Publication highlights

The publications mentioned here show particularly noteworthy current results of our excellent research.

A distinct monocyte transcriptional state links systemic immune dysregulation to pulmonary impairment in long COVID.

Kumar, S., C. Li, L. Zhou, Q. Zhan, A. Alaswad, S. Volland, B. Costa, S. A. Krooss, I. Klefenz, H. Schmaus, A. Zeuzem, D. von Witzendorff, H. Lickei, L. Pueschel, A. R. M. Kraft, M. Cornberg, A. R. Koczulla, I. Pink, M. M. Hoeper, C. J. Xu, S. Häussler, M. Wiestler, M. G. Netea, T. Illig, J. Sun, and Y. Li.
Nat Immunol

Harnessing intermediate-scale bioreactors for next-generation macrophage production and application.

Saleh, F., E. E. Valdivia Malqui, I. Gensch, M. Schinke, M. Kappelhøj, E. Nikolouli, A. H. H. Nguyen, M. S. Jang, D. Basílio-Queirós, and N. Lachmann.
Nat Protoc

Defining expansions and perturbations to the RNA polymerase III transcriptome and epitranscriptome by modified direct RNA nanopore sequencing.

Verstraten, R., P. Cetraro, A. H. Fitzpatrick, Y. Alwie, Y. N. Frommeyer, E. Loliashvili, S. C. Stein, S. Häussler, W. J. D. Ouwendijk, and D. P. Depledge.
Nat Commun

Live-Cell RNA Imaging via Clickable TriPPPro Nucleotide Reporters.

Knaack, J. I. H., E. List, D. Stalling, V. T. Sterrenberg, C. Meier, H. A. Wagenknecht, and J. B. Bosse.
Angew Chem Int Ed Engl

Differentiation-induced reduction in functional diversity restricts the ability of cytomegalovirus-specific CD8 T cells to eliminate virus-infected cells.

Fritz, L., A. Hassan, L. Riemann, B. Čuvalo, B. Costa, B. Wieland, B. Eiz-Vesper, C. Falk, L. M. Roesner, T. Werfel, U. Kalinke, H. Georgiev, R. Förster, and B. Bošnjak.
EBioMedicine

Autoantibodies against IFN-γ in a subgroup of patients with atopic dermatitis and a history of eczema herpeticum.

Traidl, S., P. Kienlin, G. Begemann, I. Klug, K. Döhner, E. Moennig, K. W. Sühs, P. Schwenkenbecher, L. M. Roesner, and T. Werfel.
J Allergy Clin Immunol.

Selected RESIST publications

Here you will find publications by RESIST researchers.
  1. PEG is back: revisiting the role of pegylated interferon alfa and benchmarking its place in HBV cure strategies M. Cornberg Gut 2026 Accession Number: 41494801 DOI: 10.1136/gutjnl-2025-337336
  2. Differentiation-induced reduction in functional diversity restricts the ability of cytomegalovirus-specific CD8 T cells to eliminate virus-infected cells L. Fritz, A. Hassan, L. Riemann, B. Čuvalo, B. Costa, B. Wieland, et al. EBioMedicine 2026 Vol. 123 Pages 106107 Accession Number: 41494240 DOI: 10.1016/j.ebiom.2025.106107
  3. Defining expansions and perturbations to the RNA polymerase III transcriptome and epitranscriptome by modified direct RNA nanopore sequencing R. Verstraten, P. Cetraro, A. H. Fitzpatrick, Y. Alwie, Y. N. Frommeyer, E. Loliashvili, et al. Nat Commun 2026 Vol. 17 Issue 1 Pages 143 Accession Number: 41490974 DOI: 10.1038/s41467-025-68230-1
  4. Live-Cell RNA Imaging via Clickable TriPPPro Nucleotide Reporters J. I. H. Knaack, E. List, D. Stalling, V. T. Sterrenberg, C. Meier, H. A. Wagenknecht, et al. Angew Chem Int Ed Engl 2026 Vol. 65 Issue 2 Pages e16613 Accession Number: 41310986 PMCID: PMC12790367 DOI: 10.1002/anie.202516613
  5. Commensal microflora coating endows implants with biofilm-repellent, immunomodulatory and osteogenic properties M. I. Rahim, S. Baseer, D. Paasch, M. Steglich, S. F. H. Waqas, N. Lachmann, et al. Acta Biomater 2026 Accession Number: 41519361 DOI: 10.1016/j.actbio.2026.01.017
  6. A distinct monocyte transcriptional state links systemic immune dysregulation to pulmonary impairment in long COVID S. Kumar, C. Li, L. Zhou, Q. Zhan, A. Alaswad, S. Volland, et al. Nat Immunol 2026 Accession Number: 41535626 DOI: 10.1038/s41590-025-02387-1
  7. Immune activation and response dynamics of human iPSC-derived macrophages in tuberculosis infection models D. Paasch, H. Schevel, A. Riehle, B. Costa, H. Toufaili, T. Gehnen, et al. Clin Transl Immunology 2026 Vol. 15 Issue 1 Pages e70071 Accession Number: 41541231 PMCID: PMC12800570 DOI: 10.1002/cti2.70071
  8. Toward Anti-Herpesviral PROTACs: Assessing the Challenges for Targeted Protein Degradation on the Example of Kaposi’s Sarcoma-Associated Herpesvirus Latency-Associated Nuclear Antigen A. Berwanger, S. C. Stein, S. Brandner, A. M. Kany, S. Heinz, B. Loretz, et al. ChemMedChem 2026 Vol. 21 Issue 1 Pages e202500758 Accession Number: 41252598 PMCID: PMC12811992 DOI: 10.1002/cmdc.202500758
  9. Ten-Year Follow-Up After 96 Weeks Treatment With Peginterferon Plus Tenofovir in Hepatitis D (HIDIT-II): Improved Clinical Outcome After Combination Therapy C. Yurdaydin, J. Kahlhöfer, F. A. Caruntu, K. Yalcin, S. Gürel, U. S. Akarca, et al. United European Gastroenterol J 2026 Vol. 14 Issue 1 Pages e70153 Accession Number: 41317314 PMCID: PMC12799903 DOI: 10.1002/ueg2.70153
  10. SARS-CoV-2-infected cardiomyocytes exhibit upregulated necroptosis, but no evidence of mitochondrial permeability transition C. Gross, S. Chatterjee, B. E. Nilsson-Payant, S. D. Stojanović, H. Kefalakes, C. Bär, et al. J Mol Cell Cardiol Plus 2026 Vol. 15 Pages 100833 Accession Number: 41550884 PMCID: PMC12810347 DOI: 10.1016/j.jmccpl.2025.100833
  11. S100-alarmins, antenatal corticosteroids and the risk of late-onset sepsis in preterm infants: A prospective cohort study G. Kessler, T. Ulas, T. Vogl, J. Roth, F. Albrecht, G. Hansen, et al. PLoS One 2026 Vol. 21 Issue 1 Pages e0341544 Accession Number: 41591973 DOI: 10.1371/journal.pone.0341544
  12. Functional antibody signatures following therapeutic immunization in Simian and Human immunodeficiency virus infection S. Ilan, Y. Bartsch, W. Jung, E. Kliuchnikov, V. Roy, R. Bonifer, et al. NPJ Vaccines 2026 Accession Number: 41620471 DOI: 10.1038/s41541-026-01390-3
  13. Humoral correlates of clinical response to thymectomy in myasthenia gravis C. D. F. Sousa, P. Terroba-Navajas, J. Tzartos, I. D. Orešković, M. Pučić-Baković, G. Lauc, et al. J Autoimmun 2025 Vol. 158 Pages 103517 Accession Number: 41411760 DOI: 10.1016/j.jaut.2025.103517
  14. A monocyte-derived blood transcriptomic signature reveals systemic immunosuppression in HCC and partial reversal following curative therapy L. Zhou, A. Alaswad, A. Kumthekar, D. Machtens, Y. Xi, B. Costa, et al. Front Immunol 2025 Vol. 16 Pages 1717978 Accession Number: 41646974 PMCID: PMC12867797 DOI: 10.3389/fimmu.2025.1717978
  15. Effect of gestational age on lymphocyte phenotypes in hospitalized preterm infants J. Dirks, I. Fortmann, J. Marißen, J. Pagel, L. Reichert, H. Kipke, et al. J Allergy Clin Immunol 2026 Vol. 157 Issue 2 Pages 506-516 Accession Number: 41138924 DOI: 10.1016/j.jaci.2025.09.030
  16. Letter on: ‘Impact of Frailty on the Prognosis of Patients With Liver Cirrhosis Undergoing Insertion of a TIPS’. Authors’ Reply C. Labenz, M. A. Kabelitz, S. J. Gairing, L. Sandmann and B. Maasoumy Aliment Pharmacol Ther 2026 Accession Number: 41623226 DOI: 10.1111/apt.70554
  17. Pseudopaline-mediated zinc uptake by Pseudomonas aeruginosa drives clinically relevant phenotypes and infection outcomes L. Bosc, T. Sécher, G. Ball, D. Le Pennec, M. Tribout, M. Ba, et al. Infect Immun 2026 Vol. 94 Issue 2 Pages e0045325 Accession Number: 41532760 PMCID: PMC12890022 DOI: 10.1128/iai.00453-25
  18. A comparative ex vivo evaluation of colonization resistance against multidrug-resistant Enterobacterales in fecal samples from various animal species and strategies to augment it L. Osbelt, E. Eger, T. Homeier-Bachmann, M. Schwabe, M. Wende, B. Hammerschmidt, et al. Front Microbiol 2025 Vol. 16 Pages 1695208 Accession Number: 41669693 PMCID: PMC12883652 DOI: 10.3389/fmicb.2025.1695208
  19. Autoantibodies against IFN-γ in a subgroup of patients with atopic dermatitis and a history of eczema herpeticum S. Traidl, P. Kienlin, G. Begemann, I. Klug, K. Döhner, E. Moennig, et al. J Allergy Clin Immunol 2026 Accession Number: 41677483 DOI: 10.1016/j.jaci.2026.01.010
  20. Interpreting Survival Models in Post-TIPS Hepatic Encephalopathy M. A. Kabelitz, L. Sandmann and B. Maasoumy Clin Gastroenterol Hepatol 2026 Accession Number: 41687905 DOI: 10.1016/j.cgh.2026.02.004
  21. Treatment response to bulevirtide is linked to amelioration of portal hypertension in patients with chronic hepatitis D L. Sandmann, M. Jachs, T. L. Tergast, L. Hartl, B. Bremer, M. A. Kabelitz, et al. JHEP Rep 2026 Vol. 8 Issue 1 Pages 101643 Accession Number: 41674894 PMCID: PMC12890450 DOI: 10.1016/j.jhepr.2025.101643
  22. Harnessing intermediate-scale bioreactors for next-generation macrophage production and application F. Saleh, E. E. Valdivia Malqui, I. Gensch, M. Schinke, M. Kappelhøj, E. Nikolouli, et al. Nat Protoc 2026 Accession Number: 41709011 DOI: 10.1038/s41596-025-01313-x
  23. The Submucosal Microbiome Correlates with Peri-implantitis Severity – PubMed A. A. Joshi, S. P. Szafrański, M. Steglich, I. Yang, W. Behrens, P. Schaefer-Dreyer, et al. J Dent Res 2025 Pages 220345251352809 Accession Number: 40719760 DOI: 10.1177/00220345251352809
  24. Association between specialized nutrition support and 90-day mortality relative to standard of care in malnourished adults with decompensated cirrhosis: A retrospective cohort study K. L. Hupa-Breier, L. Buttler, C. Seipt, A. Markowski, M. Griemsmann, T. L. Tergast, et al. JPEN J Parenter Enteral Nutr 2026 Accession Number: 41720466 DOI: 10.1002/jpen.70066
  25. Acsbg1 maintains intestinal immune homeostasis and controls inflammation by regulating ST2(+) Tregs M. Palatella, F. Kruse, H. Ji, A. K. Loriani Fard, M. Becker, C. Daniel, et al. Mucosal Immunol 2026 Vol. 19 Issue 1 Pages 1526-1537 Accession Number: 41151718 DOI: 10.1016/j.mucimm.2025.10.009
  26. Human cytomegalovirus strain-specific differences in protein expression of type I IFN pathway proteins do not impact virus replication K. A. Latham, T. K. Soh, R. J. Stanton, J. B. Bosse, S. Goodbourn and B. L. Strang Access Microbiol 2026 Vol. 8 Issue 2 Accession Number: 41728058 PMCID: PMC12917765 DOI: 10.1099/acmi.0.001104.v3
  27. Spatial Transcriptomics Uncovers Hybrid, Pro-Inflammatory and Pro-Fibrotic Cellular Niches in Pulmonary Granuloma of Patients with Chronic Sarcoidosis L. Christian, H. Yilmaz, J. Ruwisch, L. Giercke, B. Seeliger, J. C. Kamp, et al. Am J Respir Crit Care Med 2026 Accession Number: 41738160 DOI: 10.1093/ajrccm/aamaf089
  28. Hepatitis delta virus co-infection in patients with hepatocellular carcinoma and people living with HIV in Nigeria I. Ifeorah, B. Bremer, Y. Musa, J. Kahlhöfer, O. Oguntoye, C. Tishiya, et al. BMC Infect Dis 2026 Accession Number: 41749169 DOI: 10.1186/s12879-026-12913-7
  29. RNA Polymerase III suppresses varicella zoster virus in human neurons J. Wang, M. E. Carter-Timofte, B. Ritter, M. M. Thomsen, A. Viejo-Borbolla and T. H. Mogensen J Infect Dis 2026 Accession Number: 41739639 DOI: 10.1093/infdis/jiag117
  30. Thymic stromal lymphopoietin (TSLP) – pro-inflammatory cytokine and antimicrobial peptide K. Döhner, O. P. John and T. Werfel Biochim Biophys Acta Mol Cell Res 2026 Pages 120127 Accession Number: 41791676 DOI: 10.1016/j.bbamcr.2026.120127
  31. Phenotypic spectrum of RNU4ATAC-related spliceosomopathies: four novel cases and integrated reevaluation of previously reported patients S. Lovric, A. C. Berking, F. C. Ringshausen, J. Körholz, J. Porrmann, S. Hütter, et al. Orphanet J Rare Dis 2026 Accession Number: 41808109 DOI: 10.1186/s13023-026-04300-x
  32. Neutrophil and macrophage zonation in liver disease: from spatiotemporal dynamics to advanced computational analysis H. Kim and N. Lachmann Front Immunol 2026 Vol. 17 Pages 1767691 Accession Number: 41816345 PMCID: PMC12971471 DOI: 10.3389/fimmu.2026.1767691
  33. Human Systems Immunology in the Omics Era: Challenges, Methods, and Emerging Directions L. Riemann and R. Förster Eur J Immunol 2026 Vol. 56 Issue 3 Pages e70164 Accession Number: 41830074 PMCID: PMC12988318 DOI: 10.1002/eji.70164
  34. Quality of Life of Patients With Multi-Organ Autoimmune Disease and Its Relationship to Patient-Centered Care: Protocol for a Longitudinal Cohort Study M. Bayrhuber, C. Schlett, J. Slesaczeck, S. Herbst, G. Mueller, A. Nieters, et al. JMIR Res Protoc 2026 Vol. 15 Pages e77786 Accession Number: 41813446 PMCID: PMC12978972 DOI: 10.2196/77786
  35. Functional spectrum of γδ T cells in perinatal infectious diseases I. Lorga, X. Léon-Lara and S. Ravens Immunol Lett 2026 Vol. 280 Pages 107167 Accession Number: 41812905 DOI: 10.1016/j.imlet.2026.107167
  1. Repression of varicella zoster virus gene expression during quiescent infection in the absence of detectable histone deposition. Wang J, Brückner N, Weissmann S, Günther T, Zhu S, Vogt C, Sun G, Guo R, Bruno R, Ritter B, Steinbrück L, Kaufer BB, Depledge DP, Grundhoff A, Viejo-Borbolla A. PLoS Pathog. 2025 Feb 10;21(2):e1012367. doi: 10.1371/journal.ppat.1012367. Epub ahead of print. PMID: 39928684.
  2. The effect of HLA genotype on disease onset and severity in CTLA-4 insufficiency
    S. Posadas-Cantera, N. Mitsuiki, F. Emmerich, V. Patiño, H. M. Lorenz, O. Neth, et al. Front Immunol 2025 Vol. 15 Pages 1447995 Accession Number: 39835139 PMCID: PMC11744039 DOI: 10.3389/fimmu.2024.1447995
  3. Influenza Immunization in Very-Low-Birth-Weight Infants: Epidemiology and Long-Term Outcomes M. T. Dammann, H. Kraft, G. Stichtenoth, K. Hanke, M. Zemlin, J. Soler Wenglein, et al. Vaccines (Basel) 2025 Vol. 13 Issue 1 Accession Number: 39852821 PMCID: PMC11769184 DOI: 10.3390/vaccines13010042
  4. A corpus of GA4GH phenopackets: Case-level phenotyping for genomic diagnostics and discovery D. Danis, M. J. Bamshad, Y. Bridges, A. Caballero-Oteyza, P. Cacheiro, L. C. Carmody, et al. HGG Adv 2025 Vol. 6 Issue 1 Pages 100371 Accession Number: 39394689 PMCID: PMC11564936 DOI: 10.1016/j.xhgg.2024.100371
  5. Identification of optimal portal pressure decrease to control ascites while minimizing hepatic encephalopathy after TIPS: A multicenter study M. A. Kabelitz, L. Hartl, G. Schaub, A. Tiede, H. Rieland, A. Kornfehl, et al. Hepatology 2025 Accession Number: 39773850 DOI: 10.1097/hep.0000000000001219
  6. Integrative deep immune profiling of the elderly reveals systems-level signatures of aging, sex, smoking, and clinical traits L. Riemann, R. Gutierrez, I. Odak, J. Barros-Martins, L. M. Roesner, X. Leon Lara, et al. EBioMedicine 2025 Vol. 112 Pages 105558 Accession Number: 39862806 DOI: 10.1016/j.ebiom.2025.105558
  7. Comparison of clinical outcomes in patients with refractory ascites treated with either TIPS, tunneled peritoneal catheter, or ascites pump S. L. Schütte, A. Tiede, J. B. Mauz, H. Rieland, M. Kabelitz, R. Iker, et al. Hepatol Commun 2025 Vol. 9 Issue 2 Accession Number: 39813591 PMCID: PMC11737501 DOI: 10.1097/hc9.0000000000000620
  8. A clinical protocol for a German birth cohort study of the Maturation of Immunity Against respiratory viral Infections (MIAI) C. R. Hartmann, R. Khan, J. Schöning, M. Richter, M. Willers, S. Pirr, et al. Front Immunol 2024 Vol. 15 Pages 1443665 Accession Number: 39355253 PMCID: PMC11442434 DOI: 10.3389/fimmu.2024.1443665
  9. Editorial: Stopping NUCs-When to Restart NUCs for the Best Outcome? M. Urbanek-Quaing and M. Cornberg Aliment Pharmacol Ther 2025 Vol. 61 Issue 1 Pages 204-205 Accession Number: 39499186 DOI: 10.1111/apt.18370
  10. Ablation of the deubiquitinating enzyme cylindromatosis (CYLD) augments STAT1-mediated M1 macrophage polarization and fosters Staphylococcus aureus control C. Schmidt, K. Harit, S. Traidl, M. Naumann, T. Werfel, L. M. Roesner, et al. Front Immunol 2025 Vol. 16 Pages 1507989 Accession Number: 39958342 PMCID: PMC11827430 DOI: 10.3389/fimmu.2025.1507989
  11. TIGIT-expression on natural killer cell subsets is an early indicator of alleviating liver inflammation following bulevirtide treatment in chronic hepatitis D P. C. Chen, K. Deterding, S. A. Engelskircher, K. Port, L. Sandmann, A. Chakkadath, et al. Hepatology 2025 Accession Number: 39847437 DOI: 10.1097/hep.0000000000001238
  12. Phase 2 Randomised Study of Bulevirtide as Monotherapy or Combined With Peg-IFNα-2a as Treatment for Chronic Hepatitis Delta P. Lampertico, P. O. Bogomolov, V. Chulanov, T. Stepanova, V. Morozov, L. Allweiss, et al. Liver Int 2025 Vol. 45 Issue 2 Pages e70008 Accession Number: 39853842 PMCID: PMC11760647 DOI: 10.1111/liv.70008
  13. Value and Kinetics of Virological Markers in the Natural Course of Chronic Hepatitis D Virus Infection L. Sandmann, V. Ohlendorf, A. Ehrenbauer, B. Bremer, A. R. M. Kraft, M. Cornberg, et al. Liver Int 2025 Vol. 45 Issue 2 Pages e70003 Accession Number: 39846714 PMCID: PMC11756344 DOI: 10.1111/liv.70003
  14. microGWAS: a computational pipeline to perform large-scale bacterial genome-wide association studies J. Burgaya, B. F. Damaris, J. Fiebig and M. Galardini Microb Genom 2025 Vol. 11 Issue 2 Accession Number: 39932497 DOI: 10.1099/mgen.0.001349
  15. Identification and characterization of the functional tetrameric UDP-glucose pyrophosphorylase from Klebsiella pneumoniae I. Ramón Roth, P. Kats, T. Fiebig, F. Routier, R. Fedorov, L. Dirr, et al. mBio 2025 Vol. 16 Issue 2 Pages e0207124 Accession Number: 39704542 PMCID: PMC11796359 DOI: 10.1128/mbio.02071-24
  16. Highly potent quinoxalinediones inhibit α-hemolysin and ameliorate Staphylococcus aureus lung infections A. Shekhar, R. Di Lucrezia, K. Jerye, V. S. Korotkov, K. Harmrolfs, K. Rox, et al. Cell Host Microbe 2025 Accession Number: 40168998 DOI: 10.1016/j.chom.2025.03.006
  17. Combinatorial Fc modifications for complementary antibody functionality Y. C. Bartsch, N. E. Webb, E. Burgess, J. Kang, D. A. Lauffenburger and B. D. Julg MAbs 2025 Vol. 17 Issue 1 Pages 2465391 Accession Number: 39950649 PMCID: PMC11834420 DOI: 10.1080/19420862.2025.2465391
  18. Dysphoric Milk Ejection Reflex: Prevalence, persistence, and implications R. Cappenberg, J. G. Garcia, I. Liolios, C. Happle and A. Zychlinsky Scharff Eur J Obstet Gynecol Reprod Biol 2025 Vol. 308 Pages 127-131 Accession Number: 40043530 DOI: 10.1016/j.ejogrb.2025.02.051
  19. Molecular mechanisms of hotspot variants in cytoskeletal β-actin associated with Baraitser-Winter syndrome  J. N. Greve and D. J. Manstein Febs j 2025 Accession Number: 39930656 DOI: 10.1111/febs.70018
  20. Single-cell immune aging clocks reveal inter-individual heterogeneity during infection and vaccination W. Li, Z. Zhang, S. Kumar, J. Botey-Bataller, M. Zoodsma, A. Ehsani, et al. Nat Aging 2025 Accession Number: 40044970 DOI: 10.1038/s43587-025-00819-z
  21. Acsbg1 regulates differentiation and inflammatory properties of CD4+ T cells M. Palatella, F. Kruse, S. Glage, A. Bleich, M. Greweling-Pils and J. Huehn Eur J Microbiol Immunol (Bp) 2025 Accession Number: 39937199 DOI: 10.1556/1886.2025.00003
  22. Distinctive CD8(+) T cell activation by antigen-presenting plasmacytoid dendritic cells compared to conventional dendritic cells R. M. van der Sluis, J. L. García-Rodríguez, I. H. Nielsen, A. Gris-Oliver, J. Becker, B. Costa, et al. Cell Rep 2025 Vol. 44 Issue 3 Pages 115413 Accession Number: 40073016 DOI: 10.1016/j.celrep.2025.115413
  23. TIPS insertion and systemic inflammation: Is it ever too late to lower portal pressure? A. Tiede and B. Maasoumy Clin Mol Hepatol 2025 Accession Number: 39925001 DOI: 10.3350/cmh.2025.0135
  24. Broadly neutralizing antibodies isolated from HEV convalescents confer protective effects in human liver-chimeric mice G. Ssebyatika, K. Dinkelborg, L. J. Ströh, F. Hinte, L. Corneillie, L. Hueffner, et al. Nat Commun 2025 Vol. 16 Issue 1 Pages 1995 Accession Number: 40011441 DOI: 10.1038/s41467-025-57182-1
  25. Reappraisal of IgG subclass deficiencies: a retrospective comparative cohort study D. Dogru, Y. Dogru, F. Atschekzei, A. Elsayed, N. Dubrowinskaja, D. Ernst, et al. Front Immunol 2025 Vol. 16 Pages 1552513 Accession Number: 40313941 PMCID: PMC12043879 DOI: 10.3389/fimmu.2025.1552513
  26. A novel hemizygous nonsense variant in DOCK11 causes systemic inflammation and immunodeficiency A. Elsayed, S. von Hardenberg, F. Atschekzei, P. Siek, T. Witte, G. Sogkas, et al. Clin Immunol 2025 Vol. 276 Pages 110504 Accession Number: 40274249 DOI: 10.1016/j.clim.2025.110504
  27. A precision medicine approach to primary immunodeficiency disease: Ataluren strikes nonsense mutations once again L. Lentini, R. Perriera, F. Corrao, R. Melfi, M. Tutone, P. S. Carollo, et al. Mol Ther 2025 Accession Number: 40158206 DOI: 10.1016/j.ymthe.2025.03.045
  28. The intestinal microbiome and metabolome discern disease severity in cytotoxic T-lymphocyte-associated protein 4 deficiency P. Chandrasekaran, M. Krausz, Y. Han, N. Mitsuiki, A. Gabrysch, C. Nöltner, et al. Microbiome 2025 Vol. 13 Issue 1 Pages 51 Accession Number: 39934899 PMCID: PMC11817180 DOI: 10.1186/s40168-025-02028-7
  29. Bruton’s tyrosine kinase (BTK) and matrix metalloproteinase-9 (MMP-9) regulate NLRP3 inflammasome-dependent cytokine and neutrophil extracellular trap responses in primary neutrophils V. N. C. Leal, F. Bork, M. Mateo Tortola, J. C. von Guilleaume, C. L. Greve, S. Bugl, et al. J Allergy Clin Immunol 2025 Vol. 155 Issue 2 Pages 569-582 Accession Number: 39547282 DOI: 10.1016/j.jaci.2024.10.035
  30. Unlocking the antiviral arsenal: Structure-guided optimization of small-molecule inhibitors against RSV and hCoV-229E C. Karhan, S. M. Sake, A. P. Gunesch, C. Grethe, B. Hellwinkel, N. M. Köhler, et al. Eur J Med Chem 2025 Vol. 291 Pages 117282 Accession Number: 40199027 DOI: 10.1016/j.ejmech.2025.117282
  31. Long-term histone lactylation connects metabolic and epigenetic rewiring in innate immune memory A. Ziogas, B. Novakovic, L. Ventriglia, N. Galang, K. A. Tran, W. Li, et al. Cell 2025 Accession Number: 40318634 DOI: 10.1016/j.cell.2025.03.048
  32. Transmissible Staphylococcus pseudintermedius thwarts neutrophil extracellular trap-driven containment to promote invasive disease R. Haller, Y. Cai, N. de Buhr, J. C. Rieder, D. Schlüter, C. Baier, et al. Emerg Microbes Infect 2025 Vol. 14 Issue 1 Pages 2482709 Accession Number: 40172876 PMCID: PMC12001851 DOI: 10.1080/22221751.2025.2482709
  33. Using structure-function information from IFN-γ-binding proteins and biased agonists to uncouple immunostimulatory and immunosuppressive activities L. Mendes-Monteiro and A. Viejo-Borbolla Trends Immunol 2025 Accession Number: 40102163 DOI: 10.1016/j.it.2025.02.013
  34. Giant RNA genomes: Roles of host, translation elongation, genome architecture, and proteome in nidoviruses B. W. Neuman, A. Smart, O. Gilmer, R. P. Smyth, J. Vaas, N. Böker, et al. Proc Natl Acad Sci U S A 2025 Vol. 122 Issue 7 Pages e2413675122 Accession Number: 39928875 PMCID: PMC11848433 DOI: 10.1073/pnas.2413675122
  35. Oxidative phosphorylation is a key feature of neonatal monocyte immunometabolism promoting myeloid differentiation after birth G. Ehlers, A. M. Tödtmann, L. Holsten, M. Willers, J. Heckmann, J. Schöning, et al. Nat Commun 2025 Vol. 16 Issue 1 Pages 2239 Accession Number: 40050264 PMCID: PMC11885822 DOI: 10.1038/s41467-025-57357-w
  36. The neonate respiratory microbiome S. Pirr, M. Willers and D. Viemann Acta Physiol (Oxf) 2025 Vol. 241 Issue 2 Pages e14266Accession Number: 39840649 PMCID: PMC11752418 DOI: 10.1111/apha.14266
  37. Distinct clusters of bacterial and fungal microbiota in end-stage liver cirrhosis correlate with antibiotic treatment, intestinal barrier impairment, and systemic inflammation L. Buttler, D. A. Velázquez-Ramírez, A. Tiede, A. M. Conradi, S. Woltemate, R. Geffers, et al. Gut Microbes 2025 Vol. 17 Issue 1 Pages 2487209 Accession Number: 40255076 DOI: 10.1080/19490976.2025.2487209
  38. Reply: Refining epigenetic insights in HBV-Specific T Cell restoration Y. H. Chou and M. Cornberg Hepatology 2025 Accession Number: 40168461 DOI: 10.1097/hep.0000000000001340
  39. Limited Value of HBV-RNA for Relapse Prediction After Nucleos(t)ide Analogue Withdrawal in HBeAg-negative Hepatitis B Patients V. Ohlendorf, M. Wübbolding, C. Höner Zu Siederdissen, B. Bremer, K. Deterding, H. Wedemeyer, et al. J Viral Hepat 2025 Vol. 32 Issue 4 Pages e14026 Accession Number: 39425534 PMCID: PMC11887418 DOI: 10.1111/jvh.14026
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  103. Cross-sectional seroprevalence surveys of SARS-CoV-2 antibodies in children in Germany, June 2020 to May 2021. Sorg AL, Bergfeld L, Jank M, Corman V, Semmler I, Goertz A, Beyerlein A, Verjans E, Wagner N, Von Bernuth H, Lander F, Weil K, Hufnagel M, Spiekerkoetter U, Chao CM, Naehrlich L, Muntau AC, Schulze-Sturm U, Hansen G, Wetzke M, Jung AM, Niehues T, Fricke-Otto S, Von Both U, Huebner J, Behrends U, Liese JG, Schwerk C, Drosten C, Von Kries R, Schroten H.  Nat Commun. 2022 Jun 6;13(1):3128. doi: 10.1038/s41467-022-30482-6. PMID: 35668073; PMCID: PMC9170697.
  104. Detrimental NFKB1 missense variants affecting the Rel-homology domain of p105/p50. Fliegauf M, Kinnunen M, Posadas-Cantera S, Camacho-Ordonez N, Abolhassani H, Alsina L, Atschekzei F, Bogaert DJ, Burns SO, Church JA, Dückers G, Freeman AF, Hammarström L, Hanitsch LG, Kerre T, Kobbe R, Sharapova SO, Siepermann K, Speckmann C, Steiner S, Verma N, Walter JE, Westermann-Clark E, Goldacker S, Warnatz K, Varjosalo M, Grimbacher B.  Front Immunol. 2022 Aug 29;13:965326. doi: 10.3389/fimmu.2022.965326. PMID: 36105815; PMCID: PMC9465457.
  105. Entwicklungsansätze für Impfstoffe gegen Hepatitis-C-Virus-Infektionen [Development approaches for vaccines against hepatitis C virus infections]. Bankwitz D, Krey T, Pietschmann T.  Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz. 2022 Feb;65(2):183-191. German. doi: 10.1007/s00103-021-03477-9. Epub 2022 Jan 11. PMID: 35015104; PMCID: PMC8749110.
  106. Distinct actin-tropomyosin cofilament populations drive the functional diversification of cytoskeletal myosin motor complexes. Reindl T, Giese S, Greve JN, Reinke PY, Chizhov I, Latham SL, Mulvihill DP, Taft MH, Manstein DJ. iScience. 2022 May 30;25(7):104484. doi: 10.1016/j.isci.2022.104484. PMID: 35720262; PMCID: PMC9204724.
  107. Effects of Pre-Existing Mental Conditions on Fatigue and Psychological Symptoms Post-COVID-19. Homann S, Mikuteit M, Niewolik J, Behrens GMN, Stölting A, Müller F, Schröder D, Heinemann S, Müllenmeister C, El-Sayed I, Happle C, Steffens S, Dopfer-Jablonka A. Int J Environ Res Public Health. 2022 Aug 11;19(16):9924. doi: 10.3390/ijerph19169924. PMID: 36011559; PMCID: PMC9408008.
  108. Efficacy of dupilumab for the treatment of severe skin disease in cytotoxic T lymphocyte antigen-4 insufficiency: A role of type 2 inflammation? Arruda LK, Cordeiro DL, Langer SS, Koenigham-Santos M, Calado RT, Dias MM, Anhesini LR, Oliveira JB, Grimbacher B, Ferriani MPL.  J Allergy Clin Immunol Glob. 2022 Sep 22;2(1):114-117. doi: 10.1016/j.jacig.2022.08.004. PMID: 37780100; PMCID: PMC10509893.
  109. Frameshift mutation S368fs in the gene encoding cytoskeletal β-actin leads to ACTB-associated syndromic thrombocytopenia by impairing actin dynamics. Greve JN, Schwäbe FV, Pokrant T, Faix J, Di Donato N, Taft MH, Manstein DJ. Eur J Cell Biol. 2022 Apr;101(2):151216. doi: 10.1016/j.ejcb.2022.151216. Epub 2022 Mar 15. PMID: 35313204.
  110. Generation of Human iPSC from Small Volume Peripheral Blood Samples. Kloos D, Lachmann N. Methods Mol Biol. 2022;2429:27-39. doi: 10.1007/978-1-0716-1979-7_3. PMID: 35507153.
  111. HBcrAg Levels Are Associated With Virological Response to Treatment With Interferon in Patients With Hepatitis Delta. Sandmann L, Yurdaydin C, Deterding K, Heidrich B, Hardtke S, Lehmann P, Bremer B, Manns MP, Cornberg M, Wedemeyer H, Maasoumy B; HIDIT‐II Study Group.  Hepatol Commun. 2022 Mar;6(3):480-495. doi: 10.1002/hep4.1821. Epub 2021 Sep 24. PMID: 34561972; PMCID: PMC8870014.
  112. Human Cytomegalovirus pUL11, a CD45 Ligand, Disrupts CD4 T Cell Control of Viral Spread in Epithelial Cells. Osanyinlusi SA, Zischke J, Jacobs R, Weissinger EM, Schulz TF, Kay-Fedorov PC. HmBio. 2022 Dec 20;13(6):e0294622. doi: 10.1128/mbio.02946-22. Epub 2022 Nov 29. PMID: 36445084; PMCID: PMC9765415.
  113. It’s All in the Mix: A New Interprofessional, Blended-Learning Masters’ Program for Biomedical Data Science Addressing Physicians and Students from Life Sciences – Didactic Concept and First Experiences AuthorsMichael Marschollek, Melina Celik, Marianne Behrends, Thomas Friedrich SchulzPages56 – 60DOI10.3233/SHTI220907CategoryResearch Article Series Studies in Health Technology and Informatics Ebook Volume 298: Digital Professionalism in Health and Care: Developing the Workforce, Building the Future
  114. Low Serum Cholinesterase Identifies Patients With Worse Outcome and Increased Mortality After TIPS. Stockhoff L, Muellner-Bucsics T, Markova AA, Schultalbers M, Keimburg SA, Tergast TL, Hinrichs JB, Simon N, Gerbel S, Manns MP, Mandorfer M, Cornberg M, Meyer BC, Wedemeyer H, Reiberger T, Maasoumy B. Hepatol Commun. 2022 Mar;6(3):621-632. doi: 10.1002/hep4.1829. Epub 2021 Sep 28. PMID: 34585537; PMCID: PMC8870033.
  115. Lymph node stromal cells support the maturation of pre-DCs into cDC-like cells via colony-stimulating factor 1. Wiechers C, Pezoldt J, Beckstette M, Berner J, Schraml BU, Huehn J.  Immunology. 2022 Aug;166(4):475-491. doi: 10.1111/imm.13497. Epub 2022 Jun 2. PMID: 35569092.
  116. Metadata harmonization-Standards are the key for a better usage of omics data for integrative microbiome analysis. Cernava T, Rybakova D, Buscot F, Clavel T, McHardy AC, Meyer F, Meyer F, Overmann J, Stecher B, Sessitsch A, Schloter M, Berg G; MicrobiomeSupport Team.  Environ Microbiome. 2022 Jun 24;17(1):33. doi: 10.1186/s40793-022-00425-1. PMID: 35751093; PMCID: PMC9233336.
  117. Multi-omics analysis of naïve B cells of patients harboring the C104R mutation in TACI. Ramirez N, Posadas-Cantera S, Langer N, de Oteyza ACG, Proietti M, Keller B, Zhao F, Gernedl V, Pecoraro M, Eibel H, Warnatz K, Ballestar E, Geiger R, Bossen C, Grimbacher B. Front Immunol. 2022 Aug 16;13:938240. doi: 10.3389/fimmu.2022.938240. PMID: 36072607; PMCID: PMC9443529.
  118. Nanoscale organization of the MHC I peptide-loading complex in human dendritic cells. Koller N, Höllthaler P, Barends M, Döring M, Spahn C, Durán V, Costa B, Becker J, Heilemann M, Kalinke U, Tampé R. Cell Mol Life Sci. 2022 Aug 10;79(9):477. doi: 10.1007/s00018-022-04472-2. PMID: 35947215; PMCID: PMC9365725.
  119. Phenotype, genotype, treatment, and survival outcomes in patients with X-linked inhibitor of apoptosis deficiency. Yang L, Booth C, Speckmann C, Seidel MG, Worth AJJ, Kindle G, Lankester AC, Grimbacher B; ESID Clinical and Registry Working Parties; Gennery AR, Seppanen MRJ, Morris EC, Burns SO.  J Allergy Clin Immunol. 2022 Aug;150(2):456-466. doi: 10.1016/j.jaci.2021.10.037. Epub 2021 Dec 15. PMID: 34920033.
  120. pUL36 Deubiquitinase Activity Augments Both the Initiation and the Progression of Lytic Herpes Simplex Virus Infection in IFN-Primed Cells. Mohnke J, Stark I, Fischer M, Fischer PM, Schlosser A, Grothey A, O’Hare P, Sodeik B, Erhard F, Dölken L, Hennig T.  J Virol. 2022 Nov 23;96(22):e0096322. doi: 10.1128/jvi.00963-22. Epub 2022 Oct 31. PMID: 36314822; PMCID: PMC9683058.
  121. Resolving the polygenic aetiology of a late onset combined immune deficiency caused by NFKB1 haploinsufficiency and modified by PIK3R1 and TNFRSF13B variants. Hargreaves CE, Dhalla F, Patel AM, de Oteyza ACG, Bateman E, Miller J, Anzilotti C, Ayers L, Grimbacher B, Patel SY.  Clin Immunol. 2022 Jan;234:108910. doi: 10.1016/j.clim.2021.108910. Epub 2021 Dec 15. PMID: 34922003.
  122. SARS-CoV-2 Viral Load in the Pulmonary Compartment of Critically Ill COVID-19 Patients Correlates with Viral Serum Load and Fatal Outcomes. Ynga-Durand M, Maaß H, Milošević M, Krstanović F, Pribanić Matešić M, Jonjić S, Protić A, Brizić I, Šustić A, Čičin-Šain L.  Viruses. 2022 Jun 14;14(6):1292. doi: 10.3390/v14061292. PMID: 35746764; PMCID: PMC9228931.
  123. The First 4 Years – Outcome of Children Identified by Newborn Screening for CF in Germany. Schütz K, Kontsendorn J, Janzen N, Fuge J, Grewendorf S, Klemann C, Happle C, Junge S, Rudolf I, Dopfer C, Sedlacek L, Renz D, Hansen G, Dittrich AM. Klin Padiatr. 2022 Sep;234(5):284-292. English. doi: 10.1055/a-1700-5105. Epub 2022 Jan 28. PMID: 35098497.
  124. The Impact of Evolving SARS-CoV-2 Mutations and Variants on COVID-19 Vaccines. McLean G, Kamil J, Lee B, Moore P, Schulz TF, Muik A, Sahin U, Türeci Ö, Pather S. mBio. 2022 Apr 26;13(2):e0297921. doi: 10.1128/mbio.02979-21. Epub 2022 Mar 30. PMID: 35352979; PMCID: PMC9040821.
  125. Baseline Cellular Antiviral State Is Maintained by cGAS and Its Most Frequent Naturally Occurring Variant rs610913. Kazmierski J, Elsner C, Döhner K, Xu S, Ducroux A, Pott F, Jansen J, Thorball CW, Zeymer O, Zhou X, Fedorov R, Fellay J, Löffler MW, Weber ANR, Sodeik B, Goffinet C. A  J Immunol. 2022 Aug 1;209(3):535-547. doi: 10.4049/jimmunol.2100685. PMID: 35851540.
  126. The membrane-active polyaminoisoprenyl compound NV716 re-sensitizes Pseudomonas aeruginosa to antibiotics and reduces bacterial virulence. Wang G, Brunel JM, Preusse M, Mozaheb N, Willger SD, Larrouy-Maumus G, Baatsen P, Häussler S, Bolla JM, Van Bambeke F. Commun Biol. 2022 Aug 25;5(1):871. doi: 10.1038/s42003-022-03836-5. PMID: 36008485; PMCID: PMC9411590.
  127. NK cell dysfunction in severe COVID-19: TGF-β-induced downregulation of integrin beta-2 restricts NK cell cytotoxicity. Barros-Martins J, Förster R, Bošnjak B.  Signal Transduct Target Ther. 2022 Jan 31;7(1):32. doi: 10.1038/s41392-022-00892-5. PMID: 35102142; PMCID: PMC8801552.
  128. Atopic Eczema: Pathophysiological Findings as the Beginning of a New Era of Therapeutic Options. Traidl S, Werfel T, Traidl-Hoffmann C. Handb Exp Pharmacol. 2022;268:101-115. doi: 10.1007/164_2021_492. PMID: 34236520.
  129. Differential interferon-α subtype induced immune signatures are associated with suppression of SARS-CoV-2 infection. Schuhenn J, Meister TL, Todt D, Bracht T, Schork K, Billaud JN, Elsner C, Heinen N, Karakoese Z, Haid S, Kumar S, Brunotte L, Eisenacher M, Di Y, Lew J, Falzarano D, Chen J, Yuan Z, Pietschmann T, Wiegmann B, Uebner H, Taube C, Le-Trilling VTK, Trilling M, Krawczyk A, Ludwig S, Sitek B, Steinmann E, Dittmer U, Lavender KJ, Sutter K, Pfaender S.  Proc Natl Acad Sci U S A. 2022 Feb 22;119(8):e2111600119. doi: 10.1073/pnas.2111600119. PMID: 35131898; PMCID: PMC8872780.
  130. Editorial: Neuronal and Glial Alterations Caused by Viral Infections. Hernáez B, Viejo-Borbolla A, Cabrera JR.  Front Cell Neurosci. 2022 Apr 5;16:883221. doi: 10.3389/fncel.2022.883221. PMID: 35450209; PMCID: PMC9016110.
  131. Interventional Bronchus Occlusion Using Amplatzer Devices – A Promising Treatment Option for Children with Persistent Air Leak. Schütz K, Happel CM, Keil O, Dingemann J, Carlens J, Wetzke M, Müller C, Köditz H, Griese M, Reiter K, Schweiger-Kabesch A, Backendorf A, Scharff A, Bertram H, Schwerk N.  Klin Padiatr. 2022 Sep;234(5):293-300. English. doi: 10.1055/a-1697-5624. Epub 2022 Jan 3. PMID: 34979579.
  132. The Inflammasome Activity of NLRP3 Is Independent of NEK7 in HEK293 Cells Co-Expressing ASC. Machtens DA, Bresch IP, Eberhage J, Reubold TF, Eschenburg S.  Int J Mol Sci. 2022 Sep 7;23(18):10269. doi: 10.3390/ijms231810269. PMID: 36142182; PMCID: PMC9499477.
  133. Therapeutic targeting of endoplasmic reticulum stress in acute graft-versus-host disease. Haring E, Andrieux G, Uhl FM, Krausz M, Proietti M, Sauer B, Esser PR, Martin SF, Pfeifer D, Schmitt-Graeff A, Duyster J, Köhler N, Grimbacher B, Boerries M, Aumann K, Zeiser R, Apostolova P.  Haematologica. 2022 Jul 1;107(7):1538-1554. PMID: 34407601; PMCID: PMC9244832.
  134. Copy Number Analysis in a Large Cohort Suggestive of Inborn Errors of Immunity Indicates a Wide Spectrum of Relevant Chromosomal Losses and Gains. Wan R, Schieck M, Caballero-Oteyza A, Hofmann W, Cochino AV, Shcherbina A, Sherkat R, Wache-Mainier C, Fernandez A, Sultan M, Illig T, Grimbacher B, Proietti M, Steinemann D.  J Clin Immunol. 2022 Jul;42(5):1083-1092. Epub 2022 Apr 29.
  135. Clinical, Immunological and Molecular Findings of Patients with Severe Combined Immunodeficiency: Introducing of 7 Novel Mutations in 7 Genes. Z Alizadeh, MR Fazlollahi, M Mazinani, M Badalzadeh, H Heydarlou, …  Genes Immun
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  137. Identification of variants in genes associated with autoinflammatory disorders in a cohort of patients with psoriatic arthritis F. Atschekzei, N. Dubrowinskaja, M. Anim, T. Thiele, T. Witte and G. Sogkas RMD Open 2022 Vol. 8 Issue 2 Accession Number: 36113963 PMCID: PMC9486391 DOI: 10.1136/rmdopen-2022-002561
  138. Metamizole-Associated Risks in Decompensated Hepatic Cirrhosis B. Schulte, T. L. Tergast, M. Griemsmann, D. Menti, N. Deveci, J. Kahlhöfer, et al. Dtsch Arztebl Int 2022 Vol. 119 Issue 41 Pages 687-693 Accession Number: 35912424 PMCID: PMC9830680 DOI: 10.3238/arztebl.m2022.0280
  139. Dual Effect: High NADH Levels Contribute to Efflux-Mediated Antibiotic Resistance but Drive Lethality Mediated by Reactive Oxygen Species A. Arce-Rodríguez, D. Pankratz, M. Preusse, P. I. Nikel and S. Häussler mBio 2022 Vol. 13 Issue 1 Pages e0243421 DOI: 10.1128/mbio.02434-21
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  1. KIR3DS1 directs NK cell-mediated protection against human adenovirus infections. Jung JM, Ching W, Baumdick ME, Hofmann-Sieber H, Bosse JB, Koyro T, Möller KJ, Wegner L, Niehrs A, Russu K, Ohms M, Zhang W, Ehrhardt A, Duisters K, Spierings E, Hölzemer A, Körner C, Jansen SA, Peine S, Königs I, Lütgehetmann M, Perez D, Reinshagen K, Lindemans CA, Altfeld M, Belderbos M, Dobner T, Bunders MJ. Sci Immunol. 2021 Sep 17;6(63):eabe2942. doi: 10.1126/sciimmunol.abe2942. Epub 2021 Sep 17. PMID: 34533978.
  2. Role of the gut microbiota in airway immunity and host defense against respiratory infections. Willers M, Viemann D. Biol Chem. 2021 Oct 4. doi: 10.1515/hsz-2021-0281. Epub ahead of print. PMID: 34599869.
  3. Bowel Histology of CVID Patients Reveals Distinct Patterns of Mucosal Inflammation. van Schewick CM, Lowe DM, Burns SO, Workman S, Symes A, Guzman D, Moreira F, Watkins J, Clark I, Grimbacher B.  J Clin Immunol. 2021 Oct 1. doi: 10.1007/s10875-021-01104-5. Epub ahead of print. PMID: 34599484.
  4. Specific T cells targeting Staphylococcus aureus fibronectin-binding protein 1 induce a type 2/type 1 inflammatory response in sensitized atopic dermatitis patients. Farag AK, Roesner LM, Wieschowski S, Heratizadeh A, Eiz-Vesper B, Kwok WW, Valenta R, Werfel T. Allergy. 2021 Oct 3. doi: 10.1111/all.15120. Epub ahead of print. PMID: 34601735.
  5. Regulatory B cells control airway hyperreactivity and lung remodeling in a murine asthma model. Habener A, Happle C, Grychtol R, Skuljec J, Busse M, Dalüge K, Obernolte H, Sewald K, Braun A, Meyer-Bahlburg A, Hansen G.  J Allergy Clin Immunol. 2021 Jun;147(6):2281-2294.e7. doi: 10.1016/j.jaci.2020.09.041. Epub 2020 Nov 27. PMID: 33249168.
  6. The journey of herpesvirus capsids and genomes to the host cell nucleus. Döhner K, Cornelius A, Serrero MC, Sodeik B. Curr Opin Virol. 2021 Oct;50:147-158. doi: 10.1016/j.coviro.2021.08.005. Epub 2021 Aug 28. PMID: 34464845.
  7. Klebsiella oxytoca causes colonization resistance against multidrug-resistant K. pneumoniae in the gut via cooperative carbohydrate competition. Osbelt L, Wende M, Almási É, Derksen E, Muthukumarasamy U, Lesker TR, Galvez EJC, Pils MC, Schalk E, Chhatwal P, Färber J, Neumann-Schaal M, Fischer T, Schlüter D, Strowig T. Cell Host Microbe. 2021 Sep 29:S1931-3128(21)00419-4. doi: 10.1016/j.chom.2021.09.003. Epub ahead of print. PMID: 34610293.
  8. Bile acids regulate intestinal antigen presentation and reduce graft-versus-host disease without impairing the graft-versus-leukemia effect. Haematologica. Haring E, Uhl FM, Andrieux G, Proietti M, Bulashevska A, Sauer B, Braun LM, de Vega Gomez E, Esser PR, Martin SF, Pfeifer D, Follo M, Schmitt-Graeff A, Buescher J, Duyster J, Grimbacher B, Boerries M, Pearce EL, Zeiser R, Apostolova P. 2021 Aug 1;106(8):2131-2146. doi: 10.3324/haematol.2019.242990. PMID: 32675222; PMCID: PMC8327708.
  9. Diagnostic Yield and Therapeutic Consequences of Targeted Next-Generation Sequencing in Sporadic Primary Immunodeficiency. Sogkas G, Dubrowinskaja N, Schütz K, Steinbrück L, Götting J, Schwerk N, Baumann U, Grimbacher B, Witte T, Schmidt RE, Atschekzei F.  Int Arch Allergy Immunol. 2021 Oct 7:1-13. doi: 10.1159/000519199. Epub ahead of print. PMID: 34619682.
  10. Neutralization of the SARS-CoV-2 Delta variant after heterologous and homologous BNT162b2 or ChAdOx1 nCoV-19 vaccination. Hammerschmidt SI, Bosnjak B, Bernhardt G, Friedrichsen M, Ravens I, Dopfer-Jablonka A, Hoffmann M, Pöhlmann S, Behrens GMN, Förster R. Cell Mol Immunol. 2021 Oct;18(10):2455-2456. doi: 10.1038/s41423-021-00755-z. Epub 2021 Aug 23. PMID: 34426672; PMCID: PMC8381713.
  11. Recent Advances in Developing Treatments of Kaposi’s Sarcoma Herpesvirus-Related Diseases. Naimo E, Zischke J, Schulz TF.  Viruses. 2021 Sep 9;13(9):1797. doi: 10.3390/v13091797. PMID: 34578378; PMCID: PMC8473310.
  12. Generation of hiPSC-derived low threshold mechanoreceptors containing axonal termini resembling bulbous sensory nerve endings and expressing Piezo1 and Piezo2. Zhu S, Stanslowsky N, Fernández-Trillo J, Mamo TM, Yu P, Kalmbach N, Ritter B, Eggenschwiler R, Ouwendijk WJD, Mzinza D, Tan L, Leffler A, Spohn M, Brown RJP, Kropp KA, Kaever V, Ha TC, Narayanan P, Grundhoff A, Förster R, Schambach A, Verjans GMGM, Schmidt M, Kispert A, Cantz T, Gomis A, Wegner F, Viejo-Borbolla A. Stem Cell Res. 2021 Sep 11;56:102535. doi: 10.1016/j.scr.2021.102535. Epub ahead of print. PMID: 34607262.
  13. Pathogenesis and virulence of herpes simplex virus. Zhu S, Viejo-Borbolla A. Virulence. 2021 Dec;12(1):2670-2702. doi: 10.1080/21505594.2021.1982373. PMID: 34676800.
  14. Nitric oxide controls proliferation of Leishmania major by inhibiting the recruitment of permissive host cells. Formaglio P, Alabdullah M, Siokis A, Handschuh J, Sauerland I, Fu Y, Krone A, Gintschel P, Stettin J, Heyde S, Mohr J, Philipsen L, Schröder A, Robert PA, Zhao G, Khailaie S, Dudeck A, Bertrand J, Späth GF, Kahlfuß S, Bousso P, Schraven B, Huehn J, Binder S, Meyer-Hermann M, Müller AJ. Immunity. 2021 Oct 15:S1074-7613(21)00406-4. doi: 10.1016/j.immuni.2021.09.021. Epub ahead of print. PMID: 34687607.
  15. Toll-like Receptors in Viral Encephalitis. Gern OL, Mulenge F, Pavlou A, Ghita L, Steffen I, Stangel M, Kalinke U.  Viruses. 2021 Oct 14;13(10):2065. doi: 10.3390/v13102065. PMID: 34696494.
  16. Impact of HBsAg and HBcrAg levels on phenotype and function of HBV-specific T cells in patients with chronic hepatitis B virus infection. Aliabadi E, Urbanek-Quaing M, Maasoumy B, Bremer B, Grasshoff M, Li Y, Niehaus CE, Wedemeyer H, Kraft ARM, Cornberg M. Gut. 2021 Oct 26:gutjnl-2021-324646. doi: 10.1136/gutjnl-2021-324646. Epub ahead of print. PMID: 34702717.
  17. Mesenteric Lymph Node Transplantation in Mice to Study Immune Responses of the Gastrointestinal Tract. Haroon Shaikh, Juan Gamboa Vargas, Zeinab Mokhtari, Katja J. Jarick, Maria Ulbrich, Josefina Peña Mosca, Estibaliz Arellano Viera, Caroline Graf, Duc-Dung Le, Katrin G. Heinze, Maike Büttner-Herold, Andreas Rosenwald, Joern Pezoldt, Jochen Huehn, Andreas Beilhack.  Front Immunol. 2021; 12: 689896. Published online 2021 Jul 26.
  18. Concatemeric Broccoli reduces mRNA stability and induces aggregates. Rink MR, Baptista MAP, Flomm FJ, Hennig T, Whisnant AW, Wolf N, Seibel J, Dölken L, Bosse JB. PLoS One. 2021 Aug 4;16(8):e0244166. doi: 10.1371/journal.pone.0244166. eCollection 2021. PMID: 34347781 Free PMC article.
  19. Quo vadis clinical diagnostic microbiology? Haag S, Häussler S. Clin Microbiol Infect. 2021 Jul 26:S1198-743X(21)00404-3. doi: 10.1016/j.cmi.2021.07.013. Online ahead of print. PMID: 34325069 No abstract available.
  20. Tbx21 and Foxp3 Are Epigenetically Stabilized in T-Bet+ Tregs That Transiently Accumulate in Influenza A Virus-Infected Lungs. Elfaki Y, Yang J, Boehme J, Schultz K, Bruder D, Falk CS, Huehn J, Floess S. Int J Mol Sci. 2021 Jul 14;22(14):7522. doi: 10.3390/ijms22147522. PMID: 34299148 Free PMC article.
  21. Sequential MAVS and MyD88/TRIF signaling triggers anti-viral responses of tick-borne encephalitis virus-infected murine astrocytes. Ghita L, Breitkopf V, Mulenge F, Pavlou A, Gern OL, Durán V, Prajeeth CK, Kohls M, Jung K, Stangel M, Steffen I, Kalinke U. J Neurosci Res. 2021 Jul 23. doi: 10.1002/jnr.24923. Online ahead of print. PMID: 34296786
  22. Distribution of major lymphocyte subsets and memory T-cell subpopulations in healthy adults employing GLP-conforming multicolor flow cytometry. Schultze-Florey CR, Chukhno E, Goudeva L, Blasczyk R, Ganser A, Prinz I, Förster R, Koenecke C, Odak I. Leukemia. 2021 Jul 21. doi: 10.1038/s41375-021-01348-5. Online ahead of print. PMID: 34290358 No abstract available.
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