Publication highlights

The publications mentioned here show particularly noteworthy current results of our excellent research.

Astrocytic-OTUD7B ameliorates murine experimental autoimmune encephalomyelitis by stabilizing glial fibrillary acidic protein and preventing inflammation.

Harit, K., W. Yi, A. Jeron, J. Schmidt, R. Beckervordersandforth, E. Wyler, A. Manukyan, M. Deckert, H. Radbruch, T. Conrad, J. Altmüller, M. Landthaler, X. Wang, G. Nishanth, and D. Schlüter.
Nat Commun

Acsbg1 maintains intestinal immune homeostasis and controls inflammation by regulating ST2(+) Tregs.

Palatella, M., F. Kruse, H. Ji, A. K. Loriani Fard, M. Becker, C. Daniel, M. Rohm, and J. Huehn.
Mucosal Immunol

High Prevalence and Local Dissemination of Daptomycin-Resistance Mutations for Enterococcus faecium in Cirrhotic Patients.

Deng, Z. L., N. Safaei, S. L. Schütte, V. Ohlendorf, B. Maasoumy, and A. C. McHardy.
Gastroenterology

Laser-assisted microbial culturomics

Qu, T., L. Koch, R. Mukherjee, Y. Tu, A. L. Seidel, L. D. Püttmann, A. Winkel, I. Yang, J. Grischke, D. Liu, W. F. Wolkers, S. Kittler, B. Chichkov, M. Stiesch, and S. P. Szafrański.
Nat Commun

Selected RESIST publications

Here you will find publications by RESIST researchers.
  1. Repression of varicella zoster virus gene expression during quiescent infection in the absence of detectable histone deposition. Wang J, Brückner N, Weissmann S, Günther T, Zhu S, Vogt C, Sun G, Guo R, Bruno R, Ritter B, Steinbrück L, Kaufer BB, Depledge DP, Grundhoff A, Viejo-Borbolla A. PLoS Pathog. 2025 Feb 10;21(2):e1012367. doi: 10.1371/journal.ppat.1012367. Epub ahead of print. PMID: 39928684.
  2. The effect of HLA genotype on disease onset and severity in CTLA-4 insufficiency
    S. Posadas-Cantera, N. Mitsuiki, F. Emmerich, V. Patiño, H. M. Lorenz, O. Neth, et al. Front Immunol 2025 Vol. 15 Pages 1447995 Accession Number: 39835139 PMCID: PMC11744039 DOI: 10.3389/fimmu.2024.1447995
  3. Influenza Immunization in Very-Low-Birth-Weight Infants: Epidemiology and Long-Term Outcomes M. T. Dammann, H. Kraft, G. Stichtenoth, K. Hanke, M. Zemlin, J. Soler Wenglein, et al. Vaccines (Basel) 2025 Vol. 13 Issue 1 Accession Number: 39852821 PMCID: PMC11769184 DOI: 10.3390/vaccines13010042
  4. A corpus of GA4GH phenopackets: Case-level phenotyping for genomic diagnostics and discovery D. Danis, M. J. Bamshad, Y. Bridges, A. Caballero-Oteyza, P. Cacheiro, L. C. Carmody, et al. HGG Adv 2025 Vol. 6 Issue 1 Pages 100371 Accession Number: 39394689 PMCID: PMC11564936 DOI: 10.1016/j.xhgg.2024.100371
  5. Identification of optimal portal pressure decrease to control ascites while minimizing hepatic encephalopathy after TIPS: A multicenter study M. A. Kabelitz, L. Hartl, G. Schaub, A. Tiede, H. Rieland, A. Kornfehl, et al. Hepatology 2025 Accession Number: 39773850 DOI: 10.1097/hep.0000000000001219
  6. Integrative deep immune profiling of the elderly reveals systems-level signatures of aging, sex, smoking, and clinical traits L. Riemann, R. Gutierrez, I. Odak, J. Barros-Martins, L. M. Roesner, X. Leon Lara, et al. EBioMedicine 2025 Vol. 112 Pages 105558 Accession Number: 39862806 DOI: 10.1016/j.ebiom.2025.105558
  7. Comparison of clinical outcomes in patients with refractory ascites treated with either TIPS, tunneled peritoneal catheter, or ascites pump S. L. Schütte, A. Tiede, J. B. Mauz, H. Rieland, M. Kabelitz, R. Iker, et al. Hepatol Commun 2025 Vol. 9 Issue 2 Accession Number: 39813591 PMCID: PMC11737501 DOI: 10.1097/hc9.0000000000000620
  8. A clinical protocol for a German birth cohort study of the Maturation of Immunity Against respiratory viral Infections (MIAI) C. R. Hartmann, R. Khan, J. Schöning, M. Richter, M. Willers, S. Pirr, et al. Front Immunol 2024 Vol. 15 Pages 1443665 Accession Number: 39355253 PMCID: PMC11442434 DOI: 10.3389/fimmu.2024.1443665
  9. Editorial: Stopping NUCs-When to Restart NUCs for the Best Outcome? M. Urbanek-Quaing and M. Cornberg Aliment Pharmacol Ther 2025 Vol. 61 Issue 1 Pages 204-205 Accession Number: 39499186 DOI: 10.1111/apt.18370
  10. Ablation of the deubiquitinating enzyme cylindromatosis (CYLD) augments STAT1-mediated M1 macrophage polarization and fosters Staphylococcus aureus control C. Schmidt, K. Harit, S. Traidl, M. Naumann, T. Werfel, L. M. Roesner, et al. Front Immunol 2025 Vol. 16 Pages 1507989 Accession Number: 39958342 PMCID: PMC11827430 DOI: 10.3389/fimmu.2025.1507989
  11. TIGIT-expression on natural killer cell subsets is an early indicator of alleviating liver inflammation following bulevirtide treatment in chronic hepatitis D P. C. Chen, K. Deterding, S. A. Engelskircher, K. Port, L. Sandmann, A. Chakkadath, et al. Hepatology 2025 Accession Number: 39847437 DOI: 10.1097/hep.0000000000001238
  12. Phase 2 Randomised Study of Bulevirtide as Monotherapy or Combined With Peg-IFNα-2a as Treatment for Chronic Hepatitis Delta P. Lampertico, P. O. Bogomolov, V. Chulanov, T. Stepanova, V. Morozov, L. Allweiss, et al. Liver Int 2025 Vol. 45 Issue 2 Pages e70008 Accession Number: 39853842 PMCID: PMC11760647 DOI: 10.1111/liv.70008
  13. Value and Kinetics of Virological Markers in the Natural Course of Chronic Hepatitis D Virus Infection L. Sandmann, V. Ohlendorf, A. Ehrenbauer, B. Bremer, A. R. M. Kraft, M. Cornberg, et al. Liver Int 2025 Vol. 45 Issue 2 Pages e70003 Accession Number: 39846714 PMCID: PMC11756344 DOI: 10.1111/liv.70003
  14. microGWAS: a computational pipeline to perform large-scale bacterial genome-wide association studies J. Burgaya, B. F. Damaris, J. Fiebig and M. Galardini Microb Genom 2025 Vol. 11 Issue 2 Accession Number: 39932497 DOI: 10.1099/mgen.0.001349
  15. Identification and characterization of the functional tetrameric UDP-glucose pyrophosphorylase from Klebsiella pneumoniae I. Ramón Roth, P. Kats, T. Fiebig, F. Routier, R. Fedorov, L. Dirr, et al. mBio 2025 Vol. 16 Issue 2 Pages e0207124 Accession Number: 39704542 PMCID: PMC11796359 DOI: 10.1128/mbio.02071-24
  16. Highly potent quinoxalinediones inhibit α-hemolysin and ameliorate Staphylococcus aureus lung infections A. Shekhar, R. Di Lucrezia, K. Jerye, V. S. Korotkov, K. Harmrolfs, K. Rox, et al. Cell Host Microbe 2025 Accession Number: 40168998 DOI: 10.1016/j.chom.2025.03.006
  17. Combinatorial Fc modifications for complementary antibody functionality Y. C. Bartsch, N. E. Webb, E. Burgess, J. Kang, D. A. Lauffenburger and B. D. Julg MAbs 2025 Vol. 17 Issue 1 Pages 2465391 Accession Number: 39950649 PMCID: PMC11834420 DOI: 10.1080/19420862.2025.2465391
  18. Dysphoric Milk Ejection Reflex: Prevalence, persistence, and implications R. Cappenberg, J. G. Garcia, I. Liolios, C. Happle and A. Zychlinsky Scharff Eur J Obstet Gynecol Reprod Biol 2025 Vol. 308 Pages 127-131 Accession Number: 40043530 DOI: 10.1016/j.ejogrb.2025.02.051
  19. Molecular mechanisms of hotspot variants in cytoskeletal β-actin associated with Baraitser-Winter syndrome  J. N. Greve and D. J. Manstein Febs j 2025 Accession Number: 39930656 DOI: 10.1111/febs.70018
  20. Single-cell immune aging clocks reveal inter-individual heterogeneity during infection and vaccination W. Li, Z. Zhang, S. Kumar, J. Botey-Bataller, M. Zoodsma, A. Ehsani, et al. Nat Aging 2025 Accession Number: 40044970 DOI: 10.1038/s43587-025-00819-z
  21. Acsbg1 regulates differentiation and inflammatory properties of CD4+ T cells M. Palatella, F. Kruse, S. Glage, A. Bleich, M. Greweling-Pils and J. Huehn Eur J Microbiol Immunol (Bp) 2025 Accession Number: 39937199 DOI: 10.1556/1886.2025.00003
  22. Distinctive CD8(+) T cell activation by antigen-presenting plasmacytoid dendritic cells compared to conventional dendritic cells R. M. van der Sluis, J. L. García-Rodríguez, I. H. Nielsen, A. Gris-Oliver, J. Becker, B. Costa, et al. Cell Rep 2025 Vol. 44 Issue 3 Pages 115413 Accession Number: 40073016 DOI: 10.1016/j.celrep.2025.115413
  23. TIPS insertion and systemic inflammation: Is it ever too late to lower portal pressure? A. Tiede and B. Maasoumy Clin Mol Hepatol 2025 Accession Number: 39925001 DOI: 10.3350/cmh.2025.0135
  24. Broadly neutralizing antibodies isolated from HEV convalescents confer protective effects in human liver-chimeric mice G. Ssebyatika, K. Dinkelborg, L. J. Ströh, F. Hinte, L. Corneillie, L. Hueffner, et al. Nat Commun 2025 Vol. 16 Issue 1 Pages 1995 Accession Number: 40011441 DOI: 10.1038/s41467-025-57182-1
  25. Reappraisal of IgG subclass deficiencies: a retrospective comparative cohort study D. Dogru, Y. Dogru, F. Atschekzei, A. Elsayed, N. Dubrowinskaja, D. Ernst, et al. Front Immunol 2025 Vol. 16 Pages 1552513 Accession Number: 40313941 PMCID: PMC12043879 DOI: 10.3389/fimmu.2025.1552513
  26. A novel hemizygous nonsense variant in DOCK11 causes systemic inflammation and immunodeficiency A. Elsayed, S. von Hardenberg, F. Atschekzei, P. Siek, T. Witte, G. Sogkas, et al. Clin Immunol 2025 Vol. 276 Pages 110504 Accession Number: 40274249 DOI: 10.1016/j.clim.2025.110504
  27. A precision medicine approach to primary immunodeficiency disease: Ataluren strikes nonsense mutations once again L. Lentini, R. Perriera, F. Corrao, R. Melfi, M. Tutone, P. S. Carollo, et al. Mol Ther 2025 Accession Number: 40158206 DOI: 10.1016/j.ymthe.2025.03.045
  28. The intestinal microbiome and metabolome discern disease severity in cytotoxic T-lymphocyte-associated protein 4 deficiency P. Chandrasekaran, M. Krausz, Y. Han, N. Mitsuiki, A. Gabrysch, C. Nöltner, et al. Microbiome 2025 Vol. 13 Issue 1 Pages 51 Accession Number: 39934899 PMCID: PMC11817180 DOI: 10.1186/s40168-025-02028-7
  29. Bruton’s tyrosine kinase (BTK) and matrix metalloproteinase-9 (MMP-9) regulate NLRP3 inflammasome-dependent cytokine and neutrophil extracellular trap responses in primary neutrophils V. N. C. Leal, F. Bork, M. Mateo Tortola, J. C. von Guilleaume, C. L. Greve, S. Bugl, et al. J Allergy Clin Immunol 2025 Vol. 155 Issue 2 Pages 569-582 Accession Number: 39547282 DOI: 10.1016/j.jaci.2024.10.035
  30. Unlocking the antiviral arsenal: Structure-guided optimization of small-molecule inhibitors against RSV and hCoV-229E C. Karhan, S. M. Sake, A. P. Gunesch, C. Grethe, B. Hellwinkel, N. M. Köhler, et al. Eur J Med Chem 2025 Vol. 291 Pages 117282 Accession Number: 40199027 DOI: 10.1016/j.ejmech.2025.117282
  31. Long-term histone lactylation connects metabolic and epigenetic rewiring in innate immune memory A. Ziogas, B. Novakovic, L. Ventriglia, N. Galang, K. A. Tran, W. Li, et al. Cell 2025 Accession Number: 40318634 DOI: 10.1016/j.cell.2025.03.048
  32. Transmissible Staphylococcus pseudintermedius thwarts neutrophil extracellular trap-driven containment to promote invasive disease R. Haller, Y. Cai, N. de Buhr, J. C. Rieder, D. Schlüter, C. Baier, et al. Emerg Microbes Infect 2025 Vol. 14 Issue 1 Pages 2482709 Accession Number: 40172876 PMCID: PMC12001851 DOI: 10.1080/22221751.2025.2482709
  33. Using structure-function information from IFN-γ-binding proteins and biased agonists to uncouple immunostimulatory and immunosuppressive activities L. Mendes-Monteiro and A. Viejo-Borbolla Trends Immunol 2025 Accession Number: 40102163 DOI: 10.1016/j.it.2025.02.013
  34. Giant RNA genomes: Roles of host, translation elongation, genome architecture, and proteome in nidoviruses B. W. Neuman, A. Smart, O. Gilmer, R. P. Smyth, J. Vaas, N. Böker, et al. Proc Natl Acad Sci U S A 2025 Vol. 122 Issue 7 Pages e2413675122 Accession Number: 39928875 PMCID: PMC11848433 DOI: 10.1073/pnas.2413675122
  35. Oxidative phosphorylation is a key feature of neonatal monocyte immunometabolism promoting myeloid differentiation after birth G. Ehlers, A. M. Tödtmann, L. Holsten, M. Willers, J. Heckmann, J. Schöning, et al. Nat Commun 2025 Vol. 16 Issue 1 Pages 2239 Accession Number: 40050264 PMCID: PMC11885822 DOI: 10.1038/s41467-025-57357-w
  36. The neonate respiratory microbiome S. Pirr, M. Willers and D. Viemann Acta Physiol (Oxf) 2025 Vol. 241 Issue 2 Pages e14266Accession Number: 39840649 PMCID: PMC11752418 DOI: 10.1111/apha.14266
  37. Distinct clusters of bacterial and fungal microbiota in end-stage liver cirrhosis correlate with antibiotic treatment, intestinal barrier impairment, and systemic inflammation L. Buttler, D. A. Velázquez-Ramírez, A. Tiede, A. M. Conradi, S. Woltemate, R. Geffers, et al. Gut Microbes 2025 Vol. 17 Issue 1 Pages 2487209 Accession Number: 40255076 DOI: 10.1080/19490976.2025.2487209
  38. Reply: Refining epigenetic insights in HBV-Specific T Cell restoration Y. H. Chou and M. Cornberg Hepatology 2025 Accession Number: 40168461 DOI: 10.1097/hep.0000000000001340
  39. Limited Value of HBV-RNA for Relapse Prediction After Nucleos(t)ide Analogue Withdrawal in HBeAg-negative Hepatitis B Patients V. Ohlendorf, M. Wübbolding, C. Höner Zu Siederdissen, B. Bremer, K. Deterding, H. Wedemeyer, et al. J Viral Hepat 2025 Vol. 32 Issue 4 Pages e14026 Accession Number: 39425534 PMCID: PMC11887418 DOI: 10.1111/jvh.14026
  40. Sequence analysis of the hepatitis D virus across genotypes reveals highly conserved regions amidst evidence of recombination S. Chowdhury, C. Jacobsen, D. P. Depledge, H. Wedemeyer, L. Sandmann and H. Kefalakes Virus Evol 2025 Vol. 11 Issue 1 Pages veaf012 Accession Number: 40123834 PMCID: PMC11927530 DOI: 10.1093/ve/veaf012
  41. A novel in vitro system for simultaneous infections with hepatitis B, C, D and E viruses R. Fouillé, E. R. Verrier, A. De Meyer, L. Verhoye, M. Michelet, R. Barnault, et al JHEP Rep 2025 Vol. 7 Issue 5 Pages 101383 Accession Number: 40242313 PMCID: PMC11999259 DOI: 10.1016/j.jhepr.2025.101383
  42. Frequency, Severity and Impact of Pegylated Interferon Alpha-Associated Flares in Hepatitis D Infection S. Hardtke, C. Yurdaydin, F. A. Caruntu, M. G. Curescu, K. Yalcin, U. S. Akarca, et al. J Viral Hepat 2025 Vol. 32 Issue 4 Pages e70022 Accession Number: 40087915 PMCID: PMC11909584 DOI: 10.1111/jvh.70022
  43. Establishment and characterization of persistent Pseudomonas aeruginosa infections in air-liquid interface cultures of human airway epithelial cells S. Bouheraoua, S. Cleeves, M. Preusse, M. Müsken, P. Braubach, M. Fuchs, et al. Infect Immun 2025 Pages e0060324 Accession Number: 39964154 DOI: 10.1128/iai.00603-24
  44. Profiling the nasopharyngeal Microbiome in patients with community-acquired pneumonia caused by Streptococcus pneumoniae: diagnostic challenges and ecological insights C. Zubiria-Barrera, L. Y. Yamba, T. E. Klassert, M. Bos, J. Ahl, L. Wasserstrom, et al. Med Microbiol Immunol 2025 Vol. 214 Issue 1 Pages 19 Accession Number: 40208342 PMCID: PMC11985632 DOI: 10.1007/s00430-025-00828-0
  45. Uncovering nitroxoline activity spectrum, mode of action and resistance across Gram-negative bacteria E. Cacace, M. Tietgen, M. Steinhauer, A. Mateus, T. G. Schultze, M. Eckermann, et al. Nat Commun 2025 Vol. 16 Issue 1 Pages 3783 Accession Number: 40263263 DOI: 10.1038/s41467-025-58730-5
  46. Interaction of human cytomegalovirus pUL52 with major components of the viral DNA encapsidation network underlines its essential role in genome cleavage-packaging S. Harmening, B. Bogdanow, K. Wagner, F. Liu, M. Messerle and E. M. Borst J Virol 2025 Pages e0220124 Accession Number: 40062846 DOI: 10.1128/jvi.02201-24
  47. Herpes simplex virus assembly and spread in murine skin after infection from the outside T. Richardo, X. Liu, K. Döhner, T. Y. Chao, A. Buch, A. Binz, et al. J Virol 2025 Pages e0163824 Accession Number: 39945537 DOI: 10.1128/jvi.01638-24
  48. Adenovirus E1B-55K interferes with cellular IκB kinase complex subunit proteins W. H. Ip, L. D. Bertzbach, S. Schreiner and T. Dobner Front Immunol 2025 Vol. 16 Pages 1532742 Accession Number: 40103806 PMCID: PMC11913716 DOI: 10.3389/fimmu.2025.1532742
  49. CAMI Benchmarking Portal: online evaluation and ranking of metagenomic software F. Meyer, G. Robertson, Z. L. Deng, D. Koslicki, A. Gurevich and A. C. McHardy Nucleic Acids Res 2025 Accession Number: 40331433 DOI: 10.1093/nar/gkaf369
  50. Protective function of ex vivo-expanded CD8 T cells in a mouse model of adoptive therapy for cytomegalovirus infection depends on integrin beta 1 but not CXCR3, CTLA4, or PD-1 expression X. Liu, R. Gutierrez Jauregui, Y. Lueder, S. Halle, L. Ospina-Quintero, C. Ritter, et al. J Leukoc Biol 2025 Vol. 117 Issue 4 Accession Number: 40276928 DOI: 10.1093/jleuko/qiae256
  51. Developmental features and unique characteristics of peptide-specific PLZF(+) innate-like T cells in mice A. Hassan, N. Heise, A. Schimrock, S. Willenzon, I. Ravens, R. Förster, et al. Nat Commun 2025 Vol. 16 Issue 1 Pages 5274 Accession Number: 40480992 PMCID: PMC12144119 DOI: 10.1038/s41467-025-60617-4
  52. Identification and Genomic Characterization of Known and Novel Highly Divergent Sapoviruses in Frugivorous and Insectivorous Bats in Nigeria U. E. George, L. De Coninck, O. A. George, T. Adeyanju, A. Oragwa, J. Kamani, et al. EMI Anim Environ 2025 Pages 1-37 Accession Number: 40385501 PMCID: PMC12080456 DOI: 10.1080/29986990.2025.2503155
  53. Distinct Inflammatory Imprint in Non-Cirrhotic and Cirrhotic Patients Before and After Direct-Acting Antiviral Therapy M. Witte, C. Oltmanns, J. Tauwaldt, H. Schmaus, J. Mischke, G. Grabert, et al. Clin Mol Hepatol 2025 Accession Number: 40462644 DOI: 10.3350/cmh.2025.0292
  54. Droplet Digital PCR: A Powerful Tool for Accurate Quantification of Hepatitis D Virus RNA Levels and Verification of Detection Limits L. Sandmann, L. Windzio, B. Bremer, S. Falak, J. Beheim-Schwarzbach, A. Kummrow, et al. J Viral Hepat 2025 Vol. 32 Issue 6 Pages e70036 Accession Number: 40372088 PMCID: PMC12080313 DOI: 10.1111/jvh.70036
  55. Clinical manifestations, disease penetrance, and treatment in individuals with SOCS1 insufficiency: a registry-based and population-based study J. Hadjadj, A. Wolfers, O. Borisov, D. Hazard, R. Leahy, M. Jeanpierre, et al. Lancet Rheumatol 2025 Vol. 7 Issue 6 Pages e391-e402 Accession Number: 40024253 DOI: 10.1016/s2665-9913(24)00348-5
  56. RNase 7 and Th cytokines synergistically increase the secretion of interleukin-6 from keratinocytes S. Chopra, J. Siegl, V. Kopfnagel, S. Dreyer, F. Rademacher, J. Lokau, et al. Sci Rep 2025 Vol. 15 Issue 1 Pages 19396 Accession Number: 40461723 DOI: 10.1038/s41598-025-04403-8
  57. SKIN MANIFESTATIONS IN ADULTS WITH CHRONIC GRANULOMATOUS DISEASE IN THE UNITED KINGDOM L. Campos, C. A. Henríquez, G. Meligonis, S. Tadros, D. M. Lowe, B. Grimbacher, et al. J Allergy Clin Immunol Pract 2025 Accession Number: 40383433 DOI: 10.1016/j.jaip.2025.04.058
  58. In vivo macrophage engineering for renal cancer therapy D. Basílio-Queirós and N. Lachmann Nat Cancer 2025 Accession Number: 40301654 DOI: 10.1038/s43018-025-00912-7
  59. The RESIST Senior Individuals Cohort: Design, participant characteristics and aims. L. M. Roesner, M. K. Gupta, V. Kopfnagel, N. van Unen, Y. Kemmling, J. K. Heise, et al. Geroscience 2025 Vol. 47 Issue 3 Pages 3299-3310 Accession Number: 39141284 PMCID: PMC12181556 DOI: 10.1007/s11357-024-01299-6
  60. Hepatitis D Virus Infection: Pathophysiology, Epidemiology and Treatment. Report From the Third Delta Cure Meeting 2024 E. Degasperi, L. Sandmann, H. Wedemeyer and P. Lampertico Liver Int 2025 Vol. 45 Issue 7 Pages e70189 Accession Number: 40540405 DOI: 10.1111/liv.70189
  61. Origin of Hypofunctional CD103(+) NK Cells in Cirrhosis-Associated Ascites C. Niehaus, D. Geanon, A. Lietzau, M. Jankovic, C. Maucourant, B. Maasoumy, et al. Eur J Immunol 2025 Vol. 55 Issue 6 Pages e51311 Accession Number: 40498379 PMCID: PMC12154167 DOI: 10.1002/eji.202451311
  62. LRBA deficiency impairs autophagy and contributes to enhanced antigen presentation and T-cell dysregulation E. Sindram, M. C. Deau, L. A. Ligeon, P. Sanchez-Martin, S. Nestel, S. Jung, et al.EMBO Rep 2025 Accession Number: 40550954 DOI: 10.1038/s44319-025-00504-7
  63. Molecular signatures discriminating different types of rejection in human liver transplants B. Engel, A. Alaswad, A. Campos-Murguia, M. Zoodsma, A. Klingbeil, P. Ruiz, et al.J Hepatol 2025 Accession Number: 40669521 DOI: 10.1016/j.jhep.2025.06.036
  64. tRNA hydroxylation is an epitranscriptomic modulator of metabolic states affecting Pseudomonas aeruginosa pathogenicity Y. N. Frommeyer, N. O. Gomez, M. Preusse, A. Arce-Rodriguez, K. Neubauer, B. Kennepohl, et al. Nucleic Acids Res 2025 Vol. 53 Issue 14 Accession Number: 40705922 DOI: 10.1093/nar/gkaf719
  65. Assessing early post-TIPS hepatic encephalopathy and survival: What key factors remain unaddressed? M. A. Kabelitz, L. Sandmann and B. Maasoumy Clin Gastroenterol Hepatol 2025 Accession Number: 40633892 DOI: 10.1016/j.cgh.2025.07.001
  66. Short- and long-term impact of aseptic bathing strategies on the skin microbiome in ICU patients T. E. Klassert, C. Zubiria-Barrera, L. A. Denkel, M. Lopez, R. Neubert, A. Keles Slevogt, et al.Med Microbiol Immunol 2025 Vol. 214 Issue 1 Pages 34Accession Number: 40694140 DOI: 10.1007/s00430-025-00843-1
  67. Single-cell analysis of mature hepatocytes reveals an IRF1-driven restriction of HDV infection F. Lange, J. Garn, M. Bruhn, T. Pietschmann and A. Carpentier JHEP Rep 2025 Vol. 7 Issue 8 Pages 101429 Accession Number: 40677689 PMCID: PMC12269598 DOI: 10.1016/j.jhepr.2025.101429
  68. MAVS signaling of long-lived brain-resident myeloid cells is needed during viral encephalitis to adjust the transcriptome of CNS infiltrating CD8(+) T cells A. Pavlou, L. Ghita, F. Mulenge, I. Waltl, O. L. Gern, P. K. Larsen, et al. J Neuroinflammation 2025 Vol. 22 Issue 1 Pages 175 Accession Number: 40619428 PMCID: PMC12232705 DOI: 10.1186/s12974-025-03497-1
  69. Different CMV-specific effector T cell subtypes are associated with age, CMV serostatus, and increased systolic blood pressure L. M. Roesner, B. Bošnjak, S. Traidl, J. Huehn, R. Förster and T. Werfel Immun Ageing 2025 Vol. 22 Issue 1 Pages 27 Accession Number: 40611275 PMCID: PMC12224750 DOI: 10.1186/s12979-025-00523-x
  70. In Vitro Culture of Primary Mouse Neurons to Study Neuronal Infection G. Sun and A. Viejo-Borbolla Methods Mol Biol 2025 Vol. 2950 Pages 73-85 Accession Number: 40622529 DOI: 10.1007/978-1-0716-4674-8_6
  71. Identification of the human cytomegalovirus gHgLgO trimer as the central player in virion infectivity L. Thiessen, R. Garuti, L. Kubic, M. Kösters, D. Amarambedu Selvakumar, T. Krey, et al. PLoS Pathog 2025 Vol. 21 Issue 7 Pages e1013341 Accession Number: 40705828 DOI: 10.1371/journal.ppat.1013341
  72. Genotype and transcript processing of the tumour necrosis factor receptor TNFRSF1A in epithelial cells: implications for survival in cystic fibrosis A. Uden, I. Dunsche, S. Janciauskiene, S. Gräber, L. Feng, S. Tamm, et al. EBioMedicine 2025 Vol. 118 Pages 105848 Accession Number: 40645008 PMCID: PMC12275981 DOI: 10.1016/j.ebiom.2025.105848
  73. Suppression of gut colonization by multidrug-resistant Escherichia coli clinical isolates through cooperative niche exclusion M. Wende, L. Osbelt, L. Eisenhard, T. R. Lesker, B. F. Damaris, U. Mutukumarasamy, et al. Nat Commun 2025 Vol. 16 Issue 1 Pages 5426 Accession Number: 40593813 DOI: 10.1038/s41467-025-61327-7
  74. Differences in the incidence of cirrhosis-associated complications between MASLD, MetALD and ALD among patients with decompensated liver cirrhosis L. Buttler, A. Tiede, M. Griemsmann, H. Rieland, J. B. Mauz, H. Wedemeyer, et al. PLoS One 2025 Vol. 20 Issue 6 Pages e0325673 ,Accession Number: 40569928 PMCID: PMC12200844 DOI: 10.1371/journal.pone.0325673
  75. Novel non-coding FOXP3 transcript isoform associated to potential transcriptional interference in human regulatory T cells M. Cases, N. Ritter, H. Rincon-Arevalo, S. Kroh, A. Adam, M. Kirchner, et al. RNA Biol 2025 Vol. 22 Issue 1 Pages 1-20 Accession Number: 40605177 DOI: 10.1080/15476286.2025.2502719
  76. Exploring virus-host interactions through combined proteomic approaches identifies BANF1 as a new essential factor for African Swine Fever Virus J. Dupré, K. M. Dolata, G. Pei, A. Molouki, L. C. Goatley, R. Küchler, et al. Mol Cell Proteomics 2025 Pages 101038 Accession Number: 40707000 DOI: 10.1016/j.mcpro.2025.101038
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  132. The Inflammasome Activity of NLRP3 Is Independent of NEK7 in HEK293 Cells Co-Expressing ASC. Machtens DA, Bresch IP, Eberhage J, Reubold TF, Eschenburg S.  Int J Mol Sci. 2022 Sep 7;23(18):10269. doi: 10.3390/ijms231810269. PMID: 36142182; PMCID: PMC9499477.
  133. Therapeutic targeting of endoplasmic reticulum stress in acute graft-versus-host disease. Haring E, Andrieux G, Uhl FM, Krausz M, Proietti M, Sauer B, Esser PR, Martin SF, Pfeifer D, Schmitt-Graeff A, Duyster J, Köhler N, Grimbacher B, Boerries M, Aumann K, Zeiser R, Apostolova P.  Haematologica. 2022 Jul 1;107(7):1538-1554. PMID: 34407601; PMCID: PMC9244832.
  134. Copy Number Analysis in a Large Cohort Suggestive of Inborn Errors of Immunity Indicates a Wide Spectrum of Relevant Chromosomal Losses and Gains. Wan R, Schieck M, Caballero-Oteyza A, Hofmann W, Cochino AV, Shcherbina A, Sherkat R, Wache-Mainier C, Fernandez A, Sultan M, Illig T, Grimbacher B, Proietti M, Steinemann D.  J Clin Immunol. 2022 Jul;42(5):1083-1092. Epub 2022 Apr 29.
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  137. Identification of variants in genes associated with autoinflammatory disorders in a cohort of patients with psoriatic arthritis F. Atschekzei, N. Dubrowinskaja, M. Anim, T. Thiele, T. Witte and G. Sogkas RMD Open 2022 Vol. 8 Issue 2 Accession Number: 36113963 PMCID: PMC9486391 DOI: 10.1136/rmdopen-2022-002561
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  2. Role of the gut microbiota in airway immunity and host defense against respiratory infections. Willers M, Viemann D. Biol Chem. 2021 Oct 4. doi: 10.1515/hsz-2021-0281. Epub ahead of print. PMID: 34599869.
  3. Bowel Histology of CVID Patients Reveals Distinct Patterns of Mucosal Inflammation. van Schewick CM, Lowe DM, Burns SO, Workman S, Symes A, Guzman D, Moreira F, Watkins J, Clark I, Grimbacher B.  J Clin Immunol. 2021 Oct 1. doi: 10.1007/s10875-021-01104-5. Epub ahead of print. PMID: 34599484.
  4. Specific T cells targeting Staphylococcus aureus fibronectin-binding protein 1 induce a type 2/type 1 inflammatory response in sensitized atopic dermatitis patients. Farag AK, Roesner LM, Wieschowski S, Heratizadeh A, Eiz-Vesper B, Kwok WW, Valenta R, Werfel T. Allergy. 2021 Oct 3. doi: 10.1111/all.15120. Epub ahead of print. PMID: 34601735.
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  7. Klebsiella oxytoca causes colonization resistance against multidrug-resistant K. pneumoniae in the gut via cooperative carbohydrate competition. Osbelt L, Wende M, Almási É, Derksen E, Muthukumarasamy U, Lesker TR, Galvez EJC, Pils MC, Schalk E, Chhatwal P, Färber J, Neumann-Schaal M, Fischer T, Schlüter D, Strowig T. Cell Host Microbe. 2021 Sep 29:S1931-3128(21)00419-4. doi: 10.1016/j.chom.2021.09.003. Epub ahead of print. PMID: 34610293.
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  9. Diagnostic Yield and Therapeutic Consequences of Targeted Next-Generation Sequencing in Sporadic Primary Immunodeficiency. Sogkas G, Dubrowinskaja N, Schütz K, Steinbrück L, Götting J, Schwerk N, Baumann U, Grimbacher B, Witte T, Schmidt RE, Atschekzei F.  Int Arch Allergy Immunol. 2021 Oct 7:1-13. doi: 10.1159/000519199. Epub ahead of print. PMID: 34619682.
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  12. Generation of hiPSC-derived low threshold mechanoreceptors containing axonal termini resembling bulbous sensory nerve endings and expressing Piezo1 and Piezo2. Zhu S, Stanslowsky N, Fernández-Trillo J, Mamo TM, Yu P, Kalmbach N, Ritter B, Eggenschwiler R, Ouwendijk WJD, Mzinza D, Tan L, Leffler A, Spohn M, Brown RJP, Kropp KA, Kaever V, Ha TC, Narayanan P, Grundhoff A, Förster R, Schambach A, Verjans GMGM, Schmidt M, Kispert A, Cantz T, Gomis A, Wegner F, Viejo-Borbolla A. Stem Cell Res. 2021 Sep 11;56:102535. doi: 10.1016/j.scr.2021.102535. Epub ahead of print. PMID: 34607262.
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  17. Mesenteric Lymph Node Transplantation in Mice to Study Immune Responses of the Gastrointestinal Tract. Haroon Shaikh, Juan Gamboa Vargas, Zeinab Mokhtari, Katja J. Jarick, Maria Ulbrich, Josefina Peña Mosca, Estibaliz Arellano Viera, Caroline Graf, Duc-Dung Le, Katrin G. Heinze, Maike Büttner-Herold, Andreas Rosenwald, Joern Pezoldt, Jochen Huehn, Andreas Beilhack.  Front Immunol. 2021; 12: 689896. Published online 2021 Jul 26.
  18. Concatemeric Broccoli reduces mRNA stability and induces aggregates. Rink MR, Baptista MAP, Flomm FJ, Hennig T, Whisnant AW, Wolf N, Seibel J, Dölken L, Bosse JB. PLoS One. 2021 Aug 4;16(8):e0244166. doi: 10.1371/journal.pone.0244166. eCollection 2021. PMID: 34347781 Free PMC article.
  19. Quo vadis clinical diagnostic microbiology? Haag S, Häussler S. Clin Microbiol Infect. 2021 Jul 26:S1198-743X(21)00404-3. doi: 10.1016/j.cmi.2021.07.013. Online ahead of print. PMID: 34325069 No abstract available.
  20. Tbx21 and Foxp3 Are Epigenetically Stabilized in T-Bet+ Tregs That Transiently Accumulate in Influenza A Virus-Infected Lungs. Elfaki Y, Yang J, Boehme J, Schultz K, Bruder D, Falk CS, Huehn J, Floess S. Int J Mol Sci. 2021 Jul 14;22(14):7522. doi: 10.3390/ijms22147522. PMID: 34299148 Free PMC article.
  21. Sequential MAVS and MyD88/TRIF signaling triggers anti-viral responses of tick-borne encephalitis virus-infected murine astrocytes. Ghita L, Breitkopf V, Mulenge F, Pavlou A, Gern OL, Durán V, Prajeeth CK, Kohls M, Jung K, Stangel M, Steffen I, Kalinke U. J Neurosci Res. 2021 Jul 23. doi: 10.1002/jnr.24923. Online ahead of print. PMID: 34296786
  22. Distribution of major lymphocyte subsets and memory T-cell subpopulations in healthy adults employing GLP-conforming multicolor flow cytometry. Schultze-Florey CR, Chukhno E, Goudeva L, Blasczyk R, Ganser A, Prinz I, Förster R, Koenecke C, Odak I. Leukemia. 2021 Jul 21. doi: 10.1038/s41375-021-01348-5. Online ahead of print. PMID: 34290358 No abstract available.
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  24. Immune responses against SARS-CoV-2 variants after heterologous and homologous ChAdOx1 nCoV-19/BNT162b2 vaccination. Barros-Martins J, Hammerschmidt SI, Cossmann A, Odak I, Stankov MV, Morillas Ramos G, Dopfer-Jablonka A, Heidemann A, Ritter C, Friedrichsen M, Schultze-Florey C, Ravens I, Willenzon S, Bubke A, Ristenpart J, Janssen A, Ssebyatika G, Bernhardt G, Münch J, Hoffmann M, Pöhlmann S, Krey T, Bošnjak B, Förster R, Behrens GMN. Nat Med. 2021 Jul 14. doi: 10.1038/s41591-021-01449-9. Online ahead of print. PMID: 34262158
  25. Expression of ACKR4 demarcates the “peri-marginal sinus,” a specialized vascular compartment of the splenic red pulp. Werth K, Hub E, Gutjahr JC, Bosjnak B, Zheng X, Bubke A, Russo S, Rot A, Förster R. Cell Rep. 2021 Jul 13;36(2):109346. doi: 10.1016/j.celrep.2021.109346. PMID: 34260918
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  27. A rare case of neuro- and otosyphilis in secondary syphilis. Traidl S, Angela Y, Stender A, Kulberg A, Tronnier M, Prenzler NK, Wattjes MP, Kapp A, Stangel M, Schacht V, Werfel T. J Eur Acad Dermatol Venereol. 2021 Jul 9. doi: 10.1111/jdv.17512. Online ahead of print. PMID: 34242450 No abstract available.
  28. Atopic Eczema: Pathophysiological Findings as the Beginning of a New Era of Therapeutic Options. Traidl S, Werfel T, Traidl-Hoffmann C. Handb Exp Pharmacol. 2021 Jul 9. doi: 10.1007/164_2021_492. Online ahead of print. PMID: 34236520
  29. Transcriptome analysis following neurotropic virus infection reveals faulty innate immunity and delayed antigen presentation in mice susceptible to virus-induced demyelination. Ciurkiewicz M, Floess S, Beckstette M, Kummerfeld M, Baumgärtner W, Huehn J, Beineke A. Brain Pathol. 2021 Jul 6:e13000. doi: 10.1111/bpa.13000. Online ahead of print. PMID: 34231271
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  32. Structural and Biochemical Characterization of a Dye-Decolorizing Peroxidase from Dictyostelium discoideum. Rai A, Klare JP, Reinke PYA, Englmaier F, Fohrer J, Fedorov R, Taft MH, Chizhov I, Curth U, Plettenburg O, Manstein DJ. Int J Mol Sci. 2021 Jun 10;22(12):6265. doi: 10.3390/ijms22126265. PMID: 34200865 Free PMC article.
  33. Free human DNA attenuates the activity of antimicrobial peptides in atopic dermatitis. Kopfnagel V, Dreyer S, Zeitvogel J, Pieper DH, Buch A, Sodeik B, Rademacher F, Harder J, Werfel T. Allergy. 2021 Jun 27. doi: 10.1111/all.14992. Online ahead of print. PMID: 34176149
  34. Targeted delivery of regulatory macrophages to lymph nodes interferes with T cell priming by preventing the formation of stable immune synapses. Yu K, Hammerschmidt SI, Permanyer M, Galla M, Rothe M, Zheng X, Werth K, Martens R, Lueder Y, Janssen A, Friedrichsen M, Bernhardt G, Förster R. Cell Rep. 2021 Jun 22;35(12):109273. doi: 10.1016/j.celrep.2021.109273. PMID: 34161766
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  36. Recruitment of phospholipase Cγ1 to the non-structural membrane protein pK15 of Kaposi Sarcoma-associated herpesvirus promotes its Src-dependent phosphorylation. Samarina N, Ssebyatika G, Tikla T, Waldmann JY, Abere B, Nanna V, Marasco M, Carlomagno T, Krey T, Schulz TF. PLoS Pathog. 2021 Jun 18;17(6):e1009635. doi: 10.1371/journal.ppat.1009635. eCollection 2021 Jun. PMID: 34143834 Free PMC article.
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  40. Human IFITM3 restricts chikungunya virus and Mayaro virus infection and is susceptible to virus-mediated counteraction. Franz S, Pott F, Zillinger T, Schüler C, Dapa S, Fischer C, Passos V, Stenzel S, Chen F, Döhner K, Hartmann G, Sodeik B, Pessler F, Simmons G, Drexler JF, Goffinet C.  Life Sci Alliance. 2021 Jun 2;4(7):e202000909. doi: 10.26508/lsa.202000909. PMID: 34078739; PMCID: PMC8200292.
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  42. Elevated Free Phosphatidylcholine Levels in Cerebrospinal Fluid Distinguish Bacterial from Viral CNS Infections. Al-Mekhlafi A, Sühs KW, Schuchardt S, Kuhn M, Müller-Vahl K, Trebst C, Skripuletz T, Klawonn F, Stangel M, Pessler F.  Cells. 2021 May 6;10(5):1115. doi: 10.3390/cells10051115. PMID: 34066349; PMCID: PMC8148106.
  43. Allosteric modulation of cardiac myosin mechanics and kinetics by the conjugated omega-7,9 trans-fat rumenic acid. Irene Pertici, Manuel H. Taft, Johannes N. Greve, Roman Fedorov, Marco Caremani, Dietmar J. Manstein. Journal of Physiology. First published: 04 May 2021
  44. A fetal wave of human type 3 effector γδ cells with restricted TCR diversity persists into adulthood. Likai Tan, Alina Suzann Fichtner, Elena Bruni, Ivan Odak, Inga Sandrock, Anja Bubke, Alina Borchers, Christian Schultze-Florey, Christian Koenecke, Reinhold Förster, Michael Jarek, Constantin von Kaisenberg, Ansgar Schulz, Xiaojing Chu, Bowen Zhang, Yang Li, Ulf Panzer, Christian F. Krebs, Sarina Ravens, Immo Prinz. Science Immunology 23 Apr 2021
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  46. Ovarian tumor domain proteases in pathogen infection. Review. Trends in Microbiology. Dirk Schlüter, EricSchulze-Niemand, Matthias Stein, Michael Naumann, online 17 May 2021 https://doi.org/10.1016/j.tim.2021.04.002
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  51. Cyclin D3 drives inertial cell cycling in dark zone germinal center B cells. Pae J, Ersching J, Castro TBR, Schips M, Mesin L, Allon SJ, Ordovas-Montanes J, Mlynarczyk C, Melnick A, Efeyan A, Shalek AK, Meyer-Hermann M, Victora GD. J Exp Med. 2021 Apr 5;218(4):e20201699. doi: 10.1084/jem.20201699. PMID: 33332554
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  53. Removable denture is a risk indicator for peri-implantitis and facilitates expansion of specific periodontopathogens: a cross-sectional study. Grischke J, Szafrański SP, Muthukumarasamy U, Haeussler S, Stiesch M. BMC Oral Health. 2021 Apr 1;21(1):173. doi: 10.1186/s12903-021-01529-9. PMID: 33794847 Free PMC article.
  54. The impact of hepatitis B surface antigen on natural killer cells in patients with chronic hepatitis B infection.
    Du Y, Anastasiou OE, Strunz B, Scheuten J, Bremer B, Kraft A, Kleinsimglinhaus K, Todt D, Broering R, Hardtke-Wolenski M, Wu J, Yang D, Dittmer U, Lu M, Cornberg M, Björkström NK, Khera T, Wedemeyer H. Liver Int. 2021 Apr 1. doi: 10.1111/liv.14885. Online ahead of print. PMID: 33794040
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