{"id":9818,"date":"2020-05-06T11:40:45","date_gmt":"2020-05-06T09:40:45","guid":{"rendered":"https:\/\/www.resist-cluster.de\/about-us\/research-team\/prof-dr-thomas-krey\/"},"modified":"2022-02-02T13:37:39","modified_gmt":"2022-02-02T12:37:39","slug":"prof-dr-thomas-krey","status":"publish","type":"page","link":"https:\/\/www.resist-cluster.de\/en\/about-us\/research-team-2\/prof-dr-thomas-krey\/","title":{"rendered":"Prof. Dr. Thomas Krey"},"content":{"rendered":"

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Prof. Dr. Thomas Krey participates in\u00a0RESIST research projects B10, D1 and D3.<\/p>\n<\/div>

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<\/i><\/td>\nMy Research Interest in RESIST<\/td>\n<\/tr>\n<\/tbody>\n<\/table><\/h1><\/div>
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Our research focus in RESIST is the development and validation of a prophylactic Hepatitis C virus (HCV) vaccine based on the induction of potent broadly neutralizing antibodies (bnAbs) targeting the HCV glycoproteins. Such a vaccine will successfully complement the available treatment options and facilitate global control of HCV. Following this research strategy, we build on our longterm experience with the structural characterization of neutralization epitopes within the HCV glycoproteins. In collaboration with RESIST partner Thomas Pietschmann we will set out to characterize the evolution of bnAbs in vivo, the epitopes they target and the maturation pathways that B cells undergo to produce them. We also intend to utilize the accumulating structural information on HCV neutralization epitopes by applying novel structure-based approaches to create highly immunogenic vaccine antigens that elicit a protective humoral immune response against HCV.\u00a0<\/span><\/p>\n

In addition, together with RESIST partners Sodeik, Gr\u00fcnewald and Messerle we focus on the assembly of infectious Herpesvirus particles. We aim to better understand key mechanisms that drive Herpesvirus assembly in order to identify new protein-protein interfaces that are essential for virion assembly, and hence, might provide prime candidates for antiviral intervention.\u00a0<\/span><\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>

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<\/i><\/span>Contact<\/span><\/a><\/div>
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Prof. Krey at the University of L\u00fcbeck<\/h1><\/div>
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Prof. Dr. Thomas Krey – Curriculum Vitae<\/h1><\/div>
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Current Position<\/h3><\/div>