Prof. Dr. Yannik Bartsch

My Research Interest in RESIST

Antibodies are key components of the adaptive immune system and are critical for defense against infectious diseases. While antibodies can directly block and prevent pathogens from infecting the host through a process called neutralization, recruitment of additional innate effector mechanisms such as phagocytosis or cytotoxicity is often required for effective protection. Within RESIST, we aim to define antibody properties and effector functions that track with protection or susceptibility to infectious diseases. A better understanding of antibody-mediated immunity may lead to the development of better vaccines or antibody-based therapies.

Prof. Bartsch

Prof. Yannik Bartsch

Prof. Dr. Yannik Bartsch

Current Position

  • Since 2024: Assistant (Junior) Professor for Antiviral Antibody-Omics

  • Since 2023: Helmholtz Young Investigator Group Leader

Undergraduate and Postgraduate Training

  • B.Sc (2012) and M.Sc (2014) in Molecular Life Science University of L√ľbeck

  • PhD (2019) at University of L√ľbeck

Academic and Research Posts

  • 2019-2022: Postdoctoral Research Fellow at the Ragon Institute and Harvard Medical School (Boston, MA, USA)

Recommended Links

For further information about Prof. Bartsch’s scientific work please check the following links:

10 Selected Publications

Bartsch, Y. C., Cizmeci, D., Yuan, D., Mehta, N., Tolboom, J., De Paepe, E., . . . Bastian, A. R. (2023). Vaccine-induced antibody Fc-effector functions in humans immunized with a combination Ad26.RSV.preF/RSV preF protein vaccine. J Virol, 97(11), e0077123. doi:10.1128/jvi.00771-23

Bartsch, Y. C., Cizmeci, D., Kang, J., Gao, H., Shi, W., Chandrashekar, A., . . . Alter, G. (2023). Selective SARS-CoV2 BA.2 escape of antibody Fc/Fc-receptor interactions. iScience, 26(5), 106582. doi:10.1016/j.isci.2023.106582

Yonker, L. M., Swank, Z., Bartsch, Y. C.*, Burns, M. D., Kane, A., Boribong, B. P., . . . Walt, D. R. (2023). Circulating Spike Protein Detected in Post-COVID-19 mRNA Vaccine Myocarditis. Circulation, 147(11), 867-876. doi:10.1161/CIRCULATIONAHA.122.061025. *shared first author

Bartsch, Y. C., Cizmeci, D., Kang, J., Zohar, T., Periasamy, S., Mehta, N., . . . Alter, G. (2022). Antibody effector functions are associated with protection from respiratory syncytial virus. Cell, 185(26), 4873-4886 e4810. doi:10.1016/j.cell.2022.11.012

Bartsch, Y. C., St Denis, K. J., Kaplonek, P., Kang, J., Lam, E. C., Burns, M. D., . . . Alter, G. (2022). SARS-CoV-2 mRNA vaccination elicits robust antibody responses in children. Sci Transl Med, 14(672), eabn9237. doi:10.1126/scitranslmed.abn9237

Karsten, C. B., Bartsch, Y. C.*, Shin, S. A., Slein, M. D., Heller, H. M., Kolandaivelu, K., . . . Julg, B. (2022). Evolution of functional antibodies following acute Epstein-Barr virus infection. PLoS Pathog, 18(9), e1010738. doi:10.1371/journal.ppat.1010738. *shared first author

Bartsch, Y. C., Tong, X., Kang, J., Avendano, M. J., Serrano, E. F., Garcia-Salum, T., . . . Alter, G. (2022). Omicron variant Spike-specific antibody binding and Fc activity are preserved in recipients of mRNA or inactivated COVID-19 vaccines. Sci Transl Med, 14(642), eabn9243. doi:10.1126/scitranslmed.abn9243

Bartsch, Y. C., Loos, C., Rossignol, E., Fajnzylber, J. M., Yuan, D., Avihingsanon, A., . . . Julg, B. (2021). Viral Rebound Kinetics Correlate with Distinct HIV Antibody Features. mBio, 12(2). doi:10.1128/mBio.00170-21

Bartsch, Y. C., Wang, C., Zohar, T., Fischinger, S., Atyeo, C., Burke, J. S., . . . Alter, G. (2021). Humoral signatures of protective and pathological SARS-CoV-2 infection in children. Nat Med, 27(3), 454-462. doi:10.1038/s41591-021-01263-3

Bartsch, Y. C., Eschweiler, S., Leliavski, A., Lunding, H. B., Wagt, S., Petry, J., . . . Ehlers, M. (2020). IgG Fc sialylation is regulated during the germinal center reaction following immunization with different adjuvants. J Allergy Clin Immunol, 146(3), 652-666 e611. doi:10.1016/j.jaci.2020.04.059

Contact

  Prof. Dr. Yannik Bartsch
¬†¬† Institut f√ľr Experimentelle Infektionsforschung
TWINCORE – Zentrum f√ľr Experimentelle und Klinische Infektionsforschung GmbH
  Feodor-Lynen-Str. 7
30625 Hannover
  +49 511 532 Р71049
  yannic.bartsch@
twincore.de