Marina

RESIST Provides the Scientific Foundation for a Potential PSC Therapy The currently incurable liver disease "primary sclerosing cholangitis (PSC)" affects approximately one in 10,000 people in Germany. Characterized by chronic inflammation of the bile ducts, PSC frequently leads to severe complications, including the need for liver transplantation. To date, treatment options are limited to managing symptoms, often through the use of broad-spectrum antibiotics, which may promote the development of antimicrobial resistance. Researchers at Hannover Medical School and the Helmholtz Centre for Infection Research are now developing an innovative therapeutic approach within the “StopPSC” project. The focus is on the [...]

Big data study reveals an association with a molecular state of immune cells How Long COVID develops is still poorly understood. A recent study led by Prof. Yang Li at the Centre for Individualised Infection Medicine (CiiM) now provides new insights into potential molecular mechanisms underlying the condition. Yang Li is also a member of the RESIST Cluster of Excellence, as are other researchers who played a key role in the publication. Using modern single-cell analyses, the researchers identified a specific molecular state in immune cells that is associated with inflammatory processes as well as typical Long COVID symptoms [...]

At MHH, a Fulbright scholar is combining engineering and immunology to improve wound treatment. Chronic wounds often cause great distress to those affected, as they heal very poorly, are painful, and restrict movement. At Hannover Medical School (MHH), Fulbright scholar Samuel Sung from the USA is now spending a year researching new therapeutic approaches to improve the healing of chronic wounds in collaboration with the team of Prof. Dr. Nico Lachmann, who is part of the RESIST research group. To this end, he is combining engineering with immunology and focusing on the use of specialized immune cells. Macrophages (scavenger [...]