation. Samarina N, Ssebyatika G, Tikla T, Waldmann JY, Abere B, Nanna V, Marasco M, Carlomagno T, Krey T, Schulz TF. PLoS Pathog. 2021 Jun 18;17(6):e1009635. doi: 10.1371/journal.ppat.1009635. eCollection 2021 Jun. PMID: 34143834 Free PMC article.
- Therapeutic options for CTLA-4 insufficiency. Egg D, Rump IC, Mitsuiki N, Rojas-Restrepo J, Maccari ME, Schwab C, Gabrysch A, Warnatz K, Goldacker S, Patiño V, Wolff D, Okada S, Hayakawa S, Shikama Y, Kanda K, Imai K, Sotomatsu M, Kuwashima M, Kamiya T, Morio T, Matsumoto K, Mori T, Yoshimoto Y, Dybedal I, Kanariou M, Kucuk ZY, Chapdelaine H, Petruzelkova L, Lorenz HM, Sullivan KE, Heimall J, Moutschen M, Litzman J, Recher M, Albert MH, Hauck F, Seneviratne S, Pachlopnik Schmid J, Kolios A, Unglik G, Klemann C, Snapper S, Giulino-Roth L, Svaton M, Platt CD, Hambleton S, Neth O, Gosse G, Reinsch S, Holzinger D, Kim YJ, Bakhtiar S, Atschekzei F, Schmidt R, Sogkas G, Chandrakasan S, Rae W, Derfalvi B, Marquart HV, Ozen A, Kiykim A, Karakoc-Aydiner E, Králíčková P, de Bree G, Kiritsi D, Seidel MG, Kobbe R, Dantzer J, Alsina L, Armangue T, Lougaris V, Agyeman P, Nyström S, Buchbinder D, Arkwright PD, Grimbacher B. J Allergy Clin Immunol. 2021 Jun 7:S0091-6749(21)00891-5. doi: 10.1016/j.jaci.2021.04.039. Online ahead of print. PMID: 34111452
- S100A8/A9 is the first predictive marker for neonatal sepsis. Pirr S, Dauter L, Vogl T, Ulas T, Bohnhorst B, Roth J, Viemann D.Clin Transl Med. 2021 Apr;11(4):e338. doi: 10.1002/ctm2.338.PMID: 33931974Free PMC article.No abstract available.
- MyD88 signaling by neurons induces chemokines that recruit protective leukocytes to the virus-infected CNS. Ghita L, Spanier J, Chhatbar C, Mulenge F, Pavlou A, Larsen PK, Waltl I, Lueder Y, Kohls M, Jung K, Best SM, Förster R, Stangel M, Schreiner D, Kalinke U. Sci Immunol. 2021 Jun 25;6(60):eabc9165. doi: 10.1126/sciimmunol.abc9165. PMID: 34172587.
- Human IFITM3 restricts chikungunya virus and Mayaro virus infection and is susceptible to virus-mediated counteraction. Franz S, Pott F, Zillinger T, Schüler C, Dapa S, Fischer C, Passos V, Stenzel S, Chen F, Döhner K, Hartmann G, Sodeik B, Pessler F, Simmons G, Drexler JF, Goffinet C. Life Sci Alliance. 2021 Jun 2;4(7):e202000909. doi: 10.26508/lsa.202000909. PMID: 34078739; PMCID: PMC8200292.
- Cytomegalovirus subverts macrophage identity. Baasch S, Giansanti P, Kolter J, Riedl A, Forde AJ, Runge S, Zenke S, Elling R, Halenius A, Brabletz S, Hengel H, Kuster B, Brabletz T, Cicin-Sain L, Arens R, Vlachos A, Rohr JC, Stemmler MP, Kopf M, Ruzsics Z, Henneke P. Cell. 2021 Jun 5:S0092-8674(21)00626-7. doi: 10.1016/j.cell.2021.05.009. Online ahead of print. PMID: 34115982
- Elevated Free Phosphatidylcholine Levels in Cerebrospinal Fluid Distinguish Bacterial from Viral CNS Infections. Al-Mekhlafi A, Sühs KW, Schuchardt S, Kuhn M, Müller-Vahl K, Trebst C, Skripuletz T, Klawonn F, Stangel M, Pessler F. Cells. 2021 May 6;10(5):1115. doi: 10.3390/cells10051115. PMID: 34066349; PMCID: PMC8148106.
- Allosteric modulation of cardiac myosin mechanics and kinetics by the conjugated omega-7,9 trans-fat rumenic acid. Irene Pertici, Manuel H. Taft, Johannes N. Greve, Roman Fedorov, Marco Caremani, Dietmar J. Manstein. Journal of Physiology. First published: 04 May 2021
- A fetal wave of human type 3 effector γδ cells with restricted TCR diversity persists into adulthood. Likai Tan, Alina Suzann Fichtner, Elena Bruni, Ivan Odak, Inga Sandrock, Anja Bubke, Alina Borchers, Christian Schultze-Florey, Christian Koenecke, Reinhold Förster, Michael Jarek, Constantin von Kaisenberg, Ansgar Schulz, Xiaojing Chu, Bowen Zhang, Yang Li, Ulf Panzer, Christian F. Krebs, Sarina Ravens, Immo Prinz. Science Immunology 23 Apr 2021
- Extracellular vesicles in neuroinflammation: Pathogenesis, diagnosis, and therapy. Ruan J, Miao X, Schlüter D, Lin L, Wang X. Mol Ther. 2021 Jun 2;29(6):1946-1957. doi: 10.1016/j.ymthe.2021.04.020. Epub 2021 Apr 23. PMID: 33895328 Review.
- Ovarian tumor domain proteases in pathogen infection. Review. Trends in Microbiology. Dirk Schlüter, EricSchulze-Niemand, Matthias Stein, Michael Naumann, online 17 May 2021 https://doi.org/10.1016/j.tim.2021.04.002
- Aging and options to halt declining immunity to virus infections. Miguel Ángel Palacios-Pedrero, Albert D.M.E. Osterhaus, Tanja Becker, Husni Elbahesh, Guus F. Rimmelzwaan and Giulietta Saletti. Front. Immunol., 12 May 2021 | https://doi.org/10.3389/fimmu.2021.681449
- Eczema herpeticum in atopic dermatitis. Traidl S, Rösner L, Zeitvogel J, Werfel T. Allergy. 2021 Apr 12. doi: 10.1111/all.14853. Online ahead of print. PMID: 33844308 Review.
- Tim-3 is dispensable for allergic inflammation and respiratory tolerance in experimental asthma. Boehne C, Behrendt AK, Meyer-Bahlburg A, Boettcher M, Drube S, Kamradt T, Hansen G. PLoS One. 2021 Apr 6;16(4):e0249605. doi: 10.1371/journal.pone.0249605. eCollection 2021.
PMID: 33822811 - Reverse genetics systems for contemporary isolates of respiratory syncytial virus enable rapid evaluation of antibody escape mutants. Jo WK, Schadenhofer A, Habierski A, Kaiser FK, Saletti G, Ganzenmueller T, Hage E, Haid S, Pietschmann T, Hansen G, Schulz TF, Rimmelzwaan GF, Osterhaus ADME, Ludlow M. Proc Natl Acad Sci U S A. 2021 Apr 6;118(14):e2026558118. doi: 10.1073/pnas.2026558118.
PMID: 33811145 - Cyclin D3 drives inertial cell cycling in dark zone germinal center B cells. Pae J, Ersching J, Castro TBR, Schips M, Mesin L, Allon SJ, Ordovas-Montanes J, Mlynarczyk C, Melnick A, Efeyan A, Shalek AK, Meyer-Hermann M, Victora GD. J Exp Med. 2021 Apr 5;218(4):e20201699. doi: 10.1084/jem.20201699. PMID: 33332554
- Cellular and molecular mechanisms breaking immune tolerance in inborn errors of immunity. Sogkas G, Atschekzei F, Adriawan IR, Dubrowinskaja N, Witte T, Schmidt RE. Cell Mol Immunol. 2021 Apr 1:1-19. doi: 10.1038/s41423-020-00626-z. Online ahead of print. PMID: 33795850 Free PMC article. Review.
- Removable denture is a risk indicator for peri-implantitis and facilitates expansion of specific periodontopathogens: a cross-sectional study. Grischke J, Szafrański SP, Muthukumarasamy U, Haeussler S, Stiesch M. BMC Oral Health. 2021 Apr 1;21(1):173. doi: 10.1186/s12903-021-01529-9. PMID: 33794847 Free PMC article.
- The impact of hepatitis B surface antigen on natural killer cells in patients with chronic hepatitis B infection.
Du Y, Anastasiou OE, Strunz B, Scheuten J, Bremer B, Kraft A, Kleinsimglinhaus K, Todt D, Broering R, Hardtke-Wolenski M, Wu J, Yang D, Dittmer U, Lu M, Cornberg M, Björkström NK, Khera T, Wedemeyer H. Liver Int. 2021 Apr 1. doi: 10.1111/liv.14885. Online ahead of print. PMID: 33794040 - Beyond „Big Eaters“: The Versatile Role of Alveolar Macrophages in Health and Disease. Hetzel M, Ackermann M, Lachmann N. Int J Mol Sci. 2021 Mar 24;22(7):3308. doi: 10.3390/ijms22073308. PMID: 33804918 Free PMC article. Review.
- The microbiota is dispensable for the early stages of peripheral regulatory T cell induction within mesenteric lymph nodes. Wiechers C, Zou M, Galvez E, Beckstette M, Ebel M, Strowig T, Huehn J, Pezoldt J. Cell Mol Immunol. 2021 Mar 24. doi: 10.1038/s41423-021-00647-2. Online ahead of print. PMID: 33762684
- OTUB1 prevents lethal hepatocyte necroptosis through stabilization of c-IAP1 during murine liver inflammation. Koschel J, Nishanth G, Just S, Harit K, Kröger A, Deckert M, Naumann M, Schlüter D. Cell Death Differ. 2021 Mar 12. doi: 10.1038/s41418-021-00752-9. Online ahead of print. PMID: 33712742
- Influenza A virus-induced thymus atrophy differentially affects dynamics of conventional and regulatory T-cell development in mice. Elfaki Y, Robert PA, Binz C, Falk CS, Bruder D, Prinz I, Floess S, Meyer-Hermann M, Huehn J. Eur J Immunol. 2021 Feb 26. doi: 10.1002/eji.202048981. Online ahead of print. PMID: 33638148
- Lymph node stromal cell subsets-Emerging specialists for tailored tissue-specific immune responses. Zou M, Wiechers C, Huehn J. Int J Med Microbiol. 2021 Apr;311(3):151492. doi: 10.1016/j.ijmm.2021.151492. Epub 2021 Feb 25. PMID: 33676241
- Development of the reproduction number from coronavirus SARS-CoV-2 case data in Germany and implications for political measures. Khailaie S, Mitra T, Bandyopadhyay A, Schips M, Mascheroni P, Vanella P, Lange B, Binder SC, Meyer-Hermann M. BMC Med. 2021 Jan 28;19(1):32. doi: 10.1186/s12916-020-01884-4. PMID: 33504336 Free PMC article.
- 3D culture conditions support Kaposi’s sarcoma herpesvirus (KSHV) maintenance and viral spread in endothelial cells. Dubich T, Dittrich A, Bousset K, Geffers R, Büsche G, Köster M, Hauser H, Schulz TF, Wirth D. J Mol Med (Berl). 2021 Mar;99(3):425-438. doi: 10.1007/s00109-020-02020-8. Epub 2021 Jan 23. PMID: 33484281 Free PMC article.
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- Hepatitis E Virus (HEV)-Specific T Cell Receptor Cross-Recognition: Implications for Immunotherapy. Soon CF, Zhang S, Suneetha PV, Antunes DA, Manns MP, Raha S, Schultze-Florey C, Prinz I, Wedemeyer H, Sällberg Chen M, Cornberg M. Front Immunol. 2019 Sep 4;10:2076. eCollection 2019.
- Tau-protein concentrations are not elevated in cerebrospinal fluid of patients with progressive multifocal leukoencephalopathy. Möhn N, Luo Y, Skripuletz T, Schwenkenbecher P, Zerr I, Lange P, Stangel M. Fluids Barriers CNS. 2019 Sep 5;16(1):28.
- Injection of Antibodies against Immunodominant Epitopes Tunes Germinal Centers to Generate Broadly Neutralizing Antibodies. Meyer-Hermann M. Cell Rep. 2019 Oct 29;29(5):1066-1073.e5.
- The role of Ames dwarfism and calorie restriction on gut microbiota. Wiesenborn DS, Gálvez EJC, Spinel L, Victoria B, Allen B, Schneider A, Gesing A, Al-Regaiey KA, Strowig T, Schäfer KH, Masternak MM. J Gerontol A Biol Sci Med Sci. 2019 Oct 30.
- The Antimicrobial and Immunomodulatory Function of RNase 7 in Skin. Rademacher F, Dreyer S, Kopfnagel V, Gläser R, Werfel T, Harder J. Front Immunol. 2019 Nov 5;10:2553. eCollection 2019. Review.
- Interleukin-17 cytokines: Effectors and targets in psoriasis-A breakthrough in understanding and treatment. Prinz I, Sandrock I, Mrowietz U. J Exp Med. 2020 Jan 6;217(1):e20191397, epub 2019_11_14
- Late-Onset Antibody Deficiency Due to Monoallelic Alterations in NFKB1. Schröder C, Sogkas G, Fliegauf M, Dörk T, Liu D, Hanitsch LG, Steiner S, Scheibenbogen C, Jacobs R, Grimbacher B, Schmidt RE, Atschekzei F. Front Immunol. 2019 Nov 14;10:2618. eCollection 2019.
- Recurrent Eczema Herpeticum – A Retrospective European Multicenter Study Evaluating the Clinical Characteristics of Eczema Herpeticum Cases in Atopic Dermatitis Patients. Seegräber M, Worm M, Werfel T, Svensson A, Novak N, Simon D, Darsow U, Augustin M, Wollenberg A. J Eur Acad Dermatol Venereol 2020;34(5):1074-1079
- The CAFA challenge reports improved protein function prediction and new functional annotations for hundreds of genes through experimental screens. Zhou N, Jiang Y, Bergquist TR, Lee AJ, Kacsoh BZ, Crocker AW, Lewis KA, Georghiou G, Nguyen HN, Hamid MN, Davis L, Dogan T, Atalay V, Rifaioglu AS, Dalkıran A, Cetin Atalay R, Zhang C, Hurto RL, Freddolino PL, Zhang Y, Bhat P, Supek F, Fernández JM, Gemovic B, Perovic VR, Davidović RS, Sumonja N, Veljkovic N, Asgari E, Mofrad MRK, Profiti G, Savojardo C, Martelli PL, Casadio R, Boecker F, Schoof H, Kahanda I, Thurlby N, McHardy AC, Renaux A, Saidi R, Gough J, Freitas AA, Antczak M, Fabris F, Wass MN, Hou J, Cheng J, Wang Z, Romero AE, Paccanaro A, Yang H, Goldberg T, Zhao C, Holm L, Törönen P, Medlar AJ, Zosa E, Borukhov I, Novikov I, Wilkins A, Lichtarge O, Chi PH, Tseng WC, Linial M, Rose PW, Dessimoz C, Vidulin V, Dzeroski S, Sillitoe I, Das S, Lees JG, Jones DT, Wan C, Cozzetto D, Fa R, Torres M, Warwick Vesztrocy A, Rodriguez JM, Tress ML, Frasca M, Notaro M, Grossi G, Petrini A, Re M, Valentini G, Mesiti M, Roche DB, Reeb J, Ritchie DW, Aridhi S, Alborzi SZ, Devignes MD, Koo DCE, Bonneau R, Gligorijević V, Barot M, Fang H, Toppo S, Lavezzo E, Falda M, Berselli M, Tosatto SCE, Carraro M, Piovesan D, Ur Rehman H, Mao Q, Zhang S, Vucetic S, Black GS, Jo D, Suh E, Dayton JB, Larsen DJ, Omdahl AR, McGuffin LJ, Brackenridge DA, Babbitt PC, Yunes JM, Fontana P, Zhang F, Zhu S, You R, Zhang Z, Dai S, Yao S, Tian W, Cao R, Chandler C, Amezola M, Johnson D, Chang JM, Liao WH, Liu YW, Pascarelli S, Frank Y, Hoehndorf R, Kulmanov M, Boudellioua I, Politano G, Di Carlo S, Benso A, Hakala K, Ginter F, Mehryary F, Kaewphan S, Björne J, Moen H, Tolvanen MEE, Salakoski T, Kihara D, Jain A, Šmuc T, Altenhoff A, Ben-Hur A, Rost B, Brenner SE, Orengo CA, Jeffery CJ, Bosco G, Hogan DA, Martin MJ, O’Donovan C, Mooney SD, Greene CS, Radivojac P, Friedberg I. Genome Biol. 2019 Nov 19;20(1):244.
- Distinct molecular response patterns of activating STAT3 mutations associate with penetrance of lymphoproliferation and autoimmunity. Jägle S, Heeg M, Grün S, Rensing-Ehl A, Maccari ME, Klemann C, Jones N, Lehmberg K, Bettoni C, Warnatz K, Grimbacher B, Biebl A, Schauer U, Hague R, Neth O, Mauracher A, Pachlopnik Schmid J, Fabre A, Kostyuchenko L, Führer M, Lorenz MR, Schwarz K, Rohr J, Ehl S. Clin Immunol. 2019 Nov 23;210:108316.
- The architecture of the IgG anti-carbohydrate repertoire in primary antibody deficiencies. Jandus P, Boligan KF, Smith DF, de Graauw E, Grimbacher B, Jandus C, Abdelhafez MM, Despont A, Bovin N, Simon D, Rieben R, Simon HU, Cummings RD, von Gunten S. Blood. 2019 Nov 28;134(22):1941-1950.
- PedCAPNETZ – prospective observational study on community acquired pneumonia in children and adolescents. Wetzke M, Kopp MV, Seidenberg J, Vogelberg C, Ankermann T, Happle C, Voigt G, Köster H, Illig T, Lex C, Schuster A, Panning M, Barten G, Rohde G, Welte T, Hansen G; pedCAPNETZ Study Group. BMC Pulm Med. 2019 Dec 9;19(1):238.
- Structural Noninfectious Manifestations of the Central Nervous System in Common Variable Immunodeficiency Disorders. van de Ven A, Mader I, Wolff D, Goldacker S, Fuhrer H, Rauer S, Grimbacher B, Warnatz K. J Allergy Clin Immunol Pract. 2019 Dec 16. pii: S2213-2198(19)31026-8.
- B cell hyperactivation in an Ackr4-deficient mouse strain is not caused by lack of ACKR4 expression. Eckert N, Werth K, Willenzon S, Tan L, Förster R. J Leukoc Biol. 2019 Dec 16.
- Long-term outcome of LRBA deficiency in 76 patients after various treatment modalities as evaluated by the immune deficiency and dysregulation activity (IDDA) score Tesch VK, Abolhassani H, Shadur B, Zobel J, Mareika Y, Sharapova S, Karakoc-Aydiner E, Rivière JG, Garcia-Prat M, Moes N, Haerynck F, Gonzales-Granado LI, Santos Pérez JL, Mukhina A, Shcherbina A, Aghamohammadi A, Hammarström L, Dogu F, Haskologlu S, İkincioğulları AI, Köstel Bal S, Baris S, Kilic SS, Karaca NE, Kutukculer N, Girschick H, Kolios A, Keles S, Uygun V, Stepensky P, Worth A, van Montfrans JM, Peters AMJ, Meyts I, Adeli M, Marzollo A, Padem N, Khojah AM, Chavoshzadeh Z, Avbelj Stefanija M, Bakhtiar S, Florkin B, Meeths M, Gamez L, Grimbacher B, Seppänen MRJ, Lankester A, Gennery AR, Seidel MG; J Allergy Clin Immunol 2020 May;145(5):1452-1463. Epub 2019 Dec 27.
- Targeting the Kaposi Sarcoma Herpesvirus ORF 21 tyrosine kinase and viral lytic reactivation by tyrosine kinase inhibitors approved for clinical use. Beauclair G, Naimo E, Dubich T, Rückert J, Koch S, Dhingra A, Wirth D, Schulz TF. J Virol. 2019 Dec 11. pii: JVI.01791-19. doi: 10.1128/JVI.01791-19. [Epub ahead of print]
- Control of Nipah Virus Infection in Mice by the Host Adaptors Mitochondrial Antiviral Signaling Protein (MAVS) and Myeloid Differentiation Primary Response 88 (MyD88). Iampietro M, Aurine N, Dhondt KP, Dumont C, Pelissier R, Spanier J, Vallve A, Raoul H, Kalinke U, Horvat B. J Infect Dis. 2020 May 11;221(Suppl 4):S401-S406. Dec 19
- RNA-Based Adjuvants: Immunoenhancing Effect on Antiviral Vaccines and Regulatory Considerations. Ziegler A, Hinz T, Kalinke U. Crit Rev Immunol. 2019;39(1):1-14.
- Update of the statements on biology and clinical impact of occult hepatitis B virus infection. Raimondo G, Locarnini S, Pollicino T, Levrero M, Zoulim F, Lok AS; Taormina Workshop on Occult HBV Infection Faculty Members. J Hepatol. 2019 Aug;71(2):397-408. doi: 10.1016/j.jhep.2019.03.034. Epub 2019 Apr 18. PMID: 31004683.
- Synthesis of 4’/5′-Spirocyclopropanated Uridine and d-Xylouridine Derivatives and Their Activity against the Human Respiratory Syncytial Virus. Köllmann C, Wiechert SM, Jones PG, Pietschmann T, Werz DB. Org Lett. 2019 Sep 6;21(17):6966-6971. doi: 10.1021/acs.orglett.9b02555. Epub 2019 Aug 21. PMID: 31433193.
- Quantitative Microscopy Reveals Stepwise Alteration of Chromatin Structure during Herpesvirus Infection. Aho V, Mäntylä E, Ekman A, Hakanen S, Mattola S, Chen JH, Weinhardt V, Ruokolainen V, Sodeik B, Larabell C, Vihinen-Ranta M. Viruses. 2019 Oct 11;11(10):935. doi: 10.3390/v11100935. PMID: 31614678; PMCID: PMC6832731.
- Probabilistic variable-length segmentation of protein sequences for discriminative motif discovery (DiMotif) and sequence embedding (ProtVecX). Asgari E, McHardy AC, Mofrad MRK. Sci Rep. 2019 Mar 5;9(1):3577. doi: 10.1038/s41598-019-38746-w. PMID: 30837494; PMCID: PMC6401088.
- Keratinized mucosa width is associated with severity of peri-implant mucositis. A cross-sectional study. Jasmin Grischke, Annika Karch, Andreas Wenzlaff, Magdalena Marta Foitzik, Meike Stiesch, Jörg Eberhard. Clinical Oral Implants Research. First published: 10 April 2019. https://doi.org/10.1111/clr.13432
- Impaired cellular energy metabolism in cord blood macrophages contributes to abortive response toward inflammatory threats. Dreschers S, Ohl K, Lehrke M, Möllmann J, Denecke B, Costa I, Vogl T, Viemann D, Roth J, Orlikowsky T, Tenbrock K. Nat Commun. 2019 Apr 11;10(1):1685. doi: 10.1038/s41467-019-09359-8. PMID: 30976008; PMCID: PMC6459909.
- HSV-1 triggers paracrine fibroblast growth factor response from cortical brain cells via immediate-early protein ICP0. J Neuroinflammation. Hensel N, Raker V, Förthmann B, Detering NT, Kubinski S, Buch A, Katzilieris-Petras G, Spanier J, Gudi V, Wagenknecht S, Kopfnagel V, Werfel TA, Stangel M, Beineke A, Kalinke U, Paludan SR, Sodeik B, Claus P. 2019 Dec 2;16(1):248. doi: 10.1186/s12974-019-1647-5. PMID: 31791351; PMCID: PMC6889453.
- Hepatitis D Virus-Specific CD8+ T Cells Have a Memory-Like Phenotype Associated With Viral Immune Escape in Patients With Chronic Hepatitis D Virus Infection. Kefalakes H, Koh C, Sidney J, Amanakis G, Sette A, Heller T, Rehermann B. Gastroenterology. 2019 May;156(6):1805-1819.e9. doi: 10.1053/j.gastro.2019.01.035. Epub 2019 Jan 18. PMID: 30664876; PMCID: PMC7367679.
- Genetically diverse Pseudomonas aeruginosa populations display similar transcriptomic profiles in a cystic fibrosis explanted lung. Kordes A, Preusse M, Willger SD, Braubach P, Jonigk D, Haverich A, Warnecke G, Häussler S. Nat Commun. 2019 Jul 30;10(1):3397. doi: 10.1038/s41467-019-11414-3. PMID: 31363089; PMCID: PMC6667473.
- Fragment-Based Discovery of a Qualified Hit Targeting the Latency-Associated Nuclear Antigen of the Oncogenic Kaposi’s Sarcoma-Associated Herpesvirus/Human Herpesvirus 8 Philine Kirsch, Valentin Jakob, +4 authors M. Empting. Journal of Medicinal Chemistry. 19 March 2019 DOI:10.1021/acs.jmedchem.8b01827Corpus ID: 84183173
- Establishment of an induced memory response in Pseudomonas aeruginosa during infection of a eukaryotic host. Kordes A, Grahl N, Koska M, Preusse M, Arce-Rodriguez A, Abraham WR, Kaever V, Häussler S. ISME J. 2019 Aug;13(8):2018-2030. doi: 10.1038/s41396-019-0412-1. Epub 2019 Apr 5. PMID: 30952997; PMCID: PMC6775985.
- Diversity of Bacteria Exhibiting Bile Acid-inducible 7α-dehydroxylation Genes in the Human Gut. Vital M, Rud T, Rath S, Pieper DH, Schlüter D. Comput Struct Biotechnol J. 2019 Jul 26;17:1016-1019. doi: 10.1016/j.csbj.2019.07.012. PMID: 31428294; PMCID: PMC6692061.
- Cohort profile: The LoewenKIDS Study – life-course perspective on infections, the microbiome and the development of the immune system in early childhood. Gottschick C, Raupach-Rosin H, Langer S, Hassan L, Horn J, Dorendorf E, Caputo M, Bittner M, Beier L, Rübsamen N, Schlinkmann K, Zoch B, Guzman CA, Hansen G, Heselich V, Holzapfel E, Hübner J, Pietschmann T, Pieper DH, Pletz M, Riese P, Schmidt-Pokrzywniak A, Hartwig S, von Kaisenberg C, Aydogdu M, Buhles M, Dressler F, Eberl W, Haase R, von Koch FE, Feidicker S, Frambach T, Franz HGB, Guthmann F, Koch HG, Seeger S, Oberhoff C, Pauker W, Petry KU, Schild RL, Tchirikov M, Röhrig E, Karch A, Mikolajczyk R. Int J Epidemiol. 2019 Aug 1;48(4):1382-1383. doi: 10.1093/ije/dyz069. Erratum for: Int J Epidemiol. 2019 Aug 1;48(4):1042-1043h. PMID: 30938437; PMCID: PMC7263872.
- Clinical and Immunological Phenotype of Patients With Primary Immunodeficiency Due to Damaging Mutations in NFKB2. Klemann C, Camacho-Ordonez N, Yang L, Eskandarian Z, Rojas-Restrepo JL, Frede N, Bulashevska A, Heeg M, Al-Ddafari MS, Premm J, Seidl M, Ammann S, Sherkat R, Radhakrishnan N, Warnatz K, Unger S, Kobbe R, Hüfner A, Leahy TR, Ip W, Burns SO, Fliegauf M, Grimbacher B. Front Immunol. 2019 Mar 19;10:297. doi: 10.3389/fimmu.2019.00297. PMID: 30941118; PMCID: PMC6435015.
- Autophagic degradation of lamins facilitates the nuclear egress of herpes simplex virus type 1. Turan A, Grosche L, Krawczyk A, Mühl-Zürbes P, Drassner C, Düthorn A, Kummer M, Hasenberg M, Voortmann S, Jastrow H, Dörrie J, Schaft N, Kraner M, Döhner K, Sodeik B, Steinkasserer A, Heilingloh CS. J Cell Biol. 2019 Feb 4;218(2):508-523. doi: 10.1083/jcb.201801151. Epub 2018 Dec 26. PMID: 30587512; PMCID: PMC6363456.
- Kynurenine Is a Cerebrospinal Fluid Biomarker for Bacterial and Viral Central Nervous System Infections Sühs KW, Novoselova N, Kuhn M, Seegers L, Kaever V, Müller-Vahl K, Trebst C, Skripuletz T, Stangel M, Pessler F. J Infect Dis. 2019 Jun 5;220(1):127-138.
- HSV-1 triggers paracrine fibroblast growth factor response from cortical brain cells via immediate-early protein ICP0 Hensel N, Raker V, Förthmann B, Detering NT, Kubinski S, Buch A, Katzilieris-Petras G, Spanier J, Gudi V, Wagenknecht S, Kopfnagel V, Werfel TA, Stangel M, Beineke A, Kalinke U, Paludan SR, Sodeik B, Claus P. J Neuroinflammation 2019;16(1):248
Vorarbeiten
- Genetically diverse Pseudomonas aeruginosa populations display similar transcriptomic profiles in a cystic fibrosis explanted lung. Kordes A, Preusse M, Willger SD, Braubach P, Jonigk D, Haverich A, Warnecke G, Häussler S. Nat Commun. 2019 Jul 30;10(1):3397.
- Establishment of an induced memory response in Pseudomonas aeruginosa during infection of a eukaryotic host. Kordes A, Grahl N, Koska M, Preusse M, Arce-Rodriguez A, Abraham WR, Kaever V, Häussler S. ISME J. 2019 Aug;13(8):2018-2030.
- Single-Cell Transcriptomics Identifies the Adaptation of Scart1(+) Vγ6(+) T Cells to Skin Residency as Activated Effector Cells. Tan L*, Sandrock I*, Odak I, Aizenbud Y, Wilharm A, Barros-Martins J, Tabib Y, Borchers A, Amado T, Gangoda L, Herold MJ, Schmidt-Supprian M, Kisielow J, Silva-Santos B, Koenecke C, Hovav AH, Krebs C, Prinz I**, Ravens S**. Cell Rep. 2019 Jun 18;27(12):3657-3671.e4.
- The deubiquitinase OTUB1 inhibits central nervous system autoimmunity by preventing IFN-γ-induced hyperactivation of astrocytes through stabilization of SOCS1 X. Wang, F. Mulas, W Yi, A. Brunn, G. Nishanth, S. Just, A. Waisman, W. Brück, M. Deckert, D. Schlüter (2019) . EMBO J e100947.
- Fragment-Based Discovery of a Qualified Hit Targeting the Latency-Associated Nuclear Antigen of the Oncogenic Kaposi’s Sarcoma-Associated Herpesvirus/Human Herpesvirus 8. Kirsch P, Jakob V, Oberhausen K, Stein SC, Cucarro I, Schulz TF, Empting M. J Med Chem. 2019 Apr 25;62(8):3924-3939. doi: 10.1021/acs.jmedchem.8b01827. Epub 2019 Apr 12. PMID: 30888817.
- Identification of Leishmania major UDP-Sugar Pyrophosphorylase Inhibitors Using Biosensor-Based Small Molecule Fragment Library Screening. Prakash O, Führing J, Post J, Shepherd SM, Eadsforth TC, Gray D, Fedorov R and Routier FH. 2019, Molecules, 24(5): 996.
- Current In Vitro Models to Study Varicella Zoster Virus Latency and Reactivation. Baird NL, Zhu S, Pearce CM, Viejo-Borbolla A. Viruses. 2019 Jan 26;11(2):103. doi: 10.3390/v11020103. PMID: 30691086; PMCID: PMC6409813.
- Novel Virus Related to Kaposi’s Sarcoma-Associated Herpesvirus from Colobus Monkey Dhingra A, Ganzenmueller T, Hage E, Suárez NM, Mätz-Rensing K, Widmer D, Pöhlmann S, Davison AJ, Schulz TF, Kaul A. Emerg Infect Dis 2019;25(8):1548-1551
- Kaposi’s sarcoma-associated herpesvirus vIRF2 protein utilizes an IFN-dependent pathway to regulate viral early gene expression Koch S, Damas M, Freise A, Hage E, Dhingra A, Rückert J, Gallo A, Kremmer E, Tegge W, Brönstrup M, Brune W, Schulz TF. PLoS Pathog 2019;15(5):e1007743
- Severe Progressive Multifocal Leukoencephalopathy (PML) and Spontaneous Immune Reconstitution Inflammatory Syndrome (IRIS) in an Immunocompetent Patient. Krey L, Raab P, Sherzay R, Berding G, Stoll M, Stangel M, Wegner F. Front Immunol 2019;10:1188
- Diversity patterns of bacteriophages infecting Aggregatibacter and Haemophilus species across clades and niches. Szafrański SP, Kilian M, Yang I, Bei der Wieden G, Winkel A, Hegermann J, Stiesch M. ISME J.
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