PD Dr. Lennart Rösner participates in RESIST research projects A3, A4, B5 and in the RESIST-Cohort.

My Research Interest in RESIST

The increased risk of infections of the skin in the course of the chronic inflammatory skin disease atopic dermatitis has been my research focus over the last years. Especially the cellular immune response to Staphylococcus aureus and Herpes simplex virus are of interest, since infections can lead to a severe burden and  life-threatening complications for a subgroup patients. My research targets deep characterization and enumeration of specific T cells in order to understand the composition of this heterogeneous cell group, and to estimate its impact on the skin. I also studied T cell and keratinocyte cytokine responses to allergens and their effects on the skin barrier. I am participating in managing the RESIST senior individuals cohort, that investigates the ageing of the immune system and the associated risk of suffering from various infectious diseases.

PD Dr. Rösner

The photo shows PD Dr. Rösner (front) with Prof. Li, Prof. Werfel and Dr. Traidl (from left) in the dermatology laboratory. Copyright: Imke Arning

PD Dr. Rösner – Curriculum Vitae

Current Position

  • Senior Scientist / Junior Group Leader in the Department of Dermatology and Allergy, MHH

Undergraduate and Postgraduate Training

  • 2024 Habilitation in Immunodermatology, Hannover Medical School

  • 2007 – 2011 Doctoral thesis at the University of Braunschweig and the German Collection for Microorganisms and Cell Cultures DSMZ, Braunschweig

  • 2002 – 2007 Studies of Plant Biotechnology; University of Hannover, Bachelor/Master of Science

  • 2007 – 2007 Study visit at the University of Olsztyn, Poland, within the EU transfer of knowledge Marie Curie action within the 6th framework programme

Academic and Research Posts

  • Since 2011 Postdoctoral fellow, Department of Dermatology and Allergy, MHH

Other Scientific Roles

  • 2021 Founding member of the working group Allergology and Immunology of the German Society for Immunology (DGfI)

  • Since 2019 Scientific advisory board of the Journal Allergologie

  • Since 2016 Member of the Editorial Board of Inflammation of the Journal Frontiers in Immunology (Review Editor)

  • Since 2019 Member of the Arbeitsgemeinschaft Dermatologische Forschung (ADF)

  • 2016 – 2021 Member of the Forschungskommission (scientific council) of MHH

  • Since 2013 Member of the Deutsche Gesellschaft für Allergie und klinische Immunologie (DGAKI)

Awards and Prizes

  • 09/2022 Bright Spark Award by the American Association of Immunology (AAI), awarded during Joint Meeting of the German Society of Immunology (DGfI) and the Austrian Society for Allergy and Immunology (ÖGAI)

  • 02/2022 Research Award Atopic Dermatitis, Arbeitsgemeinschaft Dermatologische Forschung

  • 09/2020 Georg Rajka Medal by the International Symposium on Atopic Dermatitis

  • 09/2016 Nachwuchsförderpreis der Deutschen Gesellschaft für Allergologie und klinische Immunologie (DGAKI)

  • 03/2013 Abstract prize / Travelling grant, Arbeitsgemeinschaft Dermatologische Forschung

  • 04/2023 Deutscher Neurodermitis-Preis der Deutschen Dermatologischen Gesellschaft (DDG)

Recommended Links

For further information about PD Dr. Rösner’s scientific work please check the following links:

10 Selected Publications

Zhang B*, Roesner LM*, Traidl S*, Koeken VACM, Xu CJ, Werfel T#, Li Y# (2023). Single-cell profiles reveal distinctive immune response in atopic dermatitis in contrast to psoriasis. Allergy. 78:439-453. *equal contribution

Roesner LM*, Farag AK*, Pospich R, Traidl S, Werfel T (2022). T-cell receptor sequencing specifies psoriasis as a systemic and atopic dermatitis as a skin-focused, allergen-driven disease. Allergy. 78:439-453. *equal contribution

Farag AK*, Roesner LM*, Wieschowski S, Heratizadeh A, Eiz-Vesper B, Kwok WW, Valenta R, Werfel T. (2021). Specific T cells targeting Staphylococcus aureus fibronectin-binding protein 1 induce a type 2/type 1 inflammatory response in sensitized atopic dermatitis patients. Allergy. *equal contribution

Roesner LM*, Ernst M*, Chen W, Begemann G, Kienlin P, Raulf MK, Lepenies B, Werfel T (2019). Human thioredoxin, a damage-associated molecular pattern and Malassezia-crossreactive autoallergen, modulates immune responses via the C-type lectin receptors Dectin-1 and Dectin-2. Sci Rep 9, 11210. *equal contribution

Traidl S, Kienlin P, Begemann G, Jing L, Koelle DM, Werfel T, Roesner LM (2018). Patients with atopic dermatitis and history of eczema herpeticum elicit herpes simplex virus-specific type 2 immune responses. J Allergy Clin Immunol 141, 1144-1147.e5.

Roesner LM, Kienlin P, Begemann G, Dittrich-Breiholz O, Werfel T (2017). Inflammatory marker analysis in psoriatic skin under topical phosphodiesterase 4 inhibitor treatment. J Allergy Clin Immunol 140, 1184-1187.

Roesner LM, Heratizadeh A, Wieschowski S, Mittermann I, Valenta R, Eiz-Vesper B, Hennig C, Hansen G, Falk CS, and Werfel T (2016). Alpha-NAC-specific autoreactive CD8+ T cells in atopic dermatitis are of an effector memory type and secrete IL-4 and IFN-gamma. J Immunol 196, 3245-3252.

Seltmann J*, Roesner LM*, von Hesler FW, Wittmann M, and Werfel T (2015). IL-33 impacts on the skin barrier by downregulating the expression of filaggrin. J Allergy Clin Immunol 135, 1659-1661 e1654. *equal contribution

Roesner LM, Floess S, Witte T, Olek S, Huehn J, and Werfel T (2015). Foxp3+ regulatory T cells are expanded in severe atopic dermatitis patients. Allergy 70, 1656-1660.

Roesner LM*, Heratizadeh A*, Begemann G, Kienlin P, Hradetzky S, Niebuhr M, Eiz-Vesper B, Hennig C, Hansen G, Baron-Bodo V, Moingeon P, and Werfel T (2015). Der p1 and Der p2-Specific T Cells Display a Th2, Th17, and Th2/Th17 Phenotype in Atopic Dermatitis. J Invest Dermatol 135, 2324-2327. *equal contribution


  PD Dr. Lennart M. Roesner
  Experimental Research, Department of Dermatology and Allergy, Hannover Medical School (MHH)
  Carl-Neuberg-Straße 1
30625 Hannover
  +49 511 532-5054