{"id":9474,"date":"2020-04-29T10:43:28","date_gmt":"2020-04-29T08:43:28","guid":{"rendered":"https:\/\/www.resist-cluster.de\/?page_id=9474"},"modified":"2024-12-05T10:02:00","modified_gmt":"2024-12-05T09:02:00","slug":"prof-dr-torsten-witte","status":"publish","type":"page","link":"https:\/\/www.resist-cluster.de\/en\/about-us\/research-team-2\/prof-dr-torsten-witte\/","title":{"rendered":"Prof. Dr. Torsten Witte"},"content":{"rendered":"

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Prof. Dr. Torsten Witte participates in\u00a0RESIST research projects A2 and B2.<\/p>\n<\/div>

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<\/i><\/td>\nMy Research Interest in RESIST<\/td>\n<\/tr>\n<\/tbody>\n<\/table><\/h1><\/div>
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My research focus in RESIST is the identification of the role of the gut microbiota in the induction of reactive arthritis, a chronic rheumatological disorder from the group of spondyloarthritis. The longterm aim is the identification of new targets for treatments, that may be more efficacious and more tolerable than the current drugs directed at the blockade of various cytokines.\u00a0<\/span><\/p>\n

In my previous work, I have identified autoantibodies in this disorder that activate the immune system to produce pathogenic cytokines, but also crossreact with microbial antigens. In the collaboration in RESIST with Till Strowig and Alice McHardy, we will identify further microbiota that induce pathogenic autoantibody responses in reactive arthritis and possibly other subtypes of SpA and RA. These discoveries may lead to therapeutic strategies pointing at the normalization of the gut microbiota rather than on immunosuppression.\u00a0<\/span><\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>

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<\/i><\/span>Contact<\/span><\/a><\/div>
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Prof. Witte about his scientific work<\/h1><\/div>