{"id":16792,"date":"2021-01-04T12:54:26","date_gmt":"2021-01-04T11:54:26","guid":{"rendered":"https:\/\/www.resist-cluster.de\/about-us\/research-team\/dr-faranaz-atschekzei\/"},"modified":"2022-01-29T08:22:56","modified_gmt":"2022-01-29T07:22:56","slug":"dr-faranaz-atschekzei","status":"publish","type":"page","link":"https:\/\/www.resist-cluster.de\/en\/about-us\/research-team-2\/dr-faranaz-atschekzei\/","title":{"rendered":"Dr. Faranaz Atschekzei"},"content":{"rendered":"

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Dr. Faranaz Atschekzei participates in RESIST research project A2.<\/p>\n<\/div>

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<\/i><\/td>\nMy Research Interest in RESIST<\/td>\n<\/tr>\n<\/tbody>\n<\/table><\/h1><\/div>

The primary antibody deficiency syndromes are a group of rare disorders characterized by an inability to produce clinically effective immunoglobulin responses. A number of risk factors have been proposed to have a role in the aetiology of antibody-deficiency. These include genetic susceptibility, defects in innate immunity, undefined environmental factors, and alterations in the microbiome. Recent genetic studies appear to explain only a minority of the risk associated with the development of antibody-deficiency. As epigenetic changes are dynamically responsive to the environment, they are likely to play a key role in the pathogenesis of antibody-deficiency. A better understanding of those factors could provide additional insight into the fundamental processes of disease pathogenesis, offering a better perspective towards patient counselling and precision medicine.\u00a0<\/span><\/p>\n

Our main objective in RESIST is to explore the complexities of primary antibody-deficiency by combining DNA sequencing with gene expression and methylation data to identify novel disease-associated pathways and therapeutic biomarkers.<\/p>\n<\/div>

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Dr. Atschekzei about her scientific work<\/h1><\/div>