{"id":9195,"date":"2020-04-28T12:49:39","date_gmt":"2020-04-28T10:49:39","guid":{"rendered":"https:\/\/www.resist-cluster.de\/?page_id=9195"},"modified":"2024-11-07T14:19:17","modified_gmt":"2024-11-07T13:19:17","slug":"prof-dr-dietmar-manstein","status":"publish","type":"page","link":"https:\/\/www.resist-cluster.de\/en\/about-us\/research-team-2\/prof-dr-dietmar-manstein\/","title":{"rendered":"Prof. Dr. Dietmar Manstein"},"content":{"rendered":"

<\/div>
<\/div>
<\/div>
<\/div>
<\/div>
<\/div>
<\/div><\/div><\/div>
<\/a><\/span><\/div>

Prof. Dr. Dietmar Manstein participates in\u00a0RESIST research project D4.<\/p>\n<\/div>

<\/div><\/div><\/div>

\n\n\n
<\/i><\/td>\nMy Research Interest in RESIST<\/td>\n<\/tr>\n<\/tbody>\n<\/table><\/h1><\/div>
\n
\n
\n

Our aim in the context of RESIST is the development of new antiviral, antimicrobial and immunomodulatory agents that target the innate immune sensors cyclic GMP-AMP synthase (cGAS) and 2′-5′-oligoadenylate synthase (OAS). OAS and cGAS belong to the large and diverse superfamily of nucleotide triphosphate transferases. Both enzymes play key roles in the activation of interferon- driven antiviral responses upon recognition of pathogen-associated molecular patterns (PAMPs). In addition, these sensors constitute a continuous surveillance system for the presence of microorganisms in tissues.<\/p>\n

We use a structure-based approach for the identification and optimization of highly specific small-molecule allosteric effectors of cGAS and OAS. This work is based on our comprehensive structural and mechanistic description of the complete enzymatic cycle of human cGAS and OAS. Validation of the compounds is performed in collaboration with RESIST scientists Thomas Pietschmann and Ulrich Kalinke.\u00a0<\/span><\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>

<\/div>
<\/div>
<\/div>
<\/i><\/span>Contact<\/span><\/a><\/div>
<\/div><\/div><\/div><\/div><\/div>
<\/path><\/svg><\/div>
<\/div><\/div><\/div>
<\/div><\/div><\/div><\/div><\/div>
<\/div>
<\/div>
<\/div>
<\/div>
<\/div><\/div><\/div>
<\/div><\/div><\/div>

Prof. Manstein about his scientific work<\/h1><\/div>