Exciting topics, interestingly presented: Every first and third Thursday (except during school holidays), RESIST scientists or top-class researchers from external institutions present their topics at the RESIST seminar series.
Attend these exciting seminars of the Cluster of Excellence RESIST and the GRK ACME, as a member of RESIST or as a colleague or student.
On WEDNESDAY, 29 April 2026 at 13:00, Prof. Antje Flieger, Division of Bacterial Enteropathogens and Legionella, Department of Infectious Diseases, Robert Koch Institute, Berlin, will give a talk with the title “Legionella and Its Secreted Phospholipases: A Universe of Influence on Host and Pathogen”.
About Professor Antje Flieger’s research
Legionella are Gram-negative rod-shaped bacteria and the causative agents of Legionnaires’ disease, a severe form of pneumonia that is fatal in approximately 9% of cases. According to a study by the Network for Community-Acquired Pneumonia (CAPNET), approximately 3.8% of all pneumonia cases in Germany are caused by Legionella, which corresponds to approximately 20,000 cases of Legionella infection per year. The goal of our research is to characterize virulence factors of Legionella. The focus here is on secreted phospholipases. At least 15 different phospholipases A, some of which also exhibit lysophospholipase A and glycerophospholipid:cholesterol acyltransferase activity, have been described to date for L. pneumophila. Analysis of the pathogen’s phospholipolytic activity is expected to provide a better understanding of the molecular processes involved in the modulation and destruction of lung cells during Legionnaires’ disease. This forms the basis for advancing the inhibition of cytolytic factors as a new therapeutic approach for improved treatment of patients with Legionnaires’ disease.
The lecture will take place in Lecture Hall H, Building J01 of the Hannover Medical School.
If you are interested in participating online, please contact RESIST@mh-hannover.de.
Do you have any questions or suggestions about the RESIST seminar series? Then please contact us.