{"id":9489,"date":"2020-04-28T18:59:08","date_gmt":"2020-04-28T16:59:08","guid":{"rendered":"https:\/\/www.resist-cluster.de\/?page_id=9489"},"modified":"2024-12-16T12:02:37","modified_gmt":"2024-12-16T11:02:37","slug":"prof-dr-martin-messerle","status":"publish","type":"page","link":"https:\/\/www.resist-cluster.de\/en\/about-us\/research-team-2\/prof-dr-martin-messerle\/","title":{"rendered":"Prof. Dr. Martin Messerle"},"content":{"rendered":"

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Prof. Dr. Martin Messerle participates in\u00a0RESIST research projects D1 and D2.<\/p>\n<\/div>

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<\/i><\/td>\nMy Research Interest in RESIST<\/td>\n<\/tr>\n<\/tbody>\n<\/table><\/h1><\/div>
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Our aim is to understand the genome encapsidation protein network of human cytomegalovirus (CMV), which could be the target of urgently needed novel drugs against CMV. In previous work we have characterized several viral proteins that are key in this process, for instance the third subunit of the CMV terminase and the putative capsid vertex specific components. \u00a0<\/span><\/p>\n

Our further studies will build on the analysis of CMV mutants, using the BAC mutagenesis technique and a newly established highly efficient transfection technique (adenofection) that allows us to directly analyse cells transfected with mutant CMV genomes. In collaboration with the Gr\u00fcnewald, Krey and Sodeik groups we aim at a comparative and comprehensive characterization of capsid and virion assembly across the herpesviral subfamilies, including structure determination of key encapsidation proteins and analysis of the genome packaging by state-of-the-art fluorescence and cryo-electron microscopy techniques.<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>

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<\/i><\/span>Contact<\/span><\/a><\/div>
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Prof. Messerle about his scientific work<\/h1><\/div>