{"id":8009,"date":"2019-12-14T15:38:39","date_gmt":"2019-12-14T14:38:39","guid":{"rendered":"https:\/\/www.resist-cluster.de\/?p=8009"},"modified":"2022-05-12T11:13:30","modified_gmt":"2022-05-12T09:13:30","slug":"immune-system-enhances-the-formation-of-biofilms","status":"publish","type":"post","link":"https:\/\/www.resist-cluster.de\/en\/immune-system-enhances-the-formation-of-biofilms\/","title":{"rendered":"Immune system enhances the formation of biofilms"},"content":{"rendered":"<div class=\"fusion-fullwidth fullwidth-box fusion-builder-row-1 nonhundred-percent-fullwidth non-hundred-percent-height-scrolling\" style=\"--awb-border-radius-top-left:0px;--awb-border-radius-top-right:0px;--awb-border-radius-bottom-right:0px;--awb-border-radius-bottom-left:0px;--awb-flex-wrap:wrap;\" ><div class=\"fusion-builder-row fusion-row\"><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-0 fusion_builder_column_1_1 1_1 fusion-one-full fusion-column-first fusion-column-last\" style=\"--awb-bg-size:cover;\"><div class=\"fusion-column-wrapper fusion-column-has-shadow fusion-flex-column-wrapper-legacy\"><div class=\"fusion-text fusion-text-1 bgs-blocksatz\"><p>The immune system protects against the formation of biofilms. That was previously believed. In contrast, however, now RESIST researchers led by Professor Dr. Reinhold F\u00f6rster have discovered that the immune system enhances the formation of biofilms with the help of a new developed mouse model for their research.<\/p>\n<p>Biofilms \u2013 an important topic in the Cluster of Excellence RESIST \u2013 are well-organised bacterial communities that colonise implants (among others), and which are neither affected by the immune system nor by antibiotics. Professor F\u00f6rster, head of the MHH Institute of Immunology, and his research group have now established the first mouse model that can be used to investigate the formation and combating of biofilms. As part of a RESIST project, Dr. Rodrigo Gutierrez Jauregui (photo) was able to gain first insights and publish them in the journal &#8220;Frontiers in Immunology&#8221;: &#8220;In contrast to the previous assumption that the immune system counteracts the formation of biofilms, it has been shown that the defence mechanisms promote the formation of biofilms,&#8221; said Professor F\u00f6rster. The mouse model allows further biofilm research and the development of new therapies.<\/p>\n<p>The team implanted osmotic pumps into the mice in order to form biofilms that made it possible to supply immune-cell-activating substances such as cytokines. This way it was possible to investigate their effect on biofilm formation. You can find the original publication <a href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fimmu.2019.01082\/full\">here<\/a>.<\/p>\n<\/div><div class=\"fusion-sep-clear\"><\/div><div class=\"fusion-separator fusion-full-width-sep\" style=\"margin-left: auto;margin-right: auto;margin-bottom:30px;width:100%;\"><\/div><div class=\"fusion-sep-clear\"><\/div><div class=\"fusion-aligncenter\"><a class=\"fusion-button button-flat button-xlarge button-default fusion-button-default button-1 fusion-button-default-span fusion-button-default-type buttonstapel-mitte\" target=\"_self\" href=\"https:\/\/www.resist-cluster.de\/forschung\/\"><span class=\"fusion-button-text\">More information about our research<\/span><\/a><\/div><div class=\"fusion-clearfix\"><\/div><\/div><\/div><\/div><\/div>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":4,"featured_media":8239,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[51],"tags":[],"class_list":["post-8009","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news"],"_links":{"self":[{"href":"https:\/\/www.resist-cluster.de\/en\/wp-json\/wp\/v2\/posts\/8009","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.resist-cluster.de\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.resist-cluster.de\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.resist-cluster.de\/en\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/www.resist-cluster.de\/en\/wp-json\/wp\/v2\/comments?post=8009"}],"version-history":[{"count":2,"href":"https:\/\/www.resist-cluster.de\/en\/wp-json\/wp\/v2\/posts\/8009\/revisions"}],"predecessor-version":[{"id":8017,"href":"https:\/\/www.resist-cluster.de\/en\/wp-json\/wp\/v2\/posts\/8009\/revisions\/8017"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.resist-cluster.de\/en\/wp-json\/wp\/v2\/media\/8239"}],"wp:attachment":[{"href":"https:\/\/www.resist-cluster.de\/en\/wp-json\/wp\/v2\/media?parent=8009"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.resist-cluster.de\/en\/wp-json\/wp\/v2\/categories?post=8009"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.resist-cluster.de\/en\/wp-json\/wp\/v2\/tags?post=8009"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}