{"id":8777,"date":"2019-09-13T11:58:53","date_gmt":"2019-09-13T09:58:53","guid":{"rendered":"https:\/\/www.resist-cluster.de\/about-us\/research-team\/prof-dr-thomas-schulz\/"},"modified":"2024-11-07T14:38:47","modified_gmt":"2024-11-07T13:38:47","slug":"prof-dr-thomas-schulz","status":"publish","type":"page","link":"https:\/\/www.resist-cluster.de\/en\/about-us\/research-team-2\/prof-dr-thomas-schulz\/","title":{"rendered":"Prof. Dr. Thomas Schulz"},"content":{"rendered":"

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Prof. Dr. Thomas Schulz is speaker of RESIST and participates in research project D1.<\/p>\n<\/div>

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<\/i><\/td>\nMy Research Interest in RESIST<\/td>\n<\/tr>\n<\/tbody>\n<\/table><\/h1><\/div>

Our research focus in RESIST is the identification and validation of novel antiviral targets during the early stages of herpesviral replication and the development of small molecular compounds that interfere with these targets. The longterm aim is to thereby contribute to new treatment options for herpesviral disease and, in particular, to open the door for combination therapies that utilize drugs acting at different stages of the viral life cycle.<\/p>\n

In pursuing this research programme, we build on our longterm experience with Kaposi\u2019s sarcoma-associated herpesvirus. For this gammaherpesvirus, we have worked, for more than 20 years, on the functional and molecular characterization of its major latency protein LANA and a non-structural viral membrane protein, pK15, which is required for viral reactivation from latency. We have also recently, in collaboration with another RESIST scientist, Martin Empting, developed a first generation of small molecule inhibitors acting on LANA. Over the course of the next 6 years we want to continue with the development of these inhibitors and apply the experience gained in recent years to other herpesviruses.<\/p>\n<\/div>

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Thomas Schulz about his scientific work<\/h1><\/div>