Exciting topics, interestingly presented: Every first and third Thursday (except during school holidays), RESIST scientists or top-class researchers from external institutions present their topics at the RESIST seminar series.
Attend these exciting seminars of the Cluster of Excellence RESIST, as a member of RESIST or as a colleague or student.
On 28 September, Dr. Zhi-Ming (Thomas) Zheng, Senior Investigator and Head Tumor Virus RNA Biology Section HIV Dynamics and Replication Program, Center for Cancer Research, National Cancer Institute, National Institutes of Health, will give a lecture at the RESIST seminar. The title of the lecture is: “KSHV infections and antiviral RNA granules”.
This seminar will take place from 5 to 6 pm in lecture theatre Q, building J6, MHH.
If you are interested in participating via video (online), please contact RESIST@mh-hannover.de.
Do you have any questions or suggestions about the RESIST seminar series? Then please contact us.
Hier finden Sie eine kurze Beschreibung des Vortrags, der auf Englisch gehalten wird:
Two major cytoplasmic RNA granules, ubiquitous RNA-processing bodies (PB) and inducible stress granules (SG), regulate mRNA translation and play a major role in antiviral activities. We discovered that KSHV lytic infection produces a viral lytic RNA-binding protein ORF57 which inhibits formation of both PB and SG. Viral ORF57 interacts with two major RISC components of AGO2 and GW182 to block PB formation (Sharma, NR., et al. Nucleic Acid Res 47: 9368-9385, 2019) and with PACT and PKR to suppress SG formation (Sharma NR., et al. PLoS Pathog 13: e10066777, 2017). In the course of these studies, we noticed that PB and SG are intimately linked and shared exchangeable components. We found that arsenite (ARS)-induced SG formed in a stepwise process is topologically and mechanically linked to PB. Two essential PB components, GW182 and DDX6, are repurposed under stress to play direct but distinguishable roles in SG biogenesis. GW182 provides scaffolding activities for SG formation and DDX6 separates PB from SG (Majerciak V., et al. 2023 https://doi.org/10.1093/nar/gkad585). This talk will highlight a new functional paradigm between PB and SG biogenesis during the stress and virus infections and how KSHV copes the antiviral PB and SG for its replication and multiplication.