{"id":8921,"date":"2020-05-07T15:55:47","date_gmt":"2020-05-07T13:55:47","guid":{"rendered":"https:\/\/www.resist-cluster.de\/?page_id=8921"},"modified":"2022-02-02T12:42:14","modified_gmt":"2022-02-02T11:42:14","slug":"prof-dr-markus-cornberg","status":"publish","type":"page","link":"https:\/\/www.resist-cluster.de\/en\/about-us\/research-team-2\/prof-dr-markus-cornberg\/","title":{"rendered":"Prof. Dr. Markus Cornberg"},"content":{"rendered":"

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Prof. Dr. Markus Cornberg participates in RESIST research projects B8, B9 and B10.<\/p>\n<\/div>

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<\/i><\/td>\nMy Research Interest in RESIST<\/td>\n<\/tr>\n<\/tbody>\n<\/table><\/h1><\/div>

Our research focus in RESIST is to understand how the immune system is able to control or clear hepatitis viruses and how this could lead to novel treatment concepts, especially for chronic hepatitis B. Nucleoside or nucleotide analogues (NA) are the most commonly used drugs to treat chronic hepatitis B, but this therapy only suppresses the virus and rarely leads to cure or functional cure defined loss of the HBV surface antigen (HBsAg). Thus, for most patients this is a life-long treatment and new treatment strategies are needed with the aim to achieve HBsAg loss.<\/p>\n

For example, we have initiated prospective clinical trials investigating a structured NA treatment termination or interruption in patients with chronic hepatitis B. The results of the first trial was pivotal for the concept that stopping NA therapy and subsequent HBV DNA rebound may induce immune responses which could promote later HBsAg loss in 10-30% of cases.\u00a0However, several questions still remain to be answered in RESIST, such as the identification of the exact component of the immune system needed to achieve a functional cure following NA interruption, and also identifying patients who will benefit from stopping NA treatment.<\/p>\n<\/div>

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Prof. Cornberg about his scientific work<\/h1><\/div>