{"id":22286,"date":"2022-04-26T14:36:55","date_gmt":"2022-04-26T12:36:55","guid":{"rendered":"https:\/\/www.resist-cluster.de\/?page_id=22286"},"modified":"2024-11-07T14:13:08","modified_gmt":"2024-11-07T13:13:08","slug":"prof-dr-anna-k-h-hirsch","status":"publish","type":"page","link":"https:\/\/www.resist-cluster.de\/en\/about-us\/research-team-2\/prof-dr-anna-k-h-hirsch\/","title":{"rendered":"Prof. Dr. Anna K. H. Hirsch"},"content":{"rendered":"

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Prof. Dr. Anna K. H. Hirsch participates in research project D1.<\/p>\n<\/div>

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<\/i><\/td>\nMy Research Interest in RESIST<\/td>\n<\/tr>\n<\/tbody>\n<\/table><\/h1><\/div>

As a part of the RESIST consortium, we will embark on the identification and multiparameter optimisation of inihibitors targeting DNA polymerase accessory proteins involved in replication of Kaposi\u2019s sarcoma-associated herpesvirus. This underexplored antiviral drug target holds the potential to deliver new therapeutic options for herpesviral disease.<\/p>\n

Our endeavour will rely on homology modeling and docking studies as well as ligand-based approaches. Biological studies in collaboration with the Schulz group as well as early in vitro profiling of pharmacological properties will guide the design and synthesis of optimized derivatives. A photo-cross-linking probe will enable target validation and would also reveal the exact binding site and thereby facilitate optimisation.<\/p>\n<\/div>

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Anna Hirsch about her scientific work<\/h1><\/div>