Prof. Dr. Rolf Müller participates in RESIST research project C3.
| My Research Interest in RESIST |
As a part of the RESIST consortium, we will investigate molecular interactions within microbial communities relevant to human health and disease. A special focus will be put on the role of lung-based microbes and their influence on the emergence and progression of respiratory diseases. Previous studies by RESIST scientist Burkhard Tümmler identified a panel of bacteria that either positively or negatively affect the course of respiratory conditions.
We will apply a set of microbiological, analytical, and bioinformatics technologies developed in our institute to shed light on the molecular mechanisms underlying the interaction between these isolates. In these studies, we will leverage on our experience with analysing the molecular physiology of myxobacterial communities. The generated knowledge will contribute to a better understanding of the observed correlation between composition of the lung microbiome and disease progression.
Prof. Müller about his scientific work
Prof. Dr. Rolf Müller – Curriculum Vitae
Current Position
Undergraduate and Postgraduate Training
Academic and Research Posts
Other Scientific Roles
Awards and Prizes
10 Selected Publications (of > 225 original publications)
Hoffmann, T., Krug, D., Bozkurt, N., Duddela, S., Jansen, R. Garcia, R., Gerth, K., Steinmetz, H. and Müller, R. Correlating chemical diversity with taxonomic distance for discovery of natural products in myxobacteria, Nature Communications, 2018, 9(1):803.
Hüttel, S., Giambattista, T., Herrmann, J., Planke, T., Gille, F., Moreno, M., Stadler, M., Brönstrup, M., Kirschning, A. and Müller, R. Discovery and total synthesis of natural cystobactamid derivatives with superior activity against Gram-negative pathogens, Angewandte Chemie International Edition, 2017, 56 (41): 12760-64.
Fu, C., Sikandar, A., Donner, J., Zaburannyi, N., Herrmann, J., Reck, M., Wagner-Döbler, I., Koehnke, J. and Müller, R. Carolacton is a potent myxobacterial inhibitor of folate biosynthesis via specific interaction with FolD/MTHFD, Nature Communications, 2017, 8 (1):1529.
Fu, C., Keller L., Bauer, A., Brönstrup, M., Froidbise, A., Hammann, P., Herrmann, J., Mondesert, G., Kurz, M., Schiell, M., Schummer, D., Toti, L., Wink, J. and Müller, R. Biosynthetic studies of telomycin reveal new lipopeptides with enhanced activity, Journal of the American Chemical Society, 2015, 137 (24): 7692-705.
Kling, A., Lukat, P., Almeida, D.V., Bauer, A., Fontaine, E., Sordello, S., Zaburannyi, N., Herrmann, J., Wenzel, S.C., König, C., Ammerman, N.C., Barrio, M.B., Borchers, K., Bordon-Pallier, F., Brönstrup, M., Courtemanche, G., Gerlitz, M., Geslin, M., Hammann, P., Heinz, D.W., Hoffmann, H., Klieber, S., Kohlmann, M., Kurz, M. Lair, C., Matter, H., Nuermberger, E., Sandeep T., Fraisse, L., Grosset, J.H., Lagrange, S. and Müller, R. Antibiotics. Targeting DnaN for tuberculosis therapy using novel griselimycins, Science, 2015, 348 (6239): 1106-12.
Fu, J., Bian, X., Hu, S., Wang, H., Huang, F., Seibert, P.M., Plaza, A., Xia, L., Müller, R.*, Stewart, A. F.* and Zhang Y.* Full-length RecE enhances linear-linear homologous recombination and facilitates direct cloning and bioprospecting, Nature Biotechnology, 2012, 30: 440-446. (* Corresponding authors)
Quade, N., Huo, L., Rachid, S., Heinz D.W. and Müller, R. Unusual carbon fixation gives rise to diverse polyketide extender units, Nature Chemical Biology, 2012, 8 (1): 117-124.
Schneiker, S., Perlova, O., Kaiser, O., Gerth, K., Alici, A., Altmeyer, M.O., Bartels, D., Bekel, T., Beyer, S., Bode, E., Bode, H.B., Bolten, C.J., Choudhuri, J.V., Doss, S., Elnakady, Y.A., Frank, B., Gaigalat, L., Goesmann, A., Groeger, C., Gross, F., Jelsbak, L., Jelsbak, L., Kalinowski, J., Kegler, C., Knauber, T., Konietzny, S., Kopp, M., Krause, L., Krug, D., Linke, B., Mahmud, T., Martinez-Arias, R., McHardy, A.C., Merai, M., Meyer, F., Mormann, S., Muñoz-Dorado, J., Perez, J., Pradella, S., Rachid, S., Raddatz, G., Rosenau, F., Rückert, C., Sasse, F., Scharfe, M., Schuster, S.C., Suen, G., Treuner-Lange, A., Velicer, G.J., Vorhölter, F.J., Weissman, K.J., Welch, R.D., Wenzel, S.C., Whitworth, D.E., Wilhelm, S., Wittmann, C., Blöcker, H., Pühler, A. and Müller R. Complete genome sequence of the myxobacterium Sorangium cellulosum, Nature Biotechnology, 2007, 25 (11): 1281-1289.
Gemperlein, K., Zipf, G., Bernauer, B.S., Wenzel, S.C. and Müller, R. Polyunsaturated fatty acid production by Yarrowia lipolytica with myxobacterial PUFA synthases, Nature Communications, in press.
Gaitatzis, N., Kunze, B. and Müller, R. In vitro reconstitution of the myxochelin biosynthetic machinery of Stigmatella aurantiaca Sg a15: Biochemical characterization of a reductive release mechanism from nonribosomal peptide synthetases, Proceedings of the National Academy of Sciences of the United States of America, 2001, 98 (20): 11136-11141.
