{"id":9447,"date":"2020-04-29T10:32:23","date_gmt":"2020-04-29T08:32:23","guid":{"rendered":"https:\/\/www.resist-cluster.de\/?page_id=9447"},"modified":"2024-12-06T09:48:58","modified_gmt":"2024-12-06T08:48:58","slug":"prof-dr-dorothee-viemann","status":"publish","type":"page","link":"https:\/\/www.resist-cluster.de\/en\/about-us\/research-team-2\/prof-dr-dorothee-viemann\/","title":{"rendered":"Prof. Dr. Dorothee Viemann"},"content":{"rendered":"

<\/div>
<\/div>
<\/div>
<\/div>
<\/div>
<\/div>
<\/div><\/div><\/div>
<\/a><\/span><\/div>

Prof. Dr. Dorothee Viemann participates in RESIST research project B1.<\/p>\n<\/div>

<\/div><\/div><\/div>

\n\n\n
<\/i><\/td>\nMy Research Interest in RESIST<\/td>\n<\/tr>\n<\/tbody>\n<\/table><\/h1><\/div>
\n
\n
\n

Our group is interested in the maturation processes of systemic as well as mucosal immunity in preterm infants. Within RESIST we focus on the reciprocal host-microbiota interactions and how human microbiota shapes the immune system during the phase of environmental adaptation in this patient group. Our work program aims at providing detailed insights about what host factors and what microbiota members promote increased resistance against bacterial and viral infections and the development life-long immune homeostasis and overall health. The long-term aim is to characterize based on the immune profile at birth what babies would profit from iatrogenic immunomodulation and second to identify host- and microbiota-related mechanisms that could be exploited to induce and accelerate immune maturation and colonization in preterm infants.<\/p>\n

Candidate host factors in this context are S100-alarmins. We previously revealed that healthy term neonates massively release S100-alarmins in the blood and receive a huge supply of S100-alarmins via breast milk. The S100-priming of immunity at birth induces a tolerant state and prevents hyperinflammatory responses against the new extra-uterine world without impairing pathogen defense. In RESIST we keep track of whether S100-alarmins essentially prepare the host in a superior manner for the colonization of a favourable microbiota thereby ensuring long-term health.\u00a0<\/span><\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>

<\/div>
<\/div>
<\/div>
<\/i><\/span>Contact<\/span><\/a><\/div>
<\/div><\/div><\/div><\/div><\/div>
<\/path><\/svg><\/div>
<\/div><\/div><\/div>
<\/div><\/div><\/div><\/div><\/div>
<\/div>
<\/div>
<\/div>
<\/div>
<\/div><\/div><\/div>
<\/div><\/div><\/div>

Prof. Viemann about her scientific work<\/h1><\/div>