Dr. Lennart Rösner participates in RESIST research projects A3, A4, B5 and in the RESIST-Cohort.
| My Research Interest in RESIST |
The increased risk of infections of the skin in the course of the chronic inflammatory skin disease atopic dermatitis has been my research focus over the last years. Especially the cellular immune response to Staphylococcus aureus and Herpes simplex virus are of interest, since infections can lead to a severe burden and life-threatening complications for a subgroup patients. My research targets deep characterization and enumeration of specific T cells in order to understand the composition of this heterogeneous cell group, and to estimate its impact on the skin. I also studied T cell and keratinocyte cytokine responses to allergens and their effects on the skin barrier. I am participating in managing the RESIST senior individuals cohort, that investigates the ageing of the immune system and the associated risk of suffering from various infectious diseases.
Dr. Rösner
Dr. Rösner – Curriculum Vitae
Current Position
Undergraduate and Postgraduate Training
Academic and Research Posts
Other Scientific Roles
Awards and Prizes
10 Selected Publications
Zhang B*, Roesner LM*, Traidl S*, Koeken VACM, Xu CJ, Werfel T#, Li Y# (2023). Single-cell profiles reveal distinctive immune response in atopic dermatitis in contrast to psoriasis. Allergy. 78:439-453. *equal contribution
Roesner LM*, Farag AK*, Pospich R, Traidl S, Werfel T (2022). T-cell receptor sequencing specifies psoriasis as a systemic and atopic dermatitis as a skin-focused, allergen-driven disease. Allergy. 78:439-453. *equal contribution
Farag AK*, Roesner LM*, Wieschowski S, Heratizadeh A, Eiz-Vesper B, Kwok WW, Valenta R, Werfel T. (2021). Specific T cells targeting Staphylococcus aureus fibronectin-binding protein 1 induce a type 2/type 1 inflammatory response in sensitized atopic dermatitis patients. Allergy. *equal contribution
Roesner LM*, Ernst M*, Chen W, Begemann G, Kienlin P, Raulf MK, Lepenies B, Werfel T (2019). Human thioredoxin, a damage-associated molecular pattern and Malassezia-crossreactive autoallergen, modulates immune responses via the C-type lectin receptors Dectin-1 and Dectin-2. Sci Rep 9, 11210. *equal contribution
Traidl S, Kienlin P, Begemann G, Jing L, Koelle DM, Werfel T, Roesner LM (2018). Patients with atopic dermatitis and history of eczema herpeticum elicit herpes simplex virus-specific type 2 immune responses. J Allergy Clin Immunol 141, 1144-1147.e5.
Roesner LM, Kienlin P, Begemann G, Dittrich-Breiholz O, Werfel T (2017). Inflammatory marker analysis in psoriatic skin under topical phosphodiesterase 4 inhibitor treatment. J Allergy Clin Immunol 140, 1184-1187.
Roesner LM, Heratizadeh A, Wieschowski S, Mittermann I, Valenta R, Eiz-Vesper B, Hennig C, Hansen G, Falk CS, and Werfel T (2016). Alpha-NAC-specific autoreactive CD8+ T cells in atopic dermatitis are of an effector memory type and secrete IL-4 and IFN-gamma. J Immunol 196, 3245-3252.
Seltmann J*, Roesner LM*, von Hesler FW, Wittmann M, and Werfel T (2015). IL-33 impacts on the skin barrier by downregulating the expression of filaggrin. J Allergy Clin Immunol 135, 1659-1661 e1654. *equal contribution
Roesner LM, Floess S, Witte T, Olek S, Huehn J, and Werfel T (2015). Foxp3+ regulatory T cells are expanded in severe atopic dermatitis patients. Allergy 70, 1656-1660.
Roesner LM*, Heratizadeh A*, Begemann G, Kienlin P, Hradetzky S, Niebuhr M, Eiz-Vesper B, Hennig C, Hansen G, Baron-Bodo V, Moingeon P, and Werfel T (2015). Der p1 and Der p2-Specific T Cells Display a Th2, Th17, and Th2/Th17 Phenotype in Atopic Dermatitis. J Invest Dermatol 135, 2324-2327. *equal contribution
