{"id":5388,"date":"2019-09-11T16:19:16","date_gmt":"2019-09-11T14:19:16","guid":{"rendered":"https:\/\/www.resist-cluster.de\/?page_id=5388"},"modified":"2025-09-24T15:13:02","modified_gmt":"2025-09-24T13:13:02","slug":"project-b2","status":"publish","type":"page","link":"https:\/\/www.resist-cluster.de\/en\/research\/project-area-b\/project-b2\/","title":{"rendered":"Project B2"},"content":{"rendered":"

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Can intestinal bacteria trigger rheumatological diseases?<\/h1><\/div>

Prof. McHardy\u00a0 |\u00a0 Prof. Strowig\u00a0 |\u00a0 Prof. Witte<\/a><\/p><\/h2><\/div>

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What is this research project about?<\/span><\/span><\/h1><\/div>
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Professor Witte (right) is talking with a patient.<\/p>\n<\/div>

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What is this research project about?<\/h1><\/div>

Spondyloarthritis (SpA) is a group of frequent chronic rheumatological diseases which start in young adults and lead to disability of the patients. Current therapies are not efficient enough in stopping the progressive impairment of the musculoskeletal system. There is evidence that the microbiome of the gut is involved in triggering the disease. Clarifying the role of infections and the microbiome composition in the pathogenesis of SpA and its subform reactive arthritis may pave the way to new treatment modalities with better efficacy and less side effects.<\/p>\n<\/div>

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What’s the current status?<\/h1><\/div>
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With respect to a potential pathomechanism linking microbial colonization with autoimmunity and induction of SpA, it has been demonstrated that antibodies against Shigella flexneri<\/em>, Klebsiella pneumoniae<\/em> and Yersinia enterocolitica<\/em> may crossreact with HLA-B27, the dominant genetic risk factor of SpA, and that antibodies against Klebsiella were found to be cytotoxic for cells expressing HLA-B27. Whether similar autoantibodies are induced by other members of the microbiota and if yes, under which conditions remains unresolved.<\/p>\n

The image shows<\/strong><\/span>: Shigella flexneri<\/em> (Shigellen), group of bacteria. Transmission electron microscopy, negative contrast. Scale = 1 \u03bcm. Source: Hans R. Gelderblom, Gabi Schlier, Rolf Reissbrodt\/RKI<\/p>\n<\/div>

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What are the project goals?<\/h1><\/div>

We want to identify alteration in the gut microbiota that are involved in triggering spondyloarthritis. Specifically we want to characterize dynamic microbiome\u00a0 changes during the development and treatment of different forms of arthritis. Furthermore we want to identify antibodies associated with poor prognosis of SpA and members of the microbiome as well as antigens targeted by the immune system in arthritis patients. And our aim is to determine cross-reactivity between antibodies targeting microbial antigens and autoantigens develop intervention strategies to prevent the development of SpA and reactive arthritis.<\/p>\n<\/div><\/div><\/div>

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How do we get there?<\/h1><\/div>
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In the project RHEUMA-VOR we recruit a large number of patients from Lower Saxony with acute onset of SpA and control diseases. Stool, serum and DNA samples as well as PBMC and, when a joint aspiration was clinically indicated, synovial fluid (SF) and SF cells will be obtained and stored, and various disease-related clinical data as well as dietary habits will be collected. The patients from this inception cohort will be followed for > 2 years, and response to therapy, disease activity and disease progression will be monitored.<\/p>\n

The photo shows<\/strong> Professor Strowig in his laboratory. \u00a9 HZI\/Waldthausen & Kreibig<\/p>\n<\/div>

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Projectleaders<\/h1><\/div>

Project title: The microbiome \u2013 a trigger in arthritis? Linking alterations in microbiota composition to autoantibody development.<\/h4><\/div>
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Prof. Dr. Alice McHardy<\/h3><\/div>

Projects: B2<\/a>, B10<\/a>, C1<\/a><\/h3><\/div>
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CV & VIDEO<\/span><\/a><\/div>
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Prof. Dr. Till Strowig<\/h3><\/div>

Projects: B1<\/a>, B2<\/a>, RESIST-Cohort<\/a><\/h3><\/div>
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CV & VIDEO<\/span><\/a><\/div>
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Prof. Dr. Torsten Witte<\/h3><\/div>

Projects: A2<\/a>, B2<\/a><\/h3><\/div>
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CV & VIDEO<\/span><\/a><\/div>
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Project B2 Publications<\/h1><\/div>

Publications 2025<\/strong><\/p>\n

Long-term histone lactylation connects metabolic and epigenetic rewiring in innate immune memory<\/strong><\/a> A. Ziogas, B. Novakovic, L. Ventriglia, N. Galang, K. A. Tran, W. Li, et al. Cell 2025 <\/strong>Accession Number: 40318634 DOI: 10.1016\/j.cell.2025.03.048Transmissible Staphylococcus pseudintermedius thwarts neutrophil extracellular trap-driven containment to promote invasive disease<\/strong><\/a> R. Haller, Y. Cai, N. de Buhr, J. C. Rieder, D. Schl\u00fcter, C. Baier, et al. Emerg Microbes Infect 2025<\/strong> Vol. 14 Issue 1 Pages 2482709 Accession Number: 40172876 PMCID: PMC12001851 DOI: 10.1080\/22221751.2025.2482709<\/p>\n

Disruption to the gut microbiome by non-antibiotics is linked to infection risk<\/strong><\/a> C. Tawk and T. Strowig Cell Chem Biol<\/strong> 2025 Vol. 32 Issue 9 Pages 1102-1105 Accession Number: 40972521 DOI: 10.1016\/j.chembiol.2025.08.008<\/p>\n

Publications 2024<\/strong><\/p>\n

Assessing computational predictions of antimicrobial resistance phenotypes from microbial genomes<\/b><\/a>.<\/b> Hu, K., F. Meyer, Z. L. Deng, E. Asgari, T. H. Kuo, P. C. M\u00fcnch, and A. C. McHardy. 2024. Brief Bioinform<\/strong> 25.<\/p>\n

Shared and Distinct Gut Microbiota in Spondyloarthritis, Acute Anterior Uveitis, and Crohn’s Disease.<\/b><\/a>Essex, M., V. Rios Rodriguez, J. Rademacher, F. Proft, U. Lober, L. Marko, U. Pleyer, T. Strowig, J. Marchand, J. A. Kirwan, B. Siegmund, S. K. Forslund, and D. Poddubnyy. 2024. Arthritis Rheumatol<\/strong> 76: 48-58.<\/p>\n

Publications 2023<\/strong><\/p>\n

Spondyloarthritis, acute anterior uveitis, and Crohn’s disease have both shared and distinct gut microbiota.<\/strong><\/a> Essex M, Rios Rodriguez V, Rademacher J, Proft F, L\u00f6ber U, Mark\u00f3 L, Pleyer U, Strowig T, Marchand J, Kirwan JA, Siegmund B, Forslund SK, Poddubnyy D.\u00a0 Arthritis Rheumatol.<\/strong> 2023 Jul 20.<\/p>\n

Brief report: Assessment of mucosal barrier integrity using serological biomarkers in preclinical stages of rheumatoid arthritis.<\/strong> <\/a>Gilbert BTP, Lamacchia C, Amend L, Strowig T, Rodriguez E, Palmer G, Finckh A.\u00a0 Front Immunol.<\/strong> 2023 Feb 16;14:1117742.<\/p>\n

The link between rheumatic disorders and inborn errors of immunity<\/strong><\/a>. Sogkas G, Witte T. EBioMedicine.<\/strong> 2023 Apr;90:104501. Epub 2023 Mar 2.<\/p>\n

The natural product chlorotonil A preserves colonization resistance and prevents relapsing Clostridioides difficile infection.<\/strong>\u00a0<\/a>Bublitz A, Brauer M, Wagner S, Hofer W, M\u00fcsken M, Deschner F, Lesker TR, Neumann-Schaal M, Paul LS, N\u00fcbel U, Bartel J, Kany AM, Z\u00fchlke D, Bernecker S, Jansen R, Sievers S, Riedel K, Herrmann J, M\u00fcller R, Fuchs TM, Strowig T. Cell Host Microbe.<\/strong> 2023 Apr 18:S1931-3128(23)00147-6.<\/p>\n

Pulsed antibiotic treatments of gnotobiotic mice manifest in complex bacterial community dynamics and resistance effects.<\/strong> <\/a>M\u00fcnch PC, Eberl C, Woelfel S, Ring D, Fritz A, Herp S, Lade I, Geffers R, Franzosa EA, Huttenhower C, McHardy AC, Stecher B. Pulsed antibiotic treatments of gnotobiotic mice manifest in complex bacterial community dynamics and resistance effects. Cell Host Microbe.<\/strong> 2023 Jun 14;31(6):1007-1020.e4.<\/p>\n

MAGT1 Deficiency Dysregulates Platelet Cation Homeostasis and Accelerates Arterial Thrombosis and Ischemic Stroke in Mice.<\/strong>\u00a0<\/a>Gotru SK, Mammadova-Bach E, Sogkas G, Schuhmann MK, Schmitt K, Kraft P, Herterich S, Mamtimin M, Pinarci A, Beck S, Stritt S, Han C, Ren P, Freund JN, Klemann C, Ringshausen FC, Heemskerk JWM, Dietrich A, Nieswandt B, Stoll G, Gudermann T, Braun A.\u00a0 Arterioscler Thromb Vasc Biol.<\/strong> 2023 Aug;43(8):1494-1509. doi: 10.1161\/ATVBAHA.122.318115. Epub 2023 Jun 29. PMID: 37381987.<\/p>\n

Publications 2022<\/strong><\/p>\n

Identification of variants in genes associated with autoinflammatory disorders in a cohort of patients with psoriatic arthritis<\/strong><\/a> F. Atschekzei, N. Dubrowinskaja, M. Anim, T. Thiele, T. Witte and G. Sogkas RMD Open 2022<\/strong> Vol. 8 Issue 2 Accession Number: 36113963 PMCID: PMC9486391 DOI: 10.1136\/rmdopen-2022-002561<\/p>\n

Critical Assessment of Metagenome Interpretation: the second round of challenges.<\/strong><\/a>\u00a0Meyer F, Fritz A, Deng ZL, Koslicki D, Lesker TR, Gurevich A, Robertson G, Alser M, Antipov D, Beghini F, Bertrand D, Brito JJ, Brown CT, Buchmann J, Bulu\u00e7 A, Chen B, Chikhi R, Clausen PTLC, Cristian A, Dabrowski PW, Darling AE, Egan R, Eskin E, Georganas E, Goltsman E, Gray MA, Hansen LH, Hofmeyr S, Huang P, Irber L, Jia H, J\u00f8rgensen TS, Kieser SD, Klemetsen T, Kola A, Kolmogorov M, Korobeynikov A, Kwan J, LaPierre N, Lemaitre C, Li C, Limasset A, Malcher-Miranda F, Mangul S, Marcelino VR, Marchet C, Marijon P, Meleshko D, Mende DR, Milanese A, Nagarajan N, Nissen J, Nurk S, Oliker L, Paoli L, Peterlongo P, Piro VC, Porter JS, Rasmussen S, Rees ER, Reinert K, Renard B, Robertsen EM, Rosen GL, Ruscheweyh HJ, Sarwal V, Segata N, Seiler E, Shi L, Sun F, Sunagawa S, S\u00f8rensen SJ, Thomas A, Tong C, Trajkovski M, Tremblay J, Uritskiy G, Vicedomini R, Wang Z, Wang Z, Wang Z, Warren A, Willassen NP, Yelick K, You R, Zeller G, Zhao Z, Zhu S, Zhu J, Garrido-Oter R, Gastmeier P, Hacquard S, H\u00e4u\u00dfler S, Khaledi A, Maechler F, Mesny F, Radutoiu S, Schulze-Lefert P, Smit N, Strowig T, Bremges A, Sczyrba A, McHardy AC. Nat Methods.<\/strong> 2022 Apr;19(4):429-440. doi: 10.1038\/s41592-022-01431-4. Epub 2022 Apr 8. PMID: 35396482.<\/p>\n

Strain Identification and Quantitative Analysis in Microbial Communities.<\/strong> <\/a>Ghazi AR, M\u00fcnch PC, Chen D, Jensen J, Huttenhower C. J Mol Biol.<\/strong> 2022 Aug; Epub 2022 Apr 7.<\/p>\n

Primary antibody deficiency-associated arthritis shares features with spondyloarthritis and enteropathic arthritis.<\/strong>\u00a0<\/a>Pott NM, Atschekzei F, Pott CC, Ernst D, Witte T, Sogkas G. RMD Open<\/strong>. 2022 Dec<\/p>\n

Publications 2021<\/strong><\/p>\n

Klebsiella oxytoca causes colonization resistance against multidrug-resistant K. pneumoniae in the gut via cooperative carbohydrate competition.<\/a><\/strong> Osbelt L, Wende M, Alm\u00e1si \u00c9, Derksen E, Muthukumarasamy U, Lesker TR, Galvez EJC, Pils MC, Schalk E, Chhatwal P, F\u00e4rber J, Neumann-Schaal M, Fischer T, Schl\u00fcter D, Strowig T. Cell Host Microbe<\/strong>.<\/p>\n

Novel aspects of regulatory T cell dysfunction as a therapeutic target in giant cell arteritis.<\/strong> <\/a>Adriawan IR, Atschekzei F, Dittrich-Breiholz O, Garantziotis P, Hirsch S, Risser LM, Kosanke M, Schmidt RE, Witte T, Sogkas G. Ann Rheum Dis<\/strong>.<\/p>\n

B cell depletion impairs vaccination-induced CD8+<\/sup> T cell responses in a type I interferon-dependent manner.<\/strong><\/a> Graalmann T, Borst K, Manchanda H, Vaas L, Bruhn M, Graalmann L, Koster M, Verboom M, Hallensleben M, Guzm\u00e1n CA, Sutter G, Schmidt RE, Witte T, Kalinke U. Ann Rheum Dis.<\/strong><\/p>\n

Haploflow: strain-resolved de novo assembly of viral genomes.<\/a> Genome Biol <\/strong>22:212. Fritz A, Bremges A, Deng Z-L, Lesker TR, G\u00f6tting J, Ganzenmueller T, Sczyrba A, Dilthey A, Klawonn F, McHardy AC. 2021.<\/p>\n

Anti-CD74 IgA autoantibodies in radiographic axial spondyloarthritis: a longitudinal Swedish study.<\/strong> <\/a>Do L, Gran\u00e5sen G, Hellman U, Lejon K, Geijer M, Baraliakos X, Witte T, Forsblad-d’Elia H.\u00a0 Rheumatology<\/strong> (Oxford). 2021 Sep 1;60(9):4085-4093. doi: 10.1093\/rheumatology\/keaa882. PMID: 33369649; PMCID: PMC8410007.<\/p>\n

Perturbation of the gut microbiome by Prevotella spp. enhances host susceptibility to mucosal inflammation.<\/strong><\/a>\u00a0Iljazovic A, Roy U, G\u00e1lvez EJC, Lesker TR, Zhao B, Gronow A, Amend L, Will SE, Hofmann JD, Pils MC, Schmidt-Hohagen K, Neumann-Schaal M, Strowig T. Mucosal Immunol.<\/strong> 2021 Jan;14(1):113-124. doi: 10.1038\/s41385-020-0296-4. Epub 2020 May 20. PMID: 32433514; PMCID: PMC7790746.<\/p>\n

Single-cell chromatin accessibility landscape identifies tissue repair program in human regulatory T cells.<\/strong><\/a>\u00a0Delacher M, Simon M, Sanderink L, Hotz-Wagenblatt A, Wuttke M, Schambeck K, Schmidleithner L, Bittner S, Pant A, Ritter U, Hehlgans T, Riegel D, Schneider V, Groeber-Becker FK, Eigenberger A, Gebhard C, Strieder N, Fischer A, Rehli M, Hoffmann P, Edinger M, Strowig T, Huehn J, Schmidl C, Werner JM, Prantl L, Brors B, Imbusch CD, Feuerer M. Immunity.<\/strong> 2021 Apr 13;54(4):702-720.e17. doi: 10.1016\/j.immuni.2021.03.007. Epub 2021 Mar 30. PMID: 33789089; PMCID: PMC8050210.<\/p>\n

Publications 2020<\/strong><\/p>\n

Strategic Anti-SARS-CoV-2 Serology Testing in a Low Prevalence Setting: The COVID-19 Contact (CoCo) Study in Healthcare Professionals.<\/strong><\/a> Behrens GMN, Cossmann A, Stankov MV, Schulte B, Streeck H, F\u00f6rster R, Bosnjak B, Willenzon S, Boeck AL, Thu Tran A, Thiele T, Graalmann T, Kayser MZ, Zychlinsky Scharff A, Dopfer C, Horke A, Pink I, Witte T, Wetzke M, Ernst D, Jablonka A, Happle C. Infect Dis Ther<\/strong>. 2020 Dec;9(4):837-849. doi: 10.1007\/s40121-020-00334-1. Epub 2020 Sep 4. PMID: 32886335; PMCID: PMC7472691.<\/p>\n

An Integrated Metagenome Catalog Reveals New Insights into the Murine Gut Microbiome<\/a><\/strong>. Lesker TR, Durairaj AC, G\u00e1lvez EJC, Lagkouvardos I, Baines JF, Clavel T, Sczyrba A, McHardy AC, Strowig T.\u00a0 Cell Rep.<\/strong> 2020 Mar 3;30(9):2909-2922.e6. doi: 10.1016\/j.celrep.2020.02.036. PMID: 32130896; PMCID: PMC7059117.<\/p>\n

Peripheral Blood Lymphocyte Phenotype Differentiates Secondary Antibody Deficiency in Rheumatic Disease from Primary Antibody Deficiency<\/a><\/strong>. Jablonka A, Etemadi H, Adriawan IR, Ernst D, Jacobs R, Buyny S, Witte T, Schmidt RE, Atschekzei F, Sogkas G. J Clin Med.<\/strong> 2020 Apr 7;9(4):1049. doi: 10.3390\/jcm9041049. PMID: 32272789; PMCID: PMC7230453.<\/p>\n

Distinct Polysaccharide Utilization Determines Interspecies Competition between Intestinal Prevotella spp<\/a><\/strong>. G\u00e1lvez EJC, Iljazovic A, Amend L, Lesker TR, Renault T, Thiemann S, Hao L, Roy U, Gronow A, Charpentier E, Strowig T.\u00a0 Cell Host Microbe.<\/strong> 2020 Dec 9;28(6):838-852.e6. doi: 10.1016\/j.chom.2020.09.012. Epub 2020 Oct 27. PMID: 33113351.<\/p>\n

Identification of Natural CRISPR Systems and Targets in the Human Microbiome<\/strong><\/a>. Cell Host Microbe<\/strong>. M\u00fcnch PC, Franzosa EA, Stecher B, McHardy AC, Huttenhower C. 2021 Jan 13;29(1):94-106.e4. doi: 10.1016\/j.chom.2020.10.010. Epub 2020 Nov 19. PMID: 33217332; PMCID: PMC7813156.<\/p>\n

Dietary Short-Term Fiber Interventions in Arthritis Patients Increase Systemic SCFA Levels and Regulate Inflammation.<\/strong><\/a> D\u00fcrholz K, Hofmann J, Iljazovic A, H\u00e4ger J, Lucas S, Sarter K, Strowig T, Bang H, Rech J, Schett G, Zaiss MM. Nutrients.<\/strong> 2020 Oct 20;12(10):3207. doi: 10.3390\/nu12103207. PMID: 33092271; PMCID: PMC7589100.<\/p>\n

The Role of Ames Dwarfism and Calorie Restriction on Gut Microbiota.<\/span><\/a><\/strong>\u00a0Wiesenborn DS, G\u00e1lvez EJC, Spinel L, Victoria B, Allen B, Schneider A, Gesing A, Al-Regaiey KA, Strowig T, Sch\u00e4fer KH, Masternak MM. J Gerontol A Biol Sci Med Sci.<\/strong> 2020 Jun 18;75(7):e1-e8. doi: 10.1093\/gerona\/glz236.\u00a0<\/span>PMID: 31665244; PMCID: PMC7302176.<\/p>\n

Clinical, Radiological, and Laboratory Features of Spinal Cord Involvement in Primary Sj\u00f6gren\u2019s Syndrome<\/a><\/strong>. Butryn M, Neumann J, Rolfes L, Bartels C, Wattjes MP, Mahmoudi N, Seeliger T, Konen FF, Thiele T, Witte T, Meuth SG, Skripuletz T, Pawlitzki M. J Clin Med.<\/strong> 2020 May 14;9(5):1482. doi: 10.3390\/jcm9051482. PMID: 32423153; PMCID: PMC7290729.<\/p>\n

Anti-CD74 IgA autoantibodies in radiographic axial spondyloarthritis; a longitudinal Swedish study<\/a><\/strong>.<\/strong> Do L, Granasen G, Hellman U, Lejon K, Geijer M, Baraliakos X, Witte T, Forsblad-d\u2019Elia H. Rheumatology<\/strong> (Oxford) 2020<\/p>\n

High frequency of variants in genes associated with primary immunodeficiencies in patients with rheumatic diseases with secondary hypogammaglobulinaemia<\/a><\/strong> Sogkas G, Dubrowinskaja N, Adriawan IR, Anim M, Witte T, Schmidt RE, Atschekzei F.\u00a0 Ann Rheum Dis<\/strong> 2020<\/p>\n

Repertoire characterization and validation of gB-specific human IgGs directly cloned from humanized mice vaccinated with dendritic cells and protected against HCMV<\/strong><\/a>. Theobald SJ, Kreer C, Khailaie S, Bonifacius A, Eiz-Vesper B, Figueiredo C, Mach M, Backovic M, Ballmaier M, Koenig J, Olbrich H, Schneider A, Volk V, Danisch S, Gieselmann L, Ercanoglu MS, Messerle M, Kaisenberg CV, Witte T, Klawonn F, Meyer-Hermann M, Klein F, Stripecke R. PLoS Pathog.<\/strong> 2020 Jul 15;16(7):e1008560. doi: 10.1371\/journal.ppat.1008560. PMID: 32667948; PMCID: PMC7363084.<\/p>\n

Publications 2019<\/strong><\/p>\n

The CAFA challenge reports improved protein function prediction and new functional annotations for hundreds of genes through experimental screens.<\/strong><\/a> Zhou N, Jiang Y, Bergquist TR, Lee AJ, Kacsoh BZ, Crocker AW, Lewis KA, Georghiou G, Nguyen HN, Hamid MN, Davis L, Dogan T, Atalay V, Rifaioglu AS, Dalk\u0131ran A, Cetin Atalay R, Zhang C, Hurto RL, Freddolino PL, Zhang Y, Bhat P, Supek F, Fern\u00e1ndez JM, Gemovic B, Perovic VR, Davidovi\u0107 RS, Sumonja N, Veljkovic N, Asgari E, Mofrad MRK, Profiti G, Savojardo C, Martelli PL, Casadio R, Boecker F, Schoof H, Kahanda I, Thurlby N, McHardy AC, Renaux A, Saidi R, Gough J, Freitas AA, Antczak M, Fabris F, Wass MN, Hou J, Cheng J, Wang Z, Romero AE, Paccanaro A, Yang H, Goldberg T, Zhao C, Holm L, T\u00f6r\u00f6nen P, Medlar AJ, Zosa E, Borukhov I, Novikov I, Wilkins A, Lichtarge O, Chi PH, Tseng WC, Linial M, Rose PW, Dessimoz C, Vidulin V, Dzeroski S, Sillitoe I, Das S, Lees JG, Jones DT, Wan C, Cozzetto D, Fa R, Torres M, Warwick Vesztrocy A, Rodriguez JM, Tress ML, Frasca M, Notaro M, Grossi G, Petrini A, Re M, Valentini G, Mesiti M, Roche DB, Reeb J, Ritchie DW, Aridhi S, Alborzi SZ, Devignes MD, Koo DCE, Bonneau R, Gligorijevi\u0107 V, Barot M, Fang H, Toppo S, Lavezzo E, Falda M, Berselli M, Tosatto SCE, Carraro M, Piovesan D, Ur Rehman H, Mao Q, Zhang S, Vucetic S, Black GS, Jo D, Suh E, Dayton JB, Larsen DJ, Omdahl AR, McGuffin LJ, Brackenridge DA, Babbitt PC, Yunes JM, Fontana P, Zhang F, Zhu S, You R, Zhang Z, Dai S, Yao S, Tian W, Cao R, Chandler C, Amezola M, Johnson D, Chang JM, Liao WH, Liu YW, Pascarelli S, Frank Y, Hoehndorf R, Kulmanov M, Boudellioua I, Politano G, Di Carlo S, Benso A, Hakala K, Ginter F, Mehryary F, Kaewphan S, Bj\u00f6rne J, Moen H, Tolvanen MEE, Salakoski T, Kihara D, Jain A, \u0160muc T, Altenhoff A, Ben-Hur A, Rost B, Brenner SE, Orengo CA, Jeffery CJ, Bosco G, Hogan DA, Martin MJ, O\u2019Donovan C, Mooney SD, Greene CS, Radivojac P, Friedberg I. Genome Biol.<\/strong> 2019 Nov 19;20(1):244.<\/p>\n

Probabilistic variable-length segmentation of protein sequences for discriminative motif discovery (DiMotif) and sequence embedding (ProtVecX).<\/strong>\u00a0<\/a>Asgari E, McHardy AC, Mofrad MRK. Sci Rep.<\/strong> 2019 Mar 5;9(1):3577. doi: 10.1038\/s41598-019-38746-w. PMID: 30837494; PMCID: PMC6401088.<\/p>\n<\/div>

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Publications of the Project B2<\/h1><\/div>
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